神经病症的诊断或预后方法

摘要

本发明涉及一种对受试者的神经病症进行诊断或预后的方法。所述方法包括确定来自所述受试者的生物样品中一种或多种生物标志物的定量或定性水平；以及基于所述生物样品中所述或每种生物标志物的所述定量或定性水平对所述受试者的所述神经病症进行诊断或预后。

说明书

技术领域

本发明涉及一种对受试者的神经病症进行诊断或预后的方法。所述方法包括确定来自受试者的生物样品中一种或多种生物标志物的定量或定性水平；以及基于生物样品中所述或每种生物标志物的定量或定性水平对受试者的神经病症进行诊断或预后。

背景技术

肌萎缩性侧索硬化(ALS)，也称为运动神经元病(MND)，是由上下运动神经元的进行性变性和死亡、蛋白质聚集、严重肌萎缩和呼吸功能不全造成的致死性运动神经元病症。中位生存期为从症状发作开始的2年与5年之间。ALS表现为家族性ALS(FALS；～10％的病例)或散发性ALS(SALS；～90％的病例)。估计ALS的发病率介于0.3与2.6例/100,000之间(在欧洲为2.16/100,000人年，在爱尔兰为2.0/100,000人年)。

在动物模型和ALS患者中的研究表明，运动神经元变性开始于神经肌肉接点处并且突触后肌肉变化可发挥积极作用。研究已表明，骨骼肌具有功能分泌活性。肌肉分泌蛋白质组(secretome)包含外泌体-进行功能蛋白、mRNA和miRNA的细胞间运输的囊泡。外泌体可以自分泌/旁分泌的方式在肌细胞或其他类型的细胞上起作用并且有助于肌肉生长和再生、全身新陈代谢和其他功能。

错误折叠蛋白，诸如SOD1、TDP-43或FUS蛋白在受影响的神经元以及邻近神经胶质中的病理性聚集可以视为ALS的标志。若干近期研究已表明，这些细胞内蛋白可以通过囊泡介导的胞吐作用释放，并且接着被邻近细胞吞噬，从而允许以自身延续性(self-perpetuating)方式传递至相邻的运动神经元。此外，在家族性ALS中，已经鉴定出参与自噬途径和多囊泡生物发生的基因(诸如ALSIN、VAPB、CHMP2B和VCP)的突变。总而言之，这些数据强烈表明散发性和家族性ALS患者的核内体和溶酶体途径的破坏-这两条途径均参与外泌体发生。

诊断很慢，通常需要患者历经数月的时间看若干专家：从症状发作到确诊的平均时间是13-18个月。因此，问题/需要是更快速地诊断ALS。

发明内容

根据本发明的第一方面，提供一种对受试者的神经病症进行诊断或预后的方法，所述方法包括以下步骤：

(a)确定来自受试者的生物样品中一种或多种生物标志物的定量或定性水平；以及

(b)基于生物样品中所述或每种生物标志物的定量或定性水平对受试者的神经病症进行诊断或预后；

其中所述或每种生物标志物选自：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；C0L5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；EEF1D；TPI1；SSBP1；PSMB8；PSAP；PSMB7；CAPZA1；PRDX1；PGDN；MMP1；NUCB2；HMGB1；AHNAK；FNDC1；DENR；PENK；S100A11；RPL29；RPL27；RPL8；SRSF2；SF3B4；SBSN；LYAR；NUDC；CRLF1；TGFB1；CAT；CTSD；DLD；EPB41L2；PSMB9；RPS14；RPL7A；COLEC12；SMARCC2；TAGLN2；CCT4；ASPH；GPS1；CDK13；SH3GL2；HBA1；APEX1；PSMB5；TXN；AXL；RPS8；SET；RPS18；CFL1；DMKN；RPL22；RPL6；FKBP10；PAFAH1B1；S100A13；PSMA6；SERPINE1；CAPRIN1；SEPT7；VTN；ENPP2；NEO1；DKC1；CHI3L1；SK0R1；SSRP1；COL4A2；NME1；CFB；EIF2S3；DPYSL2；NUMA1；KTN1；CHID1；EFEMP1；YWHAZ；LDHB；SDCBP；TLN1；DES；APP；以及DAG1。

优选地，所述或每种生物标志物选自：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；C0L5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；以及CAPRIN1。

更优选地，所述或每种生物标志物选自：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；C0L5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；CAPRIN1；DES；APP；以及DAG1。

更优选地，所述或每种生物标志物选自：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；DES；APP；以及DAG1。

任选地，确定步骤(a)包括确定来自受试者的生物样品中的两种或更多种生物标志物的定量或定性水平。

更任选地，确定步骤(a)包括确定来自受试者的生物样品中的三种、四种、五种、八种、十种、二十种、二十五种、二十八种、三十种、四十种、五十种、六十种、七十种、八十种、九十种、一百种或更多种生物标志物的定量或定性水平。

任选地，确定步骤(a)包括确定来自受试者的生物样品中的所有生物标志物的定量或定性水平。

任选地或另外，确定步骤(a)包括确定来自受试者的生物样品中的每种生物标志物的定量或定性水平。

任选地，所述或每种生物标志物是基因。更任选地，所述或每种生物标志物是核酸。更任选地，所述或每种生物标志物是脱氧核糖核酸。

任选地，所述或每种生物标志物是基因的翻译产物。

任选地，所述或每种生物标志物是选自以下的基因的翻译产物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；C0L5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；EEF1D；TPI1；SSBP1；PSMB8；PSAP；PSMB7；CAPZA1；PRDX1；PGDN；MMP1；NUCB2；HMGB1；AHNAK；FNDC1；DENR；PENK；S100A11；RPL29；RPL27；RPL8；SRSF2；SF3B4；SBSN；LYAR；NUDC；CRLF1；TGFB1；CAT；CTSD；DLD；EPB41L2；PSMB9；RPS14；RPL7A；COLEC12；SMARCC2；TAGLN2；CCT4；ASPH；GPS1；CDK13；SH3GL2；HBA1；APEX1；PSMB5；TXN；AXL；RPS8；SET；RPS18；CFL1；DMKN；RPL22；RPL6；FKBP10；PAFAH1B1；S100A13；PSMA6；SERPINE1；CAPRIN1；SEPT7；VTN；ENPP2；NEO1；DKC1；CHI3L1；SK0R1；SSRP1；COL4A2；NME1；CFB；EIF2S3；DPYSL2；NUMA1；KTN1；CHID1；EFEMP1；YWHAZ；LDHB；SDCBP；TLN1；DES；APP；以及DAG1。

优选地，所述或每种生物标志物是选自以下的基因的翻译产物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；C0L5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；以及CAPRIN1。

更优选地，所述或每种生物标志物是选自以下的基因的翻译产物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；C0L5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；CAPRIN1；DES；APP；以及DAG1。

更优选地，所述或每种生物标志物是选自以下的基因的翻译产物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；DES；APP；以及DAG1。

任选地，所述或每种生物标志物是核糖核酸。

任选地，所述或每种生物标志物是具有选自以下的miRBase登录号的核糖核酸：MIMAT0000244；ENSG00000239126；MIMAT0016865；MIMAT0002813；MIMAT0004697；MIMAT0000245；MIMAT0000737；MIMAT0000088；MIMAT0000414；MIMAT0004955；MIMAT0000076；MIMAT0000067；MIMAT0018084；以及MIMAT0004813。

任选地，所述或每种生物标志物是具有选自SEQ ID No 109-122中的任何一个或多个的核酸序列的核糖核酸。

任选地，所述或每种生物标志物是蛋白质。更任选地，所述或每种生物标志物是肽。更任选地，所述或每种生物标志物是多肽。

任选地，所述或每种生物标志物是由选自以下的基因编码的蛋白质：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；COL5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；EEF1D；TPI1；SSBP1；PSMB8；PSAP；PSMB7；CAPZA1；PRDX1；PGDN；MMP1；NUCB2；HMGB1；AHNAK；FNDC1；DENR；PENK；S100A11；RPL29；RPL27；RPL8；SRSF2；SF3B4；SBSN；LYAR；NUDC；CRLF1；TGFB1；CAT；CTSD；DLD；EPB41L2；PSMB9；RPS14；RPL7A；COLEC12；SMARCC2；TAGLN2；CCT4；ASPH；GPS1；CDK13；SH3GL2；HBA1；APEX1；PSMB5；TXN；AXL；RPS8；SET；RPS18；CFL1；DMKN；RPL22；RPL6；FKBP10；PAFAH1B1；S100A13；PSMA6；SERPINE1；CAPRIN1；SEPT7；VTN；ENPP2；NEO1；DKC1；CHI3L1；SKOR1；SSRP1；COL4A2；NME1；CFB；EIF2S3；DPYSL2；NUMA1；KTN1；CHID1；EFEMP1；YWHAZ；LDHB；SDCBP；TLN1；DES；APP；以及DAG1。

优选地，所述或每种生物标志物是由选自以下的基因编码的蛋白质：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；COL5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；以及CAPRIN1。

更优选地，所述或每种生物标志物是由选自以下的基因编码的蛋白质：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；COL5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；CAPRIN1；DES；APP；以及DAG1。

更优选地，所述或每种生物标志物是由选自以下的基因编码的蛋白质：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；DES；APP；以及DAG1。

任选地，所述或每种生物标志物是具有选自以下的UniProtKB/Swiss-Prot登录号的蛋白质：P30101；Q76M96；P11142；P07093；Q15149；P11021；P19338；P09493；P24821；P17936；P20908；Q9Y240；P46821；Q13765；P25787；P46777；P60660；P07858；P10809；Q6NZI2；Q02818；P13667；P07237；043707；P29692；P60174；Q04837；P28062；P07602；Q99436；P52907；Q06830；Q7Z5L7；P03956；P80303；P09429；Q09666；Q4ZHG4；043583；P01210；P31949；P47914；P61353；P62917；Q01130；Q15427；Q6UWP8；Q9NX58；Q9Y266；075462；P01137；P04040；P07339；P09622；043491；P28065；P62263；P62424；Q5KU26；Q8TAQ2；P37802；P50991；Q12797；Q13098；Q14004；Q99962；P69905；P27695；P28074；P10599；P30530；P62241；Q01105；P62269；P23528；Q6E0U4；P35268；Q02878；Q96AY3；P43034；Q99584；P60900；P05121；Q14444；Q16181；P04004；Q13822；Q92859；060832；P36222；P84550；Q08945；P08572；P15531；P00751；P41091；Q16555；Q14980；Q86UP2；Q9BWS9；Q12805；P63104；P07195；000560；Q9Y490；P17661；P05067；以及Q14118。

优选地，所述或每种生物标志物是具有选自以下的UniProtKB/Swiss-Prot登录号的蛋白质：P30101；Q76M96；P11142；P07093；Q15149；P11021；P19338；P09493；P24821；P17936；P20908；Q9Y240；P46821；Q13765；P25787；P46777；P60660；P07858；P10809；Q6NZI2；Q02818；P13667；P07237；043707；以及Q14444。

更优选地，所述或每种生物标志物是具有选自以下的UniProtKB/Swiss-Prot登录号的蛋白质：P30101；Q76M96；P11142；P07093；Q15149；P11021；P19338；P09493；P24821；P17936；P20908；Q9Y240；P46821；Q13765；P25787；P46777；P60660；P07858；P10809；Q6NZI2；Q02818；P13667；P07237；043707；Q14444；P17661；P05067；以及Q14118。

更优选地，所述或每种生物标志物是具有选自以下的UniProtKB/Swiss-Prot登录号的蛋白质：P30101；Q76M96；P11142；P07093；Q15149；P17661；P05067；以及Q14118。

任选地，所述或每种生物标志物是具有选自SEQ ID No 1-108中的任何一个或多个的氨基酸序列的蛋白质。

任选地，神经病症是神经变性病症。

任选地，神经变性病症选自肌萎缩性侧索硬化(ALS；卢伽雷氏病(Lou Gehrig'sdisease)；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩。

任选地，诊断或预后步骤(b)包括将来自受试者的生物样品中的所述或每种生物标志物的定量或定性水平与正常样品中的所述或每种相应生物标志物的定量或定性水平相比较。

任选地，正常样品是来自未罹患神经病症，任选地神经变性病症，更任选地选自肌萎缩性侧索硬化(ALS；卢伽雷氏病；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩的神经变性病症的受试者的生物样品。

任选地，大于正常样品中的所述或每种相应生物标志物的定量或定性水平的来自受试者的生物样品中的所述或每种生物标志物的定量或定性水平指示神经病症，任选地神经变性病症，更任选地选自肌萎缩性侧索硬化(ALS；卢伽雷氏病；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩的神经变性病症的定量或定性水平。

任选地，来自受试者的生物样品中的所述或每种生物标志物的定量或定性水平大于正常样品中的所述或每种相应生物标志物的定量或定性水平指示神经病症，任选地神经变性病症，更任选地选自肌萎缩性侧索硬化(ALS；卢伽雷氏病；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩的神经变性病症的定量或定性存在。

任选地，确定步骤(a)包括确定来自受试者的生物样品中的一种或多种生物标志物的一个或多个子集的定量或定性水平。

任选地，确定步骤(a)包括确定来自受试者的生物样品中的一种或多种生物标志物的两个或更多个子集的定量或定性水平。

任选地，确定步骤(a)包括确定来自受试者的生物样品中的一种或多种生物标志物的三个、四个、五个、六个、七个、八个、九个、十个、十一个、十二个、十三个或十四个子集的定量或定性水平。

任选地，确定步骤(a)包括确定来自受试者的生物样品中的一种或多种生物标志物的第一、第二、第三、第四、第五、第六、第七、第八、第九、第十、第十一、第十二、第十三或第十四子集中的一个或多个的定量或定性水平。

任选地，第一子集包括选自以下的一种或多种生物标志物：PDIA3；和CCDC80。

任选地，第二子集包括HSPA8。

任选地，第三子集包括选自以下的一种或多种生物标志物：SERPINE2；和PLEC。

任选地，第四子集包括选自以下的一种或多种生物标志物：HSPA5；和NCL。

任选地，第五子集包括选自以下的一种或多种生物标志物：TPM1；和TNC。

任选地，第六子集包括IGFBP3。

任选地，第七子集包括选自以下的一种或多种生物标志物：COL5A1；CLEC11A；MAP1B；NACA；以及PSMA2。

任选地，第八子集包括选自以下的一种或多种生物标志物：RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；以及ACTN4。

任选地，第九子集包括选自以下的一种或多种生物标志物：EEF1D；TPI1；SSBP1；PSMB8；PSAP；PSMB7；CAPZA1；PRDX1；PGDN；MMP1；NUCB2；HMGB1；AHNAK；以及FNDC1。

任选地，第十子集包括选自以下的一种或多种生物标志物：DENR；PENK；S100A11；RPL29；RPL27；RPL8；SRSF2；SF3B4；SBSN；LYAR；NUDC；CRLF1；TGFB1；CAT；CTSD；DLD；EPB41L2；PSMB9；RPS14；RPL7A；COLEC12；SMARCC2；TAGLN2；CCT4；ASPH；GPS1；CDK13；SH3GL2；HBA1；APEX1；PSMB5；TXN；AXL；RPS8；SET；RPS18；CFL1；DMKN；RPL22；RPL6；FKBP10；PAFAH1B1；S100A13；PSMA6；SERPINE1；CAPRIN1；SEPT7；VTN；ENPP2；NEO1；DKC1；CHI3L1；SKOR1；SSRP1；COL4A2；NME1；CFB；EIF2S3；DPYSL2；NUMA1；KTN1；CHID1；EFEMP1；YWHAZ；LDHB；SDCBP；以及TLN1。

任选地，第十一子集包括选自以下的一种或多种生物标志物：DES；APP；以及DAG1。

任选地，第十二子集包括选自以下的一种或多种生物标志物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；COL5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；以及CAPRIN1。

任选地，第十三子集包括选自以下的一种或多种生物标志物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；COL5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；CAPRIN1；DES；APP；以及DAG1。

任选地，第十四子集包括选自以下的一种或多种生物标志物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；DES；APP；以及DAG1。

任选地，确定步骤(a)包括确定第一、第二、第三、第四、第五、第六、第七、第八、第九、第十、第十一、第十二、第十三或第十四子集中的一个或多个中的所有生物标志物的定量或定性水平。

任选地，确定步骤(a)包括确定第一、第二、第三、第四、第五、第六、第七、第八、第九、第十、第十一、第十二、第十三或第十四子集中的一个或多个中的每种生物标志物的定量或定性水平。

任选地，诊断或预后步骤(b)包括将来自受试者的生物样品中的所述或每个子集中的所述或每种生物标志物的定量或定性水平与正常样品中的所述或每种相应生物标志物的定量或定性水平相比较。

任选地，正常样品是来自未罹患神经病症，任选地神经变性病症，更任选地选自肌萎缩性侧索硬化(ALS；卢伽雷氏病；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩的神经变性病症的受试者的生物样品。

任选地，大于正常样品中的所述或每种相应生物标志物的定量或定性水平的来自受试者的生物样品中的所述或每个子集中的所述或每种生物标志物的定量或定性水平指示神经病症，任选地神经变性病症，更任选地选自肌萎缩性侧索硬化(ALS；卢伽雷氏病；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩的神经变性病症的定量或定性水平。

任选地，来自受试者的生物样品中的所述或每个子集中的所述或每种生物标志物的定量或定性水平大于正常样品中的所述或每种相应生物标志物的定量或定性水平指示神经病症，任选地神经变性病症，更任选地选自肌萎缩性侧索硬化(ALS；卢伽雷氏病；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩的神经变性病症的定量或定性存在。

任选地或另外，确定步骤(a)还包括确定来自受试者的生物样品中的一种或多种生物标志物的定量或定性水平的另外步骤，其中所述或每种生物标志物是具有选自以下的miRBase登录号的核糖核酸：MIMAT0000244；ENSG00000239126；MIMAT0016865；MIMAT0002813；MIMAT0004697；MIMAT0000245；MIMAT0000737；MIMAT0000088；MIMAT0000414；MIMAT0004955；MIMAT0000076；MIMAT0000067；MIMAT0018084；以及MIMAT0004813。

任选地，生物样品选自全血、血清、血浆、尿液、间质液、腹膜液、宫颈拭子、泪液、唾液、颊面拭子、皮肤、脑组织和脑脊液。

更任选地，生物样品选自全血、血清和血浆。

更任选地，生物样品是全血。

PDIA3与Erp57是同义的(synonymous)。

附图说明

现将参考以下非限制性实施例和附图描述本发明的实施方案，在附图中：

图1是肌肉干细胞中的ALS标签(signature)的示意图；

图2(A)示出分化的肌肉干细胞的外泌体标志物的免疫染色，(B)肌细胞的外泌体分泌，以及(C)ALS肌细胞的多囊泡体包含比对照更多的外泌体；

图3示出用ALS或对照外泌体处理的健康肌管的代表性图像，其中ALS外泌体诱导细胞应激；

图4示出显示非编码RNA微阵列的表达值的箱形图(原始：左图；背景校正：中图；背景校正并归一化：右图)；

图5示出显示非编码RNA微阵列的RLE值的箱形图(平均值接近0通过质量控制)；

图6示出显示非编码RNA微阵列的NUSE值的箱形图(平均值<1.05通过质量控制)；

图7示出使用抗DAG抗体的情况下循环血清外泌体中的DAG1表达水平。值为平均值±SD。血清来自8名ALS患者(诊断后1个月)、11名健康受试者和9名帕金森患者。进行单因素方差分析，接着进行Tukey事后检验。**，与健康值显著不同，P<0.01；

图8示出循环血清外泌体中的HSPA8表达水平。值为平均值±SD。血清来自5名ALS患者(诊断后1个月)、9名健康受试者和7名帕金森患者。进行单因素方差分析，接着进行Tukey事后检验。*，**，与ALS值显著不同，分别为P<0.05和P<0.01；并且

图9示出针对总血清外泌体(CD63)的量归一化的从ALS患者的血清中分离的外泌体中每种生物标志物的水平，并且针对病理进展速率(△ALSFRS-R)绘图。

实施例

材料和方法

参与者和伦理批准

在运动神经元疾病中心(Motor Neuron Diseases center，PitiéSalpétrière)到场的18名ALS患者的三角肌上进行开放性活检。根据欧洲建议和法国立法从BTR(Bank ofTissues for Research，EU network EuroBioBank的参与者)获得来自年龄和性别匹配的健康受试者的二十一份三角肌活检物。该方案(NCT01984957)得到了当地伦理委员会的批准并且所有受试者根据惯例指南完成了知情同意书。

肌肉干细胞提取和培养

将肌肉活检物以机械方式解离并且涂板于如先前所述(Mamchaoui等,Skeletalmuscle,2011,PMID:22040608)的增殖培养基中，使用CD56磁珠分选系统(MACS,MiltenylBiotech)根据制造商的说明分选肌原细胞群。在分选细胞之前和之后使用抗结蛋白抗体通过免疫标记检查细胞培养物的肌原性，并且使细胞在杜氏改良的伊戈尔培养基(DMEM)中分化3天。最少80％的细胞群对于结蛋白是阳性的。

从培养基中提取外泌体

简而言之，使一千万肌肉干细胞(ALS和健康受试者，n＝3/组)在DMEM中分化3天。3天后，收获条件培养基，在室温(RT)下以300x g离心5分钟并且接着在4℃下以4000g离心20分钟，以除去任何死细胞和细胞碎片。通过0.22μm的过滤器过滤上清液以除去微粒。样品用于蛋白质和miRNA提取并储存于-80℃。

从外泌体中提取蛋白质

将一定体积的细胞培养基与来自细胞培养基的0.5体积的Total ExosomeIsolation Reagent

通过质谱法确定蛋白质组特征谱(Proteome profile)

使用SmartDigest柱(Thermo)，根据制造商的说明将大约20μg的外泌体蛋白用胰蛋白酶在70℃和1400rpm下消化2小时。然后使用高pH反相自旋柱(Thermo)，根据制造商的说明将肽分级成8个级分。将分级的肽真空干燥，重悬并且在Q Exactive HF(Thermo)上通过数据依赖性质谱法分析，使用以下参数：正极性，m/z 400-2000MS分辨率70,000，AGC3e6，100ms IT，MS/MS分辨率17,500，AGC 5e5，50ms IT，隔离宽度3m/z，以及NCE 30，循环计数15。

数据库搜索和定量

使用ProteomeDiscoverer(Thermo)，针对Uniprot人数据库，针对半胰蛋白酶肽搜索所得的质谱文件以进行蛋白质鉴定并且基于<1％的错误发现率进行过滤。

蛋白质组特征谱分析

如果3个ALS平行测定的所观察到的丰度范围不与3个健康对照平行测定的范围重叠，那么选择蛋白质作为候选物。基于3个ALS平行测定的中值与健康平行测定的中值的差异对候选物排序。

从外泌体中提取miRNA

将一定体积的细胞培养基与来自细胞培养基的0.5体积的Total ExosomeIsolation Reagent

miRNA特征谱和分析

按照制造商的说明(ThermoFisher Scientific,Waltham,MA)，使用FlashTagBiotin HSR RNA标记试剂盒对总RNA(150ng)进行poly(A)加尾和生物素标记并且杂交至Affymetrix GeneChip miRNA 4.0阵列，持续16小时(48℃)。然后将杂交混合液移除并且使用针对miRNA 4.0阵列的射流轨迹(fluidics script)，将阵列洗涤并在Fluidics Station450上染色。最后，在Affymetrix GCS3000 7G扫描仪上扫描阵列并且使用AffymetrixExpression Console软件(两者均来自ThermoFisher Scientific)估计初始质量控制数据。

miRNA组(miRNome)特征谱分析

使用R/Bioconductor软件包oligo和pd.mirna.4.0进行原始数据的进一步质量控制。这些软件包用于评估各样品的表达值分布、相对对数表达值(relative logexpression value，RLE)，以及归一化的非标准化标准误差(normalized unscaledstandard error，NUSE)，所有这些均与良好质量相一致。然后使用Affymetrix ExpressionConsole v 1.4.1.46，通过分位数归一化(quantile normalization)和高于背景检测(detection above background)对表达矩阵进行归一化。然后将差异表达的miRNA(ALS相对于健康)鉴定为绝对倍数变化>2且单因素未配对的方差分析p值<0.05的那些。

来自患者的血清样品

使用二氧化硅真空采血管收集血液样品，接着轻轻地翻转8-10分钟。在冰上孵育2h使其凝固之后，将样品在1,500g下离心15分钟。将100μl血清的等分试样转移至冷冻小瓶并且在-80℃下储存。募集年龄和性别匹配的八名ALS患者、11名健康受试者和9名帕金森患者(NCT01302600和NCT02305147)。

从血清中提取外泌体

通过添加6μl的Total Exosome Isolation Reagent、涡旋并在冰上孵育30分钟来使外泌体沉淀。然后将样品在室温下以10,000g离心10分钟。将沉淀物重悬于13.5μl的Urea4M/RIPA中并保持在冰上。与此同时，将6.3μl的Total Exosome Isolation Reagent添加至其余上清液、涡旋并在冰上孵育30分钟。然后将这些第二混合物在室温下以10,000g离心10分钟。将第二外泌体沉淀物重悬于13.5μl的Urea4M/RIPA中。然后将两份外泌体蛋白提取物混合在一起并用于斑点印迹(dot-blot)分析。将外泌体蛋白提取物储存于-80℃。

用于斑点印迹的样品制备

向5μl的外泌体蛋白提取物中添加1xNuPAGE(Invitrogen

斑点印迹分析

将1μl还原或未还原的样品上样到甲醇预先活化的0.2μm PVDF

使用Zenon

将膜与稀释的生物素偶联的一抗一起在室温下孵育45分钟。然后将膜在TBS-T中冲洗3次，持续5分钟。然后将膜与以1/250稀释于TBS-T-5％牛奶中的链霉抗生素蛋白-HRP(Invitrogen

统计分析

值为平均值±SD。进行单因素方差分析，接着进行Tukey事后检验，以评估ALS、健康受试者与帕金森受试者之间的生物标志物水平的差异。生物标志物水平与ALSFRS进展之间的关联使用皮尔森关联分析进行检验。显著性差异的截止值设置为P<0.05。

实施例1-肌肉干细胞中的ALS标签的鉴定

肌肉干细胞从患者和健康受试者(均为男性，30-67岁，n＝5/6每组)的肌肉活检物中提取，纯化(>80％肌原细胞)并且持续3天分化成肌管，其中使用GeneChip Human Exon1.0ST阵列(Affymetrix,Inc.,Cleveland,OH)分析样品；并且(A)示出在第二分量(y轴)上显示出ALS患者的明确分离的PCA图，ALS：蓝色，SBMA：粉色，SMA-III/IV：红色，对照：绿色；(B)示出在具有对ALS特异性最强的表达标签的30种基因中，根据CellWhere工具的分析，已经在外泌体相关亚细胞定位上观察到许多所述基因。

实施例2-ALS肌肉干细胞积聚并分泌比对照更多的外泌体

参考图2(A)，示出分化的肌肉干细胞的外泌体标志物的免疫染色。左图：来自ALS和SMA-III/IV患者，以及来自健康对照或失神经受试者的针对外泌体标志物(TSG101、CD63)作标记的培养的肌肉干细胞的代表性图像。右图：按肌核归一化的CD63荧光信号的定量。(n＝不同的ALS、SMA-III/IV、多神经炎和对照受试者的8、4、2、5份细胞培养物)。***，P<0,001。

图2(B)示出ALS肌细胞过度分泌外泌体。左图：来自培养基的外泌体沉淀物的代表性图片。从来自ALS和对照受试者的800,000个细胞的培养基中提取外泌体。在来自ALS患者和对照受试者的肌细胞的不同培养物上重复实验8次。右图：电子显微镜观察，其证实了外泌体(杯形囊泡)在沉淀物中的存在。外泌体在ALS沉淀物中更多。值得注意的是，在这些囊泡上进行的免疫染色证实，当它们对CD63和CD82为阳性时，它们是外泌体。

图2(C)示出ALS肌细胞的多囊泡体包含比对照更多的外泌体。左图：示出与对照相比，外泌体在ALS肌细胞的多囊泡体(MVB，以绿色和橙色突出显示)中的积聚的代表性电子显微镜观察图像。比例尺＝1μm。右图：MVB中的外泌体样囊泡数量的定量。双样本KS检验(Two sample Koimogorov-Smirnov test)证实了以下直观印象：与对照相比，ALS肌细胞的MVB包含更大数量的外泌体样囊泡(P<0.05)。

实施例3-来自ALS肌细胞的外泌体对健康肌管和运动神经元有毒性

参考图3(A)，其示出ALS外泌体诱导肌细胞萎缩。左图：用ALS或对照外泌体处理的健康肌管的代表性图像。用肌球蛋白重链对肌管染色(绿色)。右图：肌核域大小的定量(肌球蛋白重链染色的面积除以核的数量)。ALS外泌体处理的肌管具有较小的肌核域(*P<0.05；n＝6/组)。

图3(B)示出ALS外泌体诱导细胞应激。用ALS或对照外泌体处理的每个健康肌管随时间推移的小泡(bleb)数量的定量(n＝6/组)。双因素方差分析(有交互作用)，时间和处理，P<0.001。

图3(C)示出ALS外泌体诱导细胞死亡。左图：用ALS或对照外泌体处理的健康肌管的H2-Ax免疫染色的代表性免疫染色。中图：每个核的H2-Ax信号的定量。右图：培养物中的运动神经元核的损失的定量。

实施例4-作为ALS的生物标志物的特异性外泌体内含物的鉴定

外泌体内含物包括各种类型的生物分子，其中可能参与信号传导任务的那些包括蛋白质及其肽以及非编码RNA。肌肉干细胞(原代成肌细胞)获自ALS患者和健康对照的三角肌并且对其进行培养以形成分化的肌管。在培养3天后，使用total exosome isolationreagent(Invitrogen

蛋白质生物标志物

蛋白质组质谱数据鉴定了105种蛋白质的肽(表1)，其水平相比于健康对照肌肉外泌体(n＝3)在ALS肌肉外泌体(n＝3)中一致增加。

由于蛋白质组样品针对蛋白质浓度归一化，还应注意，在ALS和健康肌肉外泌体两者中具有一致高水平的蛋白质也可以是良好的生物标志物，因为它们在每体积的ALS血液中仍可以是升高的，这是由于我们的以下观察：肌肉外泌体在ALS肌管中比在健康对照中以更大的丰度分泌。以此方式，鉴定了在ALS和健康肌肉外泌体中均具有一致高水平并且具有其他感兴趣的机械学特征的另外3个候选物。即，这些是DES、APP和DAG1。APP是阿尔茨海默病中的淀粉样斑块的主要组分。在所有肌肉组织类型中均观察到高水平的DES，但是在其他组织中完全不存在。DAG1是肌营养不良蛋白聚糖复合物的主要组分，其与多种肌营养不良有关。

表1.其肽通过质谱法鉴定为相比于健康对照在ALS肌细胞的外泌体中一致升高，或在ALS和健康肌肉外泌体中均具有一致高水平，并且具有病理学机械相关性的其他特征的108种蛋白质的列表。第一列给出Uniprot(http://www.uniprot.org/)所用的标准蛋白质ID，并且对应的基因名称在第2列给出。第3-5和6-8列分别示出ALS样品和健康对照样品中的肽水平。第9列指示ALS中的蛋白质肽的中值量与对照的差异，并且第10列基于第9列中的值对蛋白质排序。

表2.其肽通过质谱法鉴定为相比于健康对照在ALS肌细胞的外泌体中一致升高，或在ALS和健康肌肉外泌体中均具有一致高水平，并且具有病理学机械相关性的其他特征的25种蛋白质的列表。第一列给出Uniprot(http://www.uniprot.org/)所用的标准蛋白质ID，并且对应的基因名称在第2列给出。第3-5和6-8列分别示出ALS样品和健康对照样品中的肽水平。第9列指示ALS中的蛋白质肽的中值量与对照的差异。

非编码RNA生物标志物

非编码RNA物类的特征谱分析通过微阵列(使用Affymetrix

表3.被鉴定为相比于健康对照，在ALS肌细胞的外泌体中显著失调的14种非编码RNA的列表。倍数变化和方差分析p值在最右列指出。

实施例6-针对不同疾病组的不同生物标志物的比较

从8名ALS患者、11名健康受试者和9名帕金森患者中收集血液样品。所选患者的患者特征在表4中给出。从血清中提取外泌体并且使用所述外泌体进行斑点印迹分析。从患有ALS疾病、帕金森病(疾病对照)的患者的血清，或从健康受试者中分离的外泌体中的DAG1水平在图7中给出，并且从患有ALS疾病、帕金森病(疾病对照)的患者的血清，或从健康受试者中分离的外泌体中的HSPA8水平在图8中给出。将针对总血清外泌体(CD63)的量归一化的从ALS患者的血清中分离的外泌体中每种生物标志物的水平针对病理进展速率(△ALSFRS-R)绘图并且在图9中给出。

表4.患者特征的列表。

本发明提供了一种强大的ALS基因表达标签以及ALS患者的肌细胞毒性和肌肉-运动神经元相互作用的新驱动物。通过研究来自散发性ALS患者的肌肉活检物的分化的肌(肌管)细胞，本发明示出：(1)从ALS患者分离的肌管的基因表达谱不仅与健康对照受试者完全分开聚类，而且与SBMA和SMA-III/IV疾病对照完全分开聚类(参见图1A)。最强有力地促成此ALS特异性标签的30种基因包括编码分泌或定位于外泌体中的蛋白质的基因(参见图1B)；(2)细胞内外泌体生物发生和细胞外外泌体分泌在ALS肌管中均急剧增加(参见图2A和B)，并且通过电子显微镜观察在ALS患者的肌肉活检物中观察到富集外泌体的多囊泡体(参见图2C)；(3)在肌肉失神经的人受试者(不是健康的，也不是SBMA或SMA-lll/IV)或肌肉失神经的健康鼠肌肉的肌管中未观察到增加的外泌体生物发生和分泌(参见图1、2A以及未示出的其他数据)，这表明外泌体分泌不单纯是疾病的下游后果。

序列表

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Phe Gln Ala Ala Leu Gln Thr Gln Trp Ser Trp Met Leu Gln Leu Cys

