-tRNA N- Antibody specifically binding to the N-terminal region of lysyl- tRNA synthetase exposed at cell outer membrane

摘要

The present invention relates to an antibody that specifically binds to the N-terminal region of lysyl-tRNA synthetase exposed to the outer cell membrane, and more particularly, the outer cell membrane having a specific CDR (complementarity determining region) sequence described herein. Lysyl-tRNA synthetase (KRS, Lysyl-tRNA synthetase) N-terminal region exposed to an antibody or fragment thereof and a composition comprising the antibody or fragment as an active ingredient Cancer, cancer metastasis or It relates to the use of prevention, treatment or diagnosis of diseases related to immune cell migration. The method of the present invention can be usefully used to prepare an antibody having a higher affinity for the KRS N-terminus than a conventional antibody.