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Synthesis of 2'-Fluoro-6'-Methylene-Carbocyclic Adenosine (FMCA) and 2'-Fluoro-6'Methylene-Carbocyclic Guanosine (FMCG)
Synthesis of 2'-Fluoro-6'-Methylene-Carbocyclic Adenosine (FMCA) and 2'-Fluoro-6'Methylene-Carbocyclic Guanosine (FMCG)
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机译:2'-氟-6'-亚甲基碳环腺苷(FMCA)和2'-氟-6'亚甲基-碳环鸟苷(FMCG)的合成
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摘要
The invention provides a new convergent approach for the synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) and 2′-fluoro-6′-methylene-carbocyclic guanosine (FMCG) from a readily available starting material in eight steps. An efficient and practical methodology for stereospecific preparation of a versatile carbocyclic key intermediate, (1S,3R, 4R)-3-tert-butoxy -4-(tert-butoxymethyl)-2-fluoro-5-methylenecyclopentanol (compound 8 of scheme 1A or a) in only six (6) steps is also provided. Prodrugs of these compounds are also prepared.
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