835 840 845

Cys Cys Ile Glu Ala His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe

850 855 860

Phe Ser Asp Val Arg Glu Ala Glu Gly Gln Leu Gln Lys Leu Gln Glu

865 870 875 880

Ala Leu Arg Arg Lys Tyr Ser Cys Asp Arg Ser Ala Thr Val Thr Arg

885 890 895

Leu Glu Asp Leu Leu Gln Asp Ala Gln Asp Glu Lys Glu Gln Leu Asn

900 905 910

Glu Tyr Lys Gly His Leu Ser Gly Leu Ala Lys Arg Ala Lys Ala Val

915 920 925

Val Gln Leu Lys Pro Arg His Pro Ala His Pro Met Arg Gly Arg Leu

930 935 940

Pro Leu Leu Ala Val Cys Asp Tyr Lys Gln Val Glu Val Thr Val His

945 950 955 960

Lys Gly Asp Glu Cys Gln Leu Val Gly Pro Ala Gln Pro Ser His Trp

965 970 975

Lys Val Leu Ser Ser Ser Gly Ser Glu Ala Ala Val Pro Ser Val Cys

980 985 990

Phe Leu Val Pro Pro Pro Asn Gln Glu Ala Gln Glu Ala Val Thr Arg

995 1000 1005

Leu Glu Ala Gln His Gln Ala Leu Val Thr Leu Trp His Gln Leu

1010 1015 1020

His Val Asp Met Lys Ser Leu Leu Ala Trp Gln Ser Leu Arg Arg

1025 1030 1035

Asp Val Gln Leu Ile Arg Ser Trp Ser Leu Ala Thr Phe Arg Thr

1040 1045 1050

Leu Lys Pro Glu Glu Gln Arg Gln Ala Leu His Ser Leu Glu Leu

1055 1060 1065

His Tyr Gln Ala Phe Leu Arg Asp Ser Gln Asp Ala Gly Gly Phe

1070 1075 1080

Gly Pro Glu Asp Arg Leu Met Ala Glu Arg Glu Tyr Gly Ser Cys

1085 1090 1095

Ser His His Tyr Gln Gln Leu Leu Gln Ser Leu Glu Gln Gly Ala

1100 1105 1110

Gln Glu Glu Ser Arg Cys Gln Arg Cys Ile Ser Glu Leu Lys Asp

1115 1120 1125

Ile Arg Leu Gln Leu Glu Ala Cys Glu Thr Arg Thr Val His Arg

1130 1135 1140

Leu Arg Leu Pro Leu Asp Lys Glu Pro Ala Arg Glu Cys Ala Gln

1145 1150 1155

Arg Ile Ala Glu Gln Gln Lys Ala Gln Ala Glu Val Glu Gly Leu

1160 1165 1170

Gly Lys Gly Val Ala Arg Leu Ser Ala Glu Ala Glu Lys Val Leu

1175 1180 1185

Ala Leu Pro Glu Pro Ser Pro Ala Ala Pro Thr Leu Arg Ser Glu

1190 1195 1200

Leu Glu Leu Thr Leu Gly Lys Leu Glu Gln Val Arg Ser Leu Ser

1205 1210 1215

Ala Ile Tyr Leu Glu Lys Leu Lys Thr Ile Ser Leu Val Ile Arg

1220 1225 1230

Gly Thr Gln Gly Ala Glu Glu Val Leu Arg Ala His Glu Glu Gln

1235 1240 1245

Leu Lys Glu Ala Gln Ala Val Pro Ala Thr Leu Pro Glu Leu Glu

1250 1255 1260

Ala Thr Lys Ala Ser Leu Lys Lys Leu Arg Ala Gln Ala Glu Ala

1265 1270 1275

Gln Gln Pro Thr Phe Asp Ala Leu Arg Asp Glu Leu Arg Gly Ala

1280 1285 1290

Gln Glu Val Gly Glu Arg Leu Gln Gln Arg His Gly Glu Arg Asp

1295 1300 1305

Val Glu Val Glu Arg Trp Arg Glu Arg Val Ala Gln Leu Leu Glu

1310 1315 1320

Arg Trp Gln Ala Val Leu Ala Gln Thr Asp Val Arg Gln Arg Glu

1325 1330 1335

Leu Glu Gln Leu Gly Arg Gln Leu Arg Tyr Tyr Arg Glu Ser Ala

1340 1345 1350

Asp Pro Leu Gly Ala Trp Leu Gln Asp Ala Arg Arg Arg Gln Glu

1355 1360 1365

Gln Ile Gln Ala Met Pro Leu Ala Asp Ser Gln Ala Val Arg Glu

1370 1375 1380

Gln Leu Arg Gln Glu Gln Ala Leu Leu Glu Glu Ile Glu Arg His

1385 1390 1395

Gly Glu Lys Val Glu Glu Cys Gln Arg Phe Ala Lys Gln Tyr Ile

1400 1405 1410

Asn Ala Ile Lys Asp Tyr Glu Leu Gln Leu Val Thr Tyr Lys Ala

1415 1420 1425

Gln Leu Glu Pro Val Ala Ser Pro Ala Lys Lys Pro Lys Val Gln

1430 1435 1440

Ser Gly Ser Glu Ser Val Ile Gln Glu Tyr Val Asp Leu Arg Thr

1445 1450 1455

His Tyr Ser Glu Leu Thr Thr Leu Thr Ser Gln Tyr Ile Lys Phe

1460 1465 1470

Ile Ser Glu Thr Leu Arg Arg Met Glu Glu Glu Glu Arg Leu Ala

1475 1480 1485

Glu Gln Gln Arg Ala Glu Glu Arg Glu Arg Leu Ala Glu Val Glu

1490 1495 1500

Ala Ala Leu Glu Lys Gln Arg Gln Leu Ala Glu Ala His Ala Gln

1505 1510 1515

Ala Lys Ala Gln Ala Glu Arg Glu Ala Lys Glu Leu Gln Gln Arg

1520 1525 1530

Met Gln Glu Glu Val Val Arg Arg Glu Glu Ala Ala Val Asp Ala

1535 1540 1545

Gln Gln Gln Lys Arg Ser Ile Gln Glu Glu Leu Gln Gln Leu Arg

1550 1555 1560

Gln Ser Ser Glu Ala Glu Ile Gln Ala Lys Ala Arg Gln Ala Glu

1565 1570 1575

Ala Ala Glu Arg Ser Arg Leu Arg Ile Glu Glu Glu Ile Arg Val

1580 1585 1590

Val Arg Leu Gln Leu Glu Ala Thr Glu Arg Gln Arg Gly Gly Ala

1595 1600 1605

Glu Gly Glu Leu Gln Ala Leu Arg Ala Arg Ala Glu Glu Ala Glu

1610 1615 1620

Ala Gln Lys Arg Gln Ala Gln Glu Glu Ala Glu Arg Leu Arg Arg

1625 1630 1635

Gln Val Gln Asp Glu Ser Gln Arg Lys Arg Gln Ala Glu Val Glu

1640 1645 1650

Leu Ala Ser Arg Val Lys Ala Glu Ala Glu Ala Ala Arg Glu Lys

1655 1660 1665

Gln Arg Ala Leu Gln Ala Leu Glu Glu Leu Arg Leu Gln Ala Glu

1670 1675 1680

Glu Ala Glu Arg Arg Leu Arg Gln Ala Glu Val Glu Arg Ala Arg

1685 1690 1695

Gln Val Gln Val Ala Leu Glu Thr Ala Gln Arg Ser Ala Glu Ala

1700 1705 1710

Glu Leu Gln Ser Lys Arg Ala Ser Phe Ala Glu Lys Thr Ala Gln

1715 1720 1725

Leu Glu Arg Ser Leu Gln Glu Glu His Val Ala Val Ala Gln Leu

1730 1735 1740

Arg Glu Glu Ala Glu Arg Arg Ala Gln Gln Gln Ala Glu Ala Glu

1745 1750 1755

Arg Ala Arg Glu Glu Ala Glu Arg Glu Leu Glu Arg Trp Gln Leu

1760 1765 1770

Lys Ala Asn Glu Ala Leu Arg Leu Arg Leu Gln Ala Glu Glu Val

1775 1780 1785

Ala Gln Gln Lys Ser Leu Ala Gln Ala Glu Ala Glu Lys Gln Lys

1790 1795 1800

Glu Glu Ala Glu Arg Glu Ala Arg Arg Arg Gly Lys Ala Glu Glu

1805 1810 1815

Gln Ala Val Arg Gln Arg Glu Leu Ala Glu Gln Glu Leu Glu Lys

1820 1825 1830

Gln Arg Gln Leu Ala Glu Gly Thr Ala Gln Gln Arg Leu Ala Ala

1835 1840 1845

Glu Gln Glu Leu Ile Arg Leu Arg Ala Glu Thr Glu Gln Gly Glu

1850 1855 1860

Gln Gln Arg Gln Leu Leu Glu Glu Glu Leu Ala Arg Leu Gln Arg

1865 1870 1875

Glu Ala Ala Ala Ala Thr Gln Lys Arg Gln Glu Leu Glu Ala Glu

1880 1885 1890

Leu Ala Lys Val Arg Ala Glu Met Glu Val Leu Leu Ala Ser Lys

1895 1900 1905

Ala Arg Ala Glu Glu Glu Ser Arg Ser Thr Ser Glu Lys Ser Lys

1910 1915 1920

Gln Arg Leu Glu Ala Glu Ala Gly Arg Phe Arg Glu Leu Ala Glu

1925 1930 1935

Glu Ala Ala Arg Leu Arg Ala Leu Ala Glu Glu Ala Lys Arg Gln

1940 1945 1950

Arg Gln Leu Ala Glu Glu Asp Ala Ala Arg Gln Arg Ala Glu Ala

1955 1960 1965

Glu Arg Val Leu Ala Glu Lys Leu Ala Ala Ile Gly Glu Ala Thr

1970 1975 1980

Arg Leu Lys Thr Glu Ala Glu Ile Ala Leu Lys Glu Lys Glu Ala

1985 1990 1995

Glu Asn Glu Arg Leu Arg Arg Leu Ala Glu Asp Glu Ala Phe Gln

2000 2005 2010

Arg Arg Arg Leu Glu Glu Gln Ala Ala Gln His Lys Ala Asp Ile

2015 2020 2025

Glu Glu Arg Leu Ala Gln Leu Arg Lys Ala Ser Asp Ser Glu Leu

2030 2035 2040

Glu Arg Gln Lys Gly Leu Val Glu Asp Thr Leu Arg Gln Arg Arg

2045 2050 2055

Gln Val Glu Glu Glu Ile Leu Ala Leu Lys Ala Ser Phe Glu Lys

2060 2065 2070

Ala Ala Ala Gly Lys Ala Glu Leu Glu Leu Glu Leu Gly Arg Ile

2075 2080 2085

Arg Ser Asn Ala Glu Asp Thr Leu Arg Ser Lys Glu Gln Ala Glu

2090 2095 2100

Leu Glu Ala Ala Arg Gln Arg Gln Leu Ala Ala Glu Glu Glu Arg

2105 2110 2115

Arg Arg Arg Glu Ala Glu Glu Arg Val Gln Lys Ser Leu Ala Ala

2120 2125 2130

Glu Glu Glu Ala Ala Arg Gln Arg Lys Ala Ala Leu Glu Glu Val

2135 2140 2145

Glu Arg Leu Lys Ala Lys Val Glu Glu Ala Arg Arg Leu Arg Glu

2150 2155 2160

Arg Ala Glu Gln Glu Ser Ala Arg Gln Leu Gln Leu Ala Gln Glu

2165 2170 2175

Ala Ala Gln Lys Arg Leu Gln Ala Glu Glu Lys Ala His Ala Phe

2180 2185 2190

Ala Val Gln Gln Lys Glu Gln Glu Leu Gln Gln Thr Leu Gln Gln

2195 2200 2205

Glu Gln Ser Val Leu Asp Gln Leu Arg Gly Glu Ala Glu Ala Ala

2210 2215 2220

Arg Arg Ala Ala Glu Glu Ala Glu Glu Ala Arg Val Gln Ala Glu

2225 2230 2235

Arg Glu Ala Ala Gln Ser Arg Arg Gln Val Glu Glu Ala Glu Arg

2240 2245 2250

Leu Lys Gln Ser Ala Glu Glu Gln Ala Gln Ala Arg Ala Gln Ala

2255 2260 2265

Gln Ala Ala Ala Glu Lys Leu Arg Lys Glu Ala Glu Gln Glu Ala

2270 2275 2280

Ala Arg Arg Ala Gln Ala Glu Gln Ala Ala Leu Arg Gln Lys Gln

2285 2290 2295

Ala Ala Asp Ala Glu Met Glu Lys His Lys Lys Phe Ala Glu Gln

2300 2305 2310

Thr Leu Arg Gln Lys Ala Gln Val Glu Gln Glu Leu Thr Thr Leu

2315 2320 2325

Arg Leu Gln Leu Glu Glu Thr Asp His Gln Lys Asn Leu Leu Asp

2330 2335 2340

Glu Glu Leu Gln Arg Leu Lys Ala Glu Ala Thr Glu Ala Ala Arg

2345 2350 2355

Gln Arg Ser Gln Val Glu Glu Glu Leu Phe Ser Val Arg Val Gln

2360 2365 2370

Met Glu Glu Leu Ser Lys Leu Lys Ala Arg Ile Glu Ala Glu Asn

2375 2380 2385

Arg Ala Leu Ile Leu Arg Asp Lys Asp Asn Thr Gln Arg Phe Leu

2390 2395 2400

Gln Glu Glu Ala Glu Lys Met Lys Gln Val Ala Glu Glu Ala Ala

2405 2410 2415

Arg Leu Ser Val Ala Ala Gln Glu Ala Ala Arg Leu Arg Gln Leu

2420 2425 2430

Ala Glu Glu Asp Leu Ala Gln Gln Arg Ala Leu Ala Glu Lys Met

2435 2440 2445

Leu Lys Glu Lys Met Gln Ala Val Gln Glu Ala Thr Arg Leu Lys

2450 2455 2460

Ala Glu Ala Glu Leu Leu Gln Gln Gln Lys Glu Leu Ala Gln Glu

2465 2470 2475

Gln Ala Arg Arg Leu Gln Glu Asp Lys Glu Gln Met Ala Gln Gln

2480 2485 2490

Leu Ala Glu Glu Thr Gln Gly Phe Gln Arg Thr Leu Glu Ala Glu

2495 2500 2505

Arg Gln Arg Gln Leu Glu Met Ser Ala Glu Ala Glu Arg Leu Lys

2510 2515 2520

Leu Arg Val Ala Glu Met Ser Arg Ala Gln Ala Arg Ala Glu Glu

2525 2530 2535

Asp Ala Gln Arg Phe Arg Lys Gln Ala Glu Glu Ile Gly Glu Lys

2540 2545 2550

Leu His Arg Thr Glu Leu Ala Thr Gln Glu Lys Val Thr Leu Val

2555 2560 2565

Gln Thr Leu Glu Ile Gln Arg Gln Gln Ser Asp His Asp Ala Glu

2570 2575 2580

Arg Leu Arg Glu Ala Ile Ala Glu Leu Glu Arg Glu Lys Glu Lys

2585 2590 2595

Leu Gln Gln Glu Ala Lys Leu Leu Gln Leu Lys Ser Glu Glu Met

2600 2605 2610

Gln Thr Val Gln Gln Glu Gln Leu Leu Gln Glu Thr Gln Ala Leu

2615 2620 2625

Gln Gln Ser Phe Leu Ser Glu Lys Asp Ser Leu Leu Gln Arg Glu

2630 2635 2640

Arg Phe Ile Glu Gln Glu Lys Ala Lys Leu Glu Gln Leu Phe Gln

2645 2650 2655

Asp Glu Val Ala Lys Ala Gln Gln Leu Arg Glu Glu Gln Gln Arg

2660 2665 2670

Gln Gln Gln Gln Met Glu Gln Glu Arg Gln Arg Leu Val Ala Ser

2675 2680 2685

Met Glu Glu Ala Arg Arg Arg Gln His Glu Ala Glu Glu Gly Val

2690 2695 2700

Arg Arg Lys Gln Glu Glu Leu Gln Gln Leu Glu Gln Gln Arg Arg

2705 2710 2715

Gln Gln Glu Glu Leu Leu Ala Glu Glu Asn Gln Arg Leu Arg Glu

2720 2725 2730

Gln Leu Gln Leu Leu Glu Glu Gln His Arg Ala Ala Leu Ala His

2735 2740 2745

Ser Glu Glu Val Thr Ala Ser Gln Val Ala Ala Thr Lys Thr Leu

2750 2755 2760

Pro Asn Gly Arg Asp Ala Leu Asp Gly Pro Ala Ala Glu Ala Glu

2765 2770 2775

Pro Glu His Ser Phe Asp Gly Leu Arg Arg Lys Val Ser Ala Gln

2780 2785 2790

Arg Leu Gln Glu Ala Gly Ile Leu Ser Ala Glu Glu Leu Gln Arg

2795 2800 2805

Leu Ala Gln Gly His Thr Thr Val Asp Glu Leu Ala Arg Arg Glu

2810 2815 2820

Asp Val Arg His Tyr Leu Gln Gly Arg Ser Ser Ile Ala Gly Leu

2825 2830 2835

Leu Leu Lys Ala Thr Asn Glu Lys Leu Ser Val Tyr Ala Ala Leu

2840 2845 2850

Gln Arg Gln Leu Leu Ser Pro Gly Thr Ala Leu Ile Leu Leu Glu

2855 2860 2865

Ala Gln Ala Ala Ser Gly Phe Leu Leu Asp Pro Val Arg Asn Arg

2870 2875 2880

Arg Leu Thr Val Asn Glu Ala Val Lys Glu Gly Val Val Gly Pro

2885 2890 2895

Glu Leu His His Lys Leu Leu Ser Ala Glu Arg Ala Val Thr Gly

2900 2905 2910

Tyr Lys Asp Pro Tyr Thr Gly Gln Gln Ile Ser Leu Phe Gln Ala

2915 2920 2925

Met Gln Lys Gly Leu Ile Val Arg Glu His Gly Ile Arg Leu Leu

2930 2935 2940

Glu Ala Gln Ile Ala Thr Gly Gly Val Ile Asp Pro Val His Ser

2945 2950 2955

His Arg Val Pro Val Asp Val Ala Tyr Arg Arg Gly Tyr Phe Asp

2960 2965 2970

Glu Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr Lys

2975 2980 2985

Gly Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Leu Gln

2990 2995 3000

Leu Leu Glu Arg Cys Val Glu Asp Pro Glu Thr Gly Leu Cys Leu

3005 3010 3015

Leu Pro Leu Thr Asp Lys Ala Ala Lys Gly Gly Glu Leu Val Tyr

3020 3025 3030

Thr Asp Ser Glu Ala Arg Asp Val Phe Glu Lys Ala Thr Val Ser

3035 3040 3045

Ala Pro Phe Gly Lys Phe Gln Gly Lys Thr Val Thr Ile Trp Glu

3050 3055 3060

Ile Ile Asn Ser Glu Tyr Phe Thr Ala Glu Gln Arg Arg Asp Leu

3065 3070 3075

Leu Arg Gln Phe Arg Thr Gly Arg Ile Thr Val Glu Lys Ile Ile

3080 3085 3090

Lys Ile Ile Ile Thr Val Val Glu Glu Gln Glu Gln Lys Gly Arg

3095 3100 3105

Leu Cys Phe Glu Gly Leu Arg Ser Leu Val Pro Ala Ala Glu Leu

3110 3115 3120

Leu Glu Ser Arg Val Ile Asp Arg Glu Leu Tyr Gln Gln Leu Gln

3125 3130 3135

Arg Gly Glu Arg Ser Val Arg Asp Val Ala Glu Val Asp Thr Val

3140 3145 3150

Arg Arg Ala Leu Arg Gly Ala Asn Val Ile Ala Gly Val Trp Leu

3155 3160 3165

Glu Glu Ala Gly Gln Lys Leu Ser Ile Tyr Asn Ala Leu Lys Lys

3170 3175 3180

Asp Leu Leu Pro Ser Asp Met Ala Val Ala Leu Leu Glu Ala Gln

3185 3190 3195

Ala Gly Thr Gly His Ile Ile Asp Pro Ala Thr Ser Ala Arg Leu

3200 3205 3210

Thr Val Asp Glu Ala Val Arg Ala Gly Leu Val Gly Pro Glu Phe

3215 3220 3225

His Glu Lys Leu Leu Ser Ala Glu Lys Ala Val Thr Gly Tyr Arg

3230 3235 3240

Asp Pro Tyr Thr Gly Gln Ser Val Ser Leu Phe Gln Ala Leu Lys

3245 3250 3255

Lys Gly Leu Ile Pro Arg Glu Gln Gly Leu Arg Leu Leu Asp Ala

3260 3265 3270

Gln Leu Ser Thr Gly Gly Ile Val Asp Pro Ser Lys Ser His Arg

3275 3280 3285

Val Pro Leu Asp Val Ala Cys Ala Arg Gly Cys Leu Asp Glu Glu

3290 3295 3300

Thr Ser Arg Ala Leu Ser Ala Pro Arg Ala Asp Ala Lys Ala Tyr

3305 3310 3315

Ser Asp Pro Ser Thr Gly Glu Pro Ala Thr Tyr Gly Glu Leu Gln

3320 3325 3330

Gln Arg Cys Arg Pro Asp Gln Leu Thr Gly Leu Ser Leu Leu Pro

3335 3340 3345

Leu Ser Glu Lys Ala Ala Arg Ala Arg Gln Glu Glu Leu Tyr Ser

3350 3355 3360

Glu Leu Gln Ala Arg Glu Thr Phe Glu Lys Thr Pro Val Glu Val

3365 3370 3375

Pro Val Gly Gly Phe Lys Gly Arg Thr Val Thr Val Trp Glu Leu

3380 3385 3390

Ile Ser Ser Glu Tyr Phe Thr Ala Glu Gln Arg Gln Glu Leu Leu

3395 3400 3405

Arg Gln Phe Arg Thr Gly Lys Val Thr Val Glu Lys Val Ile Lys

3410 3415 3420

Ile Leu Ile Thr Ile Val Glu Glu Val Glu Thr Leu Arg Gln Glu

3425 3430 3435

Arg Leu Ser Phe Ser Gly Leu Arg Ala Pro Val Pro Ala Ser Glu

3440 3445 3450

Leu Leu Ala Ser Gly Val Leu Ser Arg Ala Gln Phe Glu Gln Leu

3455 3460 3465

Lys Asp Gly Lys Thr Thr Val Lys Asp Leu Ser Glu Leu Gly Ser

3470 3475 3480

Val Arg Thr Leu Leu Gln Gly Ser Gly Cys Leu Ala Gly Ile Tyr

3485 3490 3495

Leu Glu Asp Thr Lys Glu Lys Val Ser Ile Tyr Glu Ala Met Arg

3500 3505 3510

Arg Gly Leu Leu Arg Ala Thr Thr Ala Ala Leu Leu Leu Glu Ala

3515 3520 3525

Gln Ala Ala Thr Gly Phe Leu Val Asp Pro Val Arg Asn Gln Arg

3530 3535 3540

Leu Tyr Val His Glu Ala Val Lys Ala Gly Val Val Gly Pro Glu

3545 3550 3555

Leu His Glu Gln Leu Leu Ser Ala Glu Lys Ala Val Thr Gly Tyr

3560 3565 3570

Arg Asp Pro Tyr Ser Gly Ser Thr Ile Ser Leu Phe Gln Ala Met

3575 3580 3585

Gln Lys Gly Leu Val Leu Arg Gln His Gly Ile Arg Leu Leu Glu

3590 3595 3600

Ala Gln Ile Ala Thr Gly Gly Ile Ile Asp Pro Val His Ser His

3605 3610 3615

Arg Val Pro Val Asp Val Ala Tyr Gln Arg Gly Tyr Phe Ser Glu

3620 3625 3630

Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr Lys Gly

3635 3640 3645

Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Arg Gln Leu

3650 3655 3660

Leu Glu Arg Cys Val Glu Asp Pro Glu Thr Gly Leu Arg Leu Leu

3665 3670 3675

Pro Leu Lys Gly Ala Glu Lys Ala Glu Val Val Glu Thr Thr Gln

3680 3685 3690

Val Tyr Thr Glu Glu Glu Thr Arg Arg Ala Phe Glu Glu Thr Gln

3695 3700 3705

Ile Asp Ile Pro Gly Gly Gly Ser His Gly Gly Ser Thr Met Ser

3710 3715 3720

Leu Trp Glu Val Met Gln Ser Asp Leu Ile Pro Glu Glu Gln Arg

3725 3730 3735

Ala Gln Leu Met Ala Asp Phe Gln Ala Gly Arg Val Thr Lys Glu

3740 3745 3750

Arg Met Ile Ile Ile Ile Ile Glu Ile Ile Glu Lys Thr Glu Ile

3755 3760 3765

Ile Arg Gln Gln Gly Leu Ala Ser Tyr Asp Tyr Val Arg Arg Arg

3770 3775 3780

Leu Thr Ala Glu Asp Leu Phe Glu Ala Arg Ile Ile Ser Leu Glu

3785 3790 3795

Thr Tyr Asn Leu Leu Arg Glu Gly Thr Arg Ser Leu Arg Glu Ala

3800 3805 3810

Leu Glu Ala Glu Ser Ala Trp Cys Tyr Leu Tyr Gly Thr Gly Ser

3815 3820 3825

Val Ala Gly Val Tyr Leu Pro Gly Ser Arg Gln Thr Leu Ser Ile

3830 3835 3840

Tyr Gln Ala Leu Lys Lys Gly Leu Leu Ser Ala Glu Val Ala Arg

3845 3850 3855

Leu Leu Leu Glu Ala Gln Ala Ala Thr Gly Phe Leu Leu Asp Pro

3860 3865 3870

Val Lys Gly Glu Arg Leu Thr Val Asp Glu Ala Val Arg Lys Gly

3875 3880 3885

Leu Val Gly Pro Glu Leu His Asp Arg Leu Leu Ser Ala Glu Arg

3890 3895 3900

Ala Val Thr Gly Tyr Arg Asp Pro Tyr Thr Glu Gln Thr Ile Ser

3905 3910 3915

Leu Phe Gln Ala Met Lys Lys Glu Leu Ile Pro Thr Glu Glu Ala

3920 3925 3930

Leu Arg Leu Leu Asp Ala Gln Leu Ala Thr Gly Gly Ile Val Asp

3935 3940 3945

Pro Arg Leu Gly Phe His Leu Pro Leu Glu Val Ala Tyr Gln Arg

3950 3955 3960

Gly Tyr Leu Asn Lys Asp Thr His Asp Gln Leu Ser Glu Pro Ser

3965 3970 3975

Glu Val Arg Ser Tyr Val Asp Pro Ser Thr Asp Glu Arg Leu Ser

3980 3985 3990

Tyr Thr Gln Leu Leu Arg Arg Cys Arg Arg Asp Asp Gly Thr Gly

3995 4000 4005

Gln Leu Leu Leu Pro Leu Ser Asp Ala Arg Lys Leu Thr Phe Arg

4010 4015 4020

Gly Leu Arg Lys Gln Ile Thr Met Glu Glu Leu Val Arg Ser Gln

4025 4030 4035

Val Met Asp Glu Ala Thr Ala Leu Gln Leu Arg Glu Gly Leu Thr

4040 4045 4050

Ser Ile Glu Glu Val Thr Lys Asn Leu Gln Lys Phe Leu Glu Gly

4055 4060 4065

Thr Ser Cys Ile Ala Gly Val Phe Val Asp Ala Thr Lys Glu Arg

4070 4075 4080

Leu Ser Val Tyr Gln Ala Met Lys Lys Gly Ile Ile Arg Pro Gly

4085 4090 4095

Thr Ala Phe Glu Leu Leu Glu Ala Gln Ala Ala Thr Gly Tyr Val

4100 4105 4110

Ile Asp Pro Ile Lys Gly Leu Lys Leu Thr Val Glu Glu Ala Val

4115 4120 4125

Arg Met Gly Ile Val Gly Pro Glu Phe Lys Asp Lys Leu Leu Ser

4130 4135 4140

Ala Glu Arg Ala Val Thr Gly Tyr Lys Asp Pro Tyr Ser Gly Lys

4145 4150 4155

Leu Ile Ser Leu Phe Gln Ala Met Lys Lys Gly Leu Ile Leu Lys

4160 4165 4170

Asp His Gly Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly

4175 4180 4185

Ile Ile Asp Pro Glu Glu Ser His Arg Leu Pro Val Glu Val Ala

4190 4195 4200

Tyr Lys Arg Gly Leu Phe Asp Glu Glu Met Asn Glu Ile Leu Thr

4205 4210 4215

Asp Pro Ser Asp Asp Thr Lys Gly Phe Phe Asp Pro Asn Thr Glu

4220 4225 4230

Glu Asn Leu Thr Tyr Leu Gln Leu Met Glu Arg Cys Ile Thr Asp

4235 4240 4245

Pro Gln Thr Gly Leu Cys Leu Leu Pro Leu Lys Glu Lys Lys Arg

4250 4255 4260

Glu Arg Lys Thr Ser Ser Lys Ser Ser Val Arg Lys Arg Arg Val

4265 4270 4275

Val Ile Val Asp Pro Glu Thr Gly Lys Glu Met Ser Val Tyr Glu

4280 4285 4290

Ala Tyr Arg Lys Gly Leu Ile Asp His Gln Thr Tyr Leu Glu Leu

4295 4300 4305

Ser Glu Gln Glu Cys Glu Trp Glu Glu Ile Thr Ile Ser Ser Ser

4310 4315 4320

Asp Gly Val Val Lys Ser Met Ile Ile Asp Arg Arg Ser Gly Arg

4325 4330 4335

Gln Tyr Asp Ile Asp Asp Ala Ile Ala Lys Asn Leu Ile Asp Arg

4340 4345 4350

Ser Ala Leu Asp Gln Tyr Arg Ala Gly Thr Leu Ser Ile Thr Glu

4355 4360 4365

Phe Ala Asp Met Leu Ser Gly Asn Ala Gly Gly Phe Arg Ser Arg

4370 4375 4380

Ser Ser Ser Val Gly Ser Ser Ser Ser Tyr Pro Ile Ser Pro Ala

4385 4390 4395

Val Ser Arg Thr Gln Leu Ala Ser Trp Ser Asp Pro Thr Glu Glu

4400 4405 4410

Thr Gly Pro Val Ala Gly Ile Leu Asp Thr Glu Thr Leu Glu Lys

4415 4420 4425

Val Ser Ile Thr Glu Ala Met His Arg Asn Leu Val Asp Asn Ile

4430 4435 4440

Thr Gly Gln Arg Leu Leu Glu Ala Gln Ala Cys Thr Gly Gly Ile

4445 4450 4455

Ile Asp Pro Ser Thr Gly Glu Arg Phe Pro Val Thr Asp Ala Val

4460 4465 4470

Asn Lys Gly Leu Val Asp Lys Ile Met Val Asp Arg Ile Asn Leu

4475 4480 4485

Ala Gln Lys Ala Phe Cys Gly Phe Glu Asp Pro Arg Thr Lys Thr

4490 4495 4500

Lys Met Ser Ala Ala Gln Ala Leu Lys Lys Gly Trp Leu Tyr Tyr

4505 4510 4515

Glu Ala Gly Gln Arg Phe Leu Glu Val Gln Tyr Leu Thr Gly Gly

4520 4525 4530

Leu Ile Glu Pro Asp Thr Pro Gly Arg Val Pro Leu Asp Glu Ala

4535 4540 4545

Leu Gln Arg Gly Thr Val Asp Ala Arg Thr Ala Gln Lys Leu Arg

4550 4555 4560

Asp Val Gly Ala Tyr Ser Lys Tyr Leu Thr Cys Pro Lys Thr Lys

4565 4570 4575

Leu Lys Ile Ser Tyr Lys Asp Ala Leu Asp Arg Ser Met Val Glu

4580 4585 4590

Glu Gly Thr Gly Leu Arg Leu Leu Glu Ala Ala Ala Gln Ser Thr

4595 4600 4605

Lys Gly Tyr Tyr Ser Pro Tyr Ser Val Ser Gly Ser Gly Ser Thr

4610 4615 4620

Ala Gly Ser Arg Thr Gly Ser Arg Thr Gly Ser Arg Ala Gly Ser

4625 4630 4635

Arg Arg Gly Ser Phe Asp Ala Thr Gly Ser Gly Phe Ser Met Thr

4640 4645 4650

Phe Ser Ser Ser Ser Tyr Ser Ser Ser Gly Tyr Gly Arg Arg Tyr

4655 4660 4665

Ala Ser Gly Ser Ser Ala Ser Leu Gly Gly Pro Glu Ser Ala Val

4670 4675 4680

Ala

<210> 6

<211> 654

<212> PRT

<213> 智人(Homo sapiens)

<400> 6

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala

1 5 10 15

Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly

20 25 30

Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly

35 40 45

Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser

50 55 60

Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala

65 70 75 80

Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys

85 90 95

Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile

100 105 110

Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile

115 120 125

Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu

130 135 140

Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr

145 150 155 160

Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe

165 170 175

Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly

180 185 190

Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala

195 200 205

Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp

210 215 220

Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly

225 230 235 240

Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu

245 250 255

Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys

260 265 270

Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu

275 280 285

Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln

290 295 300

Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu

305 310 315 320

Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg

325 330 335

Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys

340 345 350

Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile

355 360 365

Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro

370 375 380

Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val

385 390 395 400

Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu

405 410 415

Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val

420 425 430

Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser

435 440 445

Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys

450 455 460

Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly

465 470 475 480

Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln

485 490 495

Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr

500 505 510

Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn

515 520 525

Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp

530 535 540

Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp

545 550 555 560

Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile

565 570 575

Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu

580 585 590

Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His

595 600 605

Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu

610 615 620

Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro

625 630 635 640

Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu

645 650

<210> 7

<211> 710

<212> PRT

<213> 智人(Homo sapiens)

<400> 7

Met Val Lys Leu Ala Lys Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys

1 5 10 15

Met Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu

20 25 30

Met Ser Glu Asp Glu Glu Asp Asp Ser Ser Gly Glu Glu Val Val Ile

35 40 45

Pro Gln Lys Lys Gly Lys Lys Ala Ala Ala Thr Ser Ala Lys Lys Val

50 55 60

Val Val Ser Pro Thr Lys Lys Val Ala Val Ala Thr Pro Ala Lys Lys

65 70 75 80

Ala Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys

85 90 95

Thr Val Thr Pro Ala Lys Ala Val Thr Thr Pro Gly Lys Lys Gly Ala

100 105 110

Thr Pro Gly Lys Ala Leu Val Ala Thr Pro Gly Lys Lys Gly Ala Ala

115 120 125

Ile Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp

130 135 140

Ser Asp Glu Glu Glu Asp Asp Asp Ser Glu Glu Asp Glu Glu Asp Asp

145 150 155 160

Glu Asp Glu Asp Glu Asp Glu Asp Glu Ile Glu Pro Ala Ala Met Lys

165 170 175

Ala Ala Ala Ala Ala Pro Ala Ser Glu Asp Glu Asp Asp Glu Asp Asp

180 185 190

Glu Asp Asp Glu Asp Asp Asp Asp Asp Glu Glu Asp Asp Ser Glu Glu

195 200 205

Glu Ala Met Glu Thr Thr Pro Ala Lys Gly Lys Lys Ala Ala Lys Val

210 215 220

Val Pro Val Lys Ala Lys Asn Val Ala Glu Asp Glu Asp Glu Glu Glu

225 230 235 240

Asp Asp Glu Asp Glu Asp Asp Asp Asp Asp Glu Asp Asp Glu Asp Asp

245 250 255

Asp Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro

260 265 270

Val Lys Glu Ala Pro Gly Lys Arg Lys Lys Glu Met Ala Lys Gln Lys

275 280 285

Ala Ala Pro Glu Ala Lys Lys Gln Lys Val Glu Gly Thr Glu Pro Thr

290 295 300

Thr Ala Phe Asn Leu Phe Val Gly Asn Leu Asn Phe Asn Lys Ser Ala

305 310 315 320

Pro Glu Leu Lys Thr Gly Ile Ser Asp Val Phe Ala Lys Asn Asp Leu

325 330 335

Ala Val Val Asp Val Arg Ile Gly Met Thr Arg Lys Phe Gly Tyr Val

340 345 350

Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu Leu Thr Gly

355 360 365

Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro Lys Gly Lys

370 375 380

Asp Ser Lys Lys Glu Arg Asp Ala Arg Thr Leu Leu Ala Lys Asn Leu

385 390 395 400

Pro Tyr Lys Val Thr Gln Asp Glu Leu Lys Glu Val Phe Glu Asp Ala

405 410 415

Ala Glu Ile Arg Leu Val Ser Lys Asp Gly Lys Ser Lys Gly Ile Ala

420 425 430

Tyr Ile Glu Phe Lys Thr Glu Ala Asp Ala Glu Lys Thr Phe Glu Glu

435 440 445

Lys Gln Gly Thr Glu Ile Asp Gly Arg Ser Ile Ser Leu Tyr Tyr Thr

450 455 460

Gly Glu Lys Gly Gln Asn Gln Asp Tyr Arg Gly Gly Lys Asn Ser Thr

465 470 475 480

Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser Tyr Ser

485 490 495

Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr Phe Ile

500 505 510

Lys Val Pro Gln Asn Gln Asn Gly Lys Ser Lys Gly Tyr Ala Phe Ile

515 520 525

Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser Cys Asn

530 535 540

Lys Arg Glu Ile Glu Gly Arg Ala Ile Arg Leu Glu Leu Gln Gly Pro

545 550 555 560

Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu Phe Val

565 570 575

Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu Ser Phe

580 585 590

Asp Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr Gly Ser

595 600 605

Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp Ala Lys

610 615 620

Ala Ala Lys Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn Lys Val

625 630 635 640

Thr Leu Asp Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly Gly Arg

645 650 655

Gly Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly

660 665 670

Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly

675 680 685

Gly Phe Arg Gly Gly Arg Gly Gly Gly Gly Asp His Lys Pro Gln Gly

690 695 700

Lys Lys Thr Lys Phe Glu

705 710

<210> 8

<211> 284

<212> PRT

<213> 智人(Homo sapiens)

<400> 8

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu

1 5 10 15

Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala

20 25 30

Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys

35 40 45

Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu

50 55 60

Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp

65 70 75 80

Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu

85 90 95

Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys

100 105 110

Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys

115 120 125

Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln

130 135 140

Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg

145 150 155 160

Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu

165 170 175

Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu

180 185 190

Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu

195 200 205

Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu

210 215 220

Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu

225 230 235 240

Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu

245 250 255

Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu

260 265 270

Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile

275 280

<210> 9

<211> 2201

<212> PRT

<213> 智人(Homo sapiens)

<400> 9

Met Gly Ala Met Thr Gln Leu Leu Ala Gly Val Phe Leu Ala Phe Leu

1 5 10 15

Ala Leu Ala Thr Glu Gly Gly Val Leu Lys Lys Val Ile Arg His Lys

20 25 30

Arg Gln Ser Gly Val Asn Ala Thr Leu Pro Glu Glu Asn Gln Pro Val

35 40 45

Val Phe Asn His Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys

50 55 60

Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro

65 70 75 80

Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn

85 90 95

Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly

100 105 110

Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu

115 120 125

Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala

130 135 140

Gly Cys Cys Leu Gln Pro Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe

145 150 155 160

Cys Ser Gly Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys

165 170 175

Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly

180 185 190

Asn Cys His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp

195 200 205

Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp

210 215 220

Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe Glu

225 230 235 240

Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys Pro Val Pro Cys

245 250 255

Ser Glu Glu His Gly Thr Cys Val Asp Gly Leu Cys Val Cys His Asp

260 265 270

Gly Phe Ala Gly Asp Asp Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys

275 280 285

Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly

290 295 300

Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe

305 310 315 320

Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe

325 330 335

Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr

340 345 350

Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly Phe Ala

355 360 365

Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His Asn Arg

370 375 380

Gly Arg Cys Val Asp Gly Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly

385 390 395 400

Ala Asp Cys Gly Glu Leu Lys Cys Pro Asn Gly Cys Ser Gly His Gly

405 410 415

Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu

420 425 430

Asp Cys Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg

435 440 445

Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp

450 455 460

Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys

465 470 475 480

Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys

485 490 495

Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn Arg Gly Leu Cys Val

500 505 510

Asp Gly Gln Cys Val Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala

515 520 525

Glu Leu Ser Cys Pro Asn Asp Cys His Gly Gln Gly Arg Cys Val Asn

530 535 540

Gly Gln Cys Val Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu

545 550 555 560

Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly

565 570 575

Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His

580 585 590

Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly Arg

595 600 605

Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser

610 615 620

Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn

625 630 635 640

Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr

645 650 655

Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly

660 665 670

Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr

675 680 685

Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val

690 695 700

Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe

705 710 715 720

Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp

725 730 735

Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu

740 745 750

Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr

755 760 765

Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His

770 775 780

Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr

785 790 795 800

Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp

805 810 815

Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly

820 825 830

Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr

835 840 845

Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys

850 855 860

Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met

865 870 875 880

Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro

885 890 895

Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu

900 905 910

Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala

915 920 925

Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln

930 935 940

Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu

945 950 955 960

Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn Pro

965 970 975

Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln

980 985 990

Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu Leu Trp Lys Thr Pro

995 1000 1005

Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr Ser Leu Pro Thr

1010 1015 1020

Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr Thr Ser Tyr

1025 1030 1035

Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val Leu Leu

1040 1045 1050

Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val Lys

1055 1060 1065

Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr

1070 1075 1080

Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp

1085 1090 1095

Gln Ala Tyr Glu His Phe Ile Ile Gln Val Gln Glu Ala Asn Lys

1100 1105 1110

Val Glu Ala Ala Arg Asn Leu Thr Val Pro Gly Ser Leu Arg Ala

1115 1120 1125

Val Asp Ile Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr Val Ser

1130 1135 1140

Ile Tyr Gly Val Ile Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala

1145 1150 1155

Glu Ala Ser Thr Gly Glu Thr Pro Asn Leu Gly Glu Val Val Val

1160 1165 1170

Ala Glu Val Gly Trp Asp Ala Leu Lys Leu Asn Trp Thr Ala Pro

1175 1180 1185

Glu Gly Ala Tyr Glu Tyr Phe Phe Ile Gln Val Gln Glu Ala Asp

1190 1195 1200

Thr Val Glu Ala Ala Gln Asn Leu Thr Val Pro Gly Gly Leu Arg

1205 1210 1215

Ser Thr Asp Leu Pro Gly Leu Lys Ala Ala Thr His Tyr Thr Ile

1220 1225 1230

Thr Ile Arg Gly Val Thr Gln Asp Phe Ser Thr Thr Pro Leu Ser

1235 1240 1245

Val Glu Val Leu Thr Glu Glu Val Pro Asp Met Gly Asn Leu Thr

1250 1255 1260

Val Thr Glu Val Ser Trp Asp Ala Leu Arg Leu Asn Trp Thr Thr

1265 1270 1275

Pro Asp Gly Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln Glu Ala

1280 1285 1290

Asp Gln Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser Leu

1295 1300 1305

Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr

1310 1315 1320

Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro Leu

1325 1330 1335

Ala Val Glu Val Val Thr Glu Asp Leu Pro Gln Leu Gly Asp Leu

1340 1345 1350

Ala Val Ser Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr

1355 1360 1365

Ala Ala Asp Asn Ala Tyr Glu His Phe Val Ile Gln Val Gln Glu

1370 1375 1380

Val Asn Lys Val Glu Ala Ala Gln Asn Leu Thr Leu Pro Gly Ser

1385 1390 1395

Leu Arg Ala Val Asp Ile Pro Gly Leu Glu Ala Ala Thr Pro Tyr

1400 1405 1410

Arg Val Ser Ile Tyr Gly Val Ile Arg Gly Tyr Arg Thr Pro Val

1415 1420 1425

Leu Ser Ala Glu Ala Ser Thr Ala Lys Glu Pro Glu Ile Gly Asn

1430 1435 1440

Leu Asn Val Ser Asp Ile Thr Pro Glu Ser Phe Asn Leu Ser Trp

1445 1450 1455

Met Ala Thr Asp Gly Ile Phe Glu Thr Phe Thr Ile Glu Ile Ile

1460 1465 1470

Asp Ser Asn Arg Leu Leu Glu Thr Val Glu Tyr Asn Ile Ser Gly

1475 1480 1485

Ala Glu Arg Thr Ala His Ile Ser Gly Leu Pro Pro Ser Thr Asp

1490 1495 1500

Phe Ile Val Tyr Leu Ser Gly Leu Ala Pro Ser Ile Arg Thr Lys

1505 1510 1515

Thr Ile Ser Ala Thr Ala Thr Thr Glu Ala Leu Pro Leu Leu Glu

1520 1525 1530

Asn Leu Thr Ile Ser Asp Ile Asn Pro Tyr Gly Phe Thr Val Ser

1535 1540 1545

Trp Met Ala Ser Glu Asn Ala Phe Asp Ser Phe Leu Val Thr Val

1550 1555 1560

Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu Phe Thr Leu Ser

1565 1570 1575

Gly Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile Thr Gly Ile

1580 1585 1590

Gly Tyr Glu Val Met Val Ser Gly Phe Thr Gln Gly His Gln Thr

1595 1600 1605

Lys Pro Leu Arg Ala Glu Ile Val Thr Glu Ala Glu Pro Glu Val

1610 1615 1620

Asp Asn Leu Leu Val Ser Asp Ala Thr Pro Asp Gly Phe Arg Leu

1625 1630 1635

Ser Trp Thr Ala Asp Glu Gly Val Phe Asp Asn Phe Val Leu Lys

1640 1645 1650

Ile Arg Asp Thr Lys Lys Gln Ser Glu Pro Leu Glu Ile Thr Leu

1655 1660 1665

Leu Ala Pro Glu Arg Thr Arg Asp Ile Thr Gly Leu Arg Glu Ala

1670 1675 1680

Thr Glu Tyr Glu Ile Glu Leu Tyr Gly Ile Ser Lys Gly Arg Arg

1685 1690 1695

Ser Gln Thr Val Ser Ala Ile Ala Thr Thr Ala Met Gly Ser Pro

1700 1705 1710

Lys Glu Val Ile Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val

1715 1720 1725

Ser Trp Arg Ala Pro Thr Ala Gln Val Glu Ser Phe Arg Ile Thr

1730 1735 1740

Tyr Val Pro Ile Thr Gly Gly Thr Pro Ser Met Val Thr Val Asp

1745 1750 1755

Gly Thr Lys Thr Gln Thr Arg Leu Val Lys Leu Ile Pro Gly Val

1760 1765 1770

Glu Tyr Leu Val Ser Ile Ile Ala Met Lys Gly Phe Glu Glu Ser

1775 1780 1785

Glu Pro Val Ser Gly Ser Phe Thr Thr Ala Leu Asp Gly Pro Ser

1790 1795 1800

Gly Leu Val Thr Ala Asn Ile Thr Asp Ser Glu Ala Leu Ala Arg

1805 1810 1815

Trp Gln Pro Ala Ile Ala Thr Val Asp Ser Tyr Val Ile Ser Tyr

1820 1825 1830

Thr Gly Glu Lys Val Pro Glu Ile Thr Arg Thr Val Ser Gly Asn

1835 1840 1845

Thr Val Glu Tyr Ala Leu Thr Asp Leu Glu Pro Ala Thr Glu Tyr

1850 1855 1860

Thr Leu Arg Ile Phe Ala Glu Lys Gly Pro Gln Lys Ser Ser Thr

1865 1870 1875

Ile Thr Ala Lys Phe Thr Thr Asp Leu Asp Ser Pro Arg Asp Leu

1880 1885 1890

Thr Ala Thr Glu Val Gln Ser Glu Thr Ala Leu Leu Thr Trp Arg

1895 1900 1905

Pro Pro Arg Ala Ser Val Thr Gly Tyr Leu Leu Val Tyr Glu Ser

1910 1915 1920

Val Asp Gly Thr Val Lys Glu Val Ile Val Gly Pro Asp Thr Thr

1925 1930 1935

Ser Tyr Ser Leu Ala Asp Leu Ser Pro Ser Thr His Tyr Thr Ala

1940 1945 1950

Lys Ile Gln Ala Leu Asn Gly Pro Leu Arg Ser Asn Met Ile Gln

1955 1960 1965

Thr Ile Phe Thr Thr Ile Gly Leu Leu Tyr Pro Phe Pro Lys Asp

1970 1975 1980

Cys Ser Gln Ala Met Leu Asn Gly Asp Thr Thr Ser Gly Leu Tyr

1985 1990 1995

Thr Ile Tyr Leu Asn Gly Asp Lys Ala Glu Ala Leu Glu Val Phe

2000 2005 2010

Cys Asp Met Thr Ser Asp Gly Gly Gly Trp Ile Val Phe Leu Arg

2015 2020 2025

Arg Lys Asn Gly Arg Glu Asn Phe Tyr Gln Asn Trp Lys Ala Tyr

2030 2035 2040

Ala Ala Gly Phe Gly Asp Arg Arg Glu Glu Phe Trp Leu Gly Leu

2045 2050 2055

Asp Asn Leu Asn Lys Ile Thr Ala Gln Gly Gln Tyr Glu Leu Arg

2060 2065 2070

Val Asp Leu Arg Asp His Gly Glu Thr Ala Phe Ala Val Tyr Asp

2075 2080 2085

Lys Phe Ser Val Gly Asp Ala Lys Thr Arg Tyr Lys Leu Lys Val

2090 2095 2100

Glu Gly Tyr Ser Gly Thr Ala Gly Asp Ser Met Ala Tyr His Asn

2105 2110 2115

Gly Arg Ser Phe Ser Thr Phe Asp Lys Asp Thr Asp Ser Ala Ile

2120 2125 2130

Thr Asn Cys Ala Leu Ser Tyr Lys Gly Ala Phe Trp Tyr Arg Asn

2135 2140 2145

Cys His Arg Val Asn Leu Met Gly Arg Tyr Gly Asp Asn Asn His

2150 2155 2160

Ser Gln Gly Val Asn Trp Phe His Trp Lys Gly His Glu His Ser

2165 2170 2175

Ile Gln Phe Ala Glu Met Lys Leu Arg Pro Ser Asn Phe Arg Asn

2180 2185 2190

Leu Glu Gly Arg Arg Lys Arg Ala

2195 2200

<210> 10

<211> 291

<212> PRT

<213> 智人(Homo sapiens)

<400> 10

Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu

1 5 10 15

Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala

20 25 30

Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu

35 40 45

Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu

50 55 60

Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro

65 70 75 80

Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro

85 90 95

Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly

100 105 110

Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu

115 120 125

Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg

130 135 140

Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His Arg Val

145 150 155 160

Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys

165 170 175

Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser

180 185 190

Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr

195 200 205

Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu

210 215 220

Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys

225 230 235 240

Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly

245 250 255

Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu

260 265 270

Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met

275 280 285

Gln Ser Lys

290

<210> 11

<211> 1838

<212> PRT

<213> 智人(Homo sapiens)

<400> 11

Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly

1 5 10 15

Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro

20 25 30

Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe

35 40 45

His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr

50 55 60

Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp

65 70 75 80

Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe

85 90 95

Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser

100 105 110

Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile

115 120 125

Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr

130 135 140

Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu

145 150 155 160

Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn

165 170 175

Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp

180 185 190

Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly

195 200 205

Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu

210 215 220

Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr

225 230 235 240

Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp

245 250 255

Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr

260 265 270

Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys

275 280 285

Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr

290 295 300

Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met

305 310 315 320

Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly

325 330 335

Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr

340 345 350

Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr

355 360 365

Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser

370 375 380

Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu

385 390 395 400

Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr

405 410 415

Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro

420 425 430

Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro

435 440 445

Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly

450 455 460

Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro

465 470 475 480

Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly

485 490 495

Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu

500 505 510

Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly

515 520 525

Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser

530 535 540

Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro

545 550 555 560

Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro

565 570 575

Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly

580 585 590

Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg

595 600 605

Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr

610 615 620

Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly

625 630 635 640

Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro

645 650 655

Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg

660 665 670

Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly

675 680 685

Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln

690 695 700

Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro

705 710 715 720

Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly

725 730 735

Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu

740 745 750

Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu

755 760 765

Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly

770 775 780

Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile

785 790 795 800

Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro

805 810 815

Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly

820 825 830

Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg

835 840 845

Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys

850 855 860

Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly

865 870 875 880

Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu

885 890 895

Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg

900 905 910

Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly

915 920 925

Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro

930 935 940

Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro

945 950 955 960

Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly

965 970 975

His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro

980 985 990

Pro Gly Pro Pro Gly Val Val Gly Pro Gln Gly Pro Thr Gly Glu Thr

995 1000 1005

Gly Pro Met Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro Pro

1010 1015 1020

Gly Glu Gln Gly Leu Pro Gly Leu Ala Gly Lys Glu Gly Thr Lys

1025 1030 1035

Gly Asp Pro Gly Pro Ala Gly Leu Pro Gly Lys Asp Gly Pro Pro

1040 1045 1050

Gly Leu Arg Gly Phe Pro Gly Asp Arg Gly Leu Pro Gly Pro Val

1055 1060 1065

Gly Ala Leu Gly Leu Lys Gly Asn Glu Gly Pro Pro Gly Pro Pro

1070 1075 1080

Gly Pro Ala Gly Ser Pro Gly Glu Arg Gly Pro Ala Gly Ala Ala

1085 1090 1095

Gly Pro Ile Gly Ile Pro Gly Arg Pro Gly Pro Gln Gly Pro Pro

1100 1105 1110

Gly Pro Ala Gly Glu Lys Gly Ala Pro Gly Glu Lys Gly Pro Gln

1115 1120 1125

Gly Pro Ala Gly Arg Asp Gly Leu Gln Gly Pro Val Gly Leu Pro

1130 1135 1140

Gly Pro Ala Gly Pro Val Gly Pro Pro Gly Glu Asp Gly Asp Lys

1145 1150 1155

Gly Glu Ile Gly Glu Pro Gly Gln Lys Gly Ser Lys Gly Asp Lys

1160 1165 1170

Gly Glu Gln Gly Pro Pro Gly Pro Thr Gly Pro Gln Gly Pro Ile

1175 1180 1185

Gly Gln Pro Gly Pro Ser Gly Ala Asp Gly Glu Pro Gly Pro Arg

1190 1195 1200

Gly Gln Gln Gly Leu Phe Gly Gln Lys Gly Asp Glu Gly Pro Arg

1205 1210 1215

Gly Phe Pro Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu Pro

1220 1225 1230

Gly Pro Pro Gly Glu Lys Gly Glu Thr Gly Asp Val Gly Gln Met

1235 1240 1245

Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Ser Gly Ala Pro

1250 1255 1260

Gly Ala Asp Gly Pro Gln Gly Pro Pro Gly Gly Ile Gly Asn Pro

1265 1270 1275

Gly Ala Val Gly Glu Lys Gly Glu Pro Gly Glu Ala Gly Glu Pro

1280 1285 1290

Gly Leu Pro Gly Glu Gly Gly Pro Pro Gly Pro Lys Gly Glu Arg

1295 1300 1305

Gly Glu Lys Gly Glu Ser Gly Pro Ser Gly Ala Ala Gly Pro Pro

1310 1315 1320

Gly Pro Lys Gly Pro Pro Gly Asp Asp Gly Pro Lys Gly Ser Pro

1325 1330 1335

Gly Pro Val Gly Phe Pro Gly Asp Pro Gly Pro Pro Gly Glu Pro

1340 1345 1350

Gly Pro Ala Gly Gln Asp Gly Pro Pro Gly Asp Lys Gly Asp Asp

1355 1360 1365

Gly Glu Pro Gly Gln Thr Gly Ser Pro Gly Pro Thr Gly Glu Pro

1370 1375 1380

Gly Pro Ser Gly Pro Pro Gly Lys Arg Gly Pro Pro Gly Pro Ala

1385 1390 1395

Gly Pro Glu Gly Arg Gln Gly Glu Lys Gly Ala Lys Gly Glu Ala

1400 1405 1410

Gly Leu Glu Gly Pro Pro Gly Lys Thr Gly Pro Ile Gly Pro Gln

1415 1420 1425

Gly Ala Pro Gly Lys Pro Gly Pro Asp Gly Leu Arg Gly Ile Pro

1430 1435 1440

Gly Pro Val Gly Glu Gln Gly Leu Pro Gly Ser Pro Gly Pro Asp

1445 1450 1455

Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Leu Pro Gly Leu Lys

1460 1465 1470

Gly Asp Ser Gly Pro Lys Gly Glu Lys Gly His Pro Gly Leu Ile

1475 1480 1485

Gly Leu Ile Gly Pro Pro Gly Glu Gln Gly Glu Lys Gly Asp Arg

1490 1495 1500

Gly Leu Pro Gly Pro Gln Gly Ser Ser Gly Pro Lys Gly Glu Gln

1505 1510 1515

Gly Ile Thr Gly Pro Ser Gly Pro Ile Gly Pro Pro Gly Pro Pro

1520 1525 1530

Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Ala Lys Gly Ser Ser

1535 1540 1545

Gly Pro Thr Gly Pro Lys Gly Glu Ala Gly His Pro Gly Pro Pro

1550 1555 1560

Gly Pro Pro Gly Pro Pro Gly Glu Val Ile Gln Pro Leu Pro Ile

1565 1570 1575

Gln Ala Ser Arg Thr Arg Arg Asn Ile Asp Ala Ser Gln Leu Leu

1580 1585 1590

Asp Asp Gly Asn Gly Glu Asn Tyr Val Asp Tyr Ala Asp Gly Met

1595 1600 1605

Glu Glu Ile Phe Gly Ser Leu Asn Ser Leu Lys Leu Glu Ile Glu

1610 1615 1620

Gln Met Lys Arg Pro Leu Gly Thr Gln Gln Asn Pro Ala Arg Thr

1625 1630 1635

Cys Lys Asp Leu Gln Leu Cys His Pro Asp Phe Pro Asp Gly Glu

1640 1645 1650

Tyr Trp Val Asp Pro Asn Gln Gly Cys Ser Arg Asp Ser Phe Lys

1655 1660 1665

Val Tyr Cys Asn Phe Thr Ala Gly Gly Ser Thr Cys Val Phe Pro

1670 1675 1680

Asp Lys Lys Ser Glu Gly Ala Arg Ile Thr Ser Trp Pro Lys Glu

1685 1690 1695

Asn Pro Gly Ser Trp Phe Ser Glu Phe Lys Arg Gly Lys Leu Leu

1700 1705 1710

Ser Tyr Val Asp Ala Glu Gly Asn Pro Val Gly Val Val Gln Met

1715 1720 1725

Thr Phe Leu Arg Leu Leu Ser Ala Ser Ala His Gln Asn Val Thr

1730 1735 1740

Tyr His Cys Tyr Gln Ser Val Ala Trp Gln Asp Ala Ala Thr Gly

1745 1750 1755

Ser Tyr Asp Lys Ala Leu Arg Phe Leu Gly Ser Asn Asp Glu Glu

1760 1765 1770

Met Ser Tyr Asp Asn Asn Pro Tyr Ile Arg Ala Leu Val Asp Gly

1775 1780 1785

Cys Ala Thr Lys Lys Gly Tyr Gln Lys Thr Val Leu Glu Ile Asp

1790 1795 1800

Thr Pro Lys Val Glu Gln Val Pro Ile Val Asp Ile Met Phe Asn

1805 1810 1815

Asp Phe Gly Glu Ala Ser Gln Lys Phe Gly Phe Glu Val Gly Pro

1820 1825 1830

Ala Cys Phe Met Gly

1835

<210> 12

<211> 323

<212> PRT

<213> 智人(Homo sapiens)

