methods of modulating autophagy, treating or reducing the likelihood of onset of an autophagy-mediated condition, treating, inhibiting, reducing, decreasing, or preventing an age-related disorder, modulating the expression or activity of at least one factor transcription, treatment, prevention, reduction, inhibition or reduction of a pathological condition attributable to a state of nutrient excess, promoting longevity by modulating autophagy, increasing the length of time a mammal can lead a lifestyle active without suffering from conditions associated with aging and extending the health of a mammal.

摘要

the present invention provides a composition comprising hmb. Methods for administering hmb to an animal are also described. hmb is administered to modulate autophagy and lipophagy. hmb is also administered to treat, prevent, inhibit, decrease or reduce autophagy mediated conditions or diseases.