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PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND/OR SMARCA4

机译:降解SMARCA2和/或SMARCA4的蛋白水解目标化学(PROTACS)

摘要

The present invention encompasses compounds of formula (I) wherein the groups R1,A, G, LK and t have the meanings given in the claims and specification, their use as degraders of SMARCA2 and/or SMARCA4, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
机译:本发明包括式(I)的化合物,其中基团R 1 ,A,G,LK和t具有权利要求和说明书中给出的含义,它们用作SMARCA2和/或SMARCA4的降解剂。包含此类化合物的药物组合物及其作为药物/医学用途的用途,尤其是作为治疗和/或预防肿瘤疾病的药物。

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