<400> 12

Met Gln Ala Ala Trp Leu Leu Gly Ala Leu Val Val Pro Gln Leu Leu

1 5 10 15

Gly Phe Gly His Gly Ala Arg Gly Ala Glu Arg Glu Trp Glu Gly Gly

20 25 30

Trp Gly Gly Ala Gln Glu Glu Glu Arg Glu Arg Glu Ala Leu Met Leu

35 40 45

Lys His Leu Gln Glu Ala Leu Gly Leu Pro Ala Gly Arg Gly Asp Glu

50 55 60

Asn Pro Ala Gly Thr Val Glu Gly Lys Glu Asp Trp Glu Met Glu Glu

65 70 75 80

Asp Gln Gly Glu Glu Glu Glu Glu Glu Ala Thr Pro Thr Pro Ser Ser

85 90 95

Gly Pro Ser Pro Ser Pro Thr Pro Glu Asp Ile Val Thr Tyr Ile Leu

100 105 110

Gly Arg Leu Ala Gly Leu Asp Ala Gly Leu His Gln Leu His Val Arg

115 120 125

Leu His Ala Leu Asp Thr Arg Val Val Glu Leu Thr Gln Gly Leu Arg

130 135 140

Gln Leu Arg Asn Ala Ala Gly Asp Thr Arg Asp Ala Val Gln Ala Leu

145 150 155 160

Gln Glu Ala Gln Gly Arg Ala Glu Arg Glu His Gly Arg Leu Glu Gly

165 170 175

Cys Leu Lys Gly Leu Arg Leu Gly His Lys Cys Phe Leu Leu Ser Arg

180 185 190

Asp Phe Glu Ala Gln Ala Ala Ala Gln Ala Arg Cys Thr Ala Arg Gly

195 200 205

Gly Ser Leu Ala Gln Pro Ala Asp Arg Gln Gln Met Glu Ala Leu Thr

210 215 220

Arg Tyr Leu Arg Ala Ala Leu Ala Pro Tyr Asn Trp Pro Val Trp Leu

225 230 235 240

Gly Val His Asp Arg Arg Ala Glu Gly Leu Tyr Leu Phe Glu Asn Gly

245 250 255

Gln Arg Val Ser Phe Phe Ala Trp His Arg Ser Pro Arg Pro Glu Leu

260 265 270

Gly Ala Gln Pro Ser Ala Ser Pro His Pro Leu Ser Pro Asp Gln Pro

275 280 285

Asn Gly Gly Thr Leu Glu Asn Cys Val Ala Gln Ala Ser Asp Asp Gly

290 295 300

Ser Trp Trp Asp His Asp Cys Gln Arg Arg Leu Tyr Tyr Val Cys Glu

305 310 315 320

Phe Pro Phe

<210> 13

<211> 2468

<212> PRT

<213> 智人(Homo sapiens)

<400> 13

Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser

1 5 10 15

Ile Ala Asn Pro Ala Ala Ser Thr Ser Pro Ser Leu Ser His Arg Phe

20 25 30

Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Ile Val Thr

35 40 45

Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg

50 55 60

Ser Trp Asp Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys

65 70 75 80

Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly

85 90 95

Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu

100 105 110

Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile

115 120 125

Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe

130 135 140

Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln

145 150 155 160

Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser

165 170 175

Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu

180 185 190

Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp

195 200 205

Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu

210 215 220

Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro

225 230 235 240

Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys

245 250 255

Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser

260 265 270

Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser

275 280 285

Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val

290 295 300

Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile

305 310 315 320

Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Gln Ser

325 330 335

Gln Gly Ser Thr Thr Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro

340 345 350

Asp Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro

355 360 365

Glu Pro Asn Ile Lys Met Lys Arg Ser Ile Glu Glu Ala Cys Phe Thr

370 375 380

Leu Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg

385 390 395 400

Ser Val Gly Asn Thr Ile Asp Pro Val Ile Leu Phe Gln Lys Met Gly

405 410 415

Val Gly Lys Leu Glu Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys

420 425 430

Glu Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys

435 440 445

Ala Glu Phe Ile Leu Pro Asn Gly Gln Glu Val Asp Leu Pro Ile Ser

450 455 460

Tyr Leu Thr Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro

465 470 475 480

Ala Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr

485 490 495

Asn Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys

500 505 510

Gln Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Pro Thr Pro

515 520 525

Val Val Lys Gln Thr Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser

530 535 540

Leu Lys Pro Ala Ala Lys Pro Leu Pro Ser Lys Ser Val Arg Lys Glu

545 550 555 560

Ser Lys Glu Glu Thr Pro Glu Val Thr Lys Val Asn His Val Glu Lys

565 570 575

Pro Pro Lys Val Glu Ser Lys Glu Lys Val Met Val Lys Lys Asp Lys

580 585 590

Pro Ile Lys Thr Glu Thr Lys Pro Ser Val Thr Glu Lys Glu Val Pro

595 600 605

Ser Lys Glu Glu Pro Ser Pro Val Lys Ala Glu Val Ala Glu Lys Gln

610 615 620

Ala Thr Asp Val Lys Pro Lys Ala Ala Lys Glu Lys Thr Val Lys Lys

625 630 635 640

Glu Thr Lys Val Lys Pro Glu Asp Lys Lys Glu Glu Lys Glu Lys Pro

645 650 655

Lys Lys Glu Val Ala Lys Lys Glu Asp Lys Thr Pro Ile Lys Lys Glu

660 665 670

Glu Lys Pro Lys Lys Glu Glu Val Lys Lys Glu Val Lys Lys Glu Ile

675 680 685

Lys Lys Glu Glu Lys Lys Glu Pro Lys Lys Glu Val Lys Lys Glu Thr

690 695 700

Pro Pro Lys Glu Val Lys Lys Glu Val Lys Lys Glu Glu Lys Lys Glu

705 710 715 720

Val Lys Lys Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Leu Pro

725 730 735

Lys Asp Ala Lys Lys Ser Ser Thr Pro Leu Ser Glu Ala Lys Lys Pro

740 745 750

Ala Ala Leu Lys Pro Lys Val Pro Lys Lys Glu Glu Ser Val Lys Lys

755 760 765

Asp Ser Val Ala Ala Gly Lys Pro Lys Glu Lys Gly Lys Ile Lys Val

770 775 780

Ile Lys Lys Glu Gly Lys Ala Ala Glu Ala Val Ala Ala Ala Val Gly

785 790 795 800

Thr Gly Ala Thr Thr Ala Ala Val Met Ala Ala Ala Gly Ile Ala Ala

805 810 815

Ile Gly Pro Ala Lys Glu Leu Glu Ala Glu Arg Ser Leu Met Ser Ser

820 825 830

Pro Glu Asp Leu Thr Lys Asp Phe Glu Glu Leu Lys Ala Glu Glu Val

835 840 845

Asp Val Thr Lys Asp Ile Lys Pro Gln Leu Glu Leu Ile Glu Asp Glu

850 855 860

Glu Lys Leu Lys Glu Thr Glu Pro Val Glu Ala Tyr Val Ile Gln Lys

865 870 875 880

Glu Arg Glu Val Thr Lys Gly Pro Ala Glu Ser Pro Asp Glu Gly Ile

885 890 895

Thr Thr Thr Glu Gly Glu Gly Glu Cys Glu Gln Thr Pro Glu Glu Leu

900 905 910

Glu Pro Val Glu Lys Gln Gly Val Asp Asp Ile Glu Lys Phe Glu Asp

915 920 925

Glu Gly Ala Gly Phe Glu Glu Ser Ser Glu Thr Gly Asp Tyr Glu Glu

930 935 940

Lys Ala Glu Thr Glu Glu Ala Glu Glu Pro Glu Glu Asp Gly Glu Glu

945 950 955 960

His Val Cys Val Ser Ala Ser Lys His Ser Pro Thr Glu Asp Glu Glu

965 970 975

Ser Ala Lys Ala Glu Ala Asp Ala Tyr Ile Arg Glu Lys Arg Glu Ser

980 985 990

Val Ala Ser Gly Asp Asp Arg Ala Glu Glu Asp Met Asp Glu Ala Ile

995 1000 1005

Glu Lys Gly Glu Ala Glu Gln Ser Glu Glu Glu Ala Asp Glu Glu

1010 1015 1020

Asp Lys Ala Glu Asp Ala Arg Glu Glu Glu Tyr Glu Pro Glu Lys

1025 1030 1035

Met Glu Ala Glu Asp Tyr Val Met Ala Val Val Asp Lys Ala Ala

1040 1045 1050

Glu Ala Gly Gly Ala Glu Glu Gln Tyr Gly Phe Leu Thr Thr Pro

1055 1060 1065

Thr Lys Gln Leu Gly Ala Gln Ser Pro Gly Arg Glu Pro Ala Ser

1070 1075 1080

Ser Ile His Asp Glu Thr Leu Pro Gly Gly Ser Glu Ser Glu Ala

1085 1090 1095

Thr Ala Ser Asp Glu Glu Asn Arg Glu Asp Gln Pro Glu Glu Phe

1100 1105 1110

Thr Ala Thr Ser Gly Tyr Thr Gln Ser Thr Ile Glu Ile Ser Ser

1115 1120 1125

Glu Pro Thr Pro Met Asp Glu Met Ser Thr Pro Arg Asp Val Met

1130 1135 1140

Ser Asp Glu Thr Asn Asn Glu Glu Thr Glu Ser Pro Ser Gln Glu

1145 1150 1155

Phe Val Asn Ile Thr Lys Tyr Glu Ser Ser Leu Tyr Ser Gln Glu

1160 1165 1170

Tyr Ser Lys Pro Ala Asp Val Thr Pro Leu Asn Gly Phe Ser Glu

1175 1180 1185

Gly Ser Lys Thr Asp Ala Thr Asp Gly Lys Asp Tyr Asn Ala Ser

1190 1195 1200

Ala Ser Thr Ile Ser Pro Pro Ser Ser Met Glu Glu Asp Lys Phe

1205 1210 1215

Ser Arg Ser Ala Leu Arg Asp Ala Tyr Cys Ser Glu Val Lys Ala

1220 1225 1230

Ser Thr Thr Leu Asp Ile Lys Asp Ser Ile Ser Ala Val Ser Ser

1235 1240 1245

Glu Lys Val Ser Pro Ser Lys Ser Pro Ser Leu Ser Pro Ser Pro

1250 1255 1260

Pro Ser Pro Leu Glu Lys Thr Pro Leu Gly Glu Arg Ser Val Asn

1265 1270 1275

Phe Ser Leu Thr Pro Asn Glu Ile Lys Val Ser Ala Glu Ala Glu

1280 1285 1290

Val Ala Pro Val Ser Pro Glu Val Thr Gln Glu Val Val Glu Glu

1295 1300 1305

His Cys Ala Ser Pro Glu Asp Lys Thr Leu Glu Val Val Ser Pro

1310 1315 1320

Ser Gln Ser Val Thr Gly Ser Ala Gly His Thr Pro Tyr Tyr Gln

1325 1330 1335

Ser Pro Thr Asp Glu Lys Ser Ser His Leu Pro Thr Glu Val Ile

1340 1345 1350

Glu Lys Pro Pro Ala Val Pro Val Ser Phe Glu Phe Ser Asp Ala

1355 1360 1365

Lys Asp Glu Asn Glu Arg Ala Ser Val Ser Pro Met Asp Glu Pro

1370 1375 1380

Val Pro Asp Ser Glu Ser Pro Ile Glu Lys Val Leu Ser Pro Leu

1385 1390 1395

Arg Ser Pro Pro Leu Ile Gly Ser Glu Ser Ala Tyr Glu Ser Phe

1400 1405 1410

Leu Ser Ala Asp Asp Lys Ala Ser Gly Arg Gly Ala Glu Ser Pro

1415 1420 1425

Phe Glu Glu Lys Ser Gly Lys Gln Gly Ser Pro Asp Gln Val Ser

1430 1435 1440

Pro Val Ser Glu Met Thr Ser Thr Ser Leu Tyr Gln Asp Lys Gln

1445 1450 1455

Glu Gly Lys Ser Thr Asp Phe Ala Pro Ile Lys Glu Asp Phe Gly

1460 1465 1470

Gln Glu Lys Lys Thr Asp Asp Val Glu Ala Met Ser Ser Gln Pro

1475 1480 1485

Ala Leu Ala Leu Asp Glu Arg Lys Leu Gly Asp Val Ser Pro Thr

1490 1495 1500

Gln Ile Asp Val Ser Gln Phe Gly Ser Phe Lys Glu Asp Thr Lys

1505 1510 1515

Met Ser Ile Ser Glu Gly Thr Val Ser Asp Lys Ser Ala Thr Pro

1520 1525 1530

Val Asp Glu Gly Val Ala Glu Asp Thr Tyr Ser His Met Glu Gly

1535 1540 1545

Val Ala Ser Val Ser Thr Ala Ser Val Ala Thr Ser Ser Phe Pro

1550 1555 1560

Glu Pro Thr Thr Asp Asp Val Ser Pro Ser Leu His Ala Glu Val

1565 1570 1575

Gly Ser Pro His Ser Thr Glu Val Asp Asp Ser Leu Ser Val Ser

1580 1585 1590

Val Val Gln Thr Pro Thr Thr Phe Gln Glu Thr Glu Met Ser Pro

1595 1600 1605

Ser Lys Glu Glu Cys Pro Arg Pro Met Ser Ile Ser Pro Pro Asp

1610 1615 1620

Phe Ser Pro Lys Thr Ala Lys Ser Arg Thr Pro Val Gln Asp His

1625 1630 1635

Arg Ser Glu Gln Ser Ser Met Ser Ile Glu Phe Gly Gln Glu Ser

1640 1645 1650

Pro Glu Gln Ser Leu Ala Met Asp Phe Ser Arg Gln Ser Pro Asp

1655 1660 1665

His Pro Thr Val Gly Ala Gly Val Leu His Ile Thr Glu Asn Gly

1670 1675 1680

Pro Thr Glu Val Asp Tyr Ser Pro Ser Asp Met Gln Asp Ser Ser

1685 1690 1695

Leu Ser His Lys Ile Pro Pro Met Glu Glu Pro Ser Tyr Thr Gln

1700 1705 1710

Asp Asn Asp Leu Ser Glu Leu Ile Ser Val Ser Gln Val Glu Ala

1715 1720 1725

Ser Pro Ser Thr Ser Ser Ala His Thr Pro Ser Gln Ile Ala Ser

1730 1735 1740

Pro Leu Gln Glu Asp Thr Leu Ser Asp Val Ala Pro Pro Arg Asp

1745 1750 1755

Met Ser Leu Tyr Ala Ser Leu Thr Ser Glu Lys Val Gln Ser Leu

1760 1765 1770

Glu Gly Glu Lys Leu Ser Pro Lys Ser Asp Ile Ser Pro Leu Thr

1775 1780 1785

Pro Arg Glu Ser Ser Pro Leu Tyr Ser Pro Thr Phe Ser Asp Ser

1790 1795 1800

Thr Ser Ala Val Lys Glu Lys Thr Ala Thr Cys His Ser Ser Ser

1805 1810 1815

Ser Pro Pro Ile Asp Ala Ala Ser Ala Glu Pro Tyr Gly Phe Arg

1820 1825 1830

Ala Ser Val Leu Phe Asp Thr Met Gln His His Leu Ala Leu Asn

1835 1840 1845

Arg Asp Leu Ser Thr Pro Gly Leu Glu Lys Asp Ser Gly Gly Lys

1850 1855 1860

Thr Pro Gly Asp Phe Ser Tyr Ala Tyr Gln Lys Pro Glu Glu Thr

1865 1870 1875

Thr Arg Ser Pro Asp Glu Glu Asp Tyr Asp Tyr Glu Ser Tyr Glu

1880 1885 1890

Lys Thr Thr Arg Thr Ser Asp Val Gly Gly Tyr Tyr Tyr Glu Lys

1895 1900 1905

Ile Glu Arg Thr Thr Lys Ser Pro Ser Asp Ser Gly Tyr Ser Tyr

1910 1915 1920

Glu Thr Ile Gly Lys Thr Thr Lys Thr Pro Glu Asp Gly Asp Tyr

1925 1930 1935

Ser Tyr Glu Ile Ile Glu Lys Thr Thr Arg Thr Pro Glu Glu Gly

1940 1945 1950

Gly Tyr Ser Tyr Asp Ile Ser Glu Lys Thr Thr Ser Pro Pro Glu

1955 1960 1965

Val Ser Gly Tyr Ser Tyr Glu Lys Thr Glu Arg Ser Arg Arg Leu

1970 1975 1980

Leu Asp Asp Ile Ser Asn Gly Tyr Asp Asp Ser Glu Asp Gly Gly

1985 1990 1995

His Thr Leu Gly Asp Pro Ser Tyr Ser Tyr Glu Thr Thr Glu Lys

2000 2005 2010

Ile Thr Ser Phe Pro Glu Ser Glu Gly Tyr Ser Tyr Glu Thr Ser

2015 2020 2025

Thr Lys Thr Thr Arg Thr Pro Asp Thr Ser Thr Tyr Cys Tyr Glu

2030 2035 2040

Thr Ala Glu Lys Ile Thr Arg Thr Pro Gln Ala Ser Thr Tyr Ser

2045 2050 2055

Tyr Glu Thr Ser Asp Leu Cys Tyr Thr Ala Glu Lys Lys Ser Pro

2060 2065 2070

Ser Glu Ala Arg Gln Asp Val Asp Leu Cys Leu Val Ser Ser Cys

2075 2080 2085

Glu Tyr Lys His Pro Lys Thr Glu Leu Ser Pro Ser Phe Ile Asn

2090 2095 2100

Pro Asn Pro Leu Glu Trp Phe Ala Ser Glu Glu Pro Thr Glu Glu

2105 2110 2115

Ser Glu Lys Pro Leu Thr Gln Ser Gly Gly Ala Pro Pro Pro Pro

2120 2125 2130

Gly Gly Lys Gln Gln Gly Arg Gln Cys Asp Glu Thr Pro Pro Thr

2135 2140 2145

Ser Val Ser Glu Ser Ala Pro Ser Gln Thr Asp Ser Asp Val Pro

2150 2155 2160

Pro Glu Thr Glu Glu Cys Pro Ser Ile Thr Ala Asp Ala Asn Ile

2165 2170 2175

Asp Ser Glu Asp Glu Ser Glu Thr Ile Pro Thr Asp Lys Thr Val

2180 2185 2190

Thr Tyr Lys His Met Asp Pro Pro Pro Ala Pro Val Gln Asp Arg

2195 2200 2205

Ser Pro Ser Pro Arg His Pro Asp Val Ser Met Val Asp Pro Glu

2210 2215 2220

Ala Leu Ala Ile Glu Gln Asn Leu Gly Lys Ala Leu Lys Lys Asp

2225 2230 2235

Leu Lys Glu Lys Thr Lys Thr Lys Lys Pro Gly Thr Lys Thr Lys

2240 2245 2250

Ser Ser Ser Pro Val Lys Lys Ser Asp Gly Lys Ser Lys Pro Leu

2255 2260 2265

Ala Ala Ser Pro Lys Pro Ala Gly Leu Lys Glu Ser Ser Asp Lys

2270 2275 2280

Val Ser Arg Val Ala Ser Pro Lys Lys Lys Glu Ser Val Glu Lys

2285 2290 2295

Ala Ala Lys Pro Thr Thr Thr Pro Glu Val Lys Ala Ala Arg Gly

2300 2305 2310

Glu Glu Lys Asp Lys Glu Thr Lys Asn Ala Ala Asn Ala Ser Ala

2315 2320 2325

Ser Lys Ser Ala Lys Thr Ala Thr Ala Gly Pro Gly Thr Thr Lys

2330 2335 2340

Thr Thr Lys Ser Ser Ala Val Pro Pro Gly Leu Pro Val Tyr Leu

2345 2350 2355

Asp Leu Cys Tyr Ile Pro Asn His Ser Asn Ser Lys Asn Val Asp

2360 2365 2370

Val Glu Phe Phe Lys Arg Val Arg Ser Ser Tyr Tyr Val Val Ser

2375 2380 2385

Gly Asn Asp Pro Ala Ala Glu Glu Pro Ser Arg Ala Val Leu Asp

2390 2395 2400

Ala Leu Leu Glu Gly Lys Ala Gln Trp Gly Ser Asn Met Gln Val

2405 2410 2415

Thr Leu Ile Pro Thr His Asp Ser Glu Val Met Arg Glu Trp Tyr

2420 2425 2430

Gln Glu Thr His Glu Lys Gln Gln Asp Leu Asn Ile Met Val Leu

2435 2440 2445

Ala Ser Ser Ser Thr Val Val Met Gln Asp Glu Ser Phe Pro Ala

2450 2455 2460

Cys Lys Ile Glu Leu

2465

<210> 14

<211> 215

<212> PRT

<213> 智人(Homo sapiens)

<400> 14

Met Pro Gly Glu Ala Thr Glu Thr Val Pro Ala Thr Glu Gln Glu Leu

1 5 10 15

Pro Gln Pro Gln Ala Glu Thr Gly Ser Gly Thr Glu Ser Asp Ser Asp

20 25 30

Glu Ser Val Pro Glu Leu Glu Glu Gln Asp Ser Thr Gln Ala Thr Thr

35 40 45

Gln Gln Ala Gln Leu Ala Ala Ala Ala Glu Ile Asp Glu Glu Pro Val

50 55 60

Ser Lys Ala Lys Gln Ser Arg Ser Glu Lys Lys Ala Arg Lys Ala Met

65 70 75 80

Ser Lys Leu Gly Leu Arg Gln Val Thr Gly Val Thr Arg Val Thr Ile

85 90 95

Arg Lys Ser Lys Asn Ile Leu Phe Val Ile Thr Lys Pro Asp Val Tyr

100 105 110

Lys Ser Pro Ala Ser Asp Thr Tyr Ile Val Phe Gly Glu Ala Lys Ile

115 120 125

Glu Asp Leu Ser Gln Gln Ala Gln Leu Ala Ala Ala Glu Lys Phe Lys

130 135 140

Val Gln Gly Glu Ala Val Ser Asn Ile Gln Glu Asn Thr Gln Thr Pro

145 150 155 160

Thr Val Gln Glu Glu Ser Glu Glu Glu Glu Val Asp Glu Thr Gly Val

165 170 175

Glu Val Lys Asp Ile Glu Leu Val Met Ser Gln Ala Asn Val Ser Arg

180 185 190

Ala Lys Ala Val Arg Ala Leu Lys Asn Asn Ser Asn Asp Ile Val Asn

195 200 205

Ala Ile Met Glu Leu Thr Met

210 215

<210> 15

<211> 234

<212> PRT

<213> 智人(Homo sapiens)

<400> 15

Met Ala Glu Arg Gly Tyr Ser Phe Ser Leu Thr Thr Phe Ser Pro Ser

1 5 10 15

Gly Lys Leu Val Gln Ile Glu Tyr Ala Leu Ala Ala Val Ala Gly Gly

20 25 30

Ala Pro Ser Val Gly Ile Lys Ala Ala Asn Gly Val Val Leu Ala Thr

35 40 45

Glu Lys Lys Gln Lys Ser Ile Leu Tyr Asp Glu Arg Ser Val His Lys

50 55 60

Val Glu Pro Ile Thr Lys His Ile Gly Leu Val Tyr Ser Gly Met Gly

65 70 75 80

Pro Asp Tyr Arg Val Leu Val His Arg Ala Arg Lys Leu Ala Gln Gln

85 90 95

Tyr Tyr Leu Val Tyr Gln Glu Pro Ile Pro Thr Ala Gln Leu Val Gln

100 105 110

Arg Val Ala Ser Val Met Gln Glu Tyr Thr Gln Ser Gly Gly Val Arg

115 120 125

Pro Phe Gly Val Ser Leu Leu Ile Cys Gly Trp Asn Glu Gly Arg Pro

130 135 140

Tyr Leu Phe Gln Ser Asp Pro Ser Gly Ala Tyr Phe Ala Trp Lys Ala

145 150 155 160

Thr Ala Met Gly Lys Asn Tyr Val Asn Gly Lys Thr Phe Leu Glu Lys

165 170 175

Arg Tyr Asn Glu Asp Leu Glu Leu Glu Asp Ala Ile His Thr Ala Ile

180 185 190

Leu Thr Leu Lys Glu Ser Phe Glu Gly Gln Met Thr Glu Asp Asn Ile

195 200 205

Glu Val Gly Ile Cys Asn Glu Ala Gly Phe Arg Arg Leu Thr Pro Thr

210 215 220

Glu Val Lys Asp Tyr Leu Ala Ala Ile Ala

225 230

<210> 16

<211> 297

<212> PRT

<213> 智人(Homo sapiens)

<400> 16

Met Gly Phe Val Lys Val Val Lys Asn Lys Ala Tyr Phe Lys Arg Tyr

1 5 10 15

Gln Val Lys Phe Arg Arg Arg Arg Glu Gly Lys Thr Asp Tyr Tyr Ala

20 25 30

Arg Lys Arg Leu Val Ile Gln Asp Lys Asn Lys Tyr Asn Thr Pro Lys

35 40 45

Tyr Arg Met Ile Val Arg Val Thr Asn Arg Asp Ile Ile Cys Gln Ile

50 55 60

Ala Tyr Ala Arg Ile Glu Gly Asp Met Ile Val Cys Ala Ala Tyr Ala

65 70 75 80

His Glu Leu Pro Lys Tyr Gly Val Lys Val Gly Leu Thr Asn Tyr Ala

85 90 95

Ala Ala Tyr Cys Thr Gly Leu Leu Leu Ala Arg Arg Leu Leu Asn Arg

100 105 110

Phe Gly Met Asp Lys Ile Tyr Glu Gly Gln Val Glu Val Thr Gly Asp

115 120 125

Glu Tyr Asn Val Glu Ser Ile Asp Gly Gln Pro Gly Ala Phe Thr Cys

130 135 140

Tyr Leu Asp Ala Gly Leu Ala Arg Thr Thr Thr Gly Asn Lys Val Phe

145 150 155 160

Gly Ala Leu Lys Gly Ala Val Asp Gly Gly Leu Ser Ile Pro His Ser

165 170 175

Thr Lys Arg Phe Pro Gly Tyr Asp Ser Glu Ser Lys Glu Phe Asn Ala

180 185 190

Glu Val His Arg Lys His Ile Met Gly Gln Asn Val Ala Asp Tyr Met

195 200 205

Arg Tyr Leu Met Glu Glu Asp Glu Asp Ala Tyr Lys Lys Gln Phe Ser

210 215 220

Gln Tyr Ile Lys Asn Ser Val Thr Pro Asp Met Met Glu Glu Met Tyr

225 230 235 240

Lys Lys Ala His Ala Ala Ile Arg Glu Asn Pro Val Tyr Glu Lys Lys

245 250 255

Pro Lys Lys Glu Val Lys Lys Lys Arg Trp Asn Arg Pro Lys Met Ser

260 265 270

Leu Ala Gln Lys Lys Asp Arg Val Ala Gln Lys Lys Ala Ser Phe Leu

275 280 285

Arg Ala Gln Glu Arg Ala Ala Glu Ser

290 295

<210> 17

<211> 151

<212> PRT

<213> 智人(Homo sapiens)

<400> 17

Met Cys Asp Phe Thr Glu Asp Gln Thr Ala Glu Phe Lys Glu Ala Phe

1 5 10 15

Gln Leu Phe Asp Arg Thr Gly Asp Gly Lys Ile Leu Tyr Ser Gln Cys

20 25 30

Gly Asp Val Met Arg Ala Leu Gly Gln Asn Pro Thr Asn Ala Glu Val

35 40 45

Leu Lys Val Leu Gly Asn Pro Lys Ser Asp Glu Met Asn Val Lys Val

50 55 60

Leu Asp Phe Glu His Phe Leu Pro Met Leu Gln Thr Val Ala Lys Asn

65 70 75 80

Lys Asp Gln Gly Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg Val Phe

85 90 95

Asp Lys Glu Gly Asn Gly Thr Val Met Gly Ala Glu Ile Arg His Val

100 105 110

Leu Val Thr Leu Gly Glu Lys Met Thr Glu Glu Glu Val Glu Met Leu

115 120 125

Val Ala Gly His Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe

130 135 140

Val Arg His Ile Leu Ser Gly

145 150

<210> 18

<211> 339

<212> PRT

<213> 智人(Homo sapiens)

<400> 18

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn

1 5 10 15

Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn

20 25 30

Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr

35 40 45

Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly

50 55 60

Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu

65 70 75 80

Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile

85 90 95

Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly

100 105 110

Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His

115 120 125

Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser

130 135 140

Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn

145 150 155 160

Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His

165 170 175

Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn

180 185 190

Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser

195 200 205

Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His

210 215 220

Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met

225 230 235 240

Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr

245 250 255

Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly

260 265 270

Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu

275 280 285

Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp

290 295 300

Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly

305 310 315 320

Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp

325 330 335

Glu Lys Ile

<210> 19

<211> 573

<212> PRT

<213> 智人(Homo sapiens)

<400> 19

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg

1 5 10 15

Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe

20 25 30

Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala

35 40 45

Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile

50 55 60

Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val

65 70 75 80

Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys

85 90 95

Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly

100 105 110

Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe

115 120 125

Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val

130 135 140

Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys

145 150 155 160

Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala

165 170 175

Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys

180 185 190

Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn

195 200 205

Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile

210 215 220

Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln

225 230 235 240

Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser

245 250 255

Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val

260 265 270

Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu

275 280 285

Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly

290 295 300

Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr

305 310 315 320

Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp

325 330 335

Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys

340 345 350

Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu

355 360 365

Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu

370 375 380

Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly

385 390 395 400

Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu

405 410 415

Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val

420 425 430

Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile

435 440 445

Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly

450 455 460

Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala

465 470 475 480

Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln

485 490 495

Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn

500 505 510

Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala

515 520 525

Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val

530 535 540

Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala

545 550 555 560

Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe

565 570

<210> 20

<211> 390

<212> PRT

<213> 智人(Homo sapiens)

<400> 20

Met Glu Asp Pro Thr Leu Tyr Ile Val Glu Arg Pro Leu Pro Gly Tyr

1 5 10 15

Pro Asp Ala Glu Ala Pro Glu Pro Ser Ser Ala Gly Ala Gln Ala Ala

20 25 30

Glu Glu Pro Ser Gly Ala Gly Ser Glu Glu Leu Ile Lys Ser Asp Gln

35 40 45

Val Asn Gly Val Leu Val Leu Ser Leu Leu Asp Lys Ile Ile Gly Ala

50 55 60

Val Asp Gln Ile Gln Leu Thr Gln Ala Gln Leu Glu Glu Arg Gln Ala

65 70 75 80

Glu Met Glu Gly Ala Val Gln Ser Ile Gln Gly Glu Leu Ser Lys Leu

85 90 95

Gly Lys Ala His Ala Thr Thr Ser Asn Thr Val Ser Lys Leu Leu Glu

100 105 110

Lys Val Arg Lys Val Ser Val Asn Val Lys Thr Val Arg Gly Ser Leu

115 120 125

Glu Arg Gln Ala Gly Gln Ile Lys Lys Leu Glu Val Asn Glu Ala Glu

130 135 140

Leu Leu Arg Arg Arg Asn Phe Lys Val Met Ile Tyr Gln Asp Glu Val

145 150 155 160

Lys Leu Pro Ala Lys Leu Ser Ile Ser Lys Ser Leu Lys Glu Ser Glu

165 170 175

Ala Leu Pro Glu Lys Glu Gly Glu Glu Leu Gly Glu Gly Glu Arg Pro

180 185 190

Glu Glu Asp Ala Ala Ala Leu Glu Leu Ser Ser Asp Glu Ala Val Glu

195 200 205

Val Glu Glu Val Ile Glu Glu Ser Arg Ala Glu Arg Ile Lys Arg Ser

210 215 220

Gly Leu Arg Arg Val Asp Asp Phe Lys Lys Ala Phe Ser Lys Glu Lys

225 230 235 240

Met Glu Lys Thr Lys Val Arg Thr Arg Glu Asn Leu Glu Lys Thr Arg

245 250 255

Leu Lys Thr Lys Glu Asn Leu Glu Lys Thr Arg His Thr Leu Glu Lys

260 265 270

Arg Met Asn Lys Leu Gly Thr Arg Leu Val Pro Ala Glu Arg Arg Glu

275 280 285

Lys Leu Lys Thr Ser Arg Asp Lys Leu Arg Lys Ser Phe Thr Pro Asp

290 295 300

His Val Val Tyr Ala Arg Ser Lys Thr Ala Val Tyr Lys Val Pro Pro

305 310 315 320

Phe Thr Phe His Val Lys Lys Ile Arg Glu Gly Gln Val Glu Val Leu

325 330 335

Lys Ala Thr Glu Met Val Glu Val Gly Ala Asp Asp Asp Glu Gly Gly

340 345 350

Ala Glu Arg Gly Glu Ala Gly Asp Leu Arg Arg Gly Ser Ser Pro Asp

355 360 365

Val His Ala Leu Leu Glu Ile Thr Glu Glu Ser Asp Ala Val Leu Val

370 375 380

Asp Lys Ser Asp Ser Asp

385 390

<210> 21

<211> 461

<212> PRT

<213> 智人(Homo sapiens)

<400> 21

Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu

1 5 10 15

Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly

20 25 30

Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly

35 40 45

Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr

50 55 60

Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile

65 70 75 80

Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val

85 90 95

Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg

100 105 110

Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln

115 120 125

Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln

130 135 140

Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr

145 150 155 160

Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe

165 170 175

Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu

180 185 190

Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu

195 200 205

Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser

210 215 220

Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro

225 230 235 240

Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser

245 250 255

Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu

260 265 270

Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu

275 280 285

Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val

290 295 300

Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser

305 310 315 320

Thr Gln Arg Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val

325 330 335

Glu Met His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu

340 345 350

Glu Leu Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu

355 360 365

Ser Gln Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala

370 375 380

Gln Lys Arg Glu Leu Gln Gln Ala Val Leu His Met Glu Gln Arg Lys

385 390 395 400

Gln Gln Gln Gln Gln Gln Gln Gly His Lys Ala Pro Ala Ala His Pro

405 410 415

Glu Gly Gln Leu Lys Phe His Pro Asp Thr Asp Asp Val Pro Val Pro

420 425 430

Ala Pro Ala Gly Asp Gln Lys Glu Val Asp Thr Ser Glu Lys Lys Leu

435 440 445

Leu Glu Arg Leu Pro Glu Val Glu Val Pro Gln His Leu

450 455 460

<210> 22

<211> 645

<212> PRT

<213> 智人(Homo sapiens)

<400> 22

Met Arg Pro Arg Lys Ala Phe Leu Leu Leu Leu Leu Leu Gly Leu Val

1 5 10 15

Gln Leu Leu Ala Val Ala Gly Ala Glu Gly Pro Asp Glu Asp Ser Ser

20 25 30

Asn Arg Glu Asn Ala Ile Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp

35 40 45

Asp Asp Glu Glu Glu Asp Asp Leu Glu Val Lys Glu Glu Asn Gly Val

50 55 60

Leu Val Leu Asn Asp Ala Asn Phe Asp Asn Phe Val Ala Asp Lys Asp

65 70 75 80

Thr Val Leu Leu Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln

85 90 95

Phe Ala Pro Glu Tyr Glu Lys Ile Ala Asn Ile Leu Lys Asp Lys Asp

100 105 110

Pro Pro Ile Pro Val Ala Lys Ile Asp Ala Thr Ser Ala Ser Val Leu

115 120 125

Ala Ser Arg Phe Asp Val Ser Gly Tyr Pro Thr Ile Lys Ile Leu Lys

130 135 140

Lys Gly Gln Ala Val Asp Tyr Glu Gly Ser Arg Thr Gln Glu Glu Ile

145 150 155 160

Val Ala Lys Val Arg Glu Val Ser Gln Pro Asp Trp Thr Pro Pro Pro

165 170 175

Glu Val Thr Leu Val Leu Thr Lys Glu Asn Phe Asp Glu Val Val Asn

180 185 190

Asp Ala Asp Ile Ile Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His

195 200 205

Cys Lys Lys Leu Ala Pro Glu Tyr Glu Lys Ala Ala Lys Glu Leu Ser

210 215 220

Lys Arg Ser Pro Pro Ile Pro Leu Ala Lys Val Asp Ala Thr Ala Glu

225 230 235 240

Thr Asp Leu Ala Lys Arg Phe Asp Val Ser Gly Tyr Pro Thr Leu Lys

245 250 255

Ile Phe Arg Lys Gly Arg Pro Tyr Asp Tyr Asn Gly Pro Arg Glu Lys

260 265 270

Tyr Gly Ile Val Asp Tyr Met Ile Glu Gln Ser Gly Pro Pro Ser Lys

275 280 285

Glu Ile Leu Thr Leu Lys Gln Val Gln Glu Phe Leu Lys Asp Gly Asp

290 295 300

Asp Val Ile Ile Ile Gly Val Phe Lys Gly Glu Ser Asp Pro Ala Tyr

305 310 315 320

Gln Gln Tyr Gln Asp Ala Ala Asn Asn Leu Arg Glu Asp Tyr Lys Phe

325 330 335

His His Thr Phe Ser Thr Glu Ile Ala Lys Phe Leu Lys Val Ser Gln

340 345 350

Gly Gln Leu Val Val Met Gln Pro Glu Lys Phe Gln Ser Lys Tyr Glu

355 360 365

Pro Arg Ser His Met Met Asp Val Gln Gly Ser Thr Gln Asp Ser Ala

370 375 380

Ile Lys Asp Phe Val Leu Lys Tyr Ala Leu Pro Leu Val Gly His Arg

385 390 395 400

Lys Val Ser Asn Asp Ala Lys Arg Tyr Thr Arg Arg Pro Leu Val Val

405 410 415

Val Tyr Tyr Ser Val Asp Phe Ser Phe Asp Tyr Arg Ala Ala Thr Gln

420 425 430

Phe Trp Arg Ser Lys Val Leu Glu Val Ala Lys Asp Phe Pro Glu Tyr

435 440 445

Thr Phe Ala Ile Ala Asp Glu Glu Asp Tyr Ala Gly Glu Val Lys Asp

450 455 460

Leu Gly Leu Ser Glu Ser Gly Glu Asp Val Asn Ala Ala Ile Leu Asp

465 470 475 480

Glu Ser Gly Lys Lys Phe Ala Met Glu Pro Glu Glu Phe Asp Ser Asp

485 490 495

Thr Leu Arg Glu Phe Val Thr Ala Phe Lys Lys Gly Lys Leu Lys Pro

500 505 510

Val Ile Lys Ser Gln Pro Val Pro Lys Asn Asn Lys Gly Pro Val Lys

515 520 525

Val Val Val Gly Lys Thr Phe Asp Ser Ile Val Met Asp Pro Lys Lys

530 535 540

Asp Val Leu Ile Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln

545 550 555 560

Leu Glu Pro Val Tyr Asn Ser Leu Ala Lys Lys Tyr Lys Gly Gln Lys

565 570 575

Gly Leu Val Ile Ala Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser

580 585 590

Asp Arg Tyr Lys Val Glu Gly Phe Pro Thr Ile Tyr Phe Ala Pro Ser

595 600 605

Gly Asp Lys Lys Asn Pro Val Lys Phe Glu Gly Gly Asp Arg Asp Leu

610 615 620

Glu His Leu Ser Lys Phe Ile Glu Glu His Ala Thr Lys Leu Ser Arg

625 630 635 640

Thr Lys Glu Glu Leu

645

<210> 23

<211> 508

<212> PRT

<213> 智人(Homo sapiens)

<400> 23

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg

1 5 10 15

Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser

20 25 30

Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe

35 40 45

Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala

50 55 60

Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala

65 70 75 80

Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val

85 90 95

Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser

100 105 110

Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp

115 120 125

Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala

130 135 140

Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe

145 150 155 160

Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala

165 170 175

Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val

180 185 190

Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys

195 200 205

Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn

210 215 220

Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe

225 230 235 240

Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His

245 250 255

Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu

260 265 270

Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe

275 280 285

Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe

290 295 300

Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu

305 310 315 320

Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala

325 330 335

Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys

340 345 350

Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro

355 360 365

Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu

370 375 380

Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys

385 390 395 400

Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp

405 410 415

His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val

420 425 430

Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala

435 440 445

Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp

450 455 460

Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp

465 470 475 480

Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu

485 490 495

Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu

500 505

<210> 24

<211> 911

<212> PRT

<213> 智人(Homo sapiens)

<400> 24

Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser

1 5 10 15

Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met

20 25 30

Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp

35 40 45

Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu

50 55 60

Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp

65 70 75 80

Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu

85 90 95

Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val

100 105 110

Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser

115 120 125

Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly

130 135 140

Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val

145 150 155 160

Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys

165 170 175

Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp

180 185 190

Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu

195 200 205

Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu

210 215 220

Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met

225 230 235 240

Leu Asp Ala Glu Asp Ile Val Asn Thr Ala Arg Pro Asp Glu Lys Ala

245 250 255

Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln

260 265 270

Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn

275 280 285

Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp

290 295 300

Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asp Arg Val

305 310 315 320

Pro Gln Lys Thr Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg

325 330 335

Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln

340 345 350

Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn

355 360 365

Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val Ser Asp Ile Asn

370 375 380

Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp

385 390 395 400

Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu

405 410 415

Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys

420 425 430

Glu Ala Met Leu Lys His Arg Asp Tyr Glu Thr Ala Thr Leu Ser Asp

435 440 445

Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala

450 455 460

Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu

465 470 475 480

Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Thr Arg Cys Gln

485 490 495

Lys Ile Cys Asp Gln Trp Asp Ala Leu Gly Ser Leu Thr His Ser Arg

500 505 510

Arg Glu Ala Leu Glu Lys Thr Glu Lys Gln Leu Glu Ala Ile Asp Gln

515 520 525

Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met

530 535 540

Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe Ile Val His Thr Ile

545 550 555 560

Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Thr

565 570 575

Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys

580 585 590

Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser

595 600 605

Asn Pro Tyr Thr Thr Val Thr Pro Gln Ile Ile Asn Ser Lys Trp Glu

610 615 620

Lys Val Gln Gln Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu

625 630 635 640

Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser

645 650 655

Gln Ala Asn Val Val Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile

660 665 670

Gly Arg Ile Ser Ile Glu Met Asn Gly Thr Leu Glu Asp Gln Leu Ser

675 680 685

His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu

690 695 700

Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe

705 710 715 720

Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp

725 730 735

Glu Gln Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn

740 745 750

Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln

755 760 765

Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys Asp His Gly Gly Ala

770 775 780

Leu Gly Pro Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp

785 790 795 800

Val Glu Asn Asp Arg Gln Gly Glu Ala Glu Phe Asn Arg Ile Met Ser

805 810 815

Leu Val Asp Pro Asn His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile

820 825 830

Asp Phe Met Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Gln Val

835 840 845

Ile Ala Ser Phe Lys Val Leu Ala Gly Asp Lys Asn Phe Ile Thr Ala

850 855 860

Glu Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile

865 870 875 880

Ala Arg Met Ala Pro Tyr Gln Gly Pro Asp Ala Val Pro Gly Ala Leu

885 890 895

Asp Tyr Lys Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu

900 905 910

<210> 25

<211> 281

<212> PRT

<213> 智人(Homo sapiens)

<400> 25

Met Ala Thr Asn Phe Leu Ala His Glu Lys Ile Trp Phe Asp Lys Phe

1 5 10 15

Lys Tyr Asp Asp Ala Glu Arg Arg Phe Tyr Glu Gln Met Asn Gly Pro

20 25 30

Val Ala Gly Ala Ser Arg Gln Glu Asn Gly Ala Ser Val Ile Leu Arg

35 40 45

Asp Ile Ala Arg Ala Arg Glu Asn Ile Gln Lys Ser Leu Ala Gly Ser

50 55 60

Ser Gly Pro Gly Ala Ser Ser Gly Thr Ser Gly Asp His Gly Glu Leu

65 70 75 80

Val Val Arg Ile Ala Ser Leu Glu Val Glu Asn Gln Ser Leu Arg Gly

85 90 95

Val Val Gln Glu Leu Gln Gln Ala Ile Ser Lys Leu Glu Ala Arg Leu

100 105 110

Asn Val Leu Glu Lys Ser Ser Pro Gly His Arg Ala Thr Ala Pro Gln

115 120 125

Thr Gln His Val Ser Pro Met Arg Gln Val Glu Pro Pro Ala Lys Lys

130 135 140

Pro Ala Thr Pro Ala Glu Asp Asp Glu Asp Asp Asp Ile Asp Leu Phe

145 150 155 160

Gly Ser Asp Asn Glu Glu Glu Asp Lys Glu Ala Ala Gln Leu Arg Glu

165 170 175

Glu Arg Leu Arg Gln Tyr Ala Glu Lys Lys Ala Lys Lys Pro Ala Leu

180 185 190

Val Ala Lys Ser Ser Ile Leu Leu Asp Val Lys Pro Trp Asp Asp Glu

195 200 205

Thr Asp Met Ala Gln Leu Glu Ala Cys Val Arg Ser Ile Gln Leu Asp

210 215 220

Gly Leu Val Trp Gly Ala Ser Lys Leu Val Pro Val Gly Tyr Gly Ile

225 230 235 240

Arg Lys Leu Gln Ile Gln Cys Val Val Glu Asp Asp Lys Val Gly Thr

245 250 255

Asp Leu Leu Glu Glu Glu Ile Thr Lys Phe Glu Glu His Val Gln Ser

260 265 270

Val Asp Ile Ala Ala Phe Asn Lys Ile

275 280

<210> 26

<211> 286

<212> PRT

<213> 智人(Homo sapiens)

