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DIHYDROQUINOXALINE BROMODOMAIN RECOGNITION PROTEIN INHIBITOR, PREPARATION METHOD AND USE THEREOF

机译:双羟基喹喔啉溴联蛋白识别蛋白抑制剂,制备方法及其用途

摘要

The present invention relates to dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof. The inhibitor of the present invention is compound represented by general formula (I), or stereoisomer, pharmaceutically acceptable salt, prodrug, solvate, hydrate and crystal form thereof. The definition of each substituent is as described in the description and claims. The compound represented by general formula (I) of the present invention may inhibit bromodomain recognition protein and may be used for preparing medicament which regulates the apparent state of cells and treats series of diseases and symptoms which are mediated by the bromodomain recognition protein.; embedded image
机译:本发明涉及二氢喹喔啉溴结构域识别蛋白抑制剂,其制备方法和用途。本发明的抑制剂是由通式(I)表示的化合物或其立体异构体,药学上可接受的盐,前药,溶剂化物,水合物和晶体形式。每个取代基的定义如说明书和权利要求书中所述。本发明的通式(I)表示的化合物可以抑制溴结构域识别蛋白,并且可以用于制备调节细胞表观状态并治疗由溴结构域识别蛋白介导的一系列疾病和症状的药物。 “嵌入式图像”

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