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7-azaindole derivatives as selective type-11-beta-hydroxysteroid dehydrogenase inhibitors

机译:7-氮杂吲哚衍生物作为选择性的11-β-羟基类固醇脱氢酶抑制剂

摘要

7-azaindole derivatives as selective type-11-beta-hydroxysteroid dehydrogenase inhibitors the present invention relates to 7-azaindole derivatives of formula (i) as selective inhibitors of the type 11-beta-hydroxysteroid dehydrogenase (11beta- hsd-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions .
机译:7-氮杂吲哚衍生物作为选择性的11-β-羟基类固醇脱氢酶抑制剂本发明涉及式(i)的7-氮杂吲哚衍生物作为对11-β-羟基类固醇脱氢酶(11β-hsd-1)的选择性抑制剂。此类化合物用于治疗和预防代谢综合征,糖尿病,胰岛素抵抗,肥胖症,脂质疾病,青光眼,骨质疏松症,认知障碍,焦虑症,抑郁症,免疫疾病,高血压和其他疾病和病症的用途。

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