<400> 26

Met Ala Glu Asp Gly Glu Glu Ala Glu Phe His Phe Ala Ala Leu Tyr

1 5 10 15

Ile Ser Gly Gln Trp Pro Arg Leu Arg Ala Asp Thr Asp Leu Gln Arg

20 25 30

Leu Gly Ser Ser Ala Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly

35 40 45

Asn Trp Lys Met Asn Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly

50 55 60

Thr Leu Asn Ala Ala Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala

65 70 75 80

Pro Pro Thr Ala Tyr Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys

85 90 95

Ile Ala Val Ala Ala Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe

100 105 110

Thr Gly Glu Ile Ser Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp

115 120 125

Val Val Leu Gly His Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp

130 135 140

Glu Leu Ile Gly Gln Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly

145 150 155 160

Val Ile Ala Cys Ile Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile

165 170 175

Thr Glu Lys Val Val Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val

180 185 190

Lys Asp Trp Ser Lys Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile

195 200 205

Gly Thr Gly Lys Thr Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu

210 215 220

Lys Leu Arg Gly Trp Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln

225 230 235 240

Ser Thr Arg Ile Ile Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys

245 250 255

Glu Leu Ala Ser Gln Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala

260 265 270

Ser Leu Lys Pro Glu Phe Val Asp Ile Ile Asn Ala Lys Gln

275 280 285

<210> 27

<211> 148

<212> PRT

<213> 智人(Homo sapiens)

<400> 27

Met Phe Arg Arg Pro Val Leu Gln Val Leu Arg Gln Phe Val Arg His

1 5 10 15

Glu Ser Glu Thr Thr Thr Ser Leu Val Leu Glu Arg Ser Leu Asn Arg

20 25 30

Val His Leu Leu Gly Arg Val Gly Gln Asp Pro Val Leu Arg Gln Val

35 40 45

Glu Gly Lys Asn Pro Val Thr Ile Phe Ser Leu Ala Thr Asn Glu Met

50 55 60

Trp Arg Ser Gly Asp Ser Glu Val Tyr Gln Leu Gly Asp Val Ser Gln

65 70 75 80

Lys Thr Thr Trp His Arg Ile Ser Val Phe Arg Pro Gly Leu Arg Asp

85 90 95

Val Ala Tyr Gln Tyr Val Lys Lys Gly Ser Arg Ile Tyr Leu Glu Gly

100 105 110

Lys Ile Asp Tyr Gly Glu Tyr Met Asp Lys Asn Asn Val Arg Arg Gln

115 120 125

Ala Thr Thr Ile Ile Ala Asp Asn Ile Ile Phe Leu Ser Asp Gln Thr

130 135 140

Lys Glu Lys Glu

145

<210> 28

<211> 276

<212> PRT

<213> 智人(Homo sapiens)

<400> 28

Met Ala Leu Leu Asp Val Cys Gly Ala Pro Arg Gly Gln Arg Pro Glu

1 5 10 15

Ser Ala Leu Pro Val Ala Gly Ser Gly Arg Arg Ser Asp Pro Gly His

20 25 30

Tyr Ser Phe Ser Met Arg Ser Pro Glu Leu Ala Leu Pro Arg Gly Met

35 40 45

Gln Pro Thr Glu Phe Phe Gln Ser Leu Gly Gly Asp Gly Glu Arg Asn

50 55 60

Val Gln Ile Glu Met Ala His Gly Thr Thr Thr Leu Ala Phe Lys Phe

65 70 75 80

Gln His Gly Val Ile Ala Ala Val Asp Ser Arg Ala Ser Ala Gly Ser

85 90 95

Tyr Ile Ser Ala Leu Arg Val Asn Lys Val Ile Glu Ile Asn Pro Tyr

100 105 110

Leu Leu Gly Thr Met Ser Gly Cys Ala Ala Asp Cys Gln Tyr Trp Glu

115 120 125

Arg Leu Leu Ala Lys Glu Cys Arg Leu Tyr Tyr Leu Arg Asn Gly Glu

130 135 140

Arg Ile Ser Val Ser Ala Ala Ser Lys Leu Leu Ser Asn Met Met Cys

145 150 155 160

Gln Tyr Arg Gly Met Gly Leu Ser Met Gly Ser Met Ile Cys Gly Trp

165 170 175

Asp Lys Lys Gly Pro Gly Leu Tyr Tyr Val Asp Glu His Gly Thr Arg

180 185 190

Leu Ser Gly Asn Met Phe Ser Thr Gly Ser Gly Asn Thr Tyr Ala Tyr

195 200 205

Gly Val Met Asp Ser Gly Tyr Arg Pro Asn Leu Ser Pro Glu Glu Ala

210 215 220

Tyr Asp Leu Gly Arg Arg Ala Ile Ala Tyr Ala Thr His Arg Asp Ser

225 230 235 240

Tyr Ser Gly Gly Val Val Asn Met Tyr His Met Lys Glu Asp Gly Trp

245 250 255

Val Lys Val Glu Ser Thr Asp Val Ser Asp Leu Leu His Gln Tyr Arg

260 265 270

Glu Ala Asn Gln

275

<210> 29

<211> 524

<212> PRT

<213> 智人(Homo sapiens)

<400> 29

Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala

1 5 10 15

Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp

20 25 30

Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys

35 40 45

Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp

50 55 60

Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn

65 70 75 80

Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp

85 90 95

Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser

100 105 110

Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro

115 120 125

Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His

130 135 140

Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro

145 150 155 160

Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro

165 170 175

Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys

180 185 190

Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile

195 200 205

Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu

210 215 220

His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile

225 230 235 240

Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met

245 250 255

Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp

260 265 270

Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala

275 280 285

Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys

290 295 300

His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe

305 310 315 320

Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys

325 330 335

Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser

340 345 350

Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile

355 360 365

Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met

370 375 380

Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val

385 390 395 400

Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val

405 410 415

Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile

420 425 430

Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln

435 440 445

Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu

450 455 460

Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly

465 470 475 480

Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile

485 490 495

Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys

500 505 510

Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn

515 520

<210> 30

<211> 277

<212> PRT

<213> 智人(Homo sapiens)

<400> 30

Met Ala Ala Val Ser Val Tyr Ala Pro Pro Val Gly Gly Phe Ser Phe

1 5 10 15

Asp Asn Cys Arg Arg Asn Ala Val Leu Glu Ala Asp Phe Ala Lys Arg

20 25 30

Gly Tyr Lys Leu Pro Lys Val Arg Lys Thr Gly Thr Thr Ile Ala Gly

35 40 45

Val Val Tyr Lys Asp Gly Ile Val Leu Gly Ala Asp Thr Arg Ala Thr

50 55 60

Glu Gly Met Val Val Ala Asp Lys Asn Cys Ser Lys Ile His Phe Ile

65 70 75 80

Ser Pro Asn Ile Tyr Cys Cys Gly Ala Gly Thr Ala Ala Asp Thr Asp

85 90 95

Met Thr Thr Gln Leu Ile Ser Ser Asn Leu Glu Leu His Ser Leu Ser

100 105 110

Thr Gly Arg Leu Pro Arg Val Val Thr Ala Asn Arg Met Leu Lys Gln

115 120 125

Met Leu Phe Arg Tyr Gln Gly Tyr Ile Gly Ala Ala Leu Val Leu Gly

130 135 140

Gly Val Asp Val Thr Gly Pro His Leu Tyr Ser Ile Tyr Pro His Gly

145 150 155 160

Ser Thr Asp Lys Leu Pro Tyr Val Thr Met Gly Ser Gly Ser Leu Ala

165 170 175

Ala Met Ala Val Phe Glu Asp Lys Phe Arg Pro Asp Met Glu Glu Glu

180 185 190

Glu Ala Lys Asn Leu Val Ser Glu Ala Ile Ala Ala Gly Ile Phe Asn

195 200 205

Asp Leu Gly Ser Gly Ser Asn Ile Asp Leu Cys Val Ile Ser Lys Asn

210 215 220

Lys Leu Asp Phe Leu Arg Pro Tyr Thr Val Pro Asn Lys Lys Gly Thr

225 230 235 240

Arg Leu Gly Arg Tyr Arg Cys Glu Lys Gly Thr Thr Ala Val Leu Thr

245 250 255

Glu Lys Ile Thr Pro Leu Glu Ile Glu Val Leu Glu Glu Thr Val Gln

260 265 270

Thr Met Asp Thr Ser

275

<210> 31

<211> 286

<212> PRT

<213> 智人(Homo sapiens)

<400> 31

Met Ala Asp Phe Asp Asp Arg Val Ser Asp Glu Glu Lys Val Arg Ile

1 5 10 15

Ala Ala Lys Phe Ile Thr His Ala Pro Pro Gly Glu Phe Asn Glu Val

20 25 30

Phe Asn Asp Val Arg Leu Leu Leu Asn Asn Asp Asn Leu Leu Arg Glu

35 40 45

Gly Ala Ala His Ala Phe Ala Gln Tyr Asn Met Asp Gln Phe Thr Pro

50 55 60

Val Lys Ile Glu Gly Tyr Glu Asp Gln Val Leu Ile Thr Glu His Gly

65 70 75 80

Asp Leu Gly Asn Ser Arg Phe Leu Asp Pro Arg Asn Lys Ile Ser Phe

85 90 95

Lys Phe Asp His Leu Arg Lys Glu Ala Ser Asp Pro Gln Pro Glu Glu

100 105 110

Ala Asp Gly Gly Leu Lys Ser Trp Arg Glu Ser Cys Asp Ser Ala Leu

115 120 125

Arg Ala Tyr Val Lys Asp His Tyr Ser Asn Gly Phe Cys Thr Val Tyr

130 135 140

Ala Lys Thr Ile Asp Gly Gln Gln Thr Ile Ile Ala Cys Ile Glu Ser

145 150 155 160

His Gln Phe Gln Pro Lys Asn Phe Trp Asn Gly Arg Trp Arg Ser Glu

165 170 175

Trp Lys Phe Thr Ile Thr Pro Pro Thr Ala Gln Val Val Gly Val Leu

180 185 190

Lys Ile Gln Val His Tyr Tyr Glu Asp Gly Asn Val Gln Leu Val Ser

195 200 205

His Lys Asp Val Gln Asp Ser Leu Thr Val Ser Asn Glu Ala Gln Thr

210 215 220

Ala Lys Glu Phe Ile Lys Ile Ile Glu Asn Ala Glu Asn Glu Tyr Gln

225 230 235 240

Thr Ala Ile Ser Glu Asn Tyr Gln Thr Met Ser Asp Thr Thr Phe Lys

245 250 255

Ala Leu Arg Arg Gln Leu Pro Val Thr Arg Thr Lys Ile Asp Trp Asn

260 265 270

Lys Ile Leu Ser Tyr Lys Ile Gly Lys Glu Met Gln Asn Ala

275 280 285

<210> 32

<211> 199

<212> PRT

<213> 智人(Homo sapiens)

<400> 32

Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys

1 5 10 15

Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser

20 25 30

Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe

35 40 45

Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu

50 55 60

Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser

65 70 75 80

His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly

85 90 95

Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile

100 105 110

Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg

115 120 125

Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val

130 135 140

Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val

145 150 155 160

Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly

165 170 175

Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Gln Lys Ser Lys

180 185 190

Glu Tyr Phe Ser Lys Gln Lys

195

<210> 33

<211> 613

<212> PRT

<213> 智人(Homo sapiens)

<400> 33

Met Ala Gln Ser Arg Val Leu Leu Leu Leu Leu Leu Leu Pro Pro Gln

1 5 10 15

Leu His Leu Gly Pro Val Leu Ala Val Arg Ala Pro Gly Phe Gly Arg

20 25 30

Ser Gly Gly His Ser Leu Ser Pro Glu Glu Asn Glu Phe Ala Glu Glu

35 40 45

Glu Pro Val Leu Val Leu Ser Pro Glu Glu Pro Gly Pro Gly Pro Ala

50 55 60

Ala Val Ser Cys Pro Arg Asp Cys Ala Cys Ser Gln Glu Gly Val Val

65 70 75 80

Asp Cys Gly Gly Ile Asp Leu Arg Glu Phe Pro Gly Asp Leu Pro Glu

85 90 95

His Thr Asn His Leu Ser Leu Gln Asn Asn Gln Leu Glu Lys Ile Tyr

100 105 110

Pro Glu Glu Leu Ser Arg Leu His Arg Leu Glu Thr Leu Asn Leu Gln

115 120 125

Asn Asn Arg Leu Thr Ser Arg Gly Leu Pro Glu Lys Ala Phe Glu His

130 135 140

Leu Thr Asn Leu Asn Tyr Leu Tyr Leu Ala Asn Asn Lys Leu Thr Leu

145 150 155 160

Ala Pro Arg Phe Leu Pro Asn Ala Leu Ile Ser Val Asp Phe Ala Ala

165 170 175

Asn Tyr Leu Thr Lys Ile Tyr Gly Leu Thr Phe Gly Gln Lys Pro Asn

180 185 190

Leu Arg Ser Val Tyr Leu His Asn Asn Lys Leu Ala Asp Ala Gly Leu

195 200 205

Pro Asp Asn Met Phe Asn Gly Ser Ser Asn Val Glu Val Leu Ile Leu

210 215 220

Ser Ser Asn Phe Leu Arg His Val Pro Lys His Leu Pro Pro Ala Leu

225 230 235 240

Tyr Lys Leu His Leu Lys Asn Asn Lys Leu Glu Lys Ile Pro Pro Gly

245 250 255

Ala Phe Ser Glu Leu Ser Ser Leu Arg Glu Leu Tyr Leu Gln Asn Asn

260 265 270

Tyr Leu Thr Asp Glu Gly Leu Asp Asn Glu Thr Phe Trp Lys Leu Ser

275 280 285

Ser Leu Glu Tyr Leu Asp Leu Ser Ser Asn Asn Leu Ser Arg Val Pro

290 295 300

Ala Gly Leu Pro Arg Ser Leu Val Leu Leu His Leu Glu Lys Asn Ala

305 310 315 320

Ile Arg Ser Val Asp Ala Asn Val Leu Thr Pro Ile Arg Ser Leu Glu

325 330 335

Tyr Leu Leu Leu His Ser Asn Gln Leu Arg Glu Gln Gly Ile His Pro

340 345 350

Leu Ala Phe Gln Gly Leu Lys Arg Leu His Thr Val His Leu Tyr Asn

355 360 365

Asn Ala Leu Glu Arg Val Pro Ser Gly Leu Pro Arg Arg Val Arg Thr

370 375 380

Leu Met Ile Leu His Asn Gln Ile Thr Gly Ile Gly Arg Glu Asp Phe

385 390 395 400

Ala Thr Thr Tyr Phe Leu Glu Glu Leu Asn Leu Ser Tyr Asn Arg Ile

405 410 415

Thr Ser Pro Gln Val His Arg Asp Ala Phe Arg Lys Leu Arg Leu Leu

420 425 430

Arg Ser Leu Asp Leu Ser Gly Asn Arg Leu His Thr Leu Pro Pro Gly

435 440 445

Leu Pro Arg Asn Val His Val Leu Lys Val Lys Arg Asn Glu Leu Ala

450 455 460

Ala Leu Ala Arg Gly Ala Leu Val Gly Met Ala Gln Leu Arg Glu Leu

465 470 475 480

Tyr Leu Thr Ser Asn Arg Leu Arg Ser Arg Ala Leu Gly Pro Arg Ala

485 490 495

Trp Val Asp Leu Ala His Leu Gln Leu Leu Asp Ile Ala Gly Asn Gln

500 505 510

Leu Thr Glu Ile Pro Glu Gly Leu Pro Glu Ser Leu Glu Tyr Leu Tyr

515 520 525

Leu Gln Asn Asn Lys Ile Ser Ala Val Pro Ala Asn Ala Phe Asp Ser

530 535 540

Thr Pro Asn Leu Lys Gly Ile Phe Leu Arg Phe Asn Lys Leu Ala Val

545 550 555 560

Gly Ser Val Val Asp Ser Ala Phe Arg Arg Leu Lys His Leu Gln Val

565 570 575

Leu Asp Ile Glu Gly Asn Leu Glu Phe Gly Asp Ile Ser Lys Asp Arg

580 585 590

Gly Arg Leu Gly Lys Glu Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu

595 600 605

Glu Glu Glu Thr Arg

610

<210> 34

<211> 469

<212> PRT

<213> 智人(Homo sapiens)

<400> 34

Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val

1 5 10 15

Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp

20 25 30

Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly

35 40 45

Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu

50 55 60

Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp

65 70 75 80

Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp

85 90 95

Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr

100 105 110

His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala

115 120 125

Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val

130 135 140

Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met

145 150 155 160

Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly

165 170 175

Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly

180 185 190

Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg

195 200 205

Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu

210 215 220

Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr

225 230 235 240

Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile

245 250 255

Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro

260 265 270

Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr

275 280 285

Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg

290 295 300

Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe

305 310 315 320

Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp

325 330 335

Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln

340 345 350

Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe

355 360 365

Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu

370 375 380

Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr

385 390 395 400

Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala

405 410 415

His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys

420 425 430

Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp

435 440 445

Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe

450 455 460

Asn Cys Arg Lys Asn

465

<210> 35

<211> 420

<212> PRT

<213> 智人(Homo sapiens)

<400> 35

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr

1 5 10 15

Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr

20 25 30

Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro

35 40 45

Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val

50 55 60

Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile

65 70 75 80

Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser

85 90 95

His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly

100 105 110

Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile

115 120 125

Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His

130 135 140

Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys

145 150 155 160

Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu

165 170 175

Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu

180 185 190

Lys Thr Leu Asn Glu Glu Lys Arg Lys Glu Glu Glu Ser Lys Phe Glu

195 200 205

Glu Met Lys Lys Lys His Glu Asn His Pro Lys Val Asn His Pro Gly

210 215 220

Ser Lys Asp Gln Leu Lys Glu Val Trp Glu Glu Thr Asp Gly Leu Asp

225 230 235 240

Pro Asn Asp Phe Asp Pro Lys Thr Phe Phe Lys Leu His Asp Val Asn

245 250 255

Ser Asp Gly Phe Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys

260 265 270

Glu Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Val

275 280 285

Glu Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Ser Glu

290 295 300

Val Asp Thr Asn Lys Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Lys

305 310 315 320

Ala Thr Glu Lys Lys Glu Phe Leu Glu Pro Asp Ser Trp Glu Thr Leu

325 330 335

Asp Gln Gln Gln Phe Phe Thr Glu Glu Glu Leu Lys Glu Tyr Glu Asn

340 345 350

Ile Ile Ala Leu Gln Glu Asn Glu Leu Lys Lys Lys Ala Asp Glu Leu

355 360 365

Gln Lys Gln Lys Glu Glu Leu Gln Arg Gln His Asp Gln Leu Glu Ala

370 375 380

Gln Lys Leu Glu Tyr His Gln Val Ile Gln Gln Met Glu Gln Lys Lys

385 390 395 400

Leu Gln Gln Gly Ile Pro Pro Ser Gly Pro Ala Gly Glu Leu Lys Phe

405 410 415

Glu Pro His Ile

420

<210> 36

<211> 215

<212> PRT

<213> 智人(Homo sapiens)

<400> 36

Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr

1 5 10 15

Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro

20 25 30

Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg

35 40 45

Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala

50 55 60

Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro

65 70 75 80

Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys

85 90 95

Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys

100 105 110

Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys

115 120 125

Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr

130 135 140

Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala

145 150 155 160

Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val

165 170 175

Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu

180 185 190

Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu

195 200 205

Glu Glu Asp Asp Asp Asp Glu

210 215

<210> 37

<211> 5890

<212> PRT

<213> 智人(Homo sapiens)

