首页> 中国专利> 一种表达TgMIF蛋白的巨噬细胞在制备治疗肝纤维化药物中的应用

一种表达TgMIF蛋白的巨噬细胞在制备治疗肝纤维化药物中的应用

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摘要

本发明公开表达TgMIF蛋白的巨噬细胞在制备治疗肝纤维化药物中的应用，涉及肝纤维化技术领域，所述TgMIF蛋白的氨基酸序列如SEQ ID NO.1所示。本发明的有益效果在于：本发明中的TgMIF蛋白能够持续定向诱导巨噬细胞向M1偏移活化，并高表达溶解胶原的MMP9蛋白，通过缩小肝纤维化肝脏体积，减少表面颗粒度，从而为治疗肝纤维化提供精准有效的细胞治疗方法。

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公开/公告号CN113876809A

专利类型发明专利
公开/公告日2022-01-04

原文格式PDF
申请/专利权人安徽医科大学;
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申请/专利号CN202111262405.9
发明设计人都建;陈滢;陈立建;王杰;周南;安然;蔡海建;
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申请日2021-10-28
分类号A61K35/15(20150101);A61K48/00(20060101);A61P1/16(20060101);C12N15/867(20060101);C12N15/12(20060101);C12N5/10(20060101);
代理机构34124 合肥市浩智运专利代理事务所(普通合伙);
代理人缪璐欢
地址 230000 安徽省合肥市蜀山区梅山路81号
入库时间 2023-06-19 13:33:57

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1. 一种表达TgMIF蛋白的巨噬细胞在制备治疗肝纤维化药物中的应用 [P] . 中国专利： CN113876809A . 2022-01-04
2. 巨噬细胞β-抑制蛋白-1在制备预防或治疗动脉粥样硬化药物中的应用 [P] . 中国专利： CN105561297A . 2016-05-11
3. Method of inhibiting the occurrence of one or more of the following conditions: monocyte / macrophage proliferation; or the proliferation of smooth muscle cells; or the expression of cd36 receptors; or the absorption of low-density lipoprotein - oxidized ldl, method of relief of symptoms of treatment or prevention of atherosclerosis; diabetes; alzheimer's disease, method of inhibiting the occurrence of plaque formation in the vascular system, method of relieving inflammation associated with the occurrence of one or more of the following conditions: the proliferation of monocytes, the proliferation of smooth muscle cells, the expression oxidized ldl or decontaminating receptor, pharmaceutical composition, use of an effective amount of one or more derivatives or phosphate of one or more electron transfer agents together with a suitable vehicle or diluent, use of an effective amount of one or more (alpha) -tocopherol phosphate derivatives together with an appropriate vehicle or diluent an [P] . BRPI0406484A . 2005-12-06

机译：抑制下列一种或多种状况发生的方法：单核细胞/巨噬细胞增殖;或平滑肌细胞的增殖;或cd36受体的表达;或低密度脂蛋白-氧化低密度脂蛋白的吸收，缓解或治疗动脉粥样硬化症状的方法;糖尿病;阿尔茨海默氏病，抑制血管系统中斑块形成的方法，缓解与以下一种或多种状况有关的炎症的方法：单核细胞的增殖，平滑肌细胞的增殖，氧化的ldl或去污受体，药物组合物，有效量的一种或多种衍生物或一种或多种电子转移剂的磷酸盐与合适的媒介物或稀释剂一起使用，有效量的一种或多种α-生育酚磷酸酯衍生物一起使用用适当的媒介物或稀释剂
4. Pharmaceutical composition for epithelial wound prevention and treatment, immunoregulatory pharmaceutical composition, pharmaceutical composition, insecticide, insecticide composition, use of insecticide of lectin KM + in the treatment of scarring, use of lectin KM + in preparation of immunoregulatory drug , Use of lectin KM + in formulating antibacterial drugs, use of lectin KM + in formulating antiviral drugs, use of lectin KM + in formulating antifungal drugs, use of lectin KM + in formulating antiparasitic drugs, expression methods, DNA vectors, recombinant organisms , Nucleotide sequences, antibodies, proteins and extranuclear genes [P] . 日本专利： JP2007528869A . 2007-10-18

机译：用于上皮伤口预防和治疗的药物组合物，免疫调节药物组合物，药物组合物，杀虫剂，杀虫剂组合物，凝集素KM +杀虫剂在瘢痕形成中的用途，凝集素KM +在制备免疫调节药物中的用途，凝集素KM +的用途在制备抗菌药物中，凝集素KM +在抗病毒药中的应用，凝集素KM +在抗真菌药中的应用，凝集素KM +在抗寄生虫药中的应用，表达方法，DNA载体，重组生物，核苷酸序列，抗体，蛋白质和核外基因
5. methods for screening for a therapeutic agent, for suppressing the polynucleotide sequence, for treating a non-steroidal cancer, for screening for binding of an agent specifically to a polynucleotide, and for determining whether a patient is at risk for developing or having a non-steroidal cancer, pharmaceutical composition, uses of a therapeutic agent, an antisense molecule or a cell that expresses and / or contains the antisense molecule, at least one of the immunogenic membrane proteins, fragments, derivatives or homologues thereof or from a cell containing and / or expressing at least one of the immunogenic membrane proteins or fragments, derivatives or homologues thereof and an agent or antibody, agent, and kit for identifying a patient at risk of developing or have non-steroidal cancer [P] . BRPI0414446A . 2006-11-14

机译：筛选治疗剂，抑制多核苷酸序列，治疗非甾体类癌症，筛选试剂特异性结合多核苷酸的方法以及确定患者是否处于发展或患有非糖尿病风险的方法类固醇癌，药物组合物，表达和/或含有反义分子的治疗剂，反义分子或细胞，免疫原性膜蛋白，其片段，衍生物或同源物中至少一种或来自含有和/或含有细胞的细胞的用途或表达至少一种免疫原性膜蛋白或其片段，衍生物或同系物以及一种试剂或抗体，试剂和试剂盒，用于鉴定有发生或患有非甾体癌风险的患者