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Method for Manufacturing Nanosuspension Comprising Insoluble Drug Using Bottom-up Method and Nanosuspension Made thereby

机译:自底向上法制造包含不溶性药物的纳米悬浮液的方法及其制得的纳米悬浮液

摘要

The present invention relates to a method for preparing a nanosuspension comprising the step of dissolving a poorly soluble drug in a solvent, Transcutol, and a nanosuspension of a poorly soluble drug prepared therefrom, and has a low toxicity instead of a conventional organic solvent and By using the applicable Transcutol, it is possible to prepare a nano suspension without additionally removing the solvent, and the average diameter of the particle size of the nanosuspension is less than 300 nm, so long-term storage for more than 6 months is possible. It can be used usefully as a product.
机译:本发明涉及一种制备纳米悬浮液的方法,该方法包括以下步骤:将难溶性药物溶解在溶剂Transcutol中,以及由其制备的难溶性药物的纳米悬浮液,其具有低毒性,而不是常规的有机溶剂和溶剂。使用适用的Transcutol,可以制备纳米悬浮液而无需另外去除溶剂,并且纳米悬浮液的平均粒径小于300 nm,因此可以长期保存6个月以上。它可以有效地用作产品。

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