SYNTHESIS OF COMPACT LINEAR CONJUGATED GUANOSINES AND ADENOSINES USING SONOGASHIRA CROSS-COUPLING(Abstracts)

摘要

C-Modified nucleosides are used in numerous applications, particularly in pharmaceutical agents and biological probes. Covalently modified fluorescent nucleosides are valuable probes of DNA and RNA helix-to-coil transitions, DNA and RNA chain elongation, protein-nucleic acid complexes, mechano-chemical coupling in motor proteins, and cellular signal transduction pathways.