首页> 外国专利> FBLN5 GENE-DEFICIENT ANIMAL MODEL, AND METHOD FOR SCREENING NERVE OR MUSCLE DISORDER THERAPEUTIC AGENTS USING SAME

FBLN5 GENE-DEFICIENT ANIMAL MODEL, AND METHOD FOR SCREENING NERVE OR MUSCLE DISORDER THERAPEUTIC AGENTS USING SAME

机译：FBLN5基因缺陷动物模型，以及使用相同方法筛选神经或肌肉疾病治疗剂的方法

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摘要

The present invention pertains to: an Fbln5 (Fibulin-5) gene-deficient animal model; a method for screening nerve or muscle disorder therapeutic agents using the animal model; and a pharmaceutical composition containing a nerve or muscle disorder therapeutic agent screened using the method. When the animal model of the present invention is used, demyelinating disease therapeutic agents having good efficacy and few side-effects can be effectively screened, and drug candidate materials can be easily and quickly tested for in vivo side-effects due to the toxicity thereof. Moreover, substances screened by Fbln5 proteins and the zebrafish model of the present invention can be usefully used to alleviate, treat, or prevent nerve or muscle disorders.

机译：本发明涉及： Fbln5 （Fibulin-5）基因缺陷的动物模型;使用该动物模型筛选神经或肌肉疾病治疗剂的方法;药物组合物，其包含使用该方法筛选的神经或肌肉疾病治疗剂。当使用本发明的动物模型时，可以有效地筛选具有良好功效并且副作用很少的脱髓鞘疾病治疗剂，并且由于其毒性，可以容易且快速地测试候选药物材料的体内副作用。而且，由Fbln5蛋白和本发明的斑马鱼模型筛选的物质可有效地用于减轻，治疗或预防神经或肌肉疾病。 展开▼

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公开/公告号WO2020091235A1

专利类型

公开/公告日2020-05-07

原文格式PDF

申请/专利权人 SAMSUNG LIFE PUBLIC WELFARE FOUNDATION;RESEARCH BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY;
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申请/专利号WO2019KR12636

发明设计人 LEE JI EUN;CHANG JONG WOOK;WON SO YEON;
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申请日2019-09-27

分类号A01K67/027;C07K14/46;G01N33/50;

国家 WO

入库时间 2022-08-21 11:11:19

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