The present invention relates to Non-lnvasive Prenatal Screening (NIPS). Particularly, the present invention relates to methods for determining the uncertainty of the degree of placental mosaicisms in a sample obtained from a pregnant subject. In accordance with the present invention, the related width of the monosomic, trisomic, and tetrasomic mosaicism intervals are used for determining the degree of monosomic, trisomic, and tetrasomic (placental) mosaicism. The present invention further relates to methods for determining whether or not a sample qualifies for determination of the degree of placental mosaicism within the read-counting approach to NIPS.
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