POLYPEPTIDE COMPOSITION HAVING PROPERTY OF NORMALIZING CEREBRAL FUNCTIONS

摘要

FIELD: medicine.;SUBSTANCE: group of inventions relates to biology and medicine and concerns a novel composition of polypeptides recovered from bovine cerebrum cortex extract, a pharmaceutical composition based on said polypeptides and use thereof. Presented composition has nootropic, neuroprotective, antioxidant, tissue-specific action and is characterized by the following indices: molecular weight of polypeptides is approximately 1800–3510 Da; amount of bound amino acids is: arginine - 35 to 94 mcg/mg, glycine - 30 to 68 mcg/mg, asparagine - 26 to 83 mcg/mg and glutamine - 29 to 92 mcg/mg of dry residue composition; number of additional bound amino acids is as follows: lanine - from 34 to 65 mcg/mg, proline - from 24 to 65 mcg/mg, lysine - from 24 to 63 mcg/mg, leucine - from 25 to 76 mcg/mg, tyrosine - from 15 to 42 mcg/mg, phenylalanine - 18 to 44 mcg/mg, valine - 11 to 58 mcg/mg, isoleucine - 12 to 44 mcg/mg of the dry residue of the composition. Disclosed also is a pharmaceutical composition for normalizing cerebral function, comprising said polypeptide composition and a pharmaceutically acceptable carrier, as well as use of said compositions for relieving convulsive syndrome, recovering disturbed cerebral reflex activity, memory, coordination of movements, stroke, cerebral effusions or as neuroprotector.;EFFECT: composition of polypeptides has the properties of normalizing cerebral function, and has less side effects compared to the prototype when used.;11 cl, 12 tbl, 9 ex, 8 dwg