Monoolein Cubic Phase Containing Hydrophobically Modified Gelatin Hydrophobically Modified Polyethylenimine And Hydrophobically Modified Glucose Oxidase

摘要

The present invention forms a complex in the water channel with the hydrophobic gelatin and the hydrophobized polyethyleneimine fixed to the lipid bilayer to close the water channel, and then dissolve the complex in an environment where the pH in the water channel is lowered to dissolve the water channel. Since it is open, it is characterized in that the active ingredient mounted on the water channel is released. In particular, the monoolein cubic phase of the present invention has a characteristic of detecting glucose and opening a water channel by including a hydrophobicized glucose oxidase, and its size is less than 100 nm, so it has an effect of easily penetrating the skin. Therefore, when manufacturing cosmetics or the like using the monoolein of the present invention, it penetrates deep into the skin or tissue, and has the effect of releasing the active ingredient mounted inside the water channel only in an environment where glucose is present.