HUMAN MONOCLONAL ANTIBODIES TO THE PROTEIN OF PROGRAMMED DEATH 1 (PD-1) AND METHODS OF TREATING CANCER USING ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTIC AGENTS

摘要

FIELD: biotechnology.;SUBSTANCE: described is a method of treating an infectious disease in a subject, a method for modifying an immune response to an infectious agent in a subject and a method of activating T-cell responses to an infectious agent in a subject. Above methods are implemented with participation of an antibody or its antigen-binding part containing: Heavy chain CDR1 containing amino acids, having sequence given in SEQ ID NO: 15–21; CDR2 heavy chain containing amino acids having a sequence given in SEQ ID NO: 22–28; CDR3 heavy chain containing amino acids, having sequence given in SEQ ID NO: 29–35; CDR1 light chain containing amino acids having the sequence given in SEQ ID NO: 36–42; Light chain CDR2 containing amino acids, having sequence given in SEQ ID NO: 43–49; and light chain CDR3 containing amino acids having the sequence given in SEQ ID NO: 50–56.;EFFECT: invention extends the range of products for treating infectious diseases.;19 cl, 54 dwg, 7 tbl, 24 ex