-tRNA N- Antibody specifically binding to the N-terminal region of lysyl-tRNA synthetase exposed at cell outer membrane

摘要

The present invention relates to an antibody that specifically binds to the N-terminal region of a lysyl-tRNA synthetase exposed to the outer cell membrane and the use thereof, and more specifically, a specific CDR (complementarity determining region) sequence described herein. An antibody or fragment thereof having a lysyl-tRNA synthetase (KRS, Lysyl-tRNA synthetase) N-terminal specifically binding to an epitope comprising the sequence of SEQ ID NO: 97, and cancer metastasis of the antibody or fragment It is for suppression purpose and cancer diagnosis use. Since the antibody or fragments according to the present invention have a very good specific binding ability to the KRS N-terminal region exposed to the outer membrane, a disease known as a disease (eg, cancer) accompanying the specific behavior of KRS Available for diagnosis. In addition, since it is specifically targeted to the KRS N-terminal region in vivo, it can be used as a therapeutic agent because it has an excellent effect of inhibiting cancer metastasis by inhibiting the interaction between the laminin receptor and the KRS N-terminal region, so it can be used as a therapeutic agent, making it industrially applicable Big.