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一种人中期因子抑制肽及其应用

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摘要

本发明提供一种具有抗血管新生作用的，其氨基酸序列为：GPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQ。本发明申请提供了特异性抑制细胞内中期因子和颗粒蛋白前体相互作用的抑制肽，以及该肽在治疗和预防肿瘤血管新生中的作用，为制备特异性抑制由中期因子引起的肿瘤血管新生药物提供了基础。

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公开/公告号CN102558330B

专利类型发明专利
公开/公告日2016-03-30

原文格式PDF
申请/专利权人湖州市中心医院;
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申请/专利号CN201010620365.6
发明设计人戴利成;姚行;黄惠莲;
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申请日2010-12-31
分类号C07K14/435(20060101);C12N15/12(20060101);A61K38/17(20060101);A61P35/02(20060101);
代理机构33100 浙江杭州金通专利事务所有限公司;
代理人徐关寿
地址 313000 浙江省湖州市红旗路198号
入库时间 2022-08-23 09:37:06

法律信息

法律状态公告日

法律状态信息

法律状态
2016-03-30

授权

授权
2014-02-05

实质审查的生效 IPC(主分类):C07K14/435 申请日:20101231

实质审查的生效
2012-07-11

公开

公开

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1. 一种人中期因子抑制肽及其应用 [P] . 中国专利： CN102558330B . 2016.03.30
2. 一种人中期因子蛋白封闭肽在制备抗肿瘤药物中的应用 [P] . 中国专利： CN101255190B . 2010.07.14
3. PEPTIDE, PEGUILLED PEPTIDE, COMPOSITION, PHARMACEUTICAL COMPOSITION, BOTTLE, DISINFECTION SOLUTION, METHOD FOR GROWTH INHIBITION, REPLICATION OR INFECTIVITY OF A MICRO-ORGANISM, METHOD FOR INHIBITION OF A BACTERIAL GROWTH, BACTERIAL GROWTH INHIBITION, TREATMENT OF A MICRO-ORGANISM INFECTION IN A SUBJECT AND PREVENTION OF A DISEASE IN A SUBJECT CAUSED BY OR ASSOCIATED WITH A MICRO-ORGANISM INFECTION, METHOD FOR INHIBITING BACTERIAL GROWTH IN A SUBJECT, A METHOD OF TREATMENT OF A BACTERIAL TREATMENT SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION, METHOD FOR PREVENTING A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION IN A SUBJECT, METHOD FOR INHIBITION OF VIRAL REPLICATION IN A SUBJECT TO A SUBJECT TO A SUBJECT ON A SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR THE PREVENTION OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR DISINFECTING AN INA [P] . BR112017028190A2 . 2018-09-04

机译：肽，规定的肽，成分，药物成分，瓶，消毒溶液，微生物的生长抑制，复制或感染的方法，细菌生长的抑制方法，细菌生长的抑制作用，治疗由微生物感染引起或与之有关的疾病的预防，疾病的抑制方法，一种细菌治疗方法的治疗和一种或多种细菌引起的疾病的治疗感染，预防由细菌感染引起的疾病或与之相关的疾病的方法，在受试者体内抑制病毒复制的方法以及对由细菌引起或与之相关的疾病的治疗在主题中，一种预防由对象中的病毒感染引起或与之相关的疾病的方法，一种用于对INA进行消毒的方法
4. A process for isolating and purifying vasopeptidase-inhibiting peptides with specificity for the angiotensin-converting enzyme carboxylic site secreted by snake venom glands (bpps), particularly jararaca bothrops, or endogenously produced (evasins) having vasodilatory and anti- hypertensive; process of determining the starch sequence of inhibitor peptides secreted by the snake venom (bpps) or endogenous (evasin) venom; The process of determining the amino acid sequence of bpps by deducting the cdna from precursors of these molecules expressed in snake tissues, specifically bothrops jararaca. process of determining the amino acid sequence of evasins by deducing cdna from precursors of these molecules expressed in snake tissues, specifically bothrops jararaca, process of amplifying cdna from pancreatic and / or snake brain cdna libraries, specifically bothrops jararaca ; solid phase synthesis process of vasopeptidase inhibiting peptides with vasodilating and antihypertensive action, vaso [P] . BR0101088A . 2003-03-18

机译：一种分离和纯化具有对蛇毒腺（bpps），特别是贾拉卡双峰植物分泌的或具有血管扩张和抗高血压作用的内源性（evasins）分泌的血管紧张素转化酶羧基位点具有特异性的血管肽酶抑制肽的方法;确定蛇毒（bpps）或内源性（evasin）毒液分泌的抑制剂肽的淀粉序列的过程;通过从蛇组织中表达的这些分子的前体中减去cdna来确定bpps氨基酸序列的过程，尤其是杂种植物。通过从在蛇组织中表达的这些分子的前体推导cdna来确定evasins氨基酸序列的过程，特别是在蛇和蛇脑cdna文库中扩增cdna的过程，尤其是在蛇和草cdna文库中;血管肽酶抑制肽具有血管舒张和降压作用的固相合成方法
5. Method for detecting and, if necessary, quantifying the activity of at least one protease inhibitor in a mixture to be analysed, and also application of the method for determining the (residual) activity of one (or more) separate (iso)type(s) of protease inhibitor(s) and application of the method for determining the total (residual) activity of a mixture, possibly after a processing process such as a process for the removal or inactivation of protease inhibitor(s). [P] . NL9301134A . 1995-01-16

机译：检测并在必要时定量待分析混合物中至少一种蛋白酶抑制剂活性的方法，以及该方法在确定一种（或多种）单独（同）型（残余）活性（残留）活性中的应用（一种或多种）蛋白酶抑制剂和确定混合物的总（残余）活性的方法的应用，可能在诸如蛋白酶抑制剂的去除或失活过程等加工过程之后。