Compositions and Methods to Inhibit Estrogen Receptor Beta for the Treatment of Renal Cell Carcinoma

摘要

The invention provides compositions and methods for treating and preventing cancer. The invention relates to compositions and methods for treating subjects having a cancer associated with overexpression of estrogen receptors, especially in males. The invention comprises inhibitors of ERβ, inhibitors of TGFβ-1, inhibitors of SMAD, or inhibitors of HIF, or a combination thereof. In one embodiment, the invention provides a method of treating renal cancer, including renal cell carcinoma.