<400> 37

Met Glu Lys Glu Glu Thr Thr Arg Glu Leu Leu Leu Pro Asn Trp Gln

1 5 10 15

Gly Ser Gly Ser His Gly Leu Thr Ile Ala Gln Arg Asp Asp Gly Val

20 25 30

Phe Val Gln Glu Val Thr Gln Asn Ser Pro Ala Ala Arg Thr Gly Val

35 40 45

Val Lys Glu Gly Asp Gln Ile Val Gly Ala Thr Ile Tyr Phe Asp Asn

50 55 60

Leu Gln Ser Gly Glu Val Thr Gln Leu Leu Asn Thr Met Gly His His

65 70 75 80

Thr Val Gly Leu Lys Leu His Arg Lys Gly Asp Arg Ser Pro Glu Pro

85 90 95

Gly Gln Thr Trp Thr Arg Glu Val Phe Ser Ser Cys Ser Ser Glu Val

100 105 110

Val Leu Ser Gly Asp Asp Glu Glu Tyr Gln Arg Ile Tyr Thr Thr Lys

115 120 125

Ile Lys Pro Arg Leu Lys Ser Glu Asp Gly Val Glu Gly Asp Leu Gly

130 135 140

Glu Thr Gln Ser Arg Thr Ile Thr Val Thr Arg Arg Val Thr Ala Tyr

145 150 155 160

Thr Val Asp Val Thr Gly Arg Glu Gly Ala Lys Asp Ile Asp Ile Ser

165 170 175

Ser Pro Glu Phe Lys Ile Lys Ile Pro Arg His Glu Leu Thr Glu Ile

180 185 190

Ser Asn Val Asp Val Glu Thr Gln Ser Gly Lys Thr Val Ile Arg Leu

195 200 205

Pro Ser Gly Ser Gly Ala Ala Ser Pro Thr Gly Ser Ala Val Asp Ile

210 215 220

Arg Ala Gly Ala Ile Ser Ala Ser Gly Pro Glu Leu Gln Gly Ala Gly

225 230 235 240

His Ser Lys Leu Gln Val Thr Met Pro Gly Ile Lys Val Gly Gly Ser

245 250 255

Gly Val Asn Val Asn Ala Lys Gly Leu Asp Leu Gly Gly Arg Gly Gly

260 265 270

Val Gln Val Pro Ala Val Asp Ile Ser Ser Ser Leu Gly Gly Arg Ala

275 280 285

Val Glu Val Gln Gly Pro Ser Leu Glu Ser Gly Asp His Gly Lys Ile

290 295 300

Lys Phe Pro Thr Met Lys Val Pro Lys Phe Gly Val Ser Thr Gly Arg

305 310 315 320

Glu Gly Gln Thr Pro Lys Ala Gly Leu Arg Val Ser Ala Pro Glu Val

325 330 335

Ser Val Gly His Lys Gly Gly Lys Pro Gly Leu Thr Ile Gln Ala Pro

340 345 350

Gln Leu Glu Val Ser Val Pro Ser Ala Asn Ile Glu Gly Leu Glu Gly

355 360 365

Lys Leu Lys Gly Pro Gln Ile Thr Gly Pro Ser Leu Glu Gly Asp Leu

370 375 380

Gly Leu Lys Gly Ala Lys Pro Gln Gly His Ile Gly Val Asp Ala Ser

385 390 395 400

Ala Pro Gln Ile Gly Gly Ser Ile Thr Gly Pro Ser Val Glu Val Gln

405 410 415

Ala Pro Asp Ile Asp Val Gln Gly Pro Gly Ser Lys Leu Asn Val Pro

420 425 430

Lys Met Lys Val Pro Lys Phe Ser Val Ser Gly Ala Lys Gly Glu Glu

435 440 445

Thr Gly Ile Asp Val Thr Leu Pro Thr Gly Glu Val Thr Val Pro Gly

450 455 460

Val Ser Gly Asp Val Ser Leu Pro Glu Ile Ala Thr Gly Gly Leu Glu

465 470 475 480

Gly Lys Met Lys Gly Thr Lys Val Lys Thr Pro Glu Met Ile Ile Gln

485 490 495

Lys Pro Lys Ile Ser Met Gln Asp Val Asp Leu Ser Leu Gly Ser Pro

500 505 510

Lys Leu Lys Gly Asp Ile Lys Val Ser Ala Pro Gly Val Gln Gly Asp

515 520 525

Val Lys Gly Pro Gln Val Ala Leu Lys Gly Ser Arg Val Asp Ile Glu

530 535 540

Thr Pro Asn Leu Glu Gly Thr Leu Thr Gly Pro Arg Leu Gly Ser Pro

545 550 555 560

Ser Gly Lys Thr Gly Thr Cys Arg Ile Ser Met Ser Glu Val Asp Leu

565 570 575

Asn Val Ala Ala Pro Lys Val Lys Gly Gly Val Asp Val Thr Leu Pro

580 585 590

Arg Val Glu Gly Lys Val Lys Val Pro Glu Val Asp Val Arg Gly Pro

595 600 605

Lys Val Asp Val Ser Ala Pro Asp Val Glu Ala His Gly Pro Glu Trp

610 615 620

Asn Leu Lys Met Pro Lys Met Lys Met Pro Thr Phe Ser Thr Pro Gly

625 630 635 640

Ala Lys Gly Glu Gly Pro Asp Val His Met Thr Leu Pro Lys Gly Asp

645 650 655

Ile Ser Ile Ser Gly Pro Lys Val Asn Val Glu Ala Pro Asp Val Asn

660 665 670

Leu Glu Gly Leu Gly Gly Lys Leu Lys Gly Pro Asp Val Lys Leu Pro

675 680 685

Asp Met Ser Val Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu

690 695 700

His Val Lys Gly Thr Lys Val Lys Gly Glu Tyr Asp Val Thr Val Pro

705 710 715 720

Lys Leu Glu Gly Glu Leu Lys Gly Pro Lys Val Asp Ile Asp Ala Pro

725 730 735

Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Met

740 745 750

Lys Met Pro Lys Phe Ser Val Pro Gly Phe Lys Ala Glu Gly Pro Glu

755 760 765

Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys

770 775 780

Ile Asp Val Thr Ala Pro Asp Val Ser Ile Glu Glu Pro Glu Gly Lys

785 790 795 800

Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Val Pro

805 810 815

Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Asn Val

820 825 830

Lys Gly Glu Tyr Asp Val Thr Met Pro Lys Val Glu Ser Glu Ile Lys

835 840 845

Val Pro Asp Val Glu Leu Lys Ser Ala Lys Met Asp Ile Asp Val Pro

850 855 860

Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met

865 870 875 880

Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu

885 890 895

Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys

900 905 910

Val Gly Val Glu Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys

915 920 925

Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro

930 935 940

Lys Ile Ser Met Pro Asp Val Asp Leu His Met Lys Gly Pro Lys Val

945 950 955 960

Lys Gly Glu Tyr Asp Met Thr Val Pro Lys Leu Glu Gly Asp Leu Lys

965 970 975

Gly Pro Lys Val Asp Val Ser Ala Pro Asp Val Glu Met Gln Gly Pro

980 985 990

Asp Trp Asn Leu Lys Met Pro Lys Ile Lys Met Pro Lys Phe Ser Met

995 1000 1005

Pro Ser Leu Lys Gly Glu Gly Pro Glu Phe Asp Val Asn Leu Ser

1010 1015 1020

Lys Ala Asn Val Asp Ile Ser Ala Pro Lys Val Asp Thr Asn Ala

1025 1030 1035

Pro Asp Leu Ser Leu Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro

1040 1045 1050

Lys Phe Lys Met Pro Glu Met His Phe Arg Ala Pro Lys Met Ser

1055 1060 1065

Leu Pro Asp Val Asp Leu Asp Leu Lys Gly Pro Lys Met Lys Gly

1070 1075 1080

Asn Val Asp Ile Ser Ala Pro Lys Ile Glu Gly Glu Met Gln Val

1085 1090 1095

Pro Asp Val Asp Ile Arg Gly Pro Lys Val Asp Ile Lys Ala Pro

1100 1105 1110

Asp Val Glu Gly Gln Gly Leu Asp Trp Ser Leu Lys Ile Pro Lys

1115 1120 1125

Met Lys Met Pro Lys Phe Ser Met Pro Ser Leu Lys Gly Glu Gly

1130 1135 1140

Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Val Val Val Ser

1145 1150 1155

Gly Pro Lys Val Asp Ile Glu Ala Pro Asp Val Ser Leu Glu Gly

1160 1165 1170

Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met

1175 1180 1185

His Phe Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu His

1190 1195 1200

Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser Val Pro

1205 1210 1215

Lys Val Glu Gly Glu Met Lys Val Pro Asp Val Glu Ile Lys Gly

1220 1225 1230

Pro Lys Met Asp Ile Asp Ala Pro Asp Val Glu Val Gln Gly Pro

1235 1240 1245

Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser

1250 1255 1260

Met Pro Gly Phe Lys Gly Glu Gly Arg Glu Val Asp Val Asn Leu

1265 1270 1275

Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val Glu

1280 1285 1290

Val Pro Asp Val Ser Leu Glu Gly Pro Glu Gly Lys Leu Lys Gly

1295 1300 1305

Pro Lys Phe Lys Met Pro Glu Met His Phe Lys Ala Pro Lys Ile

1310 1315 1320

Ser Met Pro Asp Val Asp Leu Asn Leu Lys Gly Pro Lys Leu Lys

1325 1330 1335

Gly Asp Val Asp Val Ser Leu Pro Glu Val Glu Gly Glu Met Lys

1340 1345 1350

Val Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Ser Ala

1355 1360 1365

Pro Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro

1370 1375 1380

Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu

1385 1390 1395

Gly Pro Glu Val Asp Val Lys Leu Pro Lys Ala Asp Val Asp Val

1400 1405 1410

Ser Gly Pro Lys Met Asp Ala Glu Val Pro Asp Val Asn Ile Glu

1415 1420 1425

Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu

1430 1435 1440

Met Ser Ile Lys Pro Gln Lys Ile Ser Ile Pro Asp Val Gly Leu

1445 1450 1455

His Leu Lys Gly Pro Lys Met Lys Gly Asp Tyr Asp Val Thr Val

1460 1465 1470

Pro Lys Val Glu Gly Glu Ile Lys Ala Pro Asp Val Asp Ile Lys

1475 1480 1485

Gly Pro Lys Val Asp Ile Asn Ala Pro Asp Val Glu Val His Gly

1490 1495 1500

Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe

1505 1510 1515

Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Glu Val Asp Met Asn

1520 1525 1530

Leu Pro Lys Ala Asp Leu Gly Val Ser Gly Pro Lys Val Asp Ile

1535 1540 1545

Asp Val Pro Asp Val Asn Leu Glu Ala Pro Glu Gly Lys Leu Lys

1550 1555 1560

Gly Pro Lys Phe Lys Met Pro Ser Met Asn Ile Gln Thr His Lys

1565 1570 1575

Ile Ser Met Pro Asp Val Gly Leu Asn Leu Lys Ala Pro Lys Leu

1580 1585 1590

Lys Thr Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp Leu

1595 1600 1605

Lys Gly Pro Glu Ile Asp Val Lys Ala Pro Lys Met Asp Val Asn

1610 1615 1620

Val Gly Asp Ile Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly

1625 1630 1635

Pro Lys Phe Lys Met Pro Glu Met His Phe Lys Ala Pro Lys Ile

1640 1645 1650

Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Lys Val Lys

1655 1660 1665

Gly Asp Met Asp Val Ser Val Pro Lys Val Glu Gly Glu Met Lys

1670 1675 1680

Val Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asp Ala

1685 1690 1695

Pro Asp Val Glu Val His Asp Pro Asp Trp His Leu Lys Met Pro

1700 1705 1710

Lys Met Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu

1715 1720 1725

Gly Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Ile Asp Val

1730 1735 1740

Ser Gly Pro Ser Val Asp Thr Asp Ala Pro Asp Leu Asp Ile Glu

1745 1750 1755

Gly Pro Glu Gly Lys Leu Lys Gly Ser Lys Phe Lys Met Pro Lys

1760 1765 1770

Leu Asn Ile Lys Ala Pro Lys Val Ser Met Pro Asp Val Asp Leu

1775 1780 1785

Asn Leu Lys Gly Pro Lys Leu Lys Gly Glu Ile Asp Ala Ser Val

1790 1795 1800

Pro Glu Leu Glu Gly Asp Leu Arg Gly Pro Gln Val Asp Val Lys

1805 1810 1815

Gly Pro Phe Val Glu Ala Glu Val Pro Asp Val Asp Leu Glu Cys

1820 1825 1830

Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met

1835 1840 1845

His Phe Lys Ala Pro Lys Ile Ser Met Pro Asp Val Asp Leu His

1850 1855 1860

Leu Lys Gly Pro Lys Val Lys Gly Asp Ala Asp Val Ser Val Pro

1865 1870 1875

Lys Leu Glu Gly Asp Leu Thr Gly Pro Ser Val Gly Val Glu Val

1880 1885 1890

Pro Asp Val Glu Leu Glu Cys Pro Asp Ala Lys Leu Lys Gly Pro

1895 1900 1905

Lys Phe Lys Met Pro Asp Met His Phe Lys Ala Pro Lys Ile Ser

1910 1915 1920

Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly

1925 1930 1935

Asp Val Asp Val Ser Val Pro Lys Leu Glu Gly Asp Leu Thr Gly

1940 1945 1950

Pro Ser Val Gly Val Glu Val Pro Asp Val Glu Leu Glu Cys Pro

1955 1960 1965

Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His

1970 1975 1980

Phe Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu His Leu

1985 1990 1995

Lys Gly Pro Lys Val Lys Gly Asp Met Asp Val Ser Val Pro Lys

2000 2005 2010

Val Glu Gly Glu Met Lys Val Pro Asp Val Asp Ile Lys Gly Pro

2015 2020 2025

Lys Met Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro Asp

2030 2035 2040

Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met

2045 2050 2055

Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro

2060 2065 2070

Lys Ala Asp Val Val Val Ser Gly Pro Lys Val Asp Val Glu Val

2075 2080 2085

Pro Asp Val Ser Leu Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro

2090 2095 2100

Lys Leu Lys Met Pro Glu Met His Phe Lys Ala Pro Lys Ile Ser

2105 2110 2115

Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly

2120 2125 2130

Asp Val Asp Val Ser Leu Pro Lys Leu Glu Gly Asp Leu Thr Gly

2135 2140 2145

Pro Ser Val Asp Val Glu Val Pro Asp Val Glu Leu Glu Cys Pro

2150 2155 2160

Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His

2165 2170 2175

Phe Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asn Leu Asn Leu

2180 2185 2190

Lys Gly Pro Lys Val Lys Gly Asp Met Asp Val Ser Val Pro Lys

2195 2200 2205

Val Glu Gly Glu Met Lys Val Pro Asp Val Asp Ile Arg Gly Pro

2210 2215 2220

Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro Asp

2225 2230 2235

Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met

2240 2245 2250

Pro Gly Phe Lys Gly Glu Gly Pro Glu Val Asp Val Asn Leu Pro

2255 2260 2265

Lys Ala Asp Val Asp Val Ser Gly Pro Lys Val Asp Val Glu Val

2270 2275 2280

Pro Asp Val Ser Leu Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro

2285 2290 2295

Lys Phe Lys Met Pro Glu Met His Phe Lys Thr Pro Lys Ile Ser

2300 2305 2310

Met Pro Asp Val Asp Phe Asn Leu Lys Gly Pro Lys Ile Lys Gly

2315 2320 2325

Asp Val Asp Val Ser Ala Pro Lys Leu Glu Gly Glu Leu Lys Gly

2330 2335 2340

Pro Glu Leu Asp Val Lys Gly Pro Lys Leu Asp Ala Asp Met Pro

2345 2350 2355

Glu Val Ala Val Glu Gly Pro Asn Gly Lys Trp Lys Thr Pro Lys

2360 2365 2370

Phe Lys Met Pro Asp Met His Phe Lys Ala Pro Lys Ile Ser Met

2375 2380 2385

Pro Asp Leu Asp Leu His Leu Lys Ser Pro Lys Ala Lys Gly Glu

2390 2395 2400

Val Asp Val Asp Val Pro Lys Leu Glu Gly Asp Leu Lys Gly Pro

2405 2410 2415

His Val Asp Val Ser Gly Pro Asp Ile Asp Ile Glu Gly Pro Glu

2420 2425 2430

Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Asp Met His Phe

2435 2440 2445

Lys Ala Pro Asn Ile Ser Met Pro Asp Val Asp Leu Asn Leu Lys

2450 2455 2460

Gly Pro Lys Ile Lys Gly Asp Val Asp Val Ser Val Pro Glu Val

2465 2470 2475

Glu Gly Lys Leu Glu Val Pro Asp Met Asn Ile Arg Gly Pro Lys

2480 2485 2490

Val Asp Val Asn Ala Pro Asp Val Gln Ala Pro Asp Trp His Leu

2495 2500 2505

Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met Pro Gly Phe

2510 2515 2520

Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp

2525 2530 2535

Val Asp Ile Ser Gly Pro Lys Val Asp Ile Glu Gly Pro Asp Val

2540 2545 2550

Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys Leu Lys

2555 2560 2565

Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp

2570 2575 2580

Phe Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp

2585 2590 2595

Val Ser Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Val

2600 2605 2610

Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Ala Pro Asp Val Gly

2615 2620 2625

Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met

2630 2635 2640

Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Gly

2645 2650 2655

Asp Val Lys Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys

2660 2665 2670

Val Asp Ile Glu Gly Pro Asp Val Asn Ile Glu Gly Pro Glu Gly

2675 2680 2685

Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys

2690 2695 2700

Ala Pro Lys Ile Ser Met Pro Asp Ile Asp Leu Asn Leu Lys Gly

2705 2710 2715

Pro Lys Val Lys Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu

2720 2725 2730

Gly Asp Leu Lys Gly Pro Glu Val Asp Ile Lys Gly Pro Lys Val

2735 2740 2745

Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro Asp Trp His

2750 2755 2760

Leu Lys Met Pro Lys Ile Lys Met Pro Lys Ile Ser Met Pro Gly

2765 2770 2775

Phe Lys Gly Glu Gly Pro Asp Val Asp Val Asn Leu Pro Lys Ala

2780 2785 2790

Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val Glu Cys Pro Asp

2795 2800 2805

Val Asn Ile Glu Gly Pro Glu Gly Lys Trp Lys Ser Pro Lys Phe

2810 2815 2820

Lys Met Pro Glu Met His Phe Lys Thr Pro Lys Ile Ser Met Pro

2825 2830 2835

Asp Ile Asp Leu Asn Leu Thr Gly Pro Lys Ile Lys Gly Asp Val

2840 2845 2850

Asp Val Thr Gly Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu

2855 2860 2865

Val Asp Leu Lys Gly Pro Lys Val Asp Ile Asp Val Pro Asp Val

2870 2875 2880

Asn Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met Lys

2885 2890 2895

Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu

2900 2905 2910

Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Val Ser Gly Pro

2915 2920 2925

Lys Val Asp Val Glu Gly Pro Asp Val Asn Ile Glu Gly Pro Glu

2930 2935 2940

Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile

2945 2950 2955

Lys Ala Pro Lys Ile Pro Met Pro Asp Phe Asp Leu His Leu Lys

2960 2965 2970

Gly Pro Lys Val Lys Gly Asp Val Asp Ile Ser Leu Pro Lys Val

2975 2980 2985

Glu Gly Asp Leu Lys Gly Pro Glu Val Asp Ile Arg Gly Pro Gln

2990 2995 3000

Val Asp Ile Asp Val Pro Asp Val Gly Val Gln Gly Pro Asp Trp

3005 3010 3015

His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe Ser Met Pro

3020 3025 3030

Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val Asn Leu Pro Lys

3035 3040 3045

Ala Asp Leu Asp Val Ser Gly Pro Lys Val Asp Ile Asp Val Pro

3050 3055 3060

Asp Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys

3065 3070 3075

Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met

3080 3085 3090

Pro Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys Gly Asp

3095 3100 3105

Met Asp Val Ser Leu Pro Lys Val Glu Gly Asp Met Lys Val Pro

3110 3115 3120

Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Ala Pro Asp

3125 3130 3135

Val Asp Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Ile

3140 3145 3150

Lys Met Pro Lys Ile Ser Met Pro Gly Phe Lys Gly Glu Gly Pro

3155 3160 3165

Glu Val Asp Val Asn Leu Pro Lys Ala Asp Leu Asp Val Ser Gly

3170 3175 3180

Pro Lys Val Asp Val Asp Val Pro Asp Val Asn Ile Glu Gly Pro

3185 3190 3195

Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn

3200 3205 3210

Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Leu Asp Leu Asn Leu

3215 3220 3225

Lys Gly Pro Lys Met Lys Gly Glu Val Asp Val Ser Leu Ala Asn

3230 3235 3240

Val Glu Gly Asp Leu Lys Gly Pro Ala Leu Asp Ile Lys Gly Pro

3245 3250 3255

Lys Ile Asp Val Asp Ala Pro Asp Ile Asp Ile His Gly Pro Asp

3260 3265 3270

Ala Lys Leu Lys Gly Pro Lys Leu Lys Met Pro Asp Met His Val

3275 3280 3285

Asn Met Pro Lys Ile Ser Met Pro Glu Ile Asp Leu Asn Leu Lys

3290 3295 3300

Gly Ser Lys Leu Lys Gly Asp Val Asp Val Ser Gly Pro Lys Leu

3305 3310 3315

Glu Gly Asp Ile Lys Ala Pro Ser Leu Asp Ile Lys Gly Pro Glu

3320 3325 3330

Val Asp Val Ser Gly Pro Lys Leu Asn Ile Glu Gly Lys Ser Lys

3335 3340 3345

Lys Ser Arg Phe Lys Leu Pro Lys Phe Asn Phe Ser Gly Ser Lys

3350 3355 3360

Val Gln Thr Pro Glu Val Asp Val Lys Gly Lys Lys Pro Asp Ile

3365 3370 3375

Asp Ile Thr Gly Pro Lys Val Asp Ile Asn Ala Pro Asp Val Glu

3380 3385 3390

Val Gln Gly Lys Val Lys Gly Ser Lys Phe Lys Met Pro Phe Leu

3395 3400 3405

Ser Ile Ser Ser Pro Lys Val Ser Met Pro Asp Val Glu Leu Asn

3410 3415 3420

Leu Lys Ser Pro Lys Val Lys Gly Asp Leu Asp Ile Ala Gly Pro

3425 3430 3435

Asn Leu Glu Gly Asp Phe Lys Gly Pro Lys Val Asp Ile Lys Ala

3440 3445 3450

Pro Glu Val Asn Leu Asn Ala Pro Asp Val Asp Val His Gly Pro

3455 3460 3465

Asp Trp Asn Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser

3470 3475 3480

Val Ser Gly Leu Lys Ala Glu Gly Pro Asp Val Ala Val Asp Leu

3485 3490 3495

Pro Lys Gly Asp Ile Asn Ile Glu Gly Pro Ser Met Asn Ile Glu

3500 3505 3510

Gly Pro Asp Leu Asn Val Glu Gly Pro Glu Gly Gly Leu Lys Gly

3515 3520 3525

Pro Lys Phe Lys Met Pro Asp Met Asn Ile Lys Ala Pro Lys Ile

3530 3535 3540

Ser Met Pro Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys

3545 3550 3555

Gly Asp Val Asp Ile Ser Leu Pro Lys Leu Glu Gly Asp Leu Lys

3560 3565 3570

Gly Pro Glu Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Ala

3575 3580 3585

Pro Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro

3590 3595 3600

Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu

3605 3610 3615

Gly Pro Glu Val Asp Val Thr Leu Pro Lys Ala Asp Ile Asp Ile

3620 3625 3630

Ser Gly Pro Asn Val Asp Val Asp Val Pro Asp Val Asn Ile Glu

3635 3640 3645

Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu

3650 3655 3660

Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Phe Asp Leu

3665 3670 3675

Asn Leu Lys Gly Pro Lys Met Lys Gly Asp Val Val Val Ser Leu

3680 3685 3690

Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Val Asp Ile Lys

3695 3700 3705

Gly Pro Lys Val Asp Ile Asp Thr Pro Asp Ile Asn Ile Glu Gly

3710 3715 3720

Ser Glu Gly Lys Phe Lys Gly Pro Lys Phe Lys Ile Pro Glu Met

3725 3730 3735

His Leu Lys Ala Pro Lys Ile Ser Met Pro Asp Ile Asp Leu Asn

3740 3745 3750

Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser Leu Pro

3755 3760 3765

Lys Met Glu Gly Asp Leu Lys Gly Pro Glu Val Asp Ile Lys Gly

3770 3775 3780

Pro Lys Val Asp Ile Asn Ala Pro Asp Val Asp Val Gln Gly Pro

3785 3790 3795

Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe Ser

3800 3805 3810

Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val Asn Leu

3815 3820 3825

Pro Lys Ala Asp Leu Asp Val Ser Gly Pro Lys Val Asp Ile Asp

3830 3835 3840

Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly

3845 3850 3855

Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile

3860 3865 3870

Ser Met Pro Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys

3875 3880 3885

Gly Asp Met Asp Val Ser Leu Pro Lys Val Glu Gly Asp Met Gln

3890 3895 3900

Val Pro Asp Leu Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Ala

3905 3910 3915

Pro Asp Val Asp Val Arg Gly Pro Asp Trp His Leu Lys Met Pro

3920 3925 3930

Lys Ile Lys Met Pro Lys Ile Ser Met Pro Gly Phe Lys Gly Glu

3935 3940 3945

Gly Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Leu Asp Val

3950 3955 3960

Ser Gly Pro Lys Val Asp Val Asp Val Pro Asp Val Asn Ile Glu

3965 3970 3975

Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu

3980 3985 3990

Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Phe Asp Leu

3995 4000 4005

His Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser Leu

4010 4015 4020

Pro Lys Met Glu Gly Asp Leu Lys Ala Pro Glu Val Asp Ile Lys

4025 4030 4035

Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His Gly

4040 4045 4050

Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe

4055 4060 4065

Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Glu Val Asp Val Asn

4070 4075 4080

Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Ile

4085 4090 4095

Asp Thr Pro Asp Ile Asp Ile His Gly Pro Glu Gly Lys Leu Lys

4100 4105 4110

Gly Pro Lys Phe Lys Met Pro Asp Leu His Leu Lys Ala Pro Lys

4115 4120 4125

Ile Ser Met Pro Glu Val Asp Leu Asn Leu Lys Gly Pro Lys Met

4130 4135 4140

Lys Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp Leu

4145 4150 4155

Lys Gly Pro Glu Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asp

4160 4165 4170

Val Pro Asp Val Asp Val Gln Gly Pro Asp Trp His Leu Lys Met

4175 4180 4185

Pro Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly

4190 4195 4200

Glu Gly Pro Asp Val Asp Val Asn Leu Pro Lys Ala Asp Leu Asp

4205 4210 4215

Val Ser Gly Pro Lys Val Asp Ile Asp Val Pro Asp Val Asn Ile

4220 4225 4230

Glu Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro

4235 4240 4245

Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Phe Asp

4250 4255 4260

Leu His Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser

4265 4270 4275

Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Val Asp Ile

4280 4285 4290

Lys Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His

4295 4300 4305

Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys

4310 4315 4320

Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val

4325 4330 4335

Thr Leu Pro Lys Ala Asp Ile Glu Ile Ser Gly Pro Lys Val Asp

4340 4345 4350

Ile Asp Ala Pro Asp Val Ser Ile Glu Gly Pro Asp Ala Lys Leu

4355 4360 4365

Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro

4370 4375 4380

Lys Ile Ser Met Pro Asp Ile Asp Phe Asn Leu Lys Gly Pro Lys

4385 4390 4395

Val Lys Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp

4400 4405 4410

Leu Lys Gly Pro Glu Ile Asp Ile Lys Gly Pro Ser Leu Asp Ile

4415 4420 4425

Asp Thr Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys

4430 4435 4440

Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro Lys

4445 4450 4455

Ile Ser Met Pro Asp Phe Asp Leu His Leu Lys Gly Pro Lys Val

4460 4465 4470

Lys Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Ser Asp Leu

4475 4480 4485

Lys Gly Pro Glu Val Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys

4490 4495 4500

Gly Pro Lys Phe Lys Met Pro Asp Val His Phe Lys Ser Pro Gln

4505 4510 4515

Ile Ser Met Ser Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Ile

4520 4525 4530

Lys Gly Asp Met Asp Ile Ser Val Pro Lys Leu Glu Gly Asp Leu

4535 4540 4545

Lys Gly Pro Lys Val Asp Val Lys Gly Pro Lys Val Gly Ile Asp

4550 4555 4560

Thr Pro Asp Ile Asp Ile His Gly Pro Glu Gly Lys Leu Lys Gly

4565 4570 4575

Pro Lys Phe Lys Met Pro Asp Leu His Leu Lys Ala Pro Lys Ile

4580 4585 4590

Ser Met Pro Glu Val Asp Leu Asn Leu Lys Gly Pro Lys Val Lys

4595 4600 4605

Gly Asp Met Asp Ile Ser Leu Pro Lys Val Glu Gly Asp Leu Lys

4610 4615 4620

Gly Pro Glu Val Asp Ile Arg Asp Pro Lys Val Asp Ile Asp Val

4625 4630 4635

Pro Asp Val Asp Val Gln Gly Pro Asp Trp His Leu Lys Met Pro

4640 4645 4650

Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu

4655 4660 4665

Gly Pro Asp Val Asp Val Asn Leu Pro Lys Ala Asp Ile Asp Val

4670 4675 4680

Ser Gly Pro Lys Val Asp Val Asp Val Pro Asp Val Asn Ile Glu

4685 4690 4695

Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu

4700 4705 4710

Met Ser Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Ile Asp Leu

4715 4720 4725

Asn Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Thr Leu

4730 4735 4740

Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Ala Asp Ile Lys

4745 4750 4755

Gly Pro Lys Val Asp Ile Asn Thr Pro Asp Val Asp Val His Gly

4760 4765 4770

Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe

4775 4780 4785

Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val Ser

4790 4795 4800

Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val

4805 4810 4815

Asp Ile Pro Asp Val Asn Ile Glu Gly Pro Asp Ala Lys Leu Lys

4820 4825 4830

Gly Pro Lys Phe Lys Met Pro Glu Ile Asn Ile Lys Ala Pro Lys

4835 4840 4845

Ile Ser Ile Pro Asp Val Asp Leu Asp Leu Lys Gly Pro Lys Val

4850 4855 4860

Lys Gly Asp Phe Asp Val Ser Val Pro Lys Val Glu Gly Thr Leu

4865 4870 4875

Lys Gly Pro Glu Val Asp Leu Lys Gly Pro Arg Leu Asp Phe Glu

4880 4885 4890

Gly Pro Asp Ala Lys Leu Ser Gly Pro Ser Leu Lys Met Pro Ser

4895 4900 4905

Leu Glu Ile Ser Ala Pro Lys Val Thr Ala Pro Asp Val Asp Leu

4910 4915 4920

His Leu Lys Ala Pro Lys Ile Gly Phe Ser Gly Pro Lys Leu Glu

4925 4930 4935

Gly Gly Glu Val Asp Leu Lys Gly Pro Lys Val Glu Ala Pro Ser

4940 4945 4950

Leu Asp Val His Met Asp Ser Pro Asp Ile Asn Ile Glu Gly Pro

4955 4960 4965

Asp Val Lys Ile Pro Lys Phe Lys Lys Pro Lys Phe Gly Phe Gly

4970 4975 4980

Ala Lys Ser Pro Lys Ala Asp Ile Lys Ser Pro Ser Leu Asp Val

4985 4990 4995

Thr Val Pro Glu Ala Glu Leu Asn Leu Glu Thr Pro Glu Ile Ser

5000 5005 5010

Val Gly Gly Lys Gly Lys Lys Ser Lys Phe Lys Met Pro Lys Ile

5015 5020 5025

His Met Ser Gly Pro Lys Ile Lys Ala Lys Lys Gln Gly Phe Asp

5030 5035 5040

Leu Asn Val Pro Gly Gly Glu Ile Asp Ala Ser Leu Lys Ala Pro

5045 5050 5055

Asp Val Asp Val Asn Ile Ala Gly Pro Asp Ala Ala Leu Lys Val

5060 5065 5070

Asp Val Lys Ser Pro Lys Thr Lys Lys Thr Met Phe Gly Lys Met

5075 5080 5085

Tyr Phe Pro Asp Val Glu Phe Asp Ile Lys Ser Pro Lys Phe Lys

5090 5095 5100

Ala Glu Ala Pro Leu Pro Ser Pro Lys Leu Glu Gly Glu Leu Gln

5105 5110 5115

Ala Pro Asp Leu Glu Leu Ser Leu Pro Ala Ile His Val Glu Gly

5120 5125 5130

Leu Asp Ile Lys Ala Lys Ala Pro Lys Val Lys Met Pro Asp Val

5135 5140 5145

Asp Ile Ser Val Pro Lys Ile Glu Gly Asp Leu Lys Gly Pro Lys

5150 5155 5160

Val Gln Ala Asn Leu Gly Ala Pro Asp Ile Asn Ile Glu Gly Leu

5165 5170 5175

Asp Ala Lys Val Lys Thr Pro Ser Phe Gly Ile Ser Ala Pro Gln

5180 5185 5190

Val Ser Ile Pro Asp Val Asn Val Asn Leu Lys Gly Pro Lys Ile

5195 5200 5205

Lys Gly Asp Val Pro Ser Val Gly Leu Glu Gly Pro Asp Val Asp

5210 5215 5220

Leu Gln Gly Pro Glu Ala Lys Ile Lys Phe Pro Lys Phe Ser Met

5225 5230 5235

Pro Lys Ile Gly Ile Pro Gly Val Lys Met Glu Gly Gly Gly Ala

5240 5245 5250

Glu Val His Ala Gln Leu Pro Ser Leu Glu Gly Asp Leu Arg Gly

5255 5260 5265

Pro Asp Val Lys Leu Glu Gly Pro Asp Val Ser Leu Lys Gly Pro

5270 5275 5280

Gly Val Asp Leu Pro Ser Val Asn Leu Ser Met Pro Lys Val Ser

5285 5290 5295

Gly Pro Asp Leu Asp Leu Asn Leu Lys Gly Pro Ser Leu Lys Gly

5300 5305 5310

Asp Leu Asp Ala Ser Val Pro Ser Met Lys Val His Ala Pro Gly

5315 5320 5325

Leu Asn Leu Ser Gly Val Gly Gly Lys Met Gln Val Gly Gly Asp

5330 5335 5340

Gly Val Lys Val Pro Gly Ile Asp Ala Thr Thr Lys Leu Asn Val

5345 5350 5355

Gly Ala Pro Asp Val Thr Leu Arg Gly Pro Ser Leu Gln Gly Asp

5360 5365 5370

Leu Ala Val Ser Gly Asp Ile Lys Cys Pro Lys Val Ser Val Gly

5375 5380 5385

Ala Pro Asp Leu Ser Leu Glu Ala Ser Glu Gly Ser Ile Lys Leu

5390 5395 5400

Pro Lys Met Lys Leu Pro Gln Phe Gly Ile Ser Thr Pro Gly Ser

5405 5410 5415

Asp Leu His Val Asn Ala Lys Gly Pro Gln Val Ser Gly Glu Leu

5420 5425 5430

Lys Gly Pro Gly Val Asp Val Asn Leu Lys Gly Pro Arg Ile Ser

5435 5440 5445

Ala Pro Asn Val Asp Phe Asn Leu Glu Gly Pro Lys Val Lys Gly

5450 5455 5460

Ser Leu Gly Ala Thr Gly Glu Ile Lys Gly Pro Thr Val Gly Gly

5465 5470 5475

Gly Leu Pro Gly Ile Gly Val Gln Gly Leu Glu Gly Asn Leu Gln

5480 5485 5490

Met Pro Gly Ile Lys Ser Ser Gly Cys Asp Val Asn Leu Pro Gly

5495 5500 5505

Val Asn Val Lys Leu Pro Thr Gly Gln Ile Ser Gly Pro Glu Ile

5510 5515 5520

Lys Gly Gly Leu Lys Gly Ser Glu Val Gly Phe His Gly Ala Ala

5525 5530 5535

Pro Asp Ile Ser Val Lys Gly Pro Ala Phe Asn Met Ala Ser Pro

5540 5545 5550

Glu Ser Asp Phe Gly Ile Asn Leu Lys Gly Pro Lys Ile Lys Gly

5555 5560 5565

Gly Ala Asp Val Ser Gly Gly Val Ser Ala Pro Asp Ile Ser Leu

5570 5575 5580

Gly Glu Gly His Leu Ser Val Lys Gly Ser Gly Gly Glu Trp Lys

5585 5590 5595

Gly Pro Gln Val Ser Ser Ala Leu Asn Leu Asp Thr Ser Lys Phe

5600 5605 5610

Ala Gly Gly Leu His Phe Ser Gly Pro Lys Val Glu Gly Gly Val

5615 5620 5625

Lys Gly Gly Gln Ile Gly Leu Gln Ala Pro Gly Leu Ser Val Ser

5630 5635 5640

Gly Pro Gln Gly His Leu Glu Ser Gly Ser Gly Lys Val Thr Phe

5645 5650 5655

Pro Lys Met Lys Ile Pro Lys Phe Thr Phe Ser Gly Arg Glu Leu

5660 5665 5670

Val Gly Arg Glu Met Gly Val Asp Val His Phe Pro Lys Ala Glu

5675 5680 5685

Ala Ser Ile Gln Ala Gly Ala Gly Asp Gly Glu Trp Glu Glu Ser

5690 5695 5700

Glu Val Lys Leu Lys Lys Ser Lys Ile Lys Met Pro Lys Phe Asn

5705 5710 5715

Phe Ser Lys Pro Lys Gly Lys Gly Gly Val Thr Gly Ser Pro Glu

5720 5725 5730

Ala Ser Ile Ser Gly Ser Lys Gly Asp Leu Lys Ser Ser Lys Ala

5735 5740 5745

Ser Leu Gly Ser Leu Glu Gly Glu Ala Glu Ala Glu Ala Ser Ser

5750 5755 5760

Pro Lys Gly Lys Phe Ser Leu Phe Lys Ser Lys Lys Pro Arg His

5765 5770 5775

Arg Ser Asn Ser Phe Ser Asp Glu Arg Glu Phe Ser Gly Pro Ser

5780 5785 5790

Thr Pro Thr Gly Thr Leu Glu Phe Glu Gly Gly Glu Val Ser Leu

5795 5800 5805

Glu Gly Gly Lys Val Lys Gly Lys His Gly Lys Leu Lys Phe Gly

5810 5815 5820

Thr Phe Gly Gly Leu Gly Ser Lys Ser Lys Gly His Tyr Glu Val

5825 5830 5835

Thr Gly Ser Asp Asp Glu Thr Gly Lys Leu Gln Gly Ser Gly Val

5840 5845 5850

Ser Leu Ala Ser Lys Lys Ser Arg Leu Ser Ser Ser Ser Ser Asn

5855 5860 5865

Asp Ser Gly Asn Lys Val Gly Ile Gln Leu Pro Glu Val Glu Leu

5870 5875 5880

Ser Val Ser Thr Lys Lys Glu

5885 5890

<210> 38

<211> 1894

<212> PRT

<213> 智人(Homo sapiens)

<400> 38

Met Ala Pro Glu Ala Gly Ala Thr Leu Arg Ala Pro Arg Arg Leu Ser

1 5 10 15

Trp Ala Ala Leu Leu Leu Leu Ala Ala Leu Leu Pro Val Ala Ser Ser

20 25 30

Ala Ala Ala Ser Val Asp His Pro Leu Lys Pro Arg His Val Lys Leu

35 40 45

Leu Ser Thr Lys Met Gly Leu Lys Val Thr Trp Asp Pro Pro Lys Asp

50 55 60

Ala Thr Ser Arg Pro Val Glu His Tyr Asn Ile Ala Tyr Gly Lys Ser

65 70 75 80

Leu Lys Ser Leu Lys Tyr Ile Lys Val Asn Ala Glu Thr Tyr Ser Phe

85 90 95

Leu Ile Glu Asp Val Glu Pro Gly Val Val Tyr Phe Val Leu Leu Thr

100 105 110

Ala Glu Asn His Ser Gly Val Ser Arg Pro Val Tyr Arg Ala Glu Ser

115 120 125

Pro Pro Gly Gly Glu Trp Ile Glu Ile Asp Gly Phe Pro Ile Lys Gly

130 135 140

Pro Gly Pro Phe Asn Glu Thr Val Thr Glu Lys Glu Val Pro Asn Lys

145 150 155 160

Pro Leu Arg Val Arg Val Arg Ser Ser Asp Asp Arg Leu Ser Val Ala

165 170 175

Trp Lys Ala Pro Arg Leu Ser Gly Ala Lys Ser Pro Arg Arg Ser Arg

180 185 190

Gly Phe Leu Leu Gly Tyr Gly Glu Ser Gly Arg Lys Met Asn Tyr Val

195 200 205

Pro Leu Thr Arg Asp Glu Arg Thr His Glu Ile Lys Lys Leu Ala Ser

210 215 220

Glu Ser Val Tyr Val Val Ser Leu Gln Ser Met Asn Ser Gln Gly Arg

225 230 235 240

Ser Gln Pro Val Tyr Arg Ala Ala Leu Thr Lys Arg Lys Ile Ser Glu

245 250 255

Glu Asp Glu Leu Asp Val Pro Asp Asp Ile Ser Val Arg Val Met Ser

260 265 270

Ser Gln Ser Val Leu Val Ser Trp Val Asp Pro Val Leu Glu Lys Gln

275 280 285

Lys Lys Val Val Ala Ser Arg Gln Tyr Thr Val Arg Tyr Arg Glu Lys

290 295 300

Gly Glu Leu Ala Arg Trp Asp Tyr Lys Gln Ile Ala Asn Arg Arg Val

305 310 315 320

Leu Ile Glu Asn Leu Ile Pro Asp Thr Val Tyr Glu Phe Ala Val Arg

325 330 335

Ile Ser Gln Gly Glu Arg Asp Gly Lys Trp Ser Thr Ser Val Phe Gln

340 345 350

Arg Thr Pro Glu Ser Ala Pro Thr Thr Ala Pro Glu Asn Leu Asn Val

355 360 365

Trp Pro Val Asn Gly Lys Pro Thr Val Val Ala Ala Ser Trp Asp Ala

370 375 380

Leu Pro Glu Thr Glu Gly Lys Val Lys Glu Tyr Ile Leu Ser Tyr Ala

385 390 395 400

Pro Ala Leu Lys Pro Phe Gly Ala Lys Ser Leu Thr Tyr Pro Gly Asp

405 410 415

Thr Thr Ser Ala Leu Val Asp Gly Leu Gln Pro Gly Glu Arg Tyr Leu

420 425 430

Phe Lys Ile Arg Ala Thr Asn Arg Arg Gly Leu Gly Pro His Ser Lys

435 440 445

Ala Phe Ile Val Ala Met Pro Thr Thr Ser Lys Ala Asp Val Glu Gln

450 455 460

Asn Thr Glu Asp Asn Gly Lys Pro Glu Lys Pro Glu Pro Ser Ser Pro

465 470 475 480

Ser Pro Arg Ala Pro Ala Ser Ser Gln His Pro Ser Val Pro Ala Ser

485 490 495

Pro Gln Gly Arg Asn Ala Lys Asp Leu Leu Leu Asp Leu Lys Asn Lys

500 505 510

Ile Leu Ala Asn Gly Gly Ala Pro Arg Lys Pro Gln Leu Arg Ala Lys

515 520 525

Lys Ala Glu Glu Leu Asp Leu Gln Ser Thr Glu Ile Thr Gly Glu Glu

530 535 540

Glu Leu Gly Ser Arg Glu Asp Ser Pro Met Ser Pro Ser Asp Thr Gln

545 550 555 560

Asp Gln Lys Arg Thr Leu Arg Pro Pro Ser Arg His Gly His Ser Val

565 570 575

Val Ala Pro Gly Arg Thr Ala Val Arg Ala Arg Met Pro Ala Leu Pro

580 585 590

Arg Arg Glu Gly Val Asp Lys Pro Gly Phe Ser Leu Ala Thr Gln Pro

595 600 605

Arg Pro Gly Ala Pro Pro Ser Ala Ser Ala Ser Pro Ala His His Ala

610 615 620

Ser Thr Gln Gly Thr Ser His Arg Pro Ser Leu Pro Ala Ser Leu Asn

625 630 635 640

Asp Asn Asp Leu Val Asp Ser Asp Glu Asp Glu Arg Ala Val Gly Ser

645 650 655

Leu His Pro Lys Gly Ala Phe Ala Gln Pro Arg Pro Ala Leu Ser Pro

660 665 670

Ser Arg Gln Ser Pro Ser Ser Val Leu Arg Asp Arg Ser Ser Val His

675 680 685

Pro Gly Ala Lys Pro Ala Ser Pro Ala Arg Arg Thr Pro His Ser Gly

690 695 700

Ala Ala Glu Glu Asp Ser Ser Ala Ser Ala Pro Pro Ser Arg Leu Ser

705 710 715 720

Pro Pro His Gly Gly Ser Ser Arg Leu Leu Pro Thr Gln Pro His Leu

725 730 735

Ser Ser Pro Leu Ser Lys Gly Gly Lys Asp Gly Glu Asp Ala Pro Ala

740 745 750

Thr Asn Ser Asn Ala Pro Ser Arg Ser Thr Met Ser Ser Ser Val Ser

755 760 765

Ser His Leu Ser Ser Arg Thr Gln Val Ser Glu Gly Ala Glu Ala Ser

770 775 780

Asp Gly Glu Ser His Gly Asp Gly Asp Arg Glu Asp Gly Gly Arg Gln

785 790 795 800

Ala Glu Ala Thr Ala Gln Thr Leu Arg Ala Arg Pro Ala Ser Gly His

805 810 815

Phe His Leu Leu Arg His Lys Pro Phe Ala Ala Asn Gly Arg Ser Pro

820 825 830

Ser Arg Phe Ser Ile Gly Arg Gly Pro Arg Leu Gln Pro Ser Ser Ser

835 840 845

Pro Gln Ser Thr Val Pro Ser Arg Ala His Pro Arg Val Pro Ser His

850 855 860

Ser Asp Ser His Pro Lys Leu Ser Ser Gly Ile His Gly Asp Glu Glu

865 870 875 880

Asp Glu Lys Pro Leu Pro Ala Thr Val Val Asn Asp His Val Pro Ser

885 890 895

Ser Ser Arg Gln Pro Ile Ser Arg Gly Trp Glu Asp Leu Arg Arg Ser

900 905 910

Pro Gln Arg Gly Ala Ser Leu His Arg Lys Glu Pro Ile Pro Glu Asn

915 920 925

Pro Lys Ser Thr Gly Ala Asp Thr His Pro Gln Gly Lys Tyr Ser Ser

930 935 940

Leu Ala Ser Lys Ala Gln Asp Val Gln Gln Ser Thr Asp Ala Asp Thr

945 950 955 960

Glu Gly His Ser Pro Lys Ala Gln Pro Gly Ser Thr Asp Arg His Ala

965 970 975

Ser Pro Ala Arg Pro Pro Ala Ala Arg Ser Gln Gln His Pro Ser Val

980 985 990

Pro Arg Arg Met Thr Pro Gly Arg Ala Pro Gln Gln Gln Pro Pro Pro

995 1000 1005

Pro Val Ala Thr Ser Gln His His Pro Gly Pro Gln Ser Arg Asp

1010 1015 1020

Ala Gly Arg Ser Pro Ser Gln Pro Arg Leu Ser Leu Thr Gln Ala

1025 1030 1035

Gly Arg Pro Arg Pro Thr Ser Gln Gly Arg Ser His Ser Ser Ser

1040 1045 1050

Asp Pro Tyr Thr Ala Ser Ser Arg Gly Met Leu Pro Thr Ala Leu

1055 1060 1065

Gln Asn Gln Asp Glu Asp Ala Gln Gly Ser Tyr Asp Asp Asp Ser

1070 1075 1080

Thr Glu Val Glu Ala Gln Asp Val Arg Ala Pro Ala His Ala Ala

1085 1090 1095

Arg Ala Lys Glu Ala Ala Ala Ser Leu Pro Lys His Gln Gln Val

1100 1105 1110

Glu Ser Pro Thr Gly Ala Gly Ala Gly Gly Asp His Arg Ser Gln

1115 1120 1125

Arg Gly His Ala Ala Ser Pro Ala Arg Pro Ser Arg Pro Gly Gly

1130 1135 1140

Pro Gln Ser Arg Ala Arg Val Pro Ser Arg Ala Ala Pro Gly Lys

1145 1150 1155

Ser Glu Pro Pro Ser Lys Arg Pro Leu Ser Ser Lys Ser Gln Gln

1160 1165 1170

Ser Val Ser Ala Glu Asp Asp Glu Glu Glu Asp Ala Gly Phe Phe

1175 1180 1185

Lys Gly Gly Lys Glu Asp Leu Leu Ser Ser Ser Val Pro Lys Trp

1190 1195 1200

Pro Ser Ser Ser Thr Pro Arg Gly Gly Lys Asp Ala Asp Gly Ser

1205 1210 1215

Leu Ala Lys Glu Glu Arg Glu Pro Ala Ile Ala Leu Ala Pro Arg

1220 1225 1230

Gly Gly Ser Leu Ala Pro Val Lys Arg Pro Leu Pro Pro Pro Pro

1235 1240 1245

Gly Ser Ser Pro Arg Ala Ser His Val Pro Ser Arg Leu Pro Pro

1250 1255 1260

Arg Ser Ala Ala Thr Val Ser Pro Val Ala Gly Thr His Pro Trp

1265 1270 1275

Pro Gln Tyr Thr Thr Arg Ala Pro Pro Gly His Phe Ser Thr Thr

1280 1285 1290

Pro Met Leu Ser Leu Arg Gln Arg Met Met His Ala Arg Phe Arg

1295 1300 1305

Asn Pro Leu Ser Arg Gln Pro Ala Arg Pro Ser Tyr Arg Gln Gly

1310 1315 1320

Tyr Asn Gly Arg Pro Asn Val Glu Gly Lys Val Leu Pro Gly Ser

1325 1330 1335

Asn Gly Lys Pro Asn Gly Gln Arg Ile Ile Asn Gly Pro Gln Gly

1340 1345 1350

Thr Lys Trp Val Val Asp Leu Asp Arg Gly Leu Val Leu Asn Ala

1355 1360 1365

Glu Gly Arg Tyr Leu Gln Asp Ser His Gly Asn Pro Leu Arg Ile

1370 1375 1380

Lys Leu Gly Gly Asp Gly Arg Thr Ile Val Asp Leu Glu Gly Thr

1385 1390 1395

Pro Val Val Ser Pro Asp Gly Leu Pro Leu Phe Gly Gln Gly Arg

1400 1405 1410

His Gly Thr Pro Leu Ala Asn Ala Gln Asp Lys Pro Ile Leu Ser

1415 1420 1425

Leu Gly Gly Lys Pro Leu Val Gly Leu Glu Val Ile Lys Lys Thr

1430 1435 1440

Thr His Pro Pro Thr Thr Thr Met Gln Pro Thr Thr Thr Thr Thr

1445 1450 1455

Pro Leu Pro Thr Thr Thr Thr Pro Arg Pro Thr Thr Ala Thr Thr

1460 1465 1470

Arg Arg Thr Thr Thr Thr Arg Arg Thr Thr Thr Arg Arg Pro Thr

1475 1480 1485

Thr Thr Val Arg Thr Thr Thr Arg Thr Thr Thr Thr Thr Thr Pro

1490 1495 1500

Thr Pro Thr Thr Pro Ile Pro Thr Cys Pro Pro Gly Thr Leu Glu

1505 1510 1515

Arg His Asp Asp Asp Gly Asn Leu Ile Met Ser Ser Asn Gly Ile

1520 1525 1530

Pro Glu Cys Tyr Ala Glu Glu Asp Glu Phe Ser Gly Leu Glu Thr

1535 1540 1545

Asp Thr Ala Val Pro Thr Glu Glu Ala Tyr Val Ile Tyr Asp Glu

1550 1555 1560

Asp Tyr Glu Phe Glu Thr Ser Arg Pro Pro Thr Thr Thr Glu Pro

1565 1570 1575

Ser Thr Thr Ala Thr Thr Pro Arg Val Ile Pro Glu Glu Gly Ala

1580 1585 1590

Ile Ser Ser Phe Pro Glu Glu Glu Phe Asp Leu Ala Gly Arg Lys

1595 1600 1605

Arg Phe Val Ala Pro Tyr Val Thr Tyr Leu Asn Lys Asp Pro Ser

1610 1615 1620

Ala Pro Cys Ser Leu Thr Asp Ala Leu Asp His Phe Gln Val Asp

1625 1630 1635

Ser Leu Asp Glu Ile Ile Pro Asn Asp Leu Lys Lys Ser Asp Leu

1640 1645 1650

Pro Pro Gln His Ala Pro Arg Asn Ile Thr Val Val Ala Val Glu

1655 1660 1665

Gly Cys His Ser Phe Val Ile Val Asp Trp Asp Lys Ala Thr Pro

1670 1675 1680

Gly Asp Val Val Thr Gly Tyr Leu Val Tyr Ser Ala Ser Tyr Glu

1685 1690 1695

Asp Phe Ile Arg Asn Lys Trp Ser Thr Gln Ala Ser Ser Val Thr

1700 1705 1710

His Leu Pro Ile Glu Asn Leu Lys Pro Asn Thr Arg Tyr Tyr Phe

1715 1720 1725

Lys Val Gln Ala Gln Asn Pro His Gly Tyr Gly Pro Ile Ser Pro

1730 1735 1740

Ser Val Ser Phe Val Thr Glu Ser Asp Asn Pro Leu Leu Val Val

1745 1750 1755

Arg Pro Pro Gly Gly Glu Pro Ile Trp Ile Pro Phe Ala Phe Lys

1760 1765 1770

His Asp Pro Ser Tyr Thr Asp Cys His Gly Arg Gln Tyr Val Lys

1775 1780 1785

Arg Thr Trp Tyr Arg Lys Phe Val Gly Val Val Leu Cys Asn Ser

1790 1795 1800

Leu Arg Tyr Lys Ile Tyr Leu Ser Asp Asn Leu Lys Asp Thr Phe

1805 1810 1815

Tyr Ser Ile Gly Asp Ser Trp Gly Arg Gly Glu Asp His Cys Gln

1820 1825 1830

Phe Val Asp Ser His Leu Asp Gly Arg Thr Gly Pro Gln Ser Tyr

1835 1840 1845

Val Glu Ala Leu Pro Thr Ile Gln Gly Tyr Tyr Arg Gln Tyr Arg

1850 1855 1860

Gln Glu Pro Val Arg Phe Gly Asn Ile Gly Phe Gly Thr Pro Tyr

1865 1870 1875

Tyr Tyr Val Gly Trp Tyr Glu Cys Gly Val Ser Ile Pro Gly Lys

1880 1885 1890

Trp

<210> 39

<211> 198

<212> PRT

<213> 智人(Homo sapiens)

<400> 39

Met Ala Ala Asp Ile Ser Glu Ser Ser Gly Ala Asp Cys Lys Gly Asp

1 5 10 15

Pro Arg Asn Ser Ala Lys Leu Asp Ala Asp Tyr Pro Leu Arg Val Leu

20 25 30

Tyr Cys Gly Val Cys Ser Leu Pro Thr Glu Tyr Cys Glu Tyr Met Pro

35 40 45

Asp Val Ala Lys Cys Arg Gln Trp Leu Glu Lys Asn Phe Pro Asn Glu

50 55 60

Phe Ala Lys Leu Thr Val Glu Asn Ser Pro Lys Gln Glu Ala Gly Ile

65 70 75 80

Ser Glu Gly Gln Gly Thr Ala Gly Glu Glu Glu Glu Lys Lys Lys Gln

85 90 95

Lys Arg Gly Gly Arg Gly Gln Ile Lys Gln Lys Lys Lys Thr Val Pro

100 105 110

Gln Lys Val Thr Ile Ala Lys Ile Pro Arg Ala Lys Lys Lys Tyr Val

115 120 125

Thr Arg Val Cys Gly Leu Ala Thr Phe Glu Ile Asp Leu Lys Glu Ala

130 135 140

Gln Arg Phe Phe Ala Gln Lys Phe Ser Cys Gly Ala Ser Val Thr Gly

145 150 155 160

Glu Asp Glu Ile Ile Ile Gln Gly Asp Phe Thr Asp Asp Ile Ile Asp

165 170 175

Val Ile Gln Glu Lys Trp Pro Glu Val Asp Asp Asp Ser Ile Glu Asp

180 185 190

Leu Gly Glu Val Lys Lys

195

<210> 40

<211> 267

<212> PRT

<213> 智人(Homo sapiens)

<400> 40

Met Ala Arg Phe Leu Thr Leu Cys Thr Trp Leu Leu Leu Leu Gly Pro

1 5 10 15

Gly Leu Leu Ala Thr Val Arg Ala Glu Cys Ser Gln Asp Cys Ala Thr

20 25 30

Cys Ser Tyr Arg Leu Val Arg Pro Ala Asp Ile Asn Phe Leu Ala Cys

35 40 45

Val Met Glu Cys Glu Gly Lys Leu Pro Ser Leu Lys Ile Trp Glu Thr

50 55 60

Cys Lys Glu Leu Leu Gln Leu Ser Lys Pro Glu Leu Pro Gln Asp Gly

65 70 75 80

Thr Ser Thr Leu Arg Glu Asn Ser Lys Pro Glu Glu Ser His Leu Leu

85 90 95

Ala Lys Arg Tyr Gly Gly Phe Met Lys Arg Tyr Gly Gly Phe Met Lys

100 105 110

Lys Met Asp Glu Leu Tyr Pro Met Glu Pro Glu Glu Glu Ala Asn Gly

115 120 125

Ser Glu Ile Leu Ala Lys Arg Tyr Gly Gly Phe Met Lys Lys Asp Ala

130 135 140

Glu Glu Asp Asp Ser Leu Ala Asn Ser Ser Asp Leu Leu Lys Glu Leu

145 150 155 160

Leu Glu Thr Gly Asp Asn Arg Glu Arg Ser His His Gln Asp Gly Ser

165 170 175

Asp Asn Glu Glu Glu Val Ser Lys Arg Tyr Gly Gly Phe Met Arg Gly

180 185 190

Leu Lys Arg Ser Pro Gln Leu Glu Asp Glu Ala Lys Glu Leu Gln Lys

195 200 205

Arg Tyr Gly Gly Phe Met Arg Arg Val Gly Arg Pro Glu Trp Trp Met

210 215 220

Asp Tyr Gln Lys Arg Tyr Gly Gly Phe Leu Lys Arg Phe Ala Glu Ala

225 230 235 240

Leu Pro Ser Asp Glu Glu Gly Glu Ser Tyr Ser Lys Glu Val Pro Glu

245 250 255

Met Glu Lys Arg Tyr Gly Gly Phe Met Arg Phe

260 265

<210> 41

<211> 105

<212> PRT

<213> 智人(Homo sapiens)

<400> 41

Met Ala Lys Ile Ser Ser Pro Thr Glu Thr Glu Arg Cys Ile Glu Ser

1 5 10 15

Leu Ile Ala Val Phe Gln Lys Tyr Ala Gly Lys Asp Gly Tyr Asn Tyr

20 25 30

Thr Leu Ser Lys Thr Glu Phe Leu Ser Phe Met Asn Thr Glu Leu Ala

35 40 45

Ala Phe Thr Lys Asn Gln Lys Asp Pro Gly Val Leu Asp Arg Met Met

50 55 60

Lys Lys Leu Asp Thr Asn Ser Asp Gly Gln Leu Asp Phe Ser Glu Phe

65 70 75 80

Leu Asn Leu Ile Gly Gly Leu Ala Met Ala Cys His Asp Ser Phe Leu

85 90 95

Lys Ala Val Pro Ser Gln Lys Arg Thr

100 105

<210> 42

<211> 159

<212> PRT

<213> 智人(Homo sapiens)

<400> 42

Met Ala Lys Ser Lys Asn His Thr Thr His Asn Gln Ser Arg Lys Trp

1 5 10 15

His Arg Asn Gly Ile Lys Lys Pro Arg Ser Gln Arg Tyr Glu Ser Leu

20 25 30

Lys Gly Val Asp Pro Lys Phe Leu Arg Asn Met Arg Phe Ala Lys Lys

35 40 45

His Asn Lys Lys Gly Leu Lys Lys Met Gln Ala Asn Asn Ala Lys Ala

50 55 60

Met Ser Ala Arg Ala Glu Ala Ile Lys Ala Leu Val Lys Pro Lys Glu

65 70 75 80

Val Lys Pro Lys Ile Pro Lys Gly Val Ser Arg Lys Leu Asp Arg Leu

85 90 95

Ala Tyr Ile Ala His Pro Lys Leu Gly Lys Arg Ala Arg Ala Arg Ile

100 105 110

Ala Lys Gly Leu Arg Leu Cys Arg Pro Lys Ala Lys Ala Lys Ala Lys

115 120 125

Ala Lys Asp Gln Thr Lys Ala Gln Ala Ala Ala Pro Ala Ser Val Pro

130 135 140

Ala Gln Ala Pro Lys Arg Thr Gln Ala Pro Thr Lys Ala Ser Glu

145 150 155

<210> 43

<211> 136

<212> PRT

<213> 智人(Homo sapiens)

<400> 43

Met Gly Lys Phe Met Lys Pro Gly Lys Val Val Leu Val Leu Ala Gly

1 5 10 15

Arg Tyr Ser Gly Arg Lys Ala Val Ile Val Lys Asn Ile Asp Asp Gly

20 25 30

Thr Ser Asp Arg Pro Tyr Ser His Ala Leu Val Ala Gly Ile Asp Arg

35 40 45

Tyr Pro Arg Lys Val Thr Ala Ala Met Gly Lys Lys Lys Ile Ala Lys

50 55 60

Arg Ser Lys Ile Lys Ser Phe Val Lys Val Tyr Asn Tyr Asn His Leu

65 70 75 80

Met Pro Thr Arg Tyr Ser Val Asp Ile Pro Leu Asp Lys Thr Val Val

85 90 95

Asn Lys Asp Val Phe Arg Asp Pro Ala Leu Lys Arg Lys Ala Arg Arg

100 105 110

Glu Ala Lys Val Lys Phe Glu Glu Arg Tyr Lys Thr Gly Lys Asn Lys

115 120 125

Trp Phe Phe Gln Lys Leu Arg Phe

130 135

<210> 44

<211> 257

<212> PRT

<213> 智人(Homo sapiens)

<400> 44

Met Gly Arg Val Ile Arg Gly Gln Arg Lys Gly Ala Gly Ser Val Phe

1 5 10 15

Arg Ala His Val Lys His Arg Lys Gly Ala Ala Arg Leu Arg Ala Val

20 25 30

Asp Phe Ala Glu Arg His Gly Tyr Ile Lys Gly Ile Val Lys Asp Ile

35 40 45

Ile His Asp Pro Gly Arg Gly Ala Pro Leu Ala Lys Val Val Phe Arg

50 55 60

Asp Pro Tyr Arg Phe Lys Lys Arg Thr Glu Leu Phe Ile Ala Ala Glu

65 70 75 80

Gly Ile His Thr Gly Gln Phe Val Tyr Cys Gly Lys Lys Ala Gln Leu

85 90 95

Asn Ile Gly Asn Val Leu Pro Val Gly Thr Met Pro Glu Gly Thr Ile

100 105 110

Val Cys Cys Leu Glu Glu Lys Pro Gly Asp Arg Gly Lys Leu Ala Arg

115 120 125

Ala Ser Gly Asn Tyr Ala Thr Val Ile Ser His Asn Pro Glu Thr Lys

130 135 140

Lys Thr Arg Val Lys Leu Pro Ser Gly Ser Lys Lys Val Ile Ser Ser

145 150 155 160

Ala Asn Arg Ala Val Val Gly Val Val Ala Gly Gly Gly Arg Ile Asp

165 170 175

Lys Pro Ile Leu Lys Ala Gly Arg Ala Tyr His Lys Tyr Lys Ala Lys

180 185 190

Arg Asn Cys Trp Pro Arg Val Arg Gly Val Ala Met Asn Pro Val Glu

195 200 205

His Pro Phe Gly Gly Gly Asn His Gln His Ile Gly Lys Pro Ser Thr

210 215 220

Ile Arg Arg Asp Ala Pro Ala Gly Arg Lys Val Gly Leu Ile Ala Ala

225 230 235 240

Arg Arg Thr Gly Arg Leu Arg Gly Thr Lys Thr Val Gln Glu Lys Glu

245 250 255

Asn

<210> 45

<211> 221

<212> PRT

<213> 智人(Homo sapiens)

<400> 45

Met Ser Tyr Gly Arg Pro Pro Pro Asp Val Glu Gly Met Thr Ser Leu

1 5 10 15

Lys Val Asp Asn Leu Thr Tyr Arg Thr Ser Pro Asp Thr Leu Arg Arg

20 25 30

Val Phe Glu Lys Tyr Gly Arg Val Gly Asp Val Tyr Ile Pro Arg Asp

35 40 45

Arg Tyr Thr Lys Glu Ser Arg Gly Phe Ala Phe Val Arg Phe His Asp

50 55 60

Lys Arg Asp Ala Glu Asp Ala Met Asp Ala Met Asp Gly Ala Val Leu

65 70 75 80

Asp Gly Arg Glu Leu Arg Val Gln Met Ala Arg Tyr Gly Arg Pro Pro

85 90 95

Asp Ser His His Ser Arg Arg Gly Pro Pro Pro Arg Arg Tyr Gly Gly

100 105 110

Gly Gly Tyr Gly Arg Arg Ser Arg Ser Pro Arg Arg Arg Arg Arg Ser

115 120 125

Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Tyr

130 135 140

Ser Arg Ser Lys Ser Arg Ser Arg Thr Arg Ser Arg Ser Arg Ser Thr

145 150 155 160

Ser Lys Ser Arg Ser Ala Arg Arg Ser Lys Ser Lys Ser Ser Ser Val

165 170 175

Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Pro

180 185 190

Pro Pro Val Ser Lys Arg Glu Ser Lys Ser Arg Ser Arg Ser Lys Ser

195 200 205

Pro Pro Lys Ser Pro Glu Glu Glu Gly Ala Val Ser Ser

210 215 220

<210> 46

<211> 424

<212> PRT

<213> 智人(Homo sapiens)

<400> 46

Met Ala Ala Gly Pro Ile Ser Glu Arg Asn Gln Asp Ala Thr Val Tyr

1 5 10 15

Val Gly Gly Leu Asp Glu Lys Val Ser Glu Pro Leu Leu Trp Glu Leu

20 25 30

Phe Leu Gln Ala Gly Pro Val Val Asn Thr His Met Pro Lys Asp Arg

35 40 45

Val Thr Gly Gln His Gln Gly Tyr Gly Phe Val Glu Phe Leu Ser Glu

50 55 60

Glu Asp Ala Asp Tyr Ala Ile Lys Ile Met Asn Met Ile Lys Leu Tyr

65 70 75 80

Gly Lys Pro Ile Arg Val Asn Lys Ala Ser Ala His Asn Lys Asn Leu

85 90 95

Asp Val Gly Ala Asn Ile Phe Ile Gly Asn Leu Asp Pro Glu Ile Asp

100 105 110

Glu Lys Leu Leu Tyr Asp Thr Phe Ser Ala Phe Gly Val Ile Leu Gln

115 120 125

Thr Pro Lys Ile Met Arg Asp Pro Asp Thr Gly Asn Ser Lys Gly Tyr

130 135 140

Ala Phe Ile Asn Phe Ala Ser Phe Asp Ala Ser Asp Ala Ala Ile Glu

145 150 155 160

Ala Met Asn Gly Gln Tyr Leu Cys Asn Arg Pro Ile Thr Val Ser Tyr

165 170 175

Ala Phe Lys Lys Asp Ser Lys Gly Glu Arg His Gly Ser Ala Ala Glu

180 185 190

Arg Leu Leu Ala Ala Gln Asn Pro Leu Ser Gln Ala Asp Arg Pro His

195 200 205

Gln Leu Phe Ala Asp Ala Pro Pro Pro Pro Ser Ala Pro Asn Pro Val

210 215 220

Val Ser Ser Leu Gly Ser Gly Leu Pro Pro Pro Gly Met Pro Pro Pro

225 230 235 240

Gly Ser Phe Pro Pro Pro Val Pro Pro Pro Gly Ala Leu Pro Pro Gly

245 250 255

Ile Pro Pro Ala Met Pro Pro Pro Pro Met Pro Pro Gly Ala Ala Gly

260 265 270

His Gly Pro Pro Ser Ala Gly Thr Pro Gly Ala Gly His Pro Gly His

275 280 285

Gly His Ser His Pro His Pro Phe Pro Pro Gly Gly Met Pro His Pro

290 295 300

Gly Met Ser Gln Met Gln Leu Ala His His Gly Pro His Gly Leu Gly

305 310 315 320

His Pro His Ala Gly Pro Pro Gly Ser Gly Gly Gln Pro Pro Pro Arg

325 330 335

Pro Pro Pro Gly Met Pro His Pro Gly Pro Pro Pro Met Gly Met Pro

340 345 350

Pro Arg Gly Pro Pro Phe Gly Ser Pro Met Gly His Pro Gly Pro Met

355 360 365

Pro Pro His Gly Met Arg Gly Pro Pro Pro Leu Met Pro Pro His Gly

370 375 380

Tyr Thr Gly Pro Pro Arg Pro Pro Pro Tyr Gly Tyr Gln Arg Gly Pro

385 390 395 400

Leu Pro Pro Pro Arg Pro Thr Pro Arg Pro Pro Val Pro Pro Arg Gly

405 410 415

Pro Leu Arg Gly Pro Leu Pro Gln

420

<210> 47

<211> 590

<212> PRT

<213> 智人(Homo sapiens)

<400> 47

Met His Leu Ala Arg Leu Val Gly Ser Cys Ser Leu Leu Leu Leu Leu

1 5 10 15

Gly Ala Leu Ser Gly Trp Ala Ala Ser Asp Asp Pro Ile Glu Lys Val

20 25 30

Ile Glu Gly Ile Asn Arg Gly Leu Ser Asn Ala Glu Arg Glu Val Gly

35 40 45

Lys Ala Leu Asp Gly Ile Asn Ser Gly Ile Thr His Ala Gly Arg Glu

50 55 60

Val Glu Lys Val Phe Asn Gly Leu Ser Asn Met Gly Ser His Thr Gly

65 70 75 80

Lys Glu Leu Asp Lys Gly Val Gln Gly Leu Asn His Gly Met Asp Lys

85 90 95

Val Ala His Glu Ile Asn His Gly Ile Gly Gln Ala Gly Lys Glu Ala

100 105 110

Glu Lys Leu Gly His Gly Val Asn Asn Ala Ala Gly Gln Val Gly Lys

115 120 125

Glu Ala Asp Lys Leu Ile His His Gly Val His His Gly Ala Asn Gln

130 135 140

Ala Gly Ser Glu Ala Gly Lys Phe Gly Gln Gly Val Asp Asn Ala Ala

145 150 155 160

Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Val His His

165 170 175

Ala Ala Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Val

180 185 190

His His Ala Ala Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln

195 200 205

Gly Ala His His Gly Leu Ser Glu Gly Trp Lys Glu Thr Glu Lys Phe

210 215 220

Gly Gln Gly Ile His His Ala Ala Gly Gln Val Gly Lys Glu Ala Glu

225 230 235 240

Lys Phe Gly Gln Gly Ala His His Ala Ala Gly Gln Ala Gly Asn Glu

245 250 255

Ala Gly Arg Phe Gly Gln Gly Val His His Gly Leu Ser Glu Gly Trp

260 265 270

Lys Glu Thr Glu Lys Phe Gly Gln Gly Val His His Thr Ala Gly Gln

275 280 285

Val Gly Lys Glu Ala Glu Lys Phe Gly Gln Gly Ala His His Ala Ala

290 295 300

Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Ala His His

305 310 315 320

Ala Ala Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Val

325 330 335

His His Gly Leu Ser Glu Gly Trp Lys Glu Thr Glu Lys Phe Gly Gln

340 345 350

Gly Val His His Ala Ala Ser Gln Phe Gly Lys Glu Thr Glu Lys Leu

355 360 365

Gly His Gly Val His His Gly Val Asn Glu Ala Trp Lys Glu Ala Glu

370 375 380

Lys Phe Gly Gln Gly Val His His Ala Ala Ser Gln Val Gly Lys Glu

385 390 395 400

Glu Asp Arg Val Val Gln Gly Leu His His Gly Val Ser Gln Ala Gly

405 410 415

Arg Glu Ala Gly Gln Phe Gly His Asp Ile His His Thr Ala Gly Gln

420 425 430

Ala Gly Lys Glu Gly Asp Ile Ala Val His Gly Val Gln Pro Gly Val

435 440 445

His Glu Ala Gly Lys Glu Ala Gly Gln Phe Gly Gln Gly Val His His

450 455 460

Thr Leu Glu Gln Ala Gly Lys Glu Ala Asp Lys Ala Val Gln Gly Phe

465 470 475 480

His Thr Gly Val His Gln Ala Gly Lys Glu Ala Glu Lys Leu Gly Gln

485 490 495

Gly Val Asn His Ala Ala Asp Gln Ala Gly Lys Glu Val Glu Lys Leu

500 505 510

Gly Gln Gly Ala His His Ala Ala Gly Gln Ala Gly Lys Glu Leu Gln

515 520 525

Asn Ala His Asn Gly Val Asn Gln Ala Ser Lys Glu Ala Asn Gln Leu

530 535 540

Leu Asn Gly Asn His Gln Ser Gly Ser Ser Ser His Gln Gly Gly Ala

545 550 555 560

Thr Thr Thr Pro Leu Ala Ser Gly Ala Ser Val Asn Thr Pro Phe Ile

565 570 575

Asn Leu Pro Ala Leu Trp Arg Ser Val Ala Asn Ile Met Pro

580 585 590

<210> 48

<211> 379

<212> PRT

<213> 智人(Homo sapiens)

