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GSK872在制备治疗肠道病毒71型感染导致的疾病的药物中的用途

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摘要

本发明公开了GSK872在制备治疗肠道病毒71型感染导致的疾病的药物中的用途，涉及制药领域。GSK872是蛋白激酶3抑制剂中的一种，本发明首次通过实验验证了蛋白激酶3抑制剂GSK872能够有效抑制肠道病毒71型引起的细胞病变，并结合Vero细胞存活实验，得到了可用于治疗肠道病毒71型感染导致的婴幼儿手足口病的GSK872的安全剂量，为进一步开发治疗婴幼儿手足口病药物提供了指导，同时，该化合物可接受进一步开发为治疗手足口病的药物，剂型和给药方式多样化，具有广泛的应用前景。

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公开/公告号CN113616654A

专利类型发明专利
公开/公告日2021-11-09

原文格式PDF
申请/专利权人广州市妇女儿童医疗中心;
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申请/专利号CN202110683253.3
发明设计人许甜甜;王长兵;李英华;邝璐;郭敏;朱冰;陈海洋;
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申请日2021-06-18
分类号A61K31/4709(20060101);A61K47/18(20060101);A61P31/14(20060101);
代理机构11371 北京超凡志成知识产权代理事务所(普通合伙);
代理人宋南
地址 510000 广东省广州市越秀区人民中路318号
入库时间 2023-06-19 13:13:51

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法律状态公告日

法律状态信息

法律状态
2022-08-12

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1. GSK872在制备治疗肠道病毒71型感染导致的疾病的药物中的用途 [P] . 中国专利： CN113616654A . 2021-11-09
2. 诃黎勒酸在制备治疗人肠道病毒71型感染引发疾病药物中的应用 [P] . 中国专利： CN103110652B . 2014.08.27
3. composition, pharmaceutical composition, effervescent dosage form, multiple unit oral oral pharmaceutical composition, extended release pharmaceutical dosage form, enteric coated pharmaceutical dosage form, stable pharmaceutical dosage form for oral administration to mammalian subjects, method for treating diseases acid-related diseases by inhibiting gastric acid secretion, method for treating a bacterial infection caused or caused by helicobacter pylori, process for preparing a compound of formula 3, process for preparing a compound of formula 5, use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion, use of a compound of formula 1 for the preparation of a medicament for treating a bacterial infection caused or caused by helicobacter pyl or use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion [P] . BRPI0617987A2 . 2011-08-16

机译：组合物，药物组合物，泡腾剂型，多单位口服口服药物组合物，缓释药物剂型，肠溶衣药物剂型，向哺乳动物受试者口服给药的稳定药物剂型，通过抑制胃酸治疗疾病的方法酸分泌，治疗由幽门螺杆菌引起或引起的细菌感染的方法，制备式3化合物的方法，制备式5化合物的方法，式1化合物在制备用于治疗胃的药物中的用途通过抑制胃酸分泌来治疗与酸有关的疾病，将式1的化合物用于制备用于治疗由幽门螺杆菌引起或引起的细菌感染的药物，或将式1的化合物用于制备用于治疗的药物通过抑制胃酸分泌来治疗胃酸相关疾病
4. DNA was isolated and purified, peptu00ecdeo, sequences of amino acids of human and murine sphk2, construction of recombinant DNA, host cell.Methods for producing a peptu00ecdeo of sphingosine kinase type 2 isoform of mouse and human.And to detect an agent or a drug that inhibits or promotes the activity of sphingosine kinase type 2, agent or product, methods for regulating a biological process in a mamu00ecfero,For the treatment or the improvement of a disease resulting from cell death increased or reduced cell proliferation.For the treatment or management of a disease resulting from reduced cell death or cell proliferation increased.And for the treatment or the improvement of a disease resulting from abnormal migration or motility of cells selected from the group consisted of cancer, restenose and diabetic neuropathy.Composition for the treatment or the improvement of UIMA disease resulting from cell death increased or reduced cell proliferation.Methods for screening for agents or [P] . BR0109827A . 2004-07-06

机译：分离纯化DNA，肽，人和鼠sphk2的氨基酸序列，重组DNA的构建，宿主细胞。小鼠和人2型鞘氨醇激酶2型亚型的肽的制备方法，并检测抑制或促进2型鞘氨醇激酶活性的药物或药物，药物或产物的调节方法，用于治疗哺乳动物的生物学过程的方法，用于治疗或改善由细胞死亡引起的疾病的方法，增加或减少的细胞增殖用于治疗或管理由减少的细胞死亡或细胞增殖引起的疾病，以及用于治疗或改善由癌症，再狭窄和糖尿病性神经病变组成的组中的细胞异常迁移或运动导致的疾病。用于治疗或改善由细胞死亡引起的UIMA疾病的组合物可增加或减少细胞增殖。
5. Use of product comprising catuama extract as an antioxidant or cerebral vasodilating agent, pharmaceutical composition comprising such product for the prophylaxis or treatment of vascular disorders and disorders caused by the improper presence of free radicals, method for the prophylaxis or treatment of cerebral vascular disorders and disorders caused by improper pressing of free radicals using said product and use of said product for the production of a pharmaceutical composition, for the prophylaxis or treatment of vascular disorders and disorders caused by the improper presence of free radicals [P] . BR0102185A . 2003-02-18

机译：包含catuama提取物作为抗氧化剂或脑血管舒张剂的产品的用途，包含该产品的药物组合物用于预防或治疗由自由基的不当存在引起的血管疾病和病症，预防或治疗脑血管疾病和病症的方法由于使用所述产品不当按压自由基而导致的疾病，以及所述产品在制备药物组合物中的用途，所述药物组合物用于预防或治疗血管疾病和由自由基的不当存在引起的疾病