DIACEREIN OR ANALOGUES THEREOF FOR INHIBITING ASC EXPRESSION, NLRP3 EXPRESSION AND/OR COMPLEXING OF NLRP3 INFLAMMASOMES

摘要

FIELD: medicine.;SUBSTANCE: invention refers to treatment and/or prevention of the disease of the object in need thereof, wherein the disease is selected from a group comprising uveitis and epidermolytic ichthyosis (EI). For this purpose, the treatment and/or prevention of the disease involves administering to the said object a therapeutically effective amount of a compound selected from a group, consisting of diacerein, rhein, monoacetyl rhein and therapeutically acceptable salts and esters.;EFFECT: invention provides suppressing the expression of ASC and NLRP3, thereby inhibiting formation of an assembly of ASC-spots and the NLRP3 complex inflammasomes.;3 cl, 1 ex, 3 dwg