<400> 48

Met Val Phe Phe Thr Cys Asn Ala Cys Gly Glu Ser Val Lys Lys Ile

1 5 10 15

Gln Val Glu Lys His Val Ser Val Cys Arg Asn Cys Glu Cys Leu Ser

20 25 30

Cys Ile Asp Cys Gly Lys Asp Phe Trp Gly Asp Asp Tyr Lys Asn His

35 40 45

Val Lys Cys Ile Ser Glu Asp Gln Lys Tyr Gly Gly Lys Gly Tyr Glu

50 55 60

Gly Lys Thr His Lys Gly Asp Ile Lys Gln Gln Ala Trp Ile Gln Lys

65 70 75 80

Ile Ser Glu Leu Ile Lys Arg Pro Asn Val Ser Pro Lys Val Arg Glu

85 90 95

Leu Leu Glu Gln Ile Ser Ala Phe Asp Asn Val Pro Arg Lys Lys Ala

100 105 110

Lys Phe Gln Asn Trp Met Lys Asn Ser Leu Lys Val His Asn Glu Ser

115 120 125

Ile Leu Asp Gln Val Trp Asn Ile Phe Ser Glu Ala Ser Asn Ser Glu

130 135 140

Pro Val Asn Lys Glu Gln Asp Gln Arg Pro Leu His Pro Val Ala Asn

145 150 155 160

Pro His Ala Glu Ile Ser Thr Lys Val Pro Ala Ser Lys Val Lys Asp

165 170 175

Ala Val Glu Gln Gln Gly Glu Val Lys Lys Asn Lys Arg Glu Arg Lys

180 185 190

Glu Glu Arg Gln Lys Lys Arg Lys Arg Glu Lys Lys Glu Leu Lys Leu

195 200 205

Glu Asn His Gln Glu Asn Ser Arg Asn Gln Lys Pro Lys Lys Arg Lys

210 215 220

Lys Gly Gln Glu Ala Asp Leu Glu Ala Gly Gly Glu Glu Val Pro Glu

225 230 235 240

Ala Asn Gly Ser Ala Gly Lys Arg Ser Lys Lys Lys Lys Gln Arg Lys

245 250 255

Asp Ser Ala Ser Glu Glu Glu Ala His Val Gly Ala Gly Lys Arg Lys

260 265 270

Arg Arg His Ser Glu Val Glu Thr Asp Ser Lys Lys Lys Lys Met Lys

275 280 285

Leu Pro Glu His Pro Glu Gly Gly Glu Pro Glu Asp Asp Glu Ala Pro

290 295 300

Ala Lys Gly Lys Phe Asn Trp Lys Gly Thr Ile Lys Ala Ile Leu Lys

305 310 315 320

Gln Ala Pro Asp Asn Glu Ile Thr Ile Lys Lys Leu Arg Lys Lys Val

325 330 335

Leu Ala Gln Tyr Tyr Thr Val Thr Asp Glu His His Arg Ser Glu Glu

340 345 350

Glu Leu Leu Val Ile Phe Asn Lys Lys Ile Ser Lys Asn Pro Thr Phe

355 360 365

Lys Leu Leu Lys Asp Lys Val Lys Leu Val Lys

370 375

<210> 49

<211> 331

<212> PRT

<213> 智人(Homo sapiens)

<400> 49

Met Gly Gly Glu Gln Glu Glu Glu Arg Phe Asp Gly Met Leu Leu Ala

1 5 10 15

Met Ala Gln Gln His Glu Gly Gly Val Gln Glu Leu Val Asn Thr Phe

20 25 30

Phe Ser Phe Leu Arg Arg Lys Thr Asp Phe Phe Ile Gly Gly Glu Glu

35 40 45

Gly Met Ala Glu Lys Leu Ile Thr Gln Thr Phe Ser His His Asn Gln

50 55 60

Leu Ala Gln Lys Thr Arg Arg Glu Lys Arg Ala Arg Gln Glu Ala Glu

65 70 75 80

Arg Arg Glu Lys Ala Glu Arg Ala Ala Arg Leu Ala Lys Glu Ala Lys

85 90 95

Ser Glu Thr Ser Gly Pro Gln Ile Lys Glu Leu Thr Asp Glu Glu Ala

100 105 110

Glu Arg Leu Gln Leu Glu Ile Asp Gln Lys Lys Asp Ala Glu Asn His

115 120 125

Glu Ala Gln Leu Lys Asn Gly Ser Leu Asp Ser Pro Gly Lys Gln Asp

130 135 140

Thr Glu Glu Asp Glu Glu Glu Asp Glu Lys Asp Lys Gly Lys Leu Lys

145 150 155 160

Pro Asn Leu Gly Asn Gly Ala Asp Leu Pro Asn Tyr Arg Trp Thr Gln

165 170 175

Thr Leu Ser Glu Leu Asp Leu Ala Val Pro Phe Cys Val Asn Phe Arg

180 185 190

Leu Lys Gly Lys Asp Met Val Val Asp Ile Gln Arg Arg His Leu Arg

195 200 205

Val Gly Leu Lys Gly Gln Pro Ala Ile Ile Asp Gly Glu Leu Tyr Asn

210 215 220

Glu Val Lys Val Glu Glu Ser Ser Trp Leu Ile Glu Asp Gly Lys Val

225 230 235 240

Val Thr Val His Leu Glu Lys Ile Asn Lys Met Glu Trp Trp Ser Arg

245 250 255

Leu Val Ser Ser Asp Pro Glu Ile Asn Thr Lys Lys Ile Asn Pro Glu

260 265 270

Asn Ser Lys Leu Ser Asp Leu Asp Ser Glu Thr Arg Ser Met Val Glu

275 280 285

Lys Met Met Tyr Asp Gln Arg Gln Lys Ser Met Gly Leu Pro Thr Ser

290 295 300

Asp Glu Gln Lys Lys Gln Glu Ile Leu Lys Lys Phe Met Asp Gln His

305 310 315 320

Pro Glu Met Asp Phe Ser Lys Ala Lys Phe Asn

325 330

<210> 50

<211> 422

<212> PRT

<213> 智人(Homo sapiens)

<400> 50

Met Pro Ala Gly Arg Arg Gly Pro Ala Ala Gln Ser Ala Arg Arg Pro

1 5 10 15

Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu Cys Val Leu Gly Ala Pro

20 25 30

Arg Ala Gly Ser Gly Ala His Thr Ala Val Ile Ser Pro Gln Asp Pro

35 40 45

Thr Leu Leu Ile Gly Ser Ser Leu Leu Ala Thr Cys Ser Val His Gly

50 55 60

Asp Pro Pro Gly Ala Thr Ala Glu Gly Leu Tyr Trp Thr Leu Asn Gly

65 70 75 80

Arg Arg Leu Pro Pro Glu Leu Ser Arg Val Leu Asn Ala Ser Thr Leu

85 90 95

Ala Leu Ala Leu Ala Asn Leu Asn Gly Ser Arg Gln Arg Ser Gly Asp

100 105 110

Asn Leu Val Cys His Ala Arg Asp Gly Ser Ile Leu Ala Gly Ser Cys

115 120 125

Leu Tyr Val Gly Leu Pro Pro Glu Lys Pro Val Asn Ile Ser Cys Trp

130 135 140

Ser Lys Asn Met Lys Asp Leu Thr Cys Arg Trp Thr Pro Gly Ala His

145 150 155 160

Gly Glu Thr Phe Leu His Thr Asn Tyr Ser Leu Lys Tyr Lys Leu Arg

165 170 175

Trp Tyr Gly Gln Asp Asn Thr Cys Glu Glu Tyr His Thr Val Gly Pro

180 185 190

His Ser Cys His Ile Pro Lys Asp Leu Ala Leu Phe Thr Pro Tyr Glu

195 200 205

Ile Trp Val Glu Ala Thr Asn Arg Leu Gly Ser Ala Arg Ser Asp Val

210 215 220

Leu Thr Leu Asp Ile Leu Asp Val Val Thr Thr Asp Pro Pro Pro Asp

225 230 235 240

Val His Val Ser Arg Val Gly Gly Leu Glu Asp Gln Leu Ser Val Arg

245 250 255

Trp Val Ser Pro Pro Ala Leu Lys Asp Phe Leu Phe Gln Ala Lys Tyr

260 265 270

Gln Ile Arg Tyr Arg Val Glu Asp Ser Val Asp Trp Lys Val Val Asp

275 280 285

Asp Val Ser Asn Gln Thr Ser Cys Arg Leu Ala Gly Leu Lys Pro Gly

290 295 300

Thr Val Tyr Phe Val Gln Val Arg Cys Asn Pro Phe Gly Ile Tyr Gly

305 310 315 320

Ser Lys Lys Ala Gly Ile Trp Ser Glu Trp Ser His Pro Thr Ala Ala

325 330 335

Ser Thr Pro Arg Ser Glu Arg Pro Gly Pro Gly Gly Gly Ala Cys Glu

340 345 350

Pro Arg Gly Gly Glu Pro Ser Ser Gly Pro Val Arg Arg Glu Leu Lys

355 360 365

Gln Phe Leu Gly Trp Leu Lys Lys His Ala Tyr Cys Ser Asn Leu Ser

370 375 380

Phe Arg Leu Tyr Asp Gln Trp Arg Ala Trp Met Gln Lys Ser His Lys

385 390 395 400

Thr Arg Asn Gln Asp Glu Gly Ile Leu Pro Ser Gly Arg Arg Gly Thr

405 410 415

Ala Arg Gly Pro Ala Arg

420

<210> 51

<211> 390

<212> PRT

<213> 智人(Homo sapiens)

<400> 51

Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu

1 5 10 15

Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr

20 25 30

Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala

35 40 45

Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser

50 55 60

Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu

65 70 75 80

Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu

85 90 95

Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu

100 105 110

Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr

115 120 125

His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val

130 135 140

Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu

145 150 155 160

Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn

165 170 175

Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser

180 185 190

Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu

195 200 205

Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser

210 215 220

Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr

225 230 235 240

Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro

245 250 255

Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln

260 265 270

Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser

275 280 285

Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys

290 295 300

Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn

305 310 315 320

Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr

325 330 335

Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala

340 345 350

Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr

355 360 365

Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val

370 375 380

Arg Ser Cys Lys Cys Ser

385 390

<210> 52

<211> 527

<212> PRT

<213> 智人(Homo sapiens)

<400> 52

Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys

1 5 10 15

Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly

20 25 30

Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly

35 40 45

Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe

50 55 60

Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly

65 70 75 80

Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys

85 90 95

Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg

100 105 110

Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp

115 120 125

Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp

130 135 140

Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu

145 150 155 160

Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu

165 170 175

Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser

180 185 190

Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly

195 200 205

His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn

210 215 220

Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln

225 230 235 240

Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu

245 250 255

Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly

260 265 270

Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln

275 280 285

Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro

290 295 300

His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg

305 310 315 320

Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro

325 330 335

Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln

340 345 350

Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro

355 360 365

Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala

370 375 380

Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly

385 390 395 400

Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro

405 410 415

Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe

420 425 430

Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val

435 440 445

Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala

450 455 460

Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys

465 470 475 480

Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu

485 490 495

Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe

500 505 510

Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu

515 520 525

<210> 53

<211> 412

<212> PRT

<213> 智人(Homo sapiens)

<400> 53

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala

1 5 10 15

Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile

20 25 30

Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala

35 40 45

Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu

50 55 60

Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr

65 70 75 80

Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe

85 90 95

Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu

100 105 110

Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser

115 120 125

Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser

130 135 140

Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys

145 150 155 160

Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg

165 170 175

Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala

180 185 190

Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val

195 200 205

Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val

210 215 220

Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln

225 230 235 240

Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys

245 250 255

Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val

260 265 270

His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu

275 280 285

Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro

290 295 300

Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu

305 310 315 320

Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro

325 330 335

Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu

340 345 350

Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser

355 360 365

Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile

370 375 380

Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp

385 390 395 400

Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu

405 410

<210> 54

<211> 509

<212> PRT

<213> 智人(Homo sapiens)

<400> 54

Met Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His

1 5 10 15

Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu

20 25 30

Arg Thr Tyr Ala Asp Gln Pro Ile Asp Ala Asp Val Thr Val Ile Gly

35 40 45

Ser Gly Pro Gly Gly Tyr Val Ala Ala Ile Lys Ala Ala Gln Leu Gly

50 55 60

Phe Lys Thr Val Cys Ile Glu Lys Asn Glu Thr Leu Gly Gly Thr Cys

65 70 75 80

Leu Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Leu Asn Asn Ser His

85 90 95

Tyr Tyr His Met Ala His Gly Lys Asp Phe Ala Ser Arg Gly Ile Glu

100 105 110

Met Ser Glu Val Arg Leu Asn Leu Asp Lys Met Met Glu Gln Lys Ser

115 120 125

Thr Ala Val Lys Ala Leu Thr Gly Gly Ile Ala His Leu Phe Lys Gln

130 135 140

Asn Lys Val Val His Val Asn Gly Tyr Gly Lys Ile Thr Gly Lys Asn

145 150 155 160

Gln Val Thr Ala Thr Lys Ala Asp Gly Gly Thr Gln Val Ile Asp Thr

165 170 175

Lys Asn Ile Leu Ile Ala Thr Gly Ser Glu Val Thr Pro Phe Pro Gly

180 185 190

Ile Thr Ile Asp Glu Asp Thr Ile Val Ser Ser Thr Gly Ala Leu Ser

195 200 205

Leu Lys Lys Val Pro Glu Lys Met Val Val Ile Gly Ala Gly Val Ile

210 215 220

Gly Val Glu Leu Gly Ser Val Trp Gln Arg Leu Gly Ala Asp Val Thr

225 230 235 240

Ala Val Glu Phe Leu Gly His Val Gly Gly Val Gly Ile Asp Met Glu

245 250 255

Ile Ser Lys Asn Phe Gln Arg Ile Leu Gln Lys Gln Gly Phe Lys Phe

260 265 270

Lys Leu Asn Thr Lys Val Thr Gly Ala Thr Lys Lys Ser Asp Gly Lys

275 280 285

Ile Asp Val Ser Ile Glu Ala Ala Ser Gly Gly Lys Ala Glu Val Ile

290 295 300

Thr Cys Asp Val Leu Leu Val Cys Ile Gly Arg Arg Pro Phe Thr Lys

305 310 315 320

Asn Leu Gly Leu Glu Glu Leu Gly Ile Glu Leu Asp Pro Arg Gly Arg

325 330 335

Ile Pro Val Asn Thr Arg Phe Gln Thr Lys Ile Pro Asn Ile Tyr Ala

340 345 350

Ile Gly Asp Val Val Ala Gly Pro Met Leu Ala His Lys Ala Glu Asp

355 360 365

Glu Gly Ile Ile Cys Val Glu Gly Met Ala Gly Gly Ala Val His Ile

370 375 380

Asp Tyr Asn Cys Val Pro Ser Val Ile Tyr Thr His Pro Glu Val Ala

385 390 395 400

Trp Val Gly Lys Ser Glu Glu Gln Leu Lys Glu Glu Gly Ile Glu Tyr

405 410 415

Lys Val Gly Lys Phe Pro Phe Ala Ala Asn Ser Arg Ala Lys Thr Asn

420 425 430

Ala Asp Thr Asp Gly Met Val Lys Ile Leu Gly Gln Lys Ser Thr Asp

435 440 445

Arg Val Leu Gly Ala His Ile Leu Gly Pro Gly Ala Gly Glu Met Val

450 455 460

Asn Glu Ala Ala Leu Ala Leu Glu Tyr Gly Ala Ser Cys Glu Asp Ile

465 470 475 480

Ala Arg Val Cys His Ala His Pro Thr Leu Ser Glu Ala Phe Arg Glu

485 490 495

Ala Asn Leu Ala Ala Ser Phe Gly Lys Ser Ile Asn Phe

500 505

<210> 55

<211> 1005

<212> PRT

<213> 智人(Homo sapiens)

<400> 55

Met Thr Thr Glu Val Gly Ser Val Ser Glu Val Lys Lys Asp Ser Ser

1 5 10 15

Gln Leu Gly Thr Asp Ala Thr Lys Glu Lys Pro Lys Glu Val Ala Glu

20 25 30

Asn Gln Gln Asn Gln Ser Ser Asp Pro Glu Glu Glu Lys Gly Ser Gln

35 40 45

Pro Pro Pro Ala Ala Glu Ser Gln Ser Ser Leu Arg Arg Gln Lys Arg

50 55 60

Glu Lys Glu Thr Ser Glu Ser Arg Gly Ile Ser Arg Phe Ile Pro Pro

65 70 75 80

Trp Leu Lys Lys Gln Lys Ser Tyr Thr Leu Val Val Ala Lys Asp Gly

85 90 95

Gly Asp Lys Lys Glu Pro Thr Gln Ala Val Val Glu Glu Gln Val Leu

100 105 110

Asp Lys Glu Glu Pro Leu Pro Glu Glu Gln Arg Gln Ala Lys Gly Asp

115 120 125

Ala Glu Glu Met Ala Gln Lys Lys Gln Glu Ile Lys Val Glu Val Lys

130 135 140

Glu Glu Lys Pro Ser Val Ser Lys Glu Glu Lys Pro Ser Val Ser Lys

145 150 155 160

Val Glu Met Gln Pro Thr Glu Leu Val Ser Lys Glu Arg Glu Glu Lys

165 170 175

Val Lys Glu Thr Gln Glu Asp Lys Leu Glu Gly Gly Ala Ala Lys Arg

180 185 190

Glu Thr Lys Glu Val Gln Thr Asn Glu Leu Lys Ala Glu Lys Ala Ser

195 200 205

Gln Lys Val Thr Lys Lys Thr Lys Thr Val Gln Cys Lys Val Thr Leu

210 215 220

Leu Asp Gly Thr Glu Tyr Ser Cys Asp Leu Glu Lys His Ala Lys Gly

225 230 235 240

Gln Val Leu Phe Asp Lys Val Cys Glu His Leu Asn Leu Leu Glu Lys

245 250 255

Asp Tyr Phe Gly Leu Leu Phe Gln Glu Ser Pro Glu Gln Lys Asn Trp

260 265 270

Leu Asp Pro Ala Lys Glu Ile Lys Arg Gln Leu Arg Asn Leu Pro Trp

275 280 285

Leu Phe Thr Phe Asn Val Lys Phe Tyr Pro Pro Asp Pro Ser Gln Leu

290 295 300

Thr Glu Asp Ile Thr Arg Tyr Phe Leu Cys Leu Gln Leu Arg Gln Asp

305 310 315 320

Ile Ala Ser Gly Arg Leu Pro Cys Ser Phe Val Thr His Ala Leu Leu

325 330 335

Gly Ser Tyr Thr Leu Gln Ala Glu Leu Gly Asp Tyr Asp Pro Glu Glu

340 345 350

His Gly Ser Ile Asp Leu Ser Glu Phe Gln Phe Ala Pro Thr Gln Thr

355 360 365

Lys Glu Leu Glu Glu Lys Val Ala Glu Leu His Lys Thr His Arg Gly

370 375 380

Leu Ser Pro Ala Gln Ala Asp Ser Gln Phe Leu Glu Asn Ala Lys Arg

385 390 395 400

Leu Ser Met Tyr Gly Val Asp Leu His His Ala Lys Asp Ser Glu Gly

405 410 415

Val Asp Ile Lys Leu Gly Val Cys Ala Asn Gly Leu Leu Ile Tyr Lys

420 425 430

Asp Arg Leu Arg Ile Asn Arg Phe Ala Trp Pro Lys Ile Leu Lys Ile

435 440 445

Ser Tyr Lys Arg Ser Asn Phe Tyr Ile Lys Val Arg Pro Ala Glu Leu

450 455 460

Glu Gln Phe Glu Ser Thr Ile Gly Phe Lys Leu Pro Asn His Arg Ala

465 470 475 480

Ala Lys Arg Leu Trp Lys Val Cys Val Glu His His Thr Phe Tyr Arg

485 490 495

Leu Val Ser Pro Glu Gln Pro Pro Lys Ala Lys Phe Leu Thr Leu Gly

500 505 510

Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln Ala Gln Thr Arg Gln Ala

515 520 525

Ser Thr Leu Ile Asp Arg Pro Ala Pro His Phe Glu Arg Thr Ser Ser

530 535 540

Lys Arg Val Ser Arg Ser Leu Asp Gly Ala Pro Ile Gly Val Met Asp

545 550 555 560

Gln Ser Leu Met Lys Asp Phe Pro Gly Ala Ala Gly Glu Ile Ser Ala

565 570 575

Tyr Gly Pro Gly Leu Val Ser Ile Ala Val Val Gln Asp Gly Asp Gly

580 585 590

Arg Arg Glu Val Arg Ser Pro Thr Lys Ala Pro His Leu Gln Leu Ile

595 600 605

Glu Gly Lys Lys Asn Ser Leu Arg Val Glu Gly Asp Asn Ile Tyr Val

610 615 620

Arg His Ser Asn Leu Met Leu Glu Glu Leu Asp Lys Ala Gln Glu Asp

625 630 635 640

Ile Leu Lys His Gln Ala Ser Ile Ser Glu Leu Lys Arg Asn Phe Met

645 650 655

Glu Ser Thr Pro Glu Pro Arg Pro Asn Glu Trp Glu Lys Arg Arg Ile

660 665 670

Thr Pro Leu Ser Leu Gln Thr Gln Gly Ser Ser His Glu Thr Leu Asn

675 680 685

Ile Val Glu Glu Lys Lys Arg Ala Glu Val Gly Lys Asp Glu Arg Val

690 695 700

Ile Thr Glu Glu Met Asn Gly Lys Glu Ile Ser Pro Gly Ser Gly Pro

705 710 715 720

Gly Glu Ile Arg Lys Val Glu Pro Val Thr Gln Lys Asp Ser Thr Ser

725 730 735

Leu Ser Ser Glu Ser Ser Ser Ser Ser Ser Glu Ser Glu Glu Glu Asp

740 745 750

Val Gly Glu Tyr Arg Pro His His Arg Val Thr Glu Gly Thr Ile Arg

755 760 765

Glu Glu Gln Glu Tyr Glu Glu Glu Val Glu Glu Glu Pro Arg Pro Ala

770 775 780

Ala Lys Val Val Glu Arg Glu Glu Ala Val Pro Glu Ala Ser Pro Val

785 790 795 800

Thr Gln Ala Gly Ala Ser Val Ile Thr Val Glu Thr Val Ile Gln Glu

805 810 815

Asn Val Gly Ala Gln Lys Ile Pro Gly Glu Lys Ser Val His Glu Gly

820 825 830

Ala Leu Lys Gln Asp Met Gly Glu Glu Ala Glu Glu Glu Pro Gln Lys

835 840 845

Val Asn Gly Glu Val Ser His Val Asp Ile Asp Val Leu Pro Gln Ile

850 855 860

Ile Cys Cys Ser Glu Pro Pro Val Val Lys Thr Glu Met Val Thr Ile

865 870 875 880

Ser Asp Ala Ser Gln Arg Thr Glu Ile Ser Thr Lys Glu Val Pro Ile

885 890 895

Val Gln Thr Glu Thr Lys Thr Ile Thr Tyr Glu Ser Pro Gln Ile Asp

900 905 910

Gly Gly Ala Gly Gly Asp Ser Gly Thr Leu Leu Thr Ala Gln Thr Ile

915 920 925

Thr Ser Glu Ser Val Ser Thr Thr Thr Thr Thr His Ile Thr Lys Thr

930 935 940

Val Lys Gly Gly Ile Ser Glu Thr Arg Ile Glu Lys Arg Ile Val Ile

945 950 955 960

Thr Gly Asp Gly Asp Ile Asp His Asp Gln Ala Leu Ala Gln Ala Ile

965 970 975

Arg Glu Ala Arg Glu Gln His Pro Asp Met Ser Val Thr Arg Val Val

980 985 990

Val His Lys Glu Thr Glu Leu Ala Glu Glu Gly Glu Asp

995 1000 1005

<210> 56

<211> 219

<212> PRT

<213> 智人(Homo sapiens)

<400> 56

Met Leu Arg Ala Gly Ala Pro Thr Gly Asp Leu Pro Arg Ala Gly Glu

1 5 10 15

Val His Thr Gly Thr Thr Ile Met Ala Val Glu Phe Asp Gly Gly Val

20 25 30

Val Met Gly Ser Asp Ser Arg Val Ser Ala Gly Glu Ala Val Val Asn

35 40 45

Arg Val Phe Asp Lys Leu Ser Pro Leu His Glu Arg Ile Tyr Cys Ala

50 55 60

Leu Ser Gly Ser Ala Ala Asp Ala Gln Ala Val Ala Asp Met Ala Ala

65 70 75 80

Tyr Gln Leu Glu Leu His Gly Ile Glu Leu Glu Glu Pro Pro Leu Val

85 90 95

Leu Ala Ala Ala Asn Val Val Arg Asn Ile Ser Tyr Lys Tyr Arg Glu

100 105 110

Asp Leu Ser Ala His Leu Met Val Ala Gly Trp Asp Gln Arg Glu Gly

115 120 125

Gly Gln Val Tyr Gly Thr Leu Gly Gly Met Leu Thr Arg Gln Pro Phe

130 135 140

Ala Ile Gly Gly Ser Gly Ser Thr Phe Ile Tyr Gly Tyr Val Asp Ala

145 150 155 160

Ala Tyr Lys Pro Gly Met Ser Pro Glu Glu Cys Arg Arg Phe Thr Thr

165 170 175

Asp Ala Ile Ala Leu Ala Met Ser Arg Asp Gly Ser Ser Gly Gly Val

180 185 190

Ile Tyr Leu Val Thr Ile Thr Ala Ala Gly Val Asp His Arg Val Ile

195 200 205

Leu Gly Asn Glu Leu Pro Lys Phe Tyr Asp Glu

210 215

<210> 57

<211> 151

<212> PRT

<213> 智人(Homo sapiens)

<400> 57

Met Ala Pro Arg Lys Gly Lys Glu Lys Lys Glu Glu Gln Val Ile Ser

1 5 10 15

Leu Gly Pro Gln Val Ala Glu Gly Glu Asn Val Phe Gly Val Cys His

20 25 30

Ile Phe Ala Ser Phe Asn Asp Thr Phe Val His Val Thr Asp Leu Ser

35 40 45

Gly Lys Glu Thr Ile Cys Arg Val Thr Gly Gly Met Lys Val Lys Ala

50 55 60

Asp Arg Asp Glu Ser Ser Pro Tyr Ala Ala Met Leu Ala Ala Gln Asp

65 70 75 80

Val Ala Gln Arg Cys Lys Glu Leu Gly Ile Thr Ala Leu His Ile Lys

85 90 95

Leu Arg Ala Thr Gly Gly Asn Arg Thr Lys Thr Pro Gly Pro Gly Ala

100 105 110

Gln Ser Ala Leu Arg Ala Leu Ala Arg Ser Gly Met Lys Ile Gly Arg

115 120 125

Ile Glu Asp Val Thr Pro Ile Pro Ser Asp Ser Thr Arg Arg Lys Gly

130 135 140

Gly Arg Arg Gly Arg Arg Leu

145 150

<210> 58

<211> 266

<212> PRT

<213> 智人(Homo sapiens)

<400> 58

Met Pro Lys Gly Lys Lys Ala Lys Gly Lys Lys Val Ala Pro Ala Pro

1 5 10 15

Ala Val Val Lys Lys Gln Glu Ala Lys Lys Val Val Asn Pro Leu Phe

20 25 30

Glu Lys Arg Pro Lys Asn Phe Gly Ile Gly Gln Asp Ile Gln Pro Lys

35 40 45

Arg Asp Leu Thr Arg Phe Val Lys Trp Pro Arg Tyr Ile Arg Leu Gln

50 55 60

Arg Gln Arg Ala Ile Leu Tyr Lys Arg Leu Lys Val Pro Pro Ala Ile

65 70 75 80

Asn Gln Phe Thr Gln Ala Leu Asp Arg Gln Thr Ala Thr Gln Leu Leu

85 90 95

Lys Leu Ala His Lys Tyr Arg Pro Glu Thr Lys Gln Glu Lys Lys Gln

100 105 110

Arg Leu Leu Ala Arg Ala Glu Lys Lys Ala Ala Gly Lys Gly Asp Val

115 120 125

Pro Thr Lys Arg Pro Pro Val Leu Arg Ala Gly Val Asn Thr Val Thr

130 135 140

Thr Leu Val Glu Asn Lys Lys Ala Gln Leu Val Val Ile Ala His Asp

145 150 155 160

Val Asp Pro Ile Glu Leu Val Val Phe Leu Pro Ala Leu Cys Arg Lys

165 170 175

Met Gly Val Pro Tyr Cys Ile Ile Lys Gly Lys Ala Arg Leu Gly Arg

180 185 190

Leu Val His Arg Lys Thr Cys Thr Thr Val Ala Phe Thr Gln Val Asn

195 200 205

Ser Glu Asp Lys Gly Ala Leu Ala Lys Leu Val Glu Ala Ile Arg Thr

210 215 220

Asn Tyr Asn Asp Arg Tyr Asp Glu Ile Arg Arg His Trp Gly Gly Asn

225 230 235 240

Val Leu Gly Pro Lys Ser Val Ala Arg Ile Ala Lys Leu Glu Lys Ala

245 250 255

Lys Ala Lys Glu Leu Ala Thr Lys Leu Gly

260 265

<210> 59

<211> 742

<212> PRT

<213> 智人(Homo sapiens)

<400> 59

Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr

1 5 10 15

Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn

20 25 30

Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala

35 40 45

Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys

50 55 60

Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp

65 70 75 80

Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln

85 90 95

Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg

100 105 110

Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys

115 120 125

Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp

130 135 140

Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn

145 150 155 160

Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly

165 170 175

Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu

180 185 190

Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn

195 200 205

Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln

210 215 220

Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp

225 230 235 240

Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp

245 250 255

Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn

260 265 270

Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser

275 280 285

Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser

290 295 300

Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp

305 310 315 320

Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe

325 330 335

Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr

340 345 350

Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg

355 360 365

Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser

370 375 380

Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg

385 390 395 400

Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn

405 410 415

Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly

420 425 430

Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg

435 440 445

Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly

450 455 460

Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro

465 470 475 480

Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg

485 490 495

Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly

500 505 510

Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro

515 520 525

Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro

530 535 540

Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly

545 550 555 560

Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro

565 570 575

Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu

580 585 590

Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro

595 600 605

Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu

610 615 620

Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser

625 630 635 640

His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys

645 650 655

Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu

660 665 670

Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys

675 680 685

Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro

690 695 700

Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe

705 710 715 720

Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr

725 730 735

Val Leu Ser Ser Ala Leu

740

<210> 60

<211> 1214

<212> PRT

<213> 智人(Homo sapiens)

<400> 60

Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu

1 5 10 15

Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly

20 25 30

Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser

35 40 45

Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe

50 55 60

Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys

65 70 75 80

Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala

85 90 95

Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln

100 105 110

Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu

115 120 125

Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu

130 135 140

Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Ile

145 150 155 160

Lys Arg His Gln Gly Thr Val Thr Glu Asp Lys Asn Asn Ala Ser His

165 170 175

Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg

180 185 190

Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr

195 200 205

Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser

210 215 220

Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys

225 230 235 240

Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp

245 250 255

Tyr Glu Val Asn Asp Asp Lys Asn Pro Val Ser Arg Arg Lys Lys Ile

260 265 270

Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg

275 280 285

Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser

290 295 300

Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro

305 310 315 320

Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln

325 330 335

Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val

340 345 350

Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu

355 360 365

Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Glu

370 375 380

Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr

385 390 395 400

Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn

405 410 415

Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp

420 425 430

Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu

435 440 445

Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala

450 455 460

Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr

465 470 475 480

Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala

485 490 495

Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr

500 505 510

Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr

515 520 525

Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu

530 535 540

Gln Pro Lys Thr Pro Gln Gln Thr Ser Ala Ser Gln Gln Met Leu Asn

545 550 555 560

Phe Pro Asp Lys Gly Lys Glu Lys Pro Thr Asp Met Gln Asn Phe Gly

565 570 575

Leu Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys

580 585 590

Ala Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu

595 600 605

Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser

610 615 620

Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu

625 630 635 640

Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu

645 650 655

Gly Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro

660 665 670

Val Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val

675 680 685

Ala Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys

690 695 700

Glu Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu

705 710 715 720

Glu Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu

725 730 735

Ser Ser Gly Ile Ala Gly Thr Thr Ser Asp Glu Pro Glu Arg Ile Glu

740 745 750

Glu Ser Gly Asn Asp Glu Ala Arg Val Glu Gly Gln Ala Thr Asp Glu

755 760 765

Lys Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Ile Glu Glu

770 775 780

Glu Ala Lys Glu Lys Thr Ser Glu Ala Pro Lys Lys Asp Glu Glu Lys

785 790 795 800

Gly Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp

805 810 815

Pro Ile Val Asp Pro Glu Lys Glu Lys Glu Pro Lys Glu Gly Gln Glu

820 825 830

Glu Val Leu Lys Glu Val Val Glu Ser Glu Gly Glu Arg Lys Thr Lys

835 840 845

Val Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala

850 855 860

Ala Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu

865 870 875 880

Glu Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met

885 890 895

Lys Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile

900 905 910

Met Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu

915 920 925

Ala Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met

930 935 940

Arg Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln

945 950 955 960

Pro Pro Pro Ala Leu Pro Pro Gly Ser Gln Pro Ile Pro Pro Thr Gly

965 970 975

Ala Ala Gly Pro Pro Ala Val His Gly Leu Ala Val Ala Pro Ala Ser

980 985 990

Val Val Pro Ala Pro Ala Gly Ser Gly Ala Pro Pro Gly Ser Leu Gly

995 1000 1005

Pro Ser Glu Gln Ile Gly Gln Ala Gly Ser Thr Ala Gly Pro Gln

1010 1015 1020

Gln Gln Gln Pro Ala Gly Ala Pro Gln Pro Gly Ala Val Pro Pro

1025 1030 1035

Gly Val Pro Pro Pro Gly Pro His Gly Pro Ser Pro Phe Pro Asn

1040 1045 1050

Gln Gln Thr Pro Pro Ser Met Met Pro Gly Ala Val Pro Gly Ser

1055 1060 1065

Gly His Pro Gly Val Ala Gly Asn Ala Pro Leu Gly Leu Pro Phe

1070 1075 1080

Gly Met Pro Pro Pro Pro Pro Pro Pro Ala Pro Ser Ile Ile Pro

1085 1090 1095

Phe Gly Ser Leu Ala Asp Ser Ile Ser Ile Asn Leu Pro Ala Pro

1100 1105 1110

Pro Asn Leu His Gly His His His His Leu Pro Phe Ala Pro Gly

1115 1120 1125

Thr Leu Pro Pro Pro Asn Leu Pro Val Ser Met Ala Asn Pro Leu

1130 1135 1140

His Pro Asn Leu Pro Ala Thr Thr Thr Met Pro Ser Ser Leu Pro

1145 1150 1155

Leu Gly Pro Gly Leu Gly Ser Ala Ala Ala Gln Ser Pro Ala Ile

1160 1165 1170

Val Ala Ala Val Gln Gly Asn Leu Leu Pro Ser Ala Ser Pro Leu

1175 1180 1185

Pro Asp Pro Gly Thr Pro Leu Pro Pro Asp Pro Thr Ala Pro Ser

1190 1195 1200

Pro Gly Thr Val Thr Pro Val Pro Pro Pro Gln

1205 1210

<210> 61

<211> 199

<212> PRT

<213> 智人(Homo sapiens)

<400> 61

Met Ala Asn Arg Gly Pro Ala Tyr Gly Leu Ser Arg Glu Val Gln Gln

1 5 10 15

Lys Ile Glu Lys Gln Tyr Asp Ala Asp Leu Glu Gln Ile Leu Ile Gln

20 25 30

Trp Ile Thr Thr Gln Cys Arg Lys Asp Val Gly Arg Pro Gln Pro Gly

35 40 45

Arg Glu Asn Phe Gln Asn Trp Leu Lys Asp Gly Thr Val Leu Cys Glu

50 55 60

Leu Ile Asn Ala Leu Tyr Pro Glu Gly Gln Ala Pro Val Lys Lys Ile

65 70 75 80

Gln Ala Ser Thr Met Ala Phe Lys Gln Met Glu Gln Ile Ser Gln Phe

85 90 95

Leu Gln Ala Ala Glu Arg Tyr Gly Ile Asn Thr Thr Asp Ile Phe Gln

100 105 110

Thr Val Asp Leu Trp Glu Gly Lys Asn Met Ala Cys Val Gln Arg Thr

115 120 125

Leu Met Asn Leu Gly Gly Leu Ala Val Ala Arg Asp Asp Gly Leu Phe

130 135 140

Ser Gly Asp Pro Asn Trp Phe Pro Lys Lys Ser Lys Glu Asn Pro Arg

145 150 155 160

Asn Phe Ser Asp Asn Gln Leu Gln Glu Gly Lys Asn Val Ile Gly Leu

165 170 175

Gln Met Gly Thr Asn Arg Gly Ala Ser Gln Ala Gly Met Thr Gly Tyr

180 185 190

Gly Met Pro Arg Gln Ile Leu

195

<210> 62

<211> 539

<212> PRT

<213> 智人(Homo sapiens)

<400> 62

Met Pro Glu Asn Val Ala Pro Arg Ser Gly Ala Thr Ala Gly Ala Ala

1 5 10 15

Gly Gly Arg Gly Lys Gly Ala Tyr Gln Asp Arg Asp Lys Pro Ala Gln

20 25 30

Ile Arg Phe Ser Asn Ile Ser Ala Ala Lys Ala Val Ala Asp Ala Ile

35 40 45

Arg Thr Ser Leu Gly Pro Lys Gly Met Asp Lys Met Ile Gln Asp Gly

50 55 60

Lys Gly Asp Val Thr Ile Thr Asn Asp Gly Ala Thr Ile Leu Lys Gln

65 70 75 80

Met Gln Val Leu His Pro Ala Ala Arg Met Leu Val Glu Leu Ser Lys

85 90 95

Ala Gln Asp Ile Glu Ala Gly Asp Gly Thr Thr Ser Val Val Ile Ile

100 105 110

Ala Gly Ser Leu Leu Asp Ser Cys Thr Lys Leu Leu Gln Lys Gly Ile

115 120 125

His Pro Thr Ile Ile Ser Glu Ser Phe Gln Lys Ala Leu Glu Lys Gly

130 135 140

Ile Glu Ile Leu Thr Asp Met Ser Arg Pro Val Glu Leu Ser Asp Arg

145 150 155 160

Glu Thr Leu Leu Asn Ser Ala Thr Thr Ser Leu Asn Ser Lys Val Val

165 170 175

Ser Gln Tyr Ser Ser Leu Leu Ser Pro Met Ser Val Asn Ala Val Met

180 185 190

Lys Val Ile Asp Pro Ala Thr Ala Thr Ser Val Asp Leu Arg Asp Ile

195 200 205

Lys Ile Val Lys Lys Leu Gly Gly Thr Ile Asp Asp Cys Glu Leu Val

210 215 220

Glu Gly Leu Val Leu Thr Gln Lys Val Ser Asn Ser Gly Ile Thr Arg

225 230 235 240

Val Glu Lys Ala Lys Ile Gly Leu Ile Gln Phe Cys Leu Ser Ala Pro

245 250 255

Lys Thr Asp Met Asp Asn Gln Ile Val Val Ser Asp Tyr Ala Gln Met

260 265 270

Asp Arg Val Leu Arg Glu Glu Arg Ala Tyr Ile Leu Asn Leu Val Lys

275 280 285

Gln Ile Lys Lys Thr Gly Cys Asn Val Leu Leu Ile Gln Lys Ser Ile

290 295 300

Leu Arg Asp Ala Leu Ser Asp Leu Ala Leu His Phe Leu Asn Lys Met

305 310 315 320

Lys Ile Met Val Ile Lys Asp Ile Glu Arg Glu Asp Ile Glu Phe Ile

325 330 335

Cys Lys Thr Ile Gly Thr Lys Pro Val Ala His Ile Asp Gln Phe Thr

340 345 350

Ala Asp Met Leu Gly Ser Ala Glu Leu Ala Glu Glu Val Asn Leu Asn

355 360 365

Gly Ser Gly Lys Leu Leu Lys Ile Thr Gly Cys Ala Ser Pro Gly Lys

370 375 380

Thr Val Thr Ile Val Val Arg Gly Ser Asn Lys Leu Val Ile Glu Glu

385 390 395 400

Ala Glu Arg Ser Ile His Asp Ala Leu Cys Val Ile Arg Cys Leu Val

405 410 415

Lys Lys Arg Ala Leu Ile Ala Gly Gly Gly Ala Pro Glu Ile Glu Leu

420 425 430

Ala Leu Arg Leu Thr Glu Tyr Ser Arg Thr Leu Ser Gly Met Glu Ser

435 440 445

Tyr Cys Val Arg Ala Phe Ala Asp Ala Met Glu Val Ile Pro Ser Thr

450 455 460

Leu Ala Glu Asn Ala Gly Leu Asn Pro Ile Ser Thr Val Thr Glu Leu

465 470 475 480

Arg Asn Arg His Ala Gln Gly Glu Lys Thr Ala Gly Ile Asn Val Arg

485 490 495

Lys Gly Gly Ile Ser Asn Ile Leu Glu Glu Leu Val Val Gln Pro Leu

500 505 510

Leu Val Ser Val Ser Ala Leu Thr Leu Ala Thr Glu Thr Val Arg Ser

515 520 525

Ile Leu Lys Ile Asp Asp Val Val Asn Thr Arg

530 535

<210> 63

<211> 758

<212> PRT

<213> 智人(Homo sapiens)

<400> 63

Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser

1 5 10 15

Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala

20 25 30

Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly

35 40 45

Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu

50 55 60

Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr

65 70 75 80

Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly

85 90 95

Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg

100 105 110

Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr

115 120 125

Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu

130 135 140

Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His

145 150 155 160

Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr

165 170 175

Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val

180 185 190

Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu Glu Thr

195 200 205

Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys Asn Gln

210 215 220

Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser Ser Glu

225 230 235 240

Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp Val Thr

245 250 255

Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu Glu Asn Glu

260 265 270

Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro Val

275 280 285

Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val Glu

290 295 300

Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys Thr Asp Asp Pro

305 310 315 320

Glu Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu Leu Asn Lys

325 330 335

Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala Glu Lys Leu Arg

340 345 350

Lys Arg Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys Glu Leu Val

355 360 365

Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys Ala Gln Cys

370 375 380

Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val Leu Arg Gly

385 390 395 400

Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp Val Pro Ala

405 410 415

Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg Gln Gln Phe

420 425 430

Leu Gly His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg Leu Val Gln

435 440 445

Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly Val Gly Tyr

450 455 460

Leu Leu Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr Glu Glu Val

465 470 475 480

Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His Tyr Gly Phe

485 490 495

Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro Tyr Leu Lys

500 505 510

Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly Arg Phe Tyr

515 520 525

Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys Glu Ala Tyr

530 535 540

Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala Ser Val Trp

545 550 555 560

Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln Pro Trp Trp

565 570 575

Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys Ser Leu Glu Arg

580 585 590

Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val Met Asp Lys Ala

595 600 605

Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu Lys Gly Asp

610 615 620

Trp Ser Gln Phe Thr Leu Trp Gln Gln Gly Arg Arg Asn Glu Asn Ala

625 630 635 640

Cys Lys Gly Ala Pro Lys Thr Cys Thr Leu Leu Glu Lys Phe Pro Glu

645 650 655

Thr Thr Gly Cys Arg Arg Gly Gln Ile Lys Tyr Ser Ile Met His Pro

660 665 670

Gly Thr His Val Trp Pro His Thr Gly Pro Thr Asn Cys Arg Leu Arg

675 680 685

Met His Leu Gly Leu Val Ile Pro Lys Glu Gly Cys Lys Ile Arg Cys

690 695 700

Ala Asn Glu Thr Lys Thr Trp Glu Glu Gly Lys Val Leu Ile Phe Asp

705 710 715 720

Asp Ser Phe Glu His Glu Val Trp Gln Asp Ala Ser Ser Phe Arg Leu

725 730 735

Ile Phe Ile Val Asp Val Trp His Pro Glu Leu Thr Pro Gln Gln Arg

740 745 750

Arg Ser Leu Pro Ala Ile

755

<210> 64

<211> 491

<212> PRT

<213> 智人(Homo sapiens)

