首页> 中国专利> 一种制备3-位被酰胺基烷基取代的香豆素类化合物的方法及其产物和相关中间体

一种制备3-位被酰胺基烷基取代的香豆素类化合物的方法及其产物和相关中间体

页面导航

摘要
著录项
法律信息
相似文献

摘要

本发明涉及一种制备3‑位被酰胺基烷基取代的香豆素类化合物的方法及其相关中间体。所述方法包括：步骤(A)：使式(VI)的化合物与式(V)的化合物反应，以制备式(VII)化合物其中R1和R2各自独立地选自氢、卤素和‑O(C1‑8烷基)，其中所述烷基任选地被1或2个选自以下的基团取代：卤素、被1‑2个羟基取代的C1‑8烷基、‑O(C1‑8烷基)；R3为‑L‑C(O)NR5R6，L为C1‑3亚烷基。

著录项

公开/公告号CN113121484A

专利类型发明专利
公开/公告日2021-07-16

原文格式PDF
申请/专利权人复星弘创(苏州)医药科技有限公司;
展开▼

申请/专利号CN201911422365.2
发明设计人 Q·曾;王瑞平;段洁;魏旭东;
展开▼

申请日2019-12-31
分类号C07D311/16(20060101);A61P35/00(20060101);A61P37/06(20060101);A61P1/16(20060101);A61P35/02(20060101);A61P3/00(20060101);A61P31/12(20060101);A61P9/00(20060101);A61P31/14(20060101);A61P31/22(20060101);A61P3/10(20060101);A61P25/18(20060101);A61P29/00(20060101);A61P13/10(20060101);A61P19/02(20060101);A61P1/04(20060101);A61P25/00(20060101);A61P5/14(20060101);A61K31/5377(20060101);
代理机构11376 北京永新同创知识产权代理有限公司;
代理人栾星明;程大军
地址 215000 江苏省苏州市苏州工业园区星湖街218号生物纳米园A4楼211单元
入库时间 2023-06-19 11:54:11

法律信息

法律状态公告日

法律状态信息

法律状态
2023-07-14

发明专利申请公布后的视为撤回 IPC(主分类):C07D 311/16 专利申请号:2019114223652 申请公布日:20210716

发明专利申请公布后的视为撤回

相似文献

专利
中文文献
外文文献

1. 一种制备3-位被酰胺基烷基取代的香豆素类化合物的方法及其产物和相关中间体 [P] . 中国专利： CN113121484A . 2021-07-16
2. 一种3-苄基取代香豆素—咪唑盐类化合物及其制备方法 [P] . 中国专利： CN108299401A . 2018-07-20
3. METHOD FOR OBTAINING STEROID DERIVATIVES 1 The invention relates to a new method for producing steroid derivatives having a hydrocarbon residue in the 17a position, saturated or unsaturated, substituted or unsubstituted, or a dicloalkyl radical, and having physiological activity. a prenatal radical, for example, compounds of 3-oxo-13p-ethyl-17a-ethynyl-17, p-oxygone — 4,9,11-triene, consisting in the fact that 3-ethylenedioxy-17-oxo-13 is prepared first 3-ethylgon- 4,9,1 i-triene which is reacted with an ethynylation reagent followed by hydrolysis of the ketal group at the 3 G7a-ethynyl derivative position. However, the ketalization of the 3-oxo group of the corresponding 3,17-dioxosteroid is not selective, with a low yield of the intermediate 3-ketal, which reduces the yield of the target product. In addition, in the known method, a 4,9,11-trienoic steroid with a closed ring A is used as a starting product, which can be obtained with the complete synthesis of a steroid only from an [P] . SU422142A3 . 1974-03-30

机译：获得类固醇衍生物的方法1本发明涉及一种新的制备类固醇衍生物的方法，该类固醇衍生物具有在17a位上的烃基，饱和或不饱和，取代或未取代的，或二氯烷基基团，并具有生理活性。产前自由基，例如3-oxo-13p-ethyl-17a-ethynyl-17，p-oxygone-4,9,11-triene的化合物，其特征在于3-乙烯二氧基-17-oxo-13是首先准备使3-乙基贡-4,9,1 i-三烯与乙炔化试剂反应，然后水解3 G7a-乙炔基衍生物位置的缩酮基。然而，相应的3，17-二氧代甾族化合物的3-氧代基的缩酮化不是选择性的，中间体3-缩酮的产率低，这降低了目标产物的产率。另外，在已知方法中，具有闭环A的4,9,11-三烯类固醇被用作起始产物，其可以仅通过从甲壳素完全合成类固醇来获得。
4. METHOD FOR PREPARING COUMARIN COMPOUND, 3 POSITION OF WHICH IS SUBSTITUTED WITH AMIDOALKYL AND PRODUCTS AND RELATED INTERMEDIATES THEREOF [P] . WO2021136333A1 . 2021-07-08

机译：制备香豆素化合物的方法，其3个位置被酰胺烷基和产物及其相关中间体取代
5. METHOD FOR PREPARING COMPLEX ETHERS OF SULPHOXIDE 7-ACYLAMINO-3-acyclic cime-DZ-CEFALOSPORIN1 The invention relates to an improved method for the production of cephalosporin derivatives, which can be used in the pharmaceutical industry. CO formulas where R is an acyl group; X is hydrogen or a nucleophilic group; R 'is hydrogen, a silyl group or an alkyl or aralkyl having from 1 to 20 carbon atoms, which means that the corresponding 7-acylamido-A ^ (or A ^ ) -cephalosporin It is recommended to oxidize with peracid or hydrogen peroxide in the presence of acid, and then isolate the products in a known manner. According to the present invention, to simplify the process, it was proposed to carry out the functionalization of the exocyclic oximethyl group at position 3 of the sulfoxide 10157-acylaminodemethyl cephalosporin without associating isomerization of the double bond with a ceraflosporomer cephalosporin-type antibiotics. Described method for preparing 7-acylamino-3-hydroxymethyl-A2-ce [P] . SU422161A3 . 1974-03-30

机译：制备硫化物7-酰基氨基-3-无环肟-DZ-CEFALOSPORIN1的复杂醚的方法本发明涉及生产头孢菌素衍生物的改进方法，其可用于制药工业。其中R为酰基的CO式; X是氢或亲核基团; R′是氢，甲硅烷基或具有1至20个碳原子的烷基或芳烷基，这意味着相应的7-酰基酰胺基-A ^（或A ^）-头孢菌素。建议用过酸或过氧化氢氧化。酸的存在，然后以已知方式分离产物。根据本发明，为简化方法，提出了在亚砜10157-酰基氨基脱甲基头孢菌素的3位上进行环外氧甲基的官能化，而无需使双键的异构化与头孢菌素头孢菌素型抗生素相关联。所述的制备7-酰基氨基-3-羟甲基-A2-ce的方法