METHOD FOR CHANGING THE FUNCTIONAL STATE OF MRNA, WHICH ENABLES SELECTIVE AND SPECIFIC IDENTIFICATION THEREOF

摘要

FIELD: medicine.;SUBSTANCE: disclosed is a nucleic acid target sequence binding structure comprising two complementary oligonucleotide sequences up to 20 nucleotides long, distant from each other by means of polymer binder fragment, final length of which is from 10 to 100 angstroms based on distance between nucleotides in linear, completely elongated nucleic acid. Disclosed is a tumor targeting solution containing said construct. Disclosed is a method of binding a structure to a target nucleic acid target, which provides selective recognition of a target nucleic acid, involving contacting a target nucleic acid with a heteroduplex formation construct. Disclosed is a method of treating a patient suffering from cancer and a method for diagnosing cancer.;EFFECT: proposed group of inventions provides formation of stable heteroduplex and selective recognition of nucleic acid.;30 cl, 2 dwg, 11 ex