The present invention relates to isolated anti-thrombin antibodies that recognize the exosite 1 epitope of thrombin and selectively inhibit thrombin without promoting bleeding. These anti-thrombin antibody molecules may be useful for treating or inhibiting thrombotic and/or embolic disorders and other conditions mediated by thrombin. In particular, the present invention relates to use of the anti-thrombin antibody molecules in patients at risk for gastrointestinal (GI) bleeding.
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