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Glucagon-like peptide-1 (GLP-1) and liraglutide, a synthetic GLP-1 analog, inhibit inflammation in human aortic endothelial cells via calcium and AMPK dependent mechanisms

机译：胰高血糖素样肽-1（GLP-1）和Liraglutide，一种合成GLP-1模拟，通过钙和AMPK依赖机制抑制人主动脉内皮细胞中的炎症

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作者
Krasner, Nadia Marie;
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作者单位

Boston University;

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授予单位 Boston University;
学科
学位 Ph.D.
年度 2014
页码 168 p.
总页数 168
原文格式 PDF
正文语种 eng
中图分类 AAI3627482;
关键词
Atherosclerosis; Endothelial cell; Glucagon-like peptide-1; Incretin; Inflammation; Liraglutide;

机译：动脉粥样硬化;内皮细胞;胰高血糖素肽-1;Incetin;炎;Liraglutide.;

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专利

1. The once-daily human glucagon-like peptide-1 (GLP-1) analog liraglutide improves postprandial glucose levels in type 2 diabetes patients. [J] . Flint A, Kapitza C, Hindsberger C, Advances in therapy. . 2011,第3期

机译：每天一次的人胰高血糖素样肽1（GLP-1）类似物利拉鲁肽可改善2型糖尿病患者的餐后血糖水平。
2. The once-daily human glucagon-like peptide-1 (GLP-1) analog liraglutide improves postprandial glucose levels in type 2 diabetes patients [J] . Anne Flint, Christoph Kapitza, Charlotte Hindsberger, Advances in Therapy . 2011,第3期

机译：每日一次的人胰高血糖素样肽1（GLP-1）类似物利拉鲁肽可改善2型糖尿病患者的餐后血糖水平
3. A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells [J] . Y. Hattori, T. Jojima, A. Tomizawa, Diabetologia . 2010,第10期

机译：一种胰高血糖素样肽-1（GLP-1）类似物利拉鲁肽，可上调一氧化氮的产生并在内皮细胞中发挥抗炎作用
4. Human glucagon-like peptide-1 amide (hGLP-1(7-36)NH_2) is cleaved by plasma enzymes not only the N-terminus but also at the C-terminus-development of novel GLP-1 analogs which are highly resistant to enzymatic degradation [C] . Jesse Z.Dong, Jundong Zhang, Xiaojun Zou, European Peptide Symposium . 2002

机译：人胰高血糖素样肽-1酰胺（HGLP-1（7-36）NH_2）由血浆酶切割不仅是N-末端，而且还在具有高度抗性的新型GLP-1类似物的C-末端开发中酶促劣化
5. Sodium salicylate prevents inflammation-associated decreases in phosphorylated-enosser1177 in human aortic endothelial cells through an AMPK-dependent mechanism. [D] . Siefers, Kyle John. 2014

机译：水杨酸钠通过AMPK依赖性机制防止人主动脉内皮细胞中与炎症相关的磷酸化-enosser1177减少。
6. Glucagon-Like Peptide-1 (GLP-1) Analog Liraglutide Inhibits Endothelial Cell Inflammation through a Calcium and AMPK Dependent Mechanism [O] . Nadia M. Krasner, Yasuo Ido, Neil B. Ruderman, -1

机译：胰高血糖素样肽1（GLP-1）类似物利拉鲁肽通过钙和AMPK依赖性机制抑制内皮细胞炎症
7. Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism. [O] . Nadia M Krasner, Yasuo Ido, Neil B Ruderman, 2014

机译：胰高血糖素样肽-1（GLp-1）类似物利拉鲁肽通过钙和ampK依赖性机制抑制内皮细胞炎症。

Glucagon-like peptide-1 (GLP-1) and liraglutide, a synthetic GLP-1 analog, inhibit inflammation in human aortic endothelial cells via calcium and AMPK dependent mechanisms

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