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一种金介导的近红外光热效应与自噬抑制剂联合杀伤肿瘤细胞的方法

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摘要

本发明提供一种金介导的近红外光热效应与自噬抑制剂联合杀伤肿瘤细胞的方法，与现有技术相比，本发明中自噬抑制剂的引入，可以降低金纳米颗粒的用量，使用较低剂量的激光即可获得良好的肿瘤细胞杀伤效果，从而降低激光和金纳米颗粒对正常细胞组织造成危害的风险。

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公开/公告号CN104353074B

专利类型发明专利
公开/公告日2017-11-07

原文格式PDF
申请/专利权人中国科学技术大学;
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申请/专利号CN201410545330.9
发明设计人温龙平;魏鹏飞;张强;周伟;张云娇;梁朝朝;张力;石闪闪;
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申请日2014-10-15
分类号A61K41/00(20060101);A61K47/04(20060101);A61K47/02(20060101);A61K47/34(20170101);A61P35/00(20060101);
代理机构11021 中科专利商标代理有限责任公司;
代理人王旭
地址 230026 安徽省合肥市包河区金寨路96号
入库时间 2022-08-23 10:02:57

法律信息

法律状态公告日

法律状态信息

法律状态
2017-11-07

授权

授权
2015-03-25

实质审查的生效 IPC(主分类):A61K 41/00 申请日:20141015

实质审查的生效
2015-03-25

实质审查的生效 IPC(主分类):A61K 41/00 申请日:20141015

实质审查的生效
2015-02-18

公开

公开
2015-02-18

公开

公开

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1. 一种金介导的近红外光热效应与自噬抑制剂联合杀伤肿瘤细胞的方法 [P] . 中国专利： CN104353074B . 2017.11.07
2. 铜钯合金纳米颗粒和自噬抑制剂在制备基于光热效应杀伤肿瘤的药物或试剂盒中的应用 [P] . 中国专利： CN110893237B . 2020.12.22
3. use of a compound selected from the group consisting of a proteasome inhibitor, an autophagy inhibitor, a lysosomal inhibitor, an golgi er protein transport inhibitor, an hsp90 chaperonin inhibitor, a heat shock response activator, a and a histone deacetylase inhibitor, use of 11-cis-retinal or 9-cis-retinal and a compound selected from the group consisting of a proteasome inhibitor, an autophagy inhibitor, a lissosomal inhibitor, a er to golgi protein, a hsp90 chaperonin inhibitor, a heat shock response activator, a glycosidase inhibitor, and a histone deacetylase inhibitor, a method for increasing the amount of a biochemically functional conformation of a protein in a cell, composition pharmaceutical for the treatment of an ocular pcd, pharmaceutical composition for the treatment of retinitis pigmentosa, kit for the treatment of an ocular pcd, kit for the treatment retinitis pigmentosa, method for identifying a compound useful for the treatment of an individual having an ocular pcd, [P] . BRPI0615962A2 . 2011-05-31

机译：使用选自以下的化合物：蛋白酶体抑制剂，自噬抑制剂，溶酶体抑制剂，高尔基体蛋白转运抑制剂，hsp90伴侣蛋白抑制剂，热休克反应激活剂，α和组蛋白脱乙酰酶抑制剂，使用11 -顺式-视黄醛或9-顺式-视黄醛以及选自蛋白酶体抑制剂，自噬抑制剂，核糖体抑制剂，高尔基体蛋白er，hsp90伴侣蛋白抑制剂，热休克反应激活剂，糖苷酶的化合物抑制剂和组蛋白脱乙酰基酶抑制剂，一种增加细胞中蛋白质的生化功能构象量的方法，用于治疗眼pcd的组合物药物，用于治疗色素性视网膜炎的药物组合物，用于治疗视网膜色素变性的试剂盒眼用pcd，用于治疗色素性视网膜炎的试剂盒，用于鉴定可用于治疗具有眼用pcd的个体的化合物的方法，
4. methods of modulating autophagy, treating or reducing the likelihood of onset of an autophagy-mediated condition, treating, inhibiting, reducing, decreasing, or preventing an age-related disorder, modulating the expression or activity of at least one factor transcription, treatment, prevention, reduction, inhibition or reduction of a pathological condition attributable to a state of nutrient excess, promoting longevity by modulating autophagy, increasing the length of time a mammal can lead a lifestyle active without suffering from conditions associated with aging and extending the health of a mammal. [P] . BR112018014920A2 . 2018-12-18

机译：调节自噬，治疗或减少自噬介导的疾病发作的可能性，治疗，抑制，减少，减少或预防与年龄有关的疾病，调节至少一种因子的表达或活性的方法，转录，治疗，预防，减少，抑制或减轻由于营养过剩状态引起的病理状况，通过调节自噬促进寿命，增加哺乳动物在不遭受与衰老相关的状况并延长哺乳动物健康的情况下可以过着积极的生活方式的时间。
5. A method of identifying a molecule and a protein involved in lipid regulation, testing a substance as a therapeutic agent for modulating lipid levels, treating lipid-mediated disorders and a patient suffering from a lipid-mediated condition, lipid levels in a host, to treat or prevent a lipid-mediated disorder, to treat or prevent atherosclerosis or a condition associated with atherosclerosis, to screen for diagnosis of a genetic predisposition to atherosclerosis or a condition associated with atherosclerosis or a lipid-mediated disorder, expressing hbm protein in tissue and modulating lipid levels in a patient, diagnostic assay to determine a predisposition to a lipid-mediated disorder, composition for treating a lipid-mediated condition, and, Combination therapy to treat a patient suffering from a disease or lipid-mediated condition [P] . BR0111057A . 2003-04-15

机译：一种鉴定参与脂质调节的分子和蛋白质的方法，测试一种物质作为调节脂质水平的治疗剂，治疗脂质介导的疾病和患有脂质介导的疾病的患者，治疗宿主的脂质水平或预防脂质介导的疾病，治疗或预防动脉粥样硬化或与动脉粥样硬化有关的疾病，筛选诊断动脉粥样硬化的遗传易感性或与动脉粥样硬化或脂质介导的疾病有关的疾病，在组织中表达hbm蛋白并调节患者中的脂质水平，确定脂质介导疾病易感性的诊断测定法，用于治疗脂质介导疾病的组合物以及用于治疗患有疾病或脂质介导疾病的患者的联合疗法