<400> 64

Met Pro Leu Pro Val Gln Val Phe Asn Leu Gln Gly Ala Val Glu Pro

1 5 10 15

Met Gln Ile Asp Val Asp Pro Gln Glu Asp Pro Gln Asn Ala Pro Asp

20 25 30

Val Asn Tyr Val Val Glu Asn Pro Ser Leu Asp Leu Glu Gln Tyr Ala

35 40 45

Ala Ser Tyr Ser Gly Leu Met Arg Ile Glu Arg Leu Gln Phe Ile Ala

50 55 60

Asp His Cys Pro Thr Leu Arg Val Glu Ala Leu Lys Met Ala Leu Ser

65 70 75 80

Phe Val Gln Arg Thr Phe Asn Val Asp Met Tyr Glu Glu Ile His Arg

85 90 95

Lys Leu Ser Glu Ala Thr Arg Ser Ser Leu Arg Glu Leu Gln Asn Ala

100 105 110

Pro Asp Ala Ile Pro Glu Ser Gly Val Glu Pro Pro Ala Leu Asp Thr

115 120 125

Ala Trp Val Glu Ala Thr Arg Lys Lys Ala Leu Leu Lys Leu Glu Lys

130 135 140

Leu Asp Thr Asp Leu Lys Asn Tyr Lys Gly Asn Ser Ile Lys Glu Ser

145 150 155 160

Ile Arg Arg Gly His Asp Asp Leu Gly Asp His Tyr Leu Asp Cys Gly

165 170 175

Asp Leu Ser Asn Ala Leu Lys Cys Tyr Ser Arg Ala Arg Asp Tyr Cys

180 185 190

Thr Ser Ala Lys His Val Ile Asn Met Cys Leu Asn Val Ile Lys Val

195 200 205

Ser Val Tyr Leu Gln Asn Trp Ser His Val Leu Ser Tyr Val Ser Lys

210 215 220

Ala Glu Ser Thr Pro Glu Ile Ala Glu Gln Arg Gly Glu Arg Asp Ser

225 230 235 240

Gln Thr Gln Ala Ile Leu Thr Lys Leu Lys Cys Ala Ala Gly Leu Ala

245 250 255

Glu Leu Ala Ala Arg Lys Tyr Lys Gln Ala Ala Lys Cys Leu Leu Leu

260 265 270

Ala Ser Phe Asp His Cys Asp Phe Pro Glu Leu Leu Ser Pro Ser Asn

275 280 285

Val Ala Ile Tyr Gly Gly Leu Cys Ala Leu Ala Thr Phe Asp Arg Gln

290 295 300

Glu Leu Gln Arg Asn Val Ile Ser Ser Ser Ser Phe Lys Leu Phe Leu

305 310 315 320

Glu Leu Glu Pro Gln Val Arg Asp Ile Ile Phe Lys Phe Tyr Glu Ser

325 330 335

Lys Tyr Ala Ser Cys Leu Lys Met Leu Asp Glu Met Lys Asp Asn Leu

340 345 350

Leu Leu Asp Met Tyr Leu Ala Pro His Val Arg Thr Leu Tyr Thr Gln

355 360 365

Ile Arg Asn Arg Ala Leu Ile Gln Tyr Phe Ser Pro Tyr Val Ser Ala

370 375 380

Asp Met His Arg Met Ala Ala Ala Phe Asn Thr Thr Val Ala Ala Leu

385 390 395 400

Glu Asp Glu Leu Thr Gln Leu Ile Leu Glu Gly Leu Ile Ser Ala Arg

405 410 415

Val Asp Ser His Ser Lys Ile Leu Tyr Ala Arg Asp Val Asp Gln Arg

420 425 430

Ser Thr Thr Phe Glu Lys Ser Leu Leu Met Gly Lys Glu Phe Gln Arg

435 440 445

Arg Ala Lys Ala Met Met Leu Arg Ala Ala Val Leu Arg Asn Gln Ile

450 455 460

His Val Lys Ser Pro Pro Arg Glu Gly Ser Gln Gly Glu Leu Thr Pro

465 470 475 480

Ala Asn Ser Gln Ser Arg Met Ser Thr Asn Met

485 490

<210> 65

<211> 1512

<212> PRT

<213> 智人(Homo sapiens)

<400> 65

Met Pro Ser Ser Ser Asp Thr Ala Leu Gly Gly Gly Gly Gly Leu Ser

1 5 10 15

Trp Ala Glu Lys Lys Leu Glu Glu Arg Arg Lys Arg Arg Arg Phe Leu

20 25 30

Ser Pro Gln Gln Pro Pro Leu Leu Leu Pro Leu Leu Gln Pro Gln Leu

35 40 45

Leu Gln Pro Pro Pro Pro Pro Pro Pro Leu Leu Phe Leu Ala Ala Pro

50 55 60

Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Ser Cys

65 70 75 80

Phe Ser Pro Gly Pro Pro Leu Glu Val Lys Arg Leu Ala Arg Gly Lys

85 90 95

Arg Arg Ala Gly Gly Arg Gln Lys Arg Arg Arg Gly Pro Arg Ala Gly

100 105 110

Gln Glu Ala Glu Lys Arg Arg Val Phe Ser Leu Pro Gln Pro Gln Gln

115 120 125

Asp Gly Gly Gly Gly Ala Ser Ser Gly Gly Gly Val Thr Pro Leu Val

130 135 140

Glu Tyr Glu Asp Val Ser Ser Gln Ser Glu Gln Gly Leu Leu Leu Gly

145 150 155 160

Gly Ala Ser Ala Ala Thr Ala Ala Thr Ala Ala Gly Gly Thr Gly Gly

165 170 175

Ser Gly Gly Ser Pro Ala Ser Ser Ser Gly Thr Gln Arg Arg Gly Glu

180 185 190

Gly Ser Glu Arg Arg Pro Arg Arg Asp Arg Arg Ser Ser Ser Gly Arg

195 200 205

Ser Lys Glu Arg His Arg Glu His Arg Arg Arg Asp Gly Gln Arg Gly

210 215 220

Gly Ser Glu Ala Ser Lys Ser Arg Ser Arg His Ser His Ser Gly Glu

225 230 235 240

Glu Arg Ala Glu Val Ala Lys Ser Gly Ser Ser Ser Ser Ser Gly Gly

245 250 255

Arg Arg Lys Ser Ala Ser Ala Thr Ser Ser Ser Ser Ser Ser Arg Lys

260 265 270

Asp Arg Asp Ser Lys Ala His Arg Ser Arg Thr Lys Ser Ser Lys Glu

275 280 285

Pro Pro Ser Ala Tyr Lys Glu Pro Pro Lys Ala Tyr Arg Glu Asp Lys

290 295 300

Thr Glu Pro Lys Ala Tyr Arg Arg Arg Arg Ser Leu Ser Pro Leu Gly

305 310 315 320

Gly Arg Asp Asp Ser Pro Val Ser His Arg Ala Ser Gln Ser Leu Arg

325 330 335

Ser Arg Lys Ser Pro Ser Pro Ala Gly Gly Gly Ser Ser Pro Tyr Ser

340 345 350

Arg Arg Leu Pro Arg Ser Pro Ser Pro Tyr Ser Arg Arg Arg Ser Pro

355 360 365

Ser Tyr Ser Arg His Ser Ser Tyr Glu Arg Gly Gly Asp Val Ser Pro

370 375 380

Ser Pro Tyr Ser Ser Ser Ser Trp Arg Arg Ser Arg Ser Pro Tyr Ser

385 390 395 400

Pro Val Leu Arg Arg Ser Gly Lys Ser Arg Ser Arg Ser Pro Tyr Ser

405 410 415

Ser Arg His Ser Arg Ser Arg Ser Arg His Arg Leu Ser Arg Ser Arg

420 425 430

Ser Arg His Ser Ser Ile Ser Pro Ser Thr Leu Thr Leu Lys Ser Ser

435 440 445

Leu Ala Ala Glu Leu Asn Lys Asn Lys Lys Ala Arg Ala Ala Glu Ala

450 455 460

Ala Arg Ala Ala Glu Ala Ala Lys Ala Ala Glu Ala Thr Lys Ala Ala

465 470 475 480

Glu Ala Ala Ala Lys Ala Ala Lys Ala Ser Asn Thr Ser Thr Pro Thr

485 490 495

Lys Gly Asn Thr Glu Thr Ser Ala Ser Ala Ser Gln Thr Asn His Val

500 505 510

Lys Asp Val Lys Lys Ile Lys Ile Glu His Ala Pro Ser Pro Ser Ser

515 520 525

Gly Gly Thr Leu Lys Asn Asp Lys Ala Lys Thr Lys Pro Pro Leu Gln

530 535 540

Val Thr Lys Val Glu Asn Asn Leu Ile Val Asp Lys Ala Thr Lys Lys

545 550 555 560

Ala Val Ile Val Gly Lys Glu Ser Lys Ser Ala Ala Thr Lys Glu Glu

565 570 575

Ser Val Ser Leu Lys Glu Lys Thr Lys Pro Leu Thr Pro Ser Ile Gly

580 585 590

Ala Lys Glu Lys Glu Gln His Val Ala Leu Val Thr Ser Thr Leu Pro

595 600 605

Pro Leu Pro Leu Pro Pro Met Leu Pro Glu Asp Lys Glu Ala Asp Ser

610 615 620

Leu Arg Gly Asn Ile Ser Val Lys Ala Val Lys Lys Glu Val Glu Lys

625 630 635 640

Lys Leu Arg Cys Leu Leu Ala Asp Leu Pro Leu Pro Pro Glu Leu Pro

645 650 655

Gly Gly Asp Asp Leu Ser Lys Ser Pro Glu Glu Lys Lys Thr Ala Thr

660 665 670

Gln Leu His Ser Lys Arg Arg Pro Lys Ile Cys Gly Pro Arg Tyr Gly

675 680 685

Glu Thr Lys Glu Lys Asp Ile Asp Trp Gly Lys Arg Cys Val Asp Lys

690 695 700

Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly Thr Tyr Gly Gln Val Tyr

705 710 715 720

Lys Ala Arg Asp Lys Asp Thr Gly Glu Met Val Ala Leu Lys Lys Val

725 730 735

Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Ile Arg Glu

740 745 750

Ile Lys Ile Leu Arg Gln Leu Thr His Gln Ser Ile Ile Asn Met Lys

755 760 765

Glu Ile Val Thr Asp Lys Glu Asp Ala Leu Asp Phe Lys Lys Asp Lys

770 775 780

Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met Asp His Asp Leu Met Gly

785 790 795 800

Leu Leu Glu Ser Gly Leu Val His Phe Asn Glu Asn His Ile Lys Ser

805 810 815

Phe Met Arg Gln Leu Met Glu Gly Leu Asp Tyr Cys His Lys Lys Asn

820 825 830

Phe Leu His Arg Asp Ile Lys Cys Ser Asn Ile Leu Leu Asn Asn Arg

835 840 845

Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu Ala Arg Leu Tyr Ser Ser

850 855 860

Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val Ile Thr Leu Trp Tyr Arg

865 870 875 880

Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg Tyr Thr Pro Ala Ile Asp

885 890 895

Val Trp Ser Cys Gly Cys Ile Leu Gly Glu Leu Phe Thr Lys Lys Pro

900 905 910

Ile Phe Gln Ala Asn Gln Glu Leu Ala Gln Leu Glu Leu Ile Ser Arg

915 920 925

Ile Cys Gly Ser Pro Cys Pro Ala Val Trp Pro Asp Val Ile Lys Leu

930 935 940

Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys Gln Tyr Arg Arg Lys Leu

945 950 955 960

Arg Glu Glu Phe Val Phe Ile Pro Ala Ala Ala Leu Asp Leu Phe Asp

965 970 975

Tyr Met Leu Ala Leu Asp Pro Ser Lys Arg Cys Thr Ala Glu Gln Ala

980 985 990

Leu Gln Cys Glu Phe Leu Arg Asp Val Glu Pro Ser Lys Met Pro Pro

995 1000 1005

Pro Asp Leu Pro Leu Trp Gln Asp Cys His Glu Leu Trp Ser Lys

1010 1015 1020

Lys Arg Arg Arg Gln Lys Gln Met Gly Met Thr Asp Asp Val Ser

1025 1030 1035

Thr Ile Lys Ala Pro Arg Lys Asp Leu Ser Leu Gly Leu Asp Asp

1040 1045 1050

Ser Arg Thr Asn Thr Pro Gln Gly Val Leu Pro Ser Ser Gln Leu

1055 1060 1065

Lys Ser Gln Gly Ser Ser Asn Val Ala Pro Val Lys Thr Gly Pro

1070 1075 1080

Gly Gln His Leu Asn His Ser Glu Leu Ala Ile Leu Leu Asn Leu

1085 1090 1095

Leu Gln Ser Lys Thr Ser Val Asn Met Ala Asp Phe Val Gln Val

1100 1105 1110

Leu Asn Ile Lys Val Asn Ser Glu Thr Gln Gln Gln Leu Asn Lys

1115 1120 1125

Ile Asn Leu Pro Ala Gly Ile Leu Ala Thr Gly Glu Lys Gln Thr

1130 1135 1140

Asp Pro Ser Thr Pro Gln Gln Glu Ser Ser Lys Pro Leu Gly Gly

1145 1150 1155

Ile Gln Pro Ser Ser Gln Thr Ile Gln Pro Lys Val Glu Thr Asp

1160 1165 1170

Ala Ala Gln Ala Ala Val Gln Ser Ala Phe Ala Val Leu Leu Thr

1175 1180 1185

Gln Leu Ile Lys Ala Gln Gln Ser Lys Gln Lys Asp Val Leu Leu

1190 1195 1200

Glu Glu Arg Glu Asn Gly Ser Gly His Glu Ala Ser Leu Gln Leu

1205 1210 1215

Arg Pro Pro Pro Glu Pro Ser Thr Pro Val Ser Gly Gln Asp Asp

1220 1225 1230

Leu Ile Gln His Gln Asp Met Arg Ile Leu Glu Leu Thr Pro Glu

1235 1240 1245

Pro Asp Arg Pro Arg Ile Leu Pro Pro Asp Gln Arg Pro Pro Glu

1250 1255 1260

Pro Pro Glu Pro Pro Pro Val Thr Glu Glu Asp Leu Asp Tyr Arg

1265 1270 1275

Thr Glu Asn Gln His Val Pro Thr Thr Ser Ser Ser Leu Thr Asp

1280 1285 1290

Pro His Ala Gly Val Lys Ala Ala Leu Leu Gln Leu Leu Ala Gln

1295 1300 1305

His Gln Pro Gln Asp Asp Pro Lys Arg Glu Gly Gly Ile Asp Tyr

1310 1315 1320

Gln Ala Gly Asp Thr Tyr Val Ser Thr Ser Asp Tyr Lys Asp Asn

1325 1330 1335

Phe Gly Ser Ser Ser Phe Ser Ser Ala Pro Tyr Val Ser Asn Asp

1340 1345 1350

Gly Leu Gly Ser Ser Ser Ala Pro Pro Leu Glu Arg Arg Ser Phe

1355 1360 1365

Ile Gly Asn Ser Asp Ile Gln Ser Leu Asp Asn Tyr Ser Thr Ala

1370 1375 1380

Ser Ser His Ser Gly Gly Pro Pro Gln Pro Ser Ala Phe Ser Glu

1385 1390 1395

Ser Phe Pro Ser Ser Val Ala Gly Tyr Gly Asp Ile Tyr Leu Asn

1400 1405 1410

Ala Gly Pro Met Leu Phe Ser Gly Asp Lys Asp His Arg Phe Glu

1415 1420 1425

Tyr Ser His Gly Pro Ile Ala Val Leu Ala Asn Ser Ser Asp Pro

1430 1435 1440

Ser Thr Gly Pro Glu Ser Thr His Pro Leu Pro Ala Lys Met His

1445 1450 1455

Asn Tyr Asn Tyr Gly Gly Asn Leu Gln Glu Asn Pro Ser Gly Pro

1460 1465 1470

Ser Leu Met His Gly Gln Thr Trp Thr Ser Pro Ala Gln Gly Pro

1475 1480 1485

Gly Tyr Ser Gln Gly Tyr Arg Gly His Ile Ser Thr Ser Thr Gly

1490 1495 1500

Arg Gly Arg Gly Arg Gly Leu Pro Tyr

1505 1510

<210> 66

<211> 352

<212> PRT

<213> 智人(Homo sapiens)

<400> 66

Met Ser Val Ala Gly Leu Lys Lys Gln Phe His Lys Ala Thr Gln Lys

1 5 10 15

Val Ser Glu Lys Val Gly Gly Ala Glu Gly Thr Lys Leu Asp Asp Asp

20 25 30

Phe Lys Glu Met Glu Arg Lys Val Asp Val Thr Ser Arg Ala Val Met

35 40 45

Glu Ile Met Thr Lys Thr Ile Glu Tyr Leu Gln Pro Asn Pro Ala Ser

50 55 60

Arg Ala Lys Leu Ser Met Ile Asn Thr Met Ser Lys Ile Arg Gly Gln

65 70 75 80

Glu Lys Gly Pro Gly Tyr Pro Gln Ala Glu Ala Leu Leu Ala Glu Ala

85 90 95

Met Leu Lys Phe Gly Arg Glu Leu Gly Asp Asp Cys Asn Phe Gly Pro

100 105 110

Ala Leu Gly Glu Val Gly Glu Ala Met Arg Glu Leu Ser Glu Val Lys

115 120 125

Asp Ser Leu Asp Ile Glu Val Lys Gln Asn Phe Ile Asp Pro Leu Gln

130 135 140

Asn Leu His Asp Lys Asp Leu Arg Glu Ile Gln His His Leu Lys Lys

145 150 155 160

Leu Glu Gly Arg Arg Leu Asp Phe Asp Tyr Lys Lys Lys Arg Gln Gly

165 170 175

Lys Ile Pro Asp Glu Glu Leu Arg Gln Ala Leu Glu Lys Phe Asp Glu

180 185 190

Ser Lys Glu Ile Ala Glu Ser Ser Met Phe Asn Leu Leu Glu Met Asp

195 200 205

Ile Glu Gln Val Ser Gln Leu Ser Ala Leu Val Gln Ala Gln Leu Glu

210 215 220

Tyr His Lys Gln Ala Val Gln Ile Leu Gln Gln Val Thr Val Arg Leu

225 230 235 240

Glu Glu Arg Ile Arg Gln Ala Ser Ser Gln Pro Arg Arg Glu Tyr Gln

245 250 255

Pro Lys Pro Arg Met Ser Leu Glu Phe Pro Thr Gly Asp Ser Thr Gln

260 265 270

Pro Asn Gly Gly Leu Ser His Thr Gly Thr Pro Lys Pro Ser Gly Val

275 280 285

Gln Met Asp Gln Pro Cys Cys Arg Ala Leu Tyr Asp Phe Glu Pro Glu

290 295 300

Asn Glu Gly Glu Leu Gly Phe Lys Glu Gly Asp Ile Ile Thr Leu Thr

305 310 315 320

Asn Gln Ile Asp Glu Asn Trp Tyr Glu Gly Met Leu His Gly His Ser

325 330 335

Gly Phe Phe Pro Ile Asn Tyr Val Glu Ile Leu Val Ala Leu Pro His

340 345 350

<210> 67

<211> 142

<212> PRT

<213> 智人(Homo sapiens)

<400> 67

Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly

1 5 10 15

Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg

20 25 30

Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp

35 40 45

Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala

50 55 60

Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala

65 70 75 80

Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro

85 90 95

Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala

100 105 110

His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys

115 120 125

Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg

130 135 140

<210> 68

<211> 318

<212> PRT

<213> 智人(Homo sapiens)

<400> 68

Met Pro Lys Arg Gly Lys Lys Gly Ala Val Ala Glu Asp Gly Asp Glu

1 5 10 15

Leu Arg Thr Glu Pro Glu Ala Lys Lys Ser Lys Thr Ala Ala Lys Lys

20 25 30

Asn Asp Lys Glu Ala Ala Gly Glu Gly Pro Ala Leu Tyr Glu Asp Pro

35 40 45

Pro Asp Gln Lys Thr Ser Pro Ser Gly Lys Pro Ala Thr Leu Lys Ile

50 55 60

Cys Ser Trp Asn Val Asp Gly Leu Arg Ala Trp Ile Lys Lys Lys Gly

65 70 75 80

Leu Asp Trp Val Lys Glu Glu Ala Pro Asp Ile Leu Cys Leu Gln Glu

85 90 95

Thr Lys Cys Ser Glu Asn Lys Leu Pro Ala Glu Leu Gln Glu Leu Pro

100 105 110

Gly Leu Ser His Gln Tyr Trp Ser Ala Pro Ser Asp Lys Glu Gly Tyr

115 120 125

Ser Gly Val Gly Leu Leu Ser Arg Gln Cys Pro Leu Lys Val Ser Tyr

130 135 140

Gly Ile Gly Asp Glu Glu His Asp Gln Glu Gly Arg Val Ile Val Ala

145 150 155 160

Glu Phe Asp Ser Phe Val Leu Val Thr Ala Tyr Val Pro Asn Ala Gly

165 170 175

Arg Gly Leu Val Arg Leu Glu Tyr Arg Gln Arg Trp Asp Glu Ala Phe

180 185 190

Arg Lys Phe Leu Lys Gly Leu Ala Ser Arg Lys Pro Leu Val Leu Cys

195 200 205

Gly Asp Leu Asn Val Ala His Glu Glu Ile Asp Leu Arg Asn Pro Lys

210 215 220

Gly Asn Lys Lys Asn Ala Gly Phe Thr Pro Gln Glu Arg Gln Gly Phe

225 230 235 240

Gly Glu Leu Leu Gln Ala Val Pro Leu Ala Asp Ser Phe Arg His Leu

245 250 255

Tyr Pro Asn Thr Pro Tyr Ala Tyr Thr Phe Trp Thr Tyr Met Met Asn

260 265 270

Ala Arg Ser Lys Asn Val Gly Trp Arg Leu Asp Tyr Phe Leu Leu Ser

275 280 285

His Ser Leu Leu Pro Ala Leu Cys Asp Ser Lys Ile Arg Ser Lys Ala

290 295 300

Leu Gly Ser Asp His Cys Pro Ile Thr Leu Tyr Leu Ala Leu

305 310 315

<210> 69

<211> 263

<212> PRT

<213> 智人(Homo sapiens)

<400> 69

Met Ala Leu Ala Ser Val Leu Glu Arg Pro Leu Pro Val Asn Gln Arg

1 5 10 15

Gly Phe Phe Gly Leu Gly Gly Arg Ala Asp Leu Leu Asp Leu Gly Pro

20 25 30

Gly Ser Leu Ser Asp Gly Leu Ser Leu Ala Ala Pro Gly Trp Gly Val

35 40 45

Pro Glu Glu Pro Gly Ile Glu Met Leu His Gly Thr Thr Thr Leu Ala

50 55 60

Phe Lys Phe Arg His Gly Val Ile Val Ala Ala Asp Ser Arg Ala Thr

65 70 75 80

Ala Gly Ala Tyr Ile Ala Ser Gln Thr Val Lys Lys Val Ile Glu Ile

85 90 95

Asn Pro Tyr Leu Leu Gly Thr Met Ala Gly Gly Ala Ala Asp Cys Ser

100 105 110

Phe Trp Glu Arg Leu Leu Ala Arg Gln Cys Arg Ile Tyr Glu Leu Arg

115 120 125

Asn Lys Glu Arg Ile Ser Val Ala Ala Ala Ser Lys Leu Leu Ala Asn

130 135 140

Met Val Tyr Gln Tyr Lys Gly Met Gly Leu Ser Met Gly Thr Met Ile

145 150 155 160

Cys Gly Trp Asp Lys Arg Gly Pro Gly Leu Tyr Tyr Val Asp Ser Glu

165 170 175

Gly Asn Arg Ile Ser Gly Ala Thr Phe Ser Val Gly Ser Gly Ser Val

180 185 190

Tyr Ala Tyr Gly Val Met Asp Arg Gly Tyr Ser Tyr Asp Leu Glu Val

195 200 205

Glu Gln Ala Tyr Asp Leu Ala Arg Arg Ala Ile Tyr Gln Ala Thr Tyr

210 215 220

Arg Asp Ala Tyr Ser Gly Gly Ala Val Asn Leu Tyr His Val Arg Glu

225 230 235 240

Asp Gly Trp Ile Arg Val Ser Ser Asp Asn Val Ala Asp Leu His Glu

245 250 255

Lys Tyr Ser Gly Ser Thr Pro

260

<210> 70

<211> 105

<212> PRT

<213> 智人(Homo sapiens)

<400> 70

Met Val Lys Gln Ile Glu Ser Lys Thr Ala Phe Gln Glu Ala Leu Asp

1 5 10 15

Ala Ala Gly Asp Lys Leu Val Val Val Asp Phe Ser Ala Thr Trp Cys

20 25 30

Gly Pro Cys Lys Met Ile Lys Pro Phe Phe His Ser Leu Ser Glu Lys

35 40 45

Tyr Ser Asn Val Ile Phe Leu Glu Val Asp Val Asp Asp Cys Gln Asp

50 55 60

Val Ala Ser Glu Cys Glu Val Lys Cys Met Pro Thr Phe Gln Phe Phe

65 70 75 80

Lys Lys Gly Gln Lys Val Gly Glu Phe Ser Gly Ala Asn Lys Glu Lys

85 90 95

Leu Glu Ala Thr Ile Asn Glu Leu Val

100 105

<210> 71

<211> 894

<212> PRT

<213> 智人(Homo sapiens)

<400> 71

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys

1 5 10 15

Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala

20 25 30

Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg

35 40 45

Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro

50 55 60

Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp

65 70 75 80

Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp

85 90 95

Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr

100 105 110

Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser

115 120 125

Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu

130 135 140

Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys

145 150 155 160

Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp

165 170 175

Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu

180 185 190

His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His

195 200 205

Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu

210 215 220

Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu

225 230 235 240

Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr

245 250 255

His Cys Thr Leu Gln Ala Val Leu Ser Asn Asp Gly Met Gly Ile Gln

260 265 270

Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser

275 280 285

Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro

290 295 300

Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp

305 310 315 320

Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro

325 330 335

Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His

340 345 350

Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg

355 360 365

Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly

370 375 380

Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser

385 390 395 400

Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro

405 410 415

Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln

420 425 430

Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp

435 440 445

Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val

450 455 460

Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg

465 470 475 480

Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val

485 490 495

Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr

500 505 510

Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp

515 520 525

Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu

530 535 540

Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser

545 550 555 560

Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg

565 570 575

Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe

580 585 590

Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser

595 600 605

Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys

610 615 620

His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln

625 630 635 640

Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile

645 650 655

Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp

660 665 670

Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val

675 680 685

Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg

690 695 700

Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser

705 710 715 720

Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly

725 730 735

Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly

740 745 750

Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu

755 760 765

Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg

770 775 780

Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg

785 790 795 800

Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro

805 810 815

Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu

820 825 830

Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro

835 840 845

Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly

850 855 860

Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala

865 870 875 880

Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala

885 890

<210> 72

<211> 208

<212> PRT

<213> 智人(Homo sapiens)

<400> 72

Met Gly Ile Ser Arg Asp Asn Trp His Lys Arg Arg Lys Thr Gly Gly

1 5 10 15

Lys Arg Lys Pro Tyr His Lys Lys Arg Lys Tyr Glu Leu Gly Arg Pro

20 25 30

Ala Ala Asn Thr Lys Ile Gly Pro Arg Arg Ile His Thr Val Arg Val

35 40 45

Arg Gly Gly Asn Lys Lys Tyr Arg Ala Leu Arg Leu Asp Val Gly Asn

50 55 60

Phe Ser Trp Gly Ser Glu Cys Cys Thr Arg Lys Thr Arg Ile Ile Asp

65 70 75 80

Val Val Tyr Asn Ala Ser Asn Asn Glu Leu Val Arg Thr Lys Thr Leu

85 90 95

Val Lys Asn Cys Ile Val Leu Ile Asp Ser Thr Pro Tyr Arg Gln Trp

100 105 110

Tyr Glu Ser His Tyr Ala Leu Pro Leu Gly Arg Lys Lys Gly Ala Lys

115 120 125

Leu Thr Pro Glu Glu Glu Glu Ile Leu Asn Lys Lys Arg Ser Lys Lys

130 135 140

Ile Gln Lys Lys Tyr Asp Glu Arg Lys Lys Asn Ala Lys Ile Ser Ser

145 150 155 160

Leu Leu Glu Glu Gln Phe Gln Gln Gly Lys Leu Leu Ala Cys Ile Ala

165 170 175

Ser Arg Pro Gly Gln Cys Gly Arg Ala Asp Gly Tyr Val Leu Glu Gly

180 185 190

Lys Glu Leu Glu Phe Tyr Leu Arg Lys Ile Lys Ala Arg Lys Gly Lys

195 200 205

<210> 73

<211> 290

<212> PRT

<213> 智人(Homo sapiens)

<400> 73

Met Ala Pro Lys Arg Gln Ser Pro Leu Pro Pro Gln Lys Lys Lys Pro

1 5 10 15

Arg Pro Pro Pro Ala Leu Gly Pro Glu Glu Thr Ser Ala Ser Ala Gly

20 25 30

Leu Pro Lys Lys Gly Glu Lys Glu Gln Gln Glu Ala Ile Glu His Ile

35 40 45

Asp Glu Val Gln Asn Glu Ile Asp Arg Leu Asn Glu Gln Ala Ser Glu

50 55 60

Glu Ile Leu Lys Val Glu Gln Lys Tyr Asn Lys Leu Arg Gln Pro Phe

65 70 75 80

Phe Gln Lys Arg Ser Glu Leu Ile Ala Lys Ile Pro Asn Phe Trp Val

85 90 95

Thr Thr Phe Val Asn His Pro Gln Val Ser Ala Leu Leu Gly Glu Glu

100 105 110

Asp Glu Glu Ala Leu His Tyr Leu Thr Arg Val Glu Val Thr Glu Phe

115 120 125

Glu Asp Ile Lys Ser Gly Tyr Arg Ile Asp Phe Tyr Phe Asp Glu Asn

130 135 140

Pro Tyr Phe Glu Asn Lys Val Leu Ser Lys Glu Phe His Leu Asn Glu

145 150 155 160

Ser Gly Asp Pro Ser Ser Lys Ser Thr Glu Ile Lys Trp Lys Ser Gly

165 170 175

Lys Asp Leu Thr Lys Arg Ser Ser Gln Thr Gln Asn Lys Ala Ser Arg

180 185 190

Lys Arg Gln His Glu Glu Pro Glu Ser Phe Phe Thr Trp Phe Thr Asp

195 200 205

His Ser Asp Ala Gly Ala Asp Glu Leu Gly Glu Val Ile Lys Asp Asp

210 215 220

Ile Trp Pro Asn Pro Leu Gln Tyr Tyr Leu Val Pro Asp Met Asp Asp

225 230 235 240

Glu Glu Gly Glu Gly Glu Glu Asp Asp Asp Asp Asp Glu Glu Glu Glu

245 250 255

Gly Leu Glu Asp Ile Asp Glu Glu Gly Asp Glu Asp Glu Gly Glu Glu

260 265 270

Asp Glu Asp Asp Asp Glu Gly Glu Glu Gly Glu Glu Asp Glu Gly Glu

275 280 285

Asp Asp

290

<210> 74

<211> 152

<212> PRT

<213> 智人(Homo sapiens)

<400> 74

Met Ser Leu Val Ile Pro Glu Lys Phe Gln His Ile Leu Arg Val Leu

1 5 10 15

Asn Thr Asn Ile Asp Gly Arg Arg Lys Ile Ala Phe Ala Ile Thr Ala

20 25 30

Ile Lys Gly Val Gly Arg Arg Tyr Ala His Val Val Leu Arg Lys Ala

35 40 45

Asp Ile Asp Leu Thr Lys Arg Ala Gly Glu Leu Thr Glu Asp Glu Val

50 55 60

Glu Arg Val Ile Thr Ile Met Gln Asn Pro Arg Gln Tyr Lys Ile Pro

65 70 75 80

Asp Trp Phe Leu Asn Arg Gln Lys Asp Val Lys Asp Gly Lys Tyr Ser

85 90 95

Gln Val Leu Ala Asn Gly Leu Asp Asn Lys Leu Arg Glu Asp Leu Glu

100 105 110

Arg Leu Lys Lys Ile Arg Ala His Arg Gly Leu Arg His Phe Trp Gly

115 120 125

Leu Arg Val Arg Gly Gln His Thr Lys Thr Thr Gly Arg Arg Gly Arg

130 135 140

Thr Val Gly Val Ser Lys Lys Lys

145 150

<210> 75

<211> 166

<212> PRT

<213> 智人(Homo sapiens)

<400> 75

Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn

1 5 10 15

Asp Met Lys Val Arg Lys Ser Ser Thr Pro Glu Glu Val Lys Lys Arg

20 25 30

Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile

35 40 45

Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Thr Val

50 55 60

Asp Asp Pro Tyr Ala Thr Phe Val Lys Met Leu Pro Asp Lys Asp Cys

65 70 75 80

Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys

85 90 95

Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys

100 105 110

Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu

115 120 125

Thr Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys

130 135 140

Asp Arg Cys Thr Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser

145 150 155 160

Leu Glu Gly Lys Pro Leu

165

<210> 76

<211> 476

<212> PRT

<213> 智人(Homo sapiens)

<400> 76

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu

1 5 10 15

Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly

20 25 30

Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser

35 40 45

Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly

50 55 60

Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly

65 70 75 80

Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly

85 90 95

Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu

100 105 110

Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val

115 120 125

Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr

130 135 140

Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln

145 150 155 160

Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr

165 170 175

Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro

180 185 190

Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr

195 200 205

Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn

210 215 220

Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly

225 230 235 240

Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly

245 250 255

Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser

260 265 270

Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly

275 280 285

Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser

290 295 300

Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser

305 310 315 320

Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn Glu

325 330 335

Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser Pro

340 345 350

Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu

355 360 365

Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro

370 375 380

Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys

385 390 395 400

Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp

405 410 415

Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn

420 425 430

Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val

435 440 445

Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg

450 455 460

Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp

465 470 475

<210> 77

<211> 128

<212> PRT

<213> 智人(Homo sapiens)

<400> 77

Met Ala Pro Val Lys Lys Leu Val Val Lys Gly Gly Lys Lys Lys Lys

1 5 10 15

Gln Val Leu Lys Phe Thr Leu Asp Cys Thr His Pro Val Glu Asp Gly

20 25 30

Ile Met Asp Ala Ala Asn Phe Glu Gln Phe Leu Gln Glu Arg Ile Lys

35 40 45

Val Asn Gly Lys Ala Gly Asn Leu Gly Gly Gly Val Val Thr Ile Glu

50 55 60

Arg Ser Lys Ser Lys Ile Thr Val Thr Ser Glu Val Pro Phe Ser Lys

65 70 75 80

Arg Tyr Leu Lys Tyr Leu Thr Lys Lys Tyr Leu Lys Lys Asn Asn Leu

85 90 95

Arg Asp Trp Leu Arg Val Val Ala Asn Ser Lys Glu Ser Tyr Glu Leu

100 105 110

Arg Tyr Phe Gln Ile Asn Gln Asp Glu Glu Glu Glu Glu Asp Glu Asp

115 120 125

<210> 78

<211> 288

<212> PRT

<213> 智人(Homo sapiens)

<400> 78

Met Ala Gly Glu Lys Val Glu Lys Pro Asp Thr Lys Glu Lys Lys Pro

1 5 10 15

Glu Ala Lys Lys Val Asp Ala Gly Gly Lys Val Lys Lys Gly Asn Leu

20 25 30

Lys Ala Lys Lys Pro Lys Lys Gly Lys Pro His Cys Ser Arg Asn Pro

35 40 45

Val Leu Val Arg Gly Ile Gly Arg Tyr Ser Arg Ser Ala Met Tyr Ser

50 55 60

Arg Lys Ala Met Tyr Lys Arg Lys Tyr Ser Ala Ala Lys Ser Lys Val

65 70 75 80

Glu Lys Lys Lys Lys Glu Lys Val Leu Ala Thr Val Thr Lys Pro Val

85 90 95

Gly Gly Asp Lys Asn Gly Gly Thr Arg Val Val Lys Leu Arg Lys Met

100 105 110

Pro Arg Tyr Tyr Pro Thr Glu Asp Val Pro Arg Lys Leu Leu Ser His

115 120 125

Gly Lys Lys Pro Phe Ser Gln His Val Arg Lys Leu Arg Ala Ser Ile

130 135 140

Thr Pro Gly Thr Ile Leu Ile Ile Leu Thr Gly Arg His Arg Gly Lys

145 150 155 160

Arg Val Val Phe Leu Lys Gln Leu Ala Ser Gly Leu Leu Leu Val Thr

165 170 175

Gly Pro Leu Val Leu Asn Arg Val Pro Leu Arg Arg Thr His Gln Lys

180 185 190

Phe Val Ile Ala Thr Ser Thr Lys Ile Asp Ile Ser Asn Val Lys Ile

195 200 205

Pro Lys His Leu Thr Asp Ala Tyr Phe Lys Lys Lys Lys Leu Arg Lys

210 215 220

Pro Arg His Gln Glu Gly Glu Ile Phe Asp Thr Glu Lys Glu Lys Tyr

225 230 235 240

Glu Ile Thr Glu Gln Arg Lys Ile Asp Gln Lys Ala Val Asp Ser Gln

245 250 255

Ile Leu Pro Lys Ile Lys Ala Ile Pro Gln Leu Gln Gly Tyr Leu Arg

260 265 270

Ser Val Phe Ala Leu Thr Asn Gly Ile Tyr Pro His Lys Leu Val Phe

275 280 285

<210> 79

<211> 582

<212> PRT

<213> 智人(Homo sapiens)

<400> 79

Met Phe Pro Ala Gly Pro Pro Ser His Ser Leu Leu Arg Leu Pro Leu

1 5 10 15

Leu Gln Leu Leu Leu Leu Val Val Gln Ala Val Gly Arg Gly Leu Gly

20 25 30

Arg Ala Ser Pro Ala Gly Gly Pro Leu Glu Asp Val Val Ile Glu Arg

35 40 45

Tyr His Ile Pro Arg Ala Cys Pro Arg Glu Val Gln Met Gly Asp Phe

50 55 60

Val Arg Tyr His Tyr Asn Gly Thr Phe Glu Asp Gly Lys Lys Phe Asp

65 70 75 80

Ser Ser Tyr Asp Arg Asn Thr Leu Val Ala Ile Val Val Gly Val Gly

85 90 95

Arg Leu Ile Thr Gly Met Asp Arg Gly Leu Met Gly Met Cys Val Asn

100 105 110

Glu Arg Arg Arg Leu Ile Val Pro Pro His Leu Gly Tyr Gly Ser Ile

115 120 125

Gly Leu Ala Gly Leu Ile Pro Pro Asp Ala Thr Leu Tyr Phe Asp Val

130 135 140

Val Leu Leu Asp Val Trp Asn Lys Glu Asp Thr Val Gln Val Ser Thr

145 150 155 160

Leu Leu Arg Pro Pro His Cys Pro Arg Met Val Gln Asp Gly Asp Phe

165 170 175

Val Arg Tyr His Tyr Asn Gly Thr Leu Leu Asp Gly Thr Ser Phe Asp

180 185 190

Thr Ser Tyr Ser Lys Gly Gly Thr Tyr Asp Thr Tyr Val Gly Ser Gly

195 200 205

Trp Leu Ile Lys Gly Met Asp Gln Gly Leu Leu Gly Met Cys Pro Gly

210 215 220

Glu Arg Arg Lys Ile Ile Ile Pro Pro Phe Leu Ala Tyr Gly Glu Lys

225 230 235 240

Gly Tyr Gly Thr Val Ile Pro Pro Gln Ala Ser Leu Val Phe His Val

245 250 255

Leu Leu Ile Asp Val His Asn Pro Lys Asp Ala Val Gln Leu Glu Thr

260 265 270

Leu Glu Leu Pro Pro Gly Cys Val Arg Arg Ala Gly Ala Gly Asp Phe

275 280 285

Met Arg Tyr His Tyr Asn Gly Ser Leu Met Asp Gly Thr Leu Phe Asp

290 295 300

Ser Ser Tyr Ser Arg Asn His Thr Tyr Asn Thr Tyr Ile Gly Gln Gly

305 310 315 320

Tyr Ile Ile Pro Gly Met Asp Gln Gly Leu Gln Gly Ala Cys Met Gly

325 330 335

Glu Arg Arg Arg Ile Thr Ile Pro Pro His Leu Ala Tyr Gly Glu Asn

340 345 350

Gly Thr Gly Asp Lys Ile Pro Gly Ser Ala Val Leu Ile Phe Asn Val

355 360 365

His Val Ile Asp Phe His Asn Pro Ala Asp Val Val Glu Ile Arg Thr

370 375 380

Leu Ser Arg Pro Ser Glu Thr Cys Asn Glu Thr Thr Lys Leu Gly Asp

385 390 395 400

Phe Val Arg Tyr His Tyr Asn Cys Ser Leu Leu Asp Gly Thr Gln Leu

405 410 415

Phe Thr Ser His Asp Tyr Gly Ala Pro Gln Glu Ala Thr Leu Gly Ala

420 425 430

Asn Lys Val Ile Glu Gly Leu Asp Thr Gly Leu Gln Gly Met Cys Val

435 440 445

Gly Glu Arg Arg Gln Leu Ile Val Pro Pro His Leu Ala His Gly Glu

450 455 460

Ser Gly Ala Arg Gly Val Pro Gly Ser Ala Val Leu Leu Phe Glu Val

465 470 475 480

Glu Leu Val Ser Arg Glu Asp Gly Leu Pro Thr Gly Tyr Leu Phe Val

485 490 495

Trp His Lys Asp Pro Pro Ala Asn Leu Phe Glu Asp Met Asp Leu Asn

500 505 510

Lys Asp Gly Glu Val Pro Pro Glu Glu Phe Ser Thr Phe Ile Lys Ala

515 520 525

Gln Val Ser Glu Gly Lys Gly Arg Leu Met Pro Gly Gln Asp Pro Glu

530 535 540

Lys Thr Ile Gly Asp Met Phe Gln Asn Gln Asp Arg Asn Gln Asp Gly

545 550 555 560

Lys Ile Thr Val Asp Glu Leu Lys Leu Lys Ser Asp Glu Asp Glu Glu

565 570 575

Arg Val His Glu Glu Leu

580

<210> 80

<211> 410

<212> PRT

<213> 智人(Homo sapiens)

<400> 80

Met Val Leu Ser Gln Arg Gln Arg Asp Glu Leu Asn Arg Ala Ile Ala

1 5 10 15

Asp Tyr Leu Arg Ser Asn Gly Tyr Glu Glu Ala Tyr Ser Val Phe Lys

20 25 30

Lys Glu Ala Glu Leu Asp Val Asn Glu Glu Leu Asp Lys Lys Tyr Ala

35 40 45

Gly Leu Leu Glu Lys Lys Trp Thr Ser Val Ile Arg Leu Gln Lys Lys

50 55 60

Val Met Glu Leu Glu Ser Lys Leu Asn Glu Ala Lys Glu Glu Phe Thr

65 70 75 80

Ser Gly Gly Pro Leu Gly Gln Lys Arg Asp Pro Lys Glu Trp Ile Pro

85 90 95

Arg Pro Pro Glu Lys Tyr Ala Leu Ser Gly His Arg Ser Pro Val Thr

100 105 110

Arg Val Ile Phe His Pro Val Phe Ser Val Met Val Ser Ala Ser Glu

115 120 125

Asp Ala Thr Ile Lys Val Trp Asp Tyr Glu Thr Gly Asp Phe Glu Arg

130 135 140

Thr Leu Lys Gly His Thr Asp Ser Val Gln Asp Ile Ser Phe Asp His

145 150 155 160

Ser Gly Lys Leu Leu Ala Ser Cys Ser Ala Asp Met Thr Ile Lys Leu

165 170 175

Trp Asp Phe Gln Gly Phe Glu Cys Ile Arg Thr Met His Gly His Asp

180 185 190

His Asn Val Ser Ser Val Ala Ile Met Pro Asn Gly Asp His Ile Val

195 200 205

Ser Ala Ser Arg Asp Lys Thr Ile Lys Met Trp Glu Val Gln Thr Gly

210 215 220

Tyr Cys Val Lys Thr Phe Thr Gly His Arg Glu Trp Val Arg Met Val

225 230 235 240

Arg Pro Asn Gln Asp Gly Thr Leu Ile Ala Ser Cys Ser Asn Asp Gln

245 250 255

Thr Val Arg Val Trp Val Val Ala Thr Lys Glu Cys Lys Ala Glu Leu

260 265 270

Arg Glu His Glu His Val Val Glu Cys Ile Ser Trp Ala Pro Glu Ser

275 280 285

Ser Tyr Ser Ser Ile Ser Glu Ala Thr Gly Ser Glu Thr Lys Lys Ser

290 295 300

Gly Lys Pro Gly Pro Phe Leu Leu Ser Gly Ser Arg Asp Lys Thr Ile

305 310 315 320

Lys Met Trp Asp Val Ser Thr Gly Met Cys Leu Met Thr Leu Val Gly

325 330 335

His Asp Asn Trp Val Arg Gly Val Leu Phe His Ser Gly Gly Lys Phe

340 345 350

Ile Leu Ser Cys Ala Asp Asp Lys Thr Leu Arg Val Trp Asp Tyr Lys

355 360 365

Asn Lys Arg Cys Met Lys Thr Leu Asn Ala His Glu His Phe Val Thr

370 375 380

Ser Leu Asp Phe His Lys Thr Ala Pro Tyr Val Val Thr Gly Ser Val

385 390 395 400

Asp Gln Thr Val Lys Val Trp Glu Cys Arg

405 410

<210> 81

<211> 98

<212> PRT

<213> 智人(Homo sapiens)

<400> 81

Met Ala Ala Glu Pro Leu Thr Glu Leu Glu Glu Ser Ile Glu Thr Val

1 5 10 15

Val Thr Thr Phe Phe Thr Phe Ala Arg Gln Glu Gly Arg Lys Asp Ser

20 25 30

Leu Ser Val Asn Glu Phe Lys Glu Leu Val Thr Gln Gln Leu Pro His

35 40 45

Leu Leu Lys Asp Val Gly Ser Leu Asp Glu Lys Met Lys Ser Leu Asp

50 55 60

Val Asn Gln Asp Ser Glu Leu Lys Phe Asn Glu Tyr Trp Arg Leu Ile

65 70 75 80

Gly Glu Leu Ala Lys Glu Ile Arg Lys Lys Lys Asp Leu Lys Ile Arg

85 90 95

Lys Lys

<210> 82

<211> 246

<212> PRT

<213> 智人(Homo sapiens)

<400> 82

Met Ser Arg Gly Ser Ser Ala Gly Phe Asp Arg His Ile Thr Ile Phe

1 5 10 15

Ser Pro Glu Gly Arg Leu Tyr Gln Val Glu Tyr Ala Phe Lys Ala Ile

20 25 30

Asn Gln Gly Gly Leu Thr Ser Val Ala Val Arg Gly Lys Asp Cys Ala

35 40 45

Val Ile Val Thr Gln Lys Lys Val Pro Asp Lys Leu Leu Asp Ser Ser

50 55 60

Thr Val Thr His Leu Phe Lys Ile Thr Glu Asn Ile Gly Cys Val Met

65 70 75 80

Thr Gly Met Thr Ala Asp Ser Arg Ser Gln Val Gln Arg Ala Arg Tyr

85 90 95

Glu Ala Ala Asn Trp Lys Tyr Lys Tyr Gly Tyr Glu Ile Pro Val Asp

100 105 110

Met Leu Cys Lys Arg Ile Ala Asp Ile Ser Gln Val Tyr Thr Gln Asn

115 120 125

Ala Glu Met Arg Pro Leu Gly Cys Cys Met Ile Leu Ile Gly Ile Asp

130 135 140

Glu Glu Gln Gly Pro Gln Val Tyr Lys Cys Asp Pro Ala Gly Tyr Tyr

145 150 155 160

Cys Gly Phe Lys Ala Thr Ala Ala Gly Val Lys Gln Thr Glu Ser Thr

165 170 175

Ser Phe Leu Glu Lys Lys Val Lys Lys Lys Phe Asp Trp Thr Phe Glu

180 185 190

Gln Thr Val Glu Thr Ala Ile Thr Cys Leu Ser Thr Val Leu Ser Ile

195 200 205

Asp Phe Lys Pro Ser Glu Ile Glu Val Gly Val Val Thr Val Glu Asn

210 215 220

Pro Lys Phe Arg Ile Leu Thr Glu Ala Glu Ile Asp Ala His Leu Val

225 230 235 240

Ala Leu Ala Glu Arg Asp

245

<210> 83

<211> 402

<212> PRT

<213> 智人(Homo sapiens)

<400> 83

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu

1 5 10 15

Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala

20 25 30

His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln

35 40 45

Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser

50 55 60

Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln

65 70 75 80

Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro

85 90 95

Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp

100 105 110

Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu

115 120 125

Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val

130 135 140

Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn

145 150 155 160

Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly

165 170 175

Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu

180 185 190

Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His

195 200 205

Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met

210 215 220

Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp

225 230 235 240

Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu

245 250 255

Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala

260 265 270

Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn

275 280 285

Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu

290 295 300

Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp

305 310 315 320

Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu

325 330 335

Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn

340 345 350

Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala

355 360 365

Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val

370 375 380

Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met

385 390 395 400

Glu Pro

<210> 84

<211> 709

<212> PRT

<213> 智人(Homo sapiens)

<400> 84

Met Pro Ser Ala Thr Ser His Ser Gly Ser Gly Ser Lys Ser Ser Gly

1 5 10 15

Pro Pro Pro Pro Ser Gly Ser Ser Gly Ser Glu Ala Ala Ala Gly Ala

20 25 30

Gly Ala Ala Ala Pro Ala Ser Gln His Pro Ala Thr Gly Thr Gly Ala

35 40 45

Val Gln Thr Glu Ala Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys

50 55 60

Leu Arg Asn Leu Glu Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu

65 70 75 80

Arg Met Asn Lys Gly Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val

85 90 95

Ser Lys Tyr Gln Glu Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu

100 105 110

Gln Arg Ser Phe Met Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys

115 120 125

Lys Thr Ala Arg Arg Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys

130 135 140

Arg Leu Lys Thr Val Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly

145 150 155 160

Asp Asp Glu Val Arg Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro

165 170 175

Ile Leu Ser Glu Glu Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu

180 185 190

Val Asp Pro Glu Arg Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu

195 200 205

His Ala Ser Ile His Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro

210 215 220

Val Cys Gly Thr Thr Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val

225 230 235 240

Phe Gln Ser Asn Tyr Phe Asp Ser Thr His Asn His Gln Asn Gly Leu

245 250 255

Cys Glu Glu Glu Glu Ala Ala Ser Ala Pro Ala Val Glu Asp Gln Val

260 265 270

Pro Glu Ala Glu Pro Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu

275 280 285

Val Glu Ser Thr Glu Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln

290 295 300

Phe Thr Ser Gly Glu Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr

305 310 315 320

Val Glu Val Val Asn Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro

325 330 335

Ser Val Pro Glu Pro His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro

340 345 350

Leu Val Arg Arg Gln Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly

355 360 365

Pro Tyr Asn Phe Ile Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr

370 375 380

Leu Asp Pro Ala Ile Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn

385 390 395 400

Met Asp Met Pro Gln Leu Val Cys Pro Pro Val His Ser Glu Ser Arg

405 410 415

Leu Ala Gln Pro Asn Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val

420 425 430

Pro Leu Val Ser Ser Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu

435 440 445

Tyr Gln Pro Ser His Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile

450 455 460

Asp Gln Ile Gln Ala Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala

465 470 475 480

Ser Ser Ser Leu Pro Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly

485 490 495

Thr Ser Lys Pro Leu His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro

500 505 510

Phe Gln Ser Met Gln Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro

515 520 525

Val Asn Glu Pro Glu Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala Ser

530 535 540

Tyr Asn Gln Ser Phe Ser Ser Gln Pro His Gln Val Glu Gln Thr Glu

545 550 555 560

Leu Gln Gln Glu Gln Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser

565 570 575

Pro Asp Gln Ser His Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln

580 585 590

Gln Asn Thr Gly Phe Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser Arg

595 600 605

Gly Val Ser Arg Gly Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly

610 615 620

Tyr Arg Gly Pro Ala Asn Gly Phe Arg Gly Gly Tyr Asp Gly Tyr Arg

625 630 635 640

Pro Ser Phe Ser Asn Thr Pro Asn Ser Gly Tyr Thr Gln Ser Gln Phe

645 650 655

Ser Ala Pro Arg Asp Tyr Ser Gly Tyr Gln Arg Asp Gly Tyr Gln Gln

660 665 670

Asn Phe Lys Arg Gly Ser Gly Gln Ser Gly Pro Arg Gly Ala Pro Arg

675 680 685

Gly Arg Gly Gly Pro Pro Arg Pro Asn Arg Gly Met Pro Gln Met Asn

690 695 700

Thr Gln Gln Val Asn

705

<210> 85

<211> 437

<212> PRT

<213> 智人(Homo sapiens)

<400> 85

Met Ser Val Ser Ala Arg Ser Ala Ala Ala Glu Glu Arg Ser Val Asn

1 5 10 15

Ser Ser Thr Met Val Ala Gln Gln Lys Asn Leu Glu Gly Tyr Val Gly

20 25 30

Phe Ala Asn Leu Pro Asn Gln Val Tyr Arg Lys Ser Val Lys Arg Gly

35 40 45

Phe Glu Phe Thr Leu Met Val Val Gly Glu Ser Gly Leu Gly Lys Ser

50 55 60

Thr Leu Ile Asn Ser Leu Phe Leu Thr Asp Leu Tyr Ser Pro Glu Tyr

65 70 75 80

Pro Gly Pro Ser His Arg Ile Lys Lys Thr Val Gln Val Glu Gln Ser

85 90 95

Lys Val Leu Ile Lys Glu Gly Gly Val Gln Leu Leu Leu Thr Ile Val

100 105 110

Asp Thr Pro Gly Phe Gly Asp Ala Val Asp Asn Ser Asn Cys Trp Gln

115 120 125

Pro Val Ile Asp Tyr Ile Asp Ser Lys Phe Glu Asp Tyr Leu Asn Ala

130 135 140

Glu Ser Arg Val Asn Arg Arg Gln Met Pro Asp Asn Arg Val Gln Cys

145 150 155 160

Cys Leu Tyr Phe Ile Ala Pro Ser Gly His Gly Leu Lys Pro Leu Asp

165 170 175

Ile Glu Phe Met Lys Arg Leu His Glu Lys Val Asn Ile Ile Pro Leu

180 185 190

Ile Ala Lys Ala Asp Thr Leu Thr Pro Glu Glu Cys Gln Gln Phe Lys

195 200 205

Lys Gln Ile Met Lys Glu Ile Gln Glu His Lys Ile Lys Ile Tyr Glu

210 215 220

Phe Pro Glu Thr Asp Asp Glu Glu Glu Asn Lys Leu Val Lys Lys Ile

225 230 235 240

Lys Asp Arg Leu Pro Leu Ala Val Val Gly Ser Asn Thr Ile Ile Glu

245 250 255

Val Asn Gly Lys Arg Val Arg Gly Arg Gln Tyr Pro Trp Gly Val Ala

260 265 270

Glu Val Glu Asn Gly Glu His Cys Asp Phe Thr Ile Leu Arg Asn Met

275 280 285

Leu Ile Arg Thr His Met Gln Asp Leu Lys Asp Val Thr Asn Asn Val

290 295 300

His Tyr Glu Asn Tyr Arg Ser Arg Lys Leu Ala Ala Val Thr Tyr Asn

305 310 315 320

Gly Val Asp Asn Asn Lys Asn Lys Gly Gln Leu Thr Lys Ser Pro Leu

325 330 335

Ala Gln Met Glu Glu Glu Arg Arg Glu His Val Ala Lys Met Lys Lys

340 345 350

Met Glu Met Glu Met Glu Gln Val Phe Glu Met Lys Val Lys Glu Lys

355 360 365

Val Gln Lys Leu Lys Asp Ser Glu Ala Glu Leu Gln Arg Arg His Glu

370 375 380

Gln Met Lys Lys Asn Leu Glu Ala Gln His Lys Glu Leu Glu Glu Lys

385 390 395 400

Arg Arg Gln Phe Glu Asp Glu Lys Ala Asn Trp Glu Ala Gln Gln Arg

405 410 415

Ile Leu Glu Gln Gln Asn Ser Ser Arg Thr Leu Glu Lys Asn Lys Lys

420 425 430

Lys Gly Lys Ile Phe

435

<210> 86

<211> 478

<212> PRT

<213> 智人(Homo sapiens)

<400> 86

Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val

1 5 10 15

Ala Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe

20 25 30

Asn Val Asp Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln

35 40 45

Ser Cys Cys Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg

50 55 60

Gly Asp Val Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp

65 70 75 80

Gly Glu Glu Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro

85 90 95

Ser Leu Thr Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln

100 105 110

Thr Pro Val Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly

115 120 125

Ala Ser Lys Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro

130 135 140

Gly Arg Pro Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro

145 150 155 160

Phe Asp Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg

165 170 175

Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr

180 185 190

Pro Lys Leu Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala

195 200 205

Ala Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly

210 215 220

Ser Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro

225 230 235 240

Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala

245 250 255

Ala Leu Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr

260 265 270

Phe Phe Lys Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro

275 280 285

Ser Gln Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His

290 295 300

Phe Ala Met Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu

305 310 315 320

Phe Trp Gly Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser

325 330 335

Arg Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly

340 345 350

Arg Ile Tyr Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys

355 360 365

Gln Arg Phe Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly

370 375 380

His Ser Arg Gly Arg Asn Gln Asn Ser Arg Arg Pro Ser Arg Ala Thr

385 390 395 400

Trp Leu Ser Leu Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn

405 410 415

Tyr Asp Asp Tyr Arg Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro

420 425 430

Ile Gln Ser Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn

435 440 445

Leu Arg Thr Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser

450 455 460

Ile Ala Gln Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu

465 470 475

<210> 87

<211> 863

<212> PRT

<213> 智人(Homo sapiens)

<400> 87

Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe

1 5 10 15

Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg

20 25 30

Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser

35 40 45

Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe

50 55 60

Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys

65 70 75 80

Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys

85 90 95

Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg

100 105 110

Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly

115 120 125

Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp

130 135 140

Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly

145 150 155 160

Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala

165 170 175

Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu

180 185 190

Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr

195 200 205

Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu

210 215 220

Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala

225 230 235 240

Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly

245 250 255

Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly

260 265 270

Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr

275 280 285

Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr

290 295 300

Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro

305 310 315 320

Phe Gly Pro Glu Met Thr Asn Pro Leu Arg Glu Ile Asp Lys Ile Val

325 330 335

Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu His Arg Cys Val

340 345 350

Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp Val Thr Cys Asp

355 360 365

Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val Asp Asp Ile Thr

370 375 380

Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys Phe Ser Asn Asn

385 390 395 400

Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu Thr Cys Lys Lys

405 410 415

Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His Leu Pro Lys Arg

420 425 430

Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile His Leu Leu Val

435 440 445

Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp Val Tyr Lys Lys

450 455 460

Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly Phe Asp Asn Lys

465 470 475 480

Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly Ser Thr Phe Lys

485 490 495

Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu Leu Tyr Asn Val

500 505 510

Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn Asn Gly Thr His

515 520 525

Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe Arg Pro Thr Met

530 535 540

Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile Met Tyr Leu Gln

545 550 555 560

Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys Val Glu Pro Lys

565 570 575

Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr Lys Gly Ser Thr

580 585 590

Glu Glu Arg His Leu Leu Tyr Gly Arg Pro Ala Val Leu Tyr Arg Thr

595 600 605

Arg Tyr Asp Ile Leu Tyr His Thr Asp Phe Glu Ser Gly Tyr Ser Glu

610 615 620

Ile Phe Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Ser Lys Gln Ala

625 630 635 640

Glu Val Ser Ser Val Pro Asp His Leu Thr Ser Cys Val Arg Pro Asp

645 650 655

Val Arg Val Ser Pro Ser Phe Ser Gln Asn Cys Leu Ala Tyr Lys Asn

660 665 670

Asp Lys Gln Met Ser Tyr Gly Phe Leu Phe Pro Pro Tyr Leu Ser Ser

675 680 685

Ser Pro Glu Ala Lys Tyr Asp Ala Phe Leu Val Thr Asn Met Val Pro

690 695 700

Met Tyr Pro Ala Phe Lys Arg Val Trp Asn Tyr Phe Gln Arg Val Leu

705 710 715 720

Val Lys Lys Tyr Ala Ser Glu Arg Asn Gly Val Asn Val Ile Ser Gly

725 730 735

Pro Ile Phe Asp Tyr Asp Tyr Asp Gly Leu His Asp Thr Glu Asp Lys

740 745 750

Ile Lys Gln Tyr Val Glu Gly Ser Ser Ile Pro Val Pro Thr His Tyr

755 760 765

Tyr Ser Ile Ile Thr Ser Cys Leu Asp Phe Thr Gln Pro Ala Asp Lys

770 775 780

Cys Asp Gly Pro Leu Ser Val Ser Ser Phe Ile Leu Pro His Arg Pro

785 790 795 800

Asp Asn Glu Glu Ser Cys Asn Ser Ser Glu Asp Glu Ser Lys Trp Val

805 810 815

Glu Glu Leu Met Lys Met His Thr Ala Arg Val Arg Asp Ile Glu His

820 825 830

Leu Thr Ser Leu Asp Phe Phe Arg Lys Thr Ser Arg Ser Tyr Pro Glu

835 840 845

Ile Leu Thr Leu Lys Thr Tyr Leu His Thr Tyr Glu Ser Glu Ile

850 855 860

<210> 88

<211> 1461

<212> PRT

<213> 智人(Homo sapiens)

<400> 88

Met Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe

1 5 10 15

Trp Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala

20 25 30

Ala Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg

35 40 45

Thr Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser

50 55 60

Val Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro

65 70 75 80

Ser Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val

85 90 95

Ser Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser

100 105 110

Asn Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln

115 120 125

Cys Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala

130 135 140

Lys Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro

145 150 155 160

Ser Ser Val Tyr Ala Gly Asn Asn Ala Ile Leu Asn Cys Glu Val Asn

165 170 175

Ala Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu

180 185 190

Leu Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile

195 200 205

Ser Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu

210 215 220

Ser Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu

225 230 235 240

Pro Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser

245 250 255

Pro Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala

260 265 270

Ser Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala

275 280 285

Leu Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser

290 295 300

Leu Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys

305 310 315 320

Ile Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr

325 330 335

Val Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala

340 345 350

His Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro

355 360 365

Thr Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser

370 375 380

Asp Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu

385 390 395 400

Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val

405 410 415

Gly Asn Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Glu His Ala Pro

420 425 430

Ala Thr Thr Gly Pro Leu Pro Ser Ala Pro Arg Asp Val Val Ala Ser

435 440 445

Leu Val Ser Thr Arg Phe Ile Lys Leu Thr Trp Arg Thr Pro Ala Ser

450 455 460

Asp Pro His Gly Asp Asn Leu Thr Tyr Ser Val Phe Tyr Thr Lys Glu

465 470 475 480

Gly Ile Ala Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met

485 490 495

Gln Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg

500 505 510

Val Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu

515 520 525

Arg Val Glu Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala Pro Asn

530 535 540

Leu Arg Ala Tyr Ala Ala Ser Pro Thr Ser Ile Thr Val Thr Trp Glu

545 550 555 560

Thr Pro Val Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu Tyr Tyr

565 570 575

Met Glu Lys Gly Thr Asp Lys Glu Gln Asp Val Asp Val Ser Ser His

580 585 590

Ser Tyr Thr Ile Asn Gly Leu Lys Lys Tyr Thr Glu Tyr Ser Phe Arg

595 600 605

Val Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Pro Asp Val

610 615 620

Ala Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu

625 630 635 640

Ser Leu Glu Val Arg Asn Ser Lys Ser Ile Met Ile His Trp Gln Pro

645 650 655

Pro Ala Pro Ala Thr Gln Asn Gly Gln Ile Thr Gly Tyr Lys Ile Arg

660 665 670

Tyr Arg Lys Ala Ser Arg Lys Ser Asp Val Thr Glu Thr Leu Val Ser

675 680 685

Gly Thr Gln Leu Ser Gln Leu Ile Glu Gly Leu Asp Arg Gly Thr Glu

690 695 700

Tyr Asn Phe Arg Val Ala Ala Leu Thr Ile Asn Gly Thr Gly Pro Ala

705 710 715 720

Thr Asp Trp Leu Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu Thr

725 730 735

Arg Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val Thr

740 745 750

Ser Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val Val

755 760 765

Arg Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln Thr

770 775 780

Ile Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu Asp

785 790 795 800

Pro Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val Gly

805 810 815

Glu Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Thr Asp

820 825 830

Thr Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro Val

835 840 845

Pro Asp Pro Thr Pro Met Met Pro Pro Val Gly Val Gln Ala Ser Ile

850 855 860

Leu Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu Pro

865 870 875 880

Lys His Gln Lys Ile Thr Asp Ser Arg Tyr Tyr Thr Val Arg Trp Lys

885 890 895

Thr Asn Ile Pro Ala Asn Thr Lys Tyr Lys Asn Ala Asn Ala Thr Thr

900 905 910

Leu Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu Phe

915 920 925

Ser Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met Thr

930 935 940

Ala His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys Asp

945 950 955 960

Val Thr Val Val Ser Lys Glu Gly Lys Pro Lys Thr Ile Ile Val Asn

965 970 975

Trp Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile Ile

980 985 990

Tyr Tyr Ser Thr Asp Val Asn Ala Glu Ile His Asp Trp Val Ile Glu

995 1000 1005

Pro Val Val Gly Asn Arg Leu Thr His Gln Ile Gln Glu Leu Thr

1010 1015 1020

Leu Asp Thr Pro Tyr Tyr Phe Lys Ile Gln Ala Arg Asn Ser Lys

1025 1030 1035

Gly Met Gly Pro Met Ser Glu Ala Val Gln Phe Arg Thr Pro Lys

1040 1045 1050

Ala Asp Ser Ser Asp Lys Met Pro Asn Asp Gln Ala Ser Gly Ser

1055 1060 1065

Gly Gly Lys Gly Ser Arg Leu Pro Asp Leu Gly Ser Asp Tyr Lys

1070 1075 1080

Pro Pro Met Ser Gly Ser Asn Ser Pro His Gly Ser Pro Thr Ser

1085 1090 1095

Pro Leu Asp Ser Asn Met Leu Leu Val Ile Ile Val Ser Val Gly

1100 1105 1110

Val Ile Thr Ile Val Val Val Val Ile Ile Ala Val Phe Cys Thr

1115 1120 1125

Arg Arg Thr Thr Ser His Gln Lys Lys Lys Arg Ala Ala Cys Lys

1130 1135 1140

Ser Val Asn Gly Ser His Lys Tyr Lys Gly Asn Ser Lys Asp Val

1145 1150 1155

Lys Pro Pro Asp Leu Trp Ile His His Glu Arg Leu Glu Leu Lys

1160 1165 1170

Pro Ile Asp Lys Ser Pro Asp Pro Asn Pro Ile Met Thr Asp Thr

1175 1180 1185

Pro Ile Pro Arg Asn Ser Gln Asp Ile Thr Pro Val Asp Asn Ser

1190 1195 1200

Met Asp Ser Asn Ile His Gln Arg Arg Asn Ser Tyr Arg Gly His

1205 1210 1215

Glu Ser Glu Asp Ser Met Ser Thr Leu Ala Gly Arg Arg Gly Met

1220 1225 1230

Arg Pro Lys Met Met Met Pro Phe Asp Ser Gln Pro Pro Gln Pro

1235 1240 1245

Val Ile Ser Ala His Pro Ile His Ser Leu Asp Asn Pro His His

1250 1255 1260

His Phe His Ser Ser Ser Leu Ala Ser Pro Ala Arg Ser His Leu

1265 1270 1275

Tyr His Pro Gly Ser Pro Trp Pro Ile Gly Thr Ser Met Ser Leu

1280 1285 1290

Ser Asp Arg Ala Asn Ser Thr Glu Ser Val Arg Asn Thr Pro Ser

1295 1300 1305

Thr Asp Thr Met Pro Ala Ser Ser Ser Gln Thr Cys Cys Thr Asp

1310 1315 1320

His Gln Asp Pro Glu Gly Ala Thr Ser Ser Ser Tyr Leu Ala Ser

1325 1330 1335

Ser Gln Glu Glu Asp Ser Gly Gln Ser Leu Pro Thr Ala His Val

1340 1345 1350

Arg Pro Ser His Pro Leu Lys Ser Phe Ala Val Pro Ala Ile Pro

1355 1360 1365

Pro Pro Gly Pro Pro Thr Tyr Asp Pro Ala Leu Pro Ser Thr Pro

1370 1375 1380

Leu Leu Ser Gln Gln Ala Leu Asn His His Ile His Ser Val Lys

1385 1390 1395

Thr Ala Ser Ile Gly Thr Leu Gly Arg Ser Arg Pro Pro Met Pro

1400 1405 1410

Val Val Val Pro Ser Ala Pro Glu Val Gln Glu Thr Thr Arg Met

1415 1420 1425

Leu Glu Asp Ser Glu Ser Ser Tyr Glu Pro Asp Glu Leu Thr Lys

1430 1435 1440

Glu Met Ala His Leu Glu Gly Leu Met Lys Asp Leu Asn Ala Ile

1445 1450 1455

Thr Thr Ala

1460

<210> 89

<211> 514

<212> PRT

<213> 智人(Homo sapiens)

<400> 89

Met Ala Asp Ala Glu Val Ile Ile Leu Pro Lys Lys His Lys Lys Lys

1 5 10 15

Lys Glu Arg Lys Ser Leu Pro Glu Glu Asp Val Ala Glu Ile Gln His

20 25 30

Ala Glu Glu Phe Leu Ile Lys Pro Glu Ser Lys Val Ala Lys Leu Asp

35 40 45

Thr Ser Gln Trp Pro Leu Leu Leu Lys Asn Phe Asp Lys Leu Asn Val

50 55 60

Arg Thr Thr His Tyr Thr Pro Leu Ala Cys Gly Ser Asn Pro Leu Lys

65 70 75 80

Arg Glu Ile Gly Asp Tyr Ile Arg Thr Gly Phe Ile Asn Leu Asp Lys

85 90 95

Pro Ser Asn Pro Ser Ser His Glu Val Val Ala Trp Ile Arg Arg Ile

100 105 110

Leu Arg Val Glu Lys Thr Gly His Ser Gly Thr Leu Asp Pro Lys Val

115 120 125

Thr Gly Cys Leu Ile Val Cys Ile Glu Arg Ala Thr Arg Leu Val Lys

130 135 140

Ser Gln Gln Ser Ala Gly Lys Glu Tyr Val Gly Ile Val Arg Leu His

145 150 155 160

Asn Ala Ile Glu Gly Gly Thr Gln Leu Ser Arg Ala Leu Glu Thr Leu

165 170 175

Thr Gly Ala Leu Phe Gln Arg Pro Pro Leu Ile Ala Ala Val Lys Arg

180 185 190

Gln Leu Arg Val Arg Thr Ile Tyr Glu Ser Lys Met Ile Glu Tyr Asp

195 200 205

Pro Glu Arg Arg Leu Gly Ile Phe Trp Val Ser Cys Glu Ala Gly Thr

210 215 220

Tyr Ile Arg Thr Leu Cys Val His Leu Gly Leu Leu Leu Gly Val Gly

225 230 235 240

Gly Gln Met Gln Glu Leu Arg Arg Val Arg Ser Gly Val Met Ser Glu

245 250 255

Lys Asp His Met Val Thr Met His Asp Val Leu Asp Ala Gln Trp Leu

260 265 270

Tyr Asp Asn His Lys Asp Glu Ser Tyr Leu Arg Arg Val Val Tyr Pro

275 280 285

Leu Glu Lys Leu Leu Thr Ser His Lys Arg Leu Val Met Lys Asp Ser

290 295 300

Ala Val Asn Ala Ile Cys Tyr Gly Ala Lys Ile Met Leu Pro Gly Val

305 310 315 320

Leu Arg Tyr Glu Asp Gly Ile Glu Val Asn Gln Glu Ile Val Val Ile

325 330 335

Thr Thr Lys Gly Glu Ala Ile Cys Met Ala Ile Ala Leu Met Thr Thr

340 345 350

Ala Val Ile Ser Thr Cys Asp His Gly Ile Val Ala Lys Ile Lys Arg

355 360 365

Val Ile Met Glu Arg Asp Thr Tyr Pro Arg Lys Trp Gly Leu Gly Pro

370 375 380

Lys Ala Ser Gln Lys Lys Leu Met Ile Lys Gln Gly Leu Leu Asp Lys

385 390 395 400

His Gly Lys Pro Thr Asp Ser Thr Pro Ala Thr Trp Lys Gln Glu Tyr

405 410 415

Val Asp Tyr Ser Glu Ser Ala Lys Lys Glu Val Val Ala Glu Val Val

420 425 430

Lys Ala Pro Gln Val Val Ala Glu Ala Ala Lys Thr Ala Lys Arg Lys

435 440 445

Arg Glu Ser Glu Ser Glu Ser Asp Glu Thr Pro Pro Ala Ala Pro Gln

450 455 460

Leu Ile Lys Lys Glu Lys Lys Lys Ser Lys Lys Asp Lys Lys Ala Lys

465 470 475 480

Ala Gly Leu Glu Ser Gly Ala Glu Pro Gly Asp Gly Asp Ser Asp Thr

485 490 495

Thr Lys Lys Lys Lys Lys Lys Lys Lys Ala Lys Glu Val Glu Leu Val

500 505 510

Ser Glu

<210> 90

<211> 383

<212> PRT

<213> 智人(Homo sapiens)

<400> 90

Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu

1 5 10 15

Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser

20 25 30

Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg

35 40 45

Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp

50 55 60

His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu

65 70 75 80

Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val

85 90 95

Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn

100 105 110

Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg

115 120 125

Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg

130 135 140

Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu

145 150 155 160

Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala

165 170 175

Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala

180 185 190

Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe

195 200 205

His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg

210 215 220

Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala

225 230 235 240

Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met

245 250 255

Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr

260 265 270

Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr

275 280 285

Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg

290 295 300

Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr

305 310 315 320

Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser

325 330 335

Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp

340 345 350

Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu

355 360 365

Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr

370 375 380

<210> 91

<211> 965

<212> PRT

<213> 智人(Homo sapiens)

<400> 91

Met Ala Leu Leu Cys Gly Leu Gly Gln Val Thr Leu Arg Ile Trp Val

1 5 10 15

Ser Leu Pro Ser Gln Ser Glu Asn Gly Ile Gly Phe Leu Ala Ala Arg

20 25 30

Ala Phe Leu Arg Ser Gly Gly Met Glu Ala Leu Thr Thr Gln Leu Gly

35 40 45

Pro Gly Arg Glu Gly Ser Ser Ser Pro Asn Ser Lys Gln Glu Leu Gln

50 55 60

Pro Tyr Ser Gly Ser Ser Ala Leu Lys Pro Asn Gln Val Gly Glu Thr

65 70 75 80

Ser Leu Tyr Gly Val Pro Ile Val Ser Leu Val Ile Asp Gly Gln Glu

85 90 95

Arg Leu Cys Leu Ala Gln Ile Ser Asn Thr Leu Leu Lys Asn Tyr Ser

100 105 110

Tyr Asn Glu Ile His Asn Arg Arg Val Ala Leu Gly Ile Thr Cys Val

115 120 125

Gln Cys Thr Pro Val Gln Leu Glu Ile Leu Arg Arg Ala Gly Ala Met

130 135 140

Pro Ile Ser Ser Arg Arg Cys Gly Met Ile Thr Lys Arg Glu Ala Glu

145 150 155 160

Arg Leu Cys Lys Ser Phe Leu Gly Glu His Lys Pro Pro Lys Leu Pro

165 170 175

Glu Asn Phe Ala Phe Asp Val Val His Glu Cys Ala Trp Gly Ser Arg

180 185 190

Gly Ser Phe Ile Pro Ala Arg Tyr Asn Ser Ser Arg Ala Lys Cys Ile

195 200 205

Lys Cys Gly Tyr Cys Ser Met Tyr Phe Ser Pro Asn Lys Phe Ile Phe

210 215 220

His Ser His Arg Thr Pro Asp Ala Lys Tyr Thr Gln Pro Asp Ala Ala

225 230 235 240

Asn Phe Asn Ser Trp Arg Arg His Leu Lys Leu Ser Asp Lys Ser Ala

245 250 255

Thr Asp Glu Leu Ser His Ala Trp Glu Asp Val Lys Ala Met Phe Asn

260 265 270

Gly Gly Thr Arg Lys Arg Thr Phe Ser Leu Gln Gly Gly Gly Gly Gly

275 280 285

Gly Ala Asn Gly Gly Ser Gly Gly Gln Gly Lys Gly Gly Ala Gly Gly

290 295 300

Gly Gly Gly Gly Gly Pro Gly Cys Gly Ala Glu Met Ala Pro Gly Pro

305 310 315 320

Pro Pro His Lys Ser Leu Arg Cys Gly Glu Asp Glu Ala Ala Gly Pro

325 330 335

Pro Gly Pro Pro Pro Pro His Pro Gln Arg Gly Leu Gly Leu Ala Thr

340 345 350

Gly Ala Ser Gly Pro Ala Gly Pro Gly Gly Pro Gly Gly Gly Ala Gly

355 360 365

Val Arg Ser Tyr Pro Val Ile Pro Val Pro Ser Lys Gly Phe Gly Leu

370 375 380

Leu Gln Lys Leu Pro Pro Pro Leu Phe Pro His Pro Tyr Gly Phe Pro

385 390 395 400

Thr Ala Phe Gly Leu Cys Pro Lys Lys Asp Asp Pro Val Leu Gly Ala

405 410 415

Gly Glu Pro Lys Gly Gly Pro Gly Thr Gly Ser Gly Gly Gly Gly Ala

420 425 430

Gly Thr Gly Gly Gly Ala Gly Gly Pro Gly Ala Ser His Leu Pro Pro

435 440 445

Gly Ala Gly Ala Gly Pro Gly Gly Gly Ala Met Phe Trp Gly His Gln

450 455 460

Pro Ser Gly Ala Ala Lys Asp Ala Ala Ala Val Ala Ala Ala Ala Ala

465 470 475 480

Ala Ala Thr Val Tyr Pro Thr Phe Pro Met Phe Trp Pro Ala Ala Gly

485 490 495

Ser Leu Pro Val Pro Ser Tyr Pro Ala Ala Gln Ser Gln Ala Lys Ala

500 505 510

Val Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala

515 520 525

Gly Ser Gly Ala Pro Glu Pro Leu Asp Gly Ala Glu Pro Ala Lys Glu

530 535 540

Ser Gly Leu Gly Ala Glu Glu Arg Cys Pro Ser Ala Leu Ser Arg Gly

545 550 555 560

Pro Leu Asp Glu Asp Gly Thr Asp Glu Ala Leu Pro Pro Pro Leu Ala

565 570 575

Pro Leu Pro Pro Pro Pro Pro Pro Pro Ala Arg Lys Gly Ser Tyr Val

580 585 590

Ser Ala Phe Arg Pro Val Val Lys Asp Thr Glu Ser Ile Ala Lys Leu

595 600 605

Tyr Gly Ser Ala Arg Glu Ala Tyr Gly Ala Gly Pro Ala Arg Gly Pro

610 615 620

Gly Pro Gly Ala Gly Ser Gly Gly Tyr Val Ser Pro Asp Phe Leu Ser

625 630 635 640

Glu Gly Ser Ser Ser Tyr Asn Ser Ala Ser Pro Asp Val Asp Thr Ala

645 650 655

Asp Glu Pro Glu Val Asp Val Glu Ser Asn Arg Phe Pro Asp Asp Glu

660 665 670

Asp Ala Gln Glu Glu Thr Glu Pro Ser Ala Pro Ser Ala Gly Gly Gly

675 680 685

Pro Asp Gly Glu Gln Pro Thr Gly Pro Pro Ser Ala Thr Ser Ser Gly

690 695 700

Ala Asp Gly Pro Ala Asn Ser Pro Asp Gly Gly Ser Pro Arg Pro Arg

705 710 715 720

Arg Arg Leu Gly Pro Pro Pro Ala Gly Arg Pro Ala Phe Gly Asp Leu

725 730 735

Ala Ala Glu Asp Leu Val Arg Arg Pro Glu Arg Ser Pro Pro Ser Gly

740 745 750

Gly Gly Gly Tyr Glu Leu Arg Glu Pro Cys Gly Pro Leu Gly Gly Pro

755 760 765

Ala Pro Ala Lys Val Phe Ala Pro Glu Arg Asp Glu His Val Lys Ser

770 775 780

Ala Ala Val Ala Leu Gly Pro Ala Ala Ser Tyr Val Cys Thr Pro Glu

785 790 795 800

Ala His Glu Pro Asp Lys Glu Asp Asn His Ser Pro Ala Asp Asp Leu

805 810 815

Glu Thr Arg Lys Ser Tyr Pro Asp Gln Arg Ser Ile Ser Gln Pro Ser

820 825 830

Pro Ala Asn Thr Asp Arg Gly Glu Asp Gly Leu Thr Leu Asp Val Thr

835 840 845

Gly Thr His Leu Val Glu Lys Asp Ile Glu Asn Leu Ala Arg Glu Glu

850 855 860

Leu Gln Lys Leu Leu Leu Glu Gln Met Glu Leu Arg Lys Lys Leu Glu

865 870 875 880

Arg Glu Phe Gln Ser Leu Lys Asp Asn Phe Gln Asp Gln Met Lys Arg

885 890 895

Glu Leu Ala Tyr Arg Glu Glu Met Val Gln Gln Leu Gln Ile Val Arg

900 905 910

Asp Thr Leu Cys Asn Glu Leu Asp Gln Glu Arg Lys Ala Arg Tyr Ala

915 920 925

Ile Gln Gln Lys Leu Lys Glu Ala His Asp Ala Leu His His Phe Ser

930 935 940

Cys Lys Met Leu Thr Pro Arg His Cys Thr Gly Asn Cys Ser Phe Lys

945 950 955 960

Pro Pro Leu Leu Pro

965

<210> 92

<211> 709

<212> PRT

<213> 智人(Homo sapiens)

<400> 92

Met Ala Glu Thr Leu Glu Phe Asn Asp Val Tyr Gln Glu Val Lys Gly

1 5 10 15

Ser Met Asn Asp Gly Arg Leu Arg Leu Ser Arg Gln Gly Ile Ile Phe

20 25 30

Lys Asn Ser Lys Thr Gly Lys Val Asp Asn Ile Gln Ala Gly Glu Leu

35 40 45

Thr Glu Gly Ile Trp Arg Arg Val Ala Leu Gly His Gly Leu Lys Leu

50 55 60

Leu Thr Lys Asn Gly His Val Tyr Lys Tyr Asp Gly Phe Arg Glu Ser

65 70 75 80

Glu Phe Glu Lys Leu Ser Asp Phe Phe Lys Thr His Tyr Arg Leu Glu

85 90 95

Leu Met Glu Lys Asp Leu Cys Val Lys Gly Trp Asn Trp Gly Thr Val

100 105 110

Lys Phe Gly Gly Gln Leu Leu Ser Phe Asp Ile Gly Asp Gln Pro Val

115 120 125

Phe Glu Ile Pro Leu Ser Asn Val Ser Gln Cys Thr Thr Gly Lys Asn

130 135 140

Glu Val Thr Leu Glu Phe His Gln Asn Asp Asp Ala Glu Val Ser Leu

145 150 155 160

Met Glu Val Arg Phe Tyr Val Pro Pro Thr Gln Glu Asp Gly Val Asp

165 170 175

Pro Val Glu Ala Phe Ala Gln Asn Val Leu Ser Lys Ala Asp Val Ile

180 185 190

Gln Ala Thr Gly Asp Ala Ile Cys Ile Phe Arg Glu Leu Gln Cys Leu

195 200 205

Thr Pro Arg Gly Arg Tyr Asp Ile Arg Ile Tyr Pro Thr Phe Leu His

210 215 220

Leu His Gly Lys Thr Phe Asp Tyr Lys Ile Pro Tyr Thr Thr Val Leu

225 230 235 240

Arg Leu Phe Leu Leu Pro His Lys Asp Gln Arg Gln Met Phe Phe Val

245 250 255

Ile Ser Leu Asp Pro Pro Ile Lys Gln Gly Gln Thr Arg Tyr His Phe

260 265 270

Leu Ile Leu Leu Phe Ser Lys Asp Glu Asp Ile Ser Leu Thr Leu Asn

275 280 285

Met Asn Glu Glu Glu Val Glu Lys Arg Phe Glu Gly Arg Leu Thr Lys

290 295 300

Asn Met Ser Gly Ser Leu Tyr Glu Met Val Ser Arg Val Met Lys Ala

305 310 315 320

Leu Val Asn Arg Lys Ile Thr Val Pro Gly Asn Phe Gln Gly His Ser

325 330 335

Gly Ala Gln Cys Ile Thr Cys Ser Tyr Lys Ala Ser Ser Gly Leu Leu

340 345 350

Tyr Pro Leu Glu Arg Gly Phe Ile Tyr Val His Lys Pro Pro Val His

355 360 365

Ile Arg Phe Asp Glu Ile Ser Phe Val Asn Phe Ala Arg Gly Thr Thr

370 375 380

Thr Thr Arg Ser Phe Asp Phe Glu Ile Glu Thr Lys Gln Gly Thr Gln

385 390 395 400

Tyr Thr Phe Ser Ser Ile Glu Arg Glu Glu Tyr Gly Lys Leu Phe Asp

405 410 415

Phe Val Asn Ala Lys Lys Leu Asn Ile Lys Asn Arg Gly Leu Lys Glu

420 425 430

Gly Met Asn Pro Ser Tyr Asp Glu Tyr Ala Asp Ser Asp Glu Asp Gln

435 440 445

His Asp Ala Tyr Leu Glu Arg Met Lys Glu Glu Gly Lys Ile Arg Glu

450 455 460

Glu Asn Ala Asn Asp Ser Ser Asp Asp Ser Gly Glu Glu Thr Asp Glu

465 470 475 480

Ser Phe Asn Pro Gly Glu Glu Glu Glu Asp Val Ala Glu Glu Phe Asp

485 490 495

Ser Asn Ala Ser Ala Ser Ser Ser Ser Asn Glu Gly Asp Ser Asp Arg

500 505 510

Asp Glu Lys Lys Arg Lys Gln Leu Lys Lys Ala Lys Met Ala Lys Asp

515 520 525

Arg Lys Ser Arg Lys Lys Pro Val Glu Val Lys Lys Gly Lys Asp Pro

530 535 540

Asn Ala Pro Lys Arg Pro Met Ser Ala Tyr Met Leu Trp Leu Asn Ala

545 550 555 560

Ser Arg Glu Lys Ile Lys Ser Asp His Pro Gly Ile Ser Ile Thr Asp

565 570 575

Leu Ser Lys Lys Ala Gly Glu Ile Trp Lys Gly Met Ser Lys Glu Lys

580 585 590

Lys Glu Glu Trp Asp Arg Lys Ala Glu Asp Ala Arg Arg Asp Tyr Glu

595 600 605

Lys Ala Met Lys Glu Tyr Glu Gly Gly Arg Gly Glu Ser Ser Lys Arg

610 615 620

Asp Lys Ser Lys Lys Lys Lys Lys Val Lys Val Lys Met Glu Lys Lys

625 630 635 640

Ser Thr Pro Ser Arg Gly Ser Ser Ser Lys Ser Ser Ser Arg Gln Leu

645 650 655

Ser Glu Ser Phe Lys Ser Lys Glu Phe Val Ser Ser Asp Glu Ser Ser

660 665 670

Ser Gly Glu Asn Lys Ser Lys Lys Lys Arg Arg Arg Ser Glu Asp Ser

675 680 685

Glu Glu Glu Glu Leu Ala Ser Thr Pro Pro Ser Ser Glu Asp Ser Ala

690 695 700

Ser Gly Ser Asp Glu

705

<210> 93

<211> 1712

<212> PRT

<213> 智人(Homo sapiens)

<400> 93

Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp

1 5 10 15

Leu Leu Leu Gly Thr Val Thr Val Gly Phe Leu Ala Gln Ser Val Leu

20 25 30

Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser

35 40 45

Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly

50 55 60

Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe

65 70 75 80

Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro

85 90 95

Gly Val Thr Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser Gly

100 105 110

Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln Gly Gly Pro

115 120 125

Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly Thr Gln Gly Asp Ser

130 135 140

Gly Pro Gln Gly Pro Pro Gly Ser Glu Gly Phe Thr Gly Pro Pro Gly

145 150 155 160

Pro Gln Gly Pro Lys Gly Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys

165 170 175

Glu Glu Arg Asp Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val

180 185 190

Gly Phe Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly

195 200 205

Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro

210 215 220

Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys Gly

225 230 235 240

Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly Ile Pro Ser Asp

245 250 255

Thr Leu His Pro Ile Ile Ala Pro Thr Gly Val Thr Phe His Pro Asp

260 265 270

Gln Tyr Lys Gly Glu Lys Gly Ser Glu Gly Glu Pro Gly Ile Arg Gly

275 280 285

Ile Ser Leu Lys Gly Glu Glu Gly Ile Met Gly Phe Pro Gly Leu Arg

290 295 300

Gly Tyr Pro Gly Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly

305 310 315 320

Ser Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro

325 330 335

Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser

340 345 350

Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly Phe Pro

355 360 365

Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro Gly Asp Pro Gly

370 375 380

Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly Asp Gly Asp Gln Arg Arg

385 390 395 400

Gly Leu Pro Gly Glu Met Gly Pro Lys Gly Phe Ile Gly Asp Pro Gly

405 410 415

Ile Pro Ala Leu Tyr Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly

420 425 430

Pro Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe

435 440 445

Leu Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu

450 455 460

Pro Gly Ser Pro Gly Ala Arg Gly Pro Lys Gly Trp Lys Gly Asp Ala

465 470 475 480

Gly Glu Cys Arg Cys Thr Glu Gly Asp Glu Ala Ile Lys Gly Leu Pro

485 490 495

Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile Asn Gly Glu Pro Gly

500 505 510

Arg Lys Gly Asp Arg Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe

515 520 525

Pro Gly Leu Lys Gly Val Pro Gly Asn Ile Gly Ala Pro Gly Pro Lys

530 535 540

Gly Ala Lys Gly Asp Ser Arg Thr Ile Thr Thr Lys Gly Glu Arg Gly

545 550 555 560

Gln Pro Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser

565 570 575

Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro

580 585 590

Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly Ile

595 600 605

Pro Gly Thr Lys Gly Thr Pro Gly Glu Met Gly Pro Pro Gly Leu Gly

610 615 620

Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro Gly Asp Ala Gly Leu

625 630 635 640

Pro Gly Pro Pro Gly Phe Leu Gly Pro Pro Gly Pro Ala Gly Thr Pro

645 650 655

Gly Gln Ile Asp Cys Asp Thr Asp Val Lys Arg Ala Val Gly Gly Asp

660 665 670

Arg Gln Glu Ala Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu

675 680 685

Pro Gly Leu Pro Gly Pro Pro Gly Pro Thr Gly Ala Lys Gly Leu Arg

690 695 700

Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly

705 710 715 720

Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro Gly Phe

725 730 735

Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu Pro Gly Pro Asp

740 745 750

Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly Pro Asp Gly Pro Pro Gly

755 760 765

Glu Arg Gly Leu Pro Gly Glu Val Leu Gly Ala Gln Pro Gly Pro Arg

770 775 780

Gly Asp Ala Gly Val Pro Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly

785 790 795 800

Asp Arg Gly Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met

805 810 815

Pro Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro

820 825 830

Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly

835 840 845

Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu Gly Leu

850 855 860

Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala Pro Gly Pro Val

865 870 875 880

Gly Met Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala Gly Phe Thr Gly

885 890 895

Glu Gln Gly His Pro Gly Ser Pro Gly Phe Lys Gly Ile Asp Gly Met

900 905 910

Pro Gly Thr Pro Gly Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp

915 920 925

Gly Phe Gln Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly

930 935 940

Ser Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu

945 950 955 960

Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro Pro

965 970 975

Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile Lys Gly Glu

980 985 990

Lys Gly Asp Glu Gly Pro Met Gly Leu Lys Gly Tyr Leu Gly Ala Lys

995 1000 1005

Gly Ile Gln Gly Met Pro Gly Ile Pro Gly Leu Ser Gly Ile Pro

1010 1015 1020

Gly Leu Pro Gly Arg Pro Gly His Ile Lys Gly Val Lys Gly Asp

1025 1030 1035

Ile Gly Val Pro Gly Ile Pro Gly Leu Pro Gly Phe Pro Gly Val

1040 1045 1050

Ala Gly Pro Pro Gly Ile Thr Gly Phe Pro Gly Phe Ile Gly Ser

1055 1060 1065

Arg Gly Asp Lys Gly Ala Pro Gly Arg Ala Gly Leu Tyr Gly Glu

1070 1075 1080

Ile Gly Ala Thr Gly Asp Phe Gly Asp Ile Gly Asp Thr Ile Asn

1085 1090 1095

Leu Pro Gly Arg Pro Gly Leu Lys Gly Glu Arg Gly Thr Thr Gly

1100 1105 1110

Ile Pro Gly Leu Lys Gly Phe Phe Gly Glu Lys Gly Thr Glu Gly

1115 1120 1125

Asp Ile Gly Phe Pro Gly Ile Thr Gly Val Thr Gly Val Gln Gly

1130 1135 1140

Pro Pro Gly Leu Lys Gly Gln Thr Gly Phe Pro Gly Leu Thr Gly

1145 1150 1155

Pro Pro Gly Ser Gln Gly Glu Leu Gly Arg Ile Gly Leu Pro Gly

1160 1