METHODS AND COMPOSITIONS FOR INHIBITING PERIOSTIN-MEDIATED METASTATIC RENAL CELL CARCINOMA

摘要

Methods and pharmaceutical compositions for inhibiting metastasis of renal cell carcinoma (RCC) in a subject having RCC comprising reducing presence or biological activity of periostin. Methods for treating or preventing metastasis in a subject having RCC comprising administering to a primary RCC tumor site an anti-periostin (POSTN) monoclonal antibody and genetically modifying RCC tumor cells to delete the POSTN gene in RCC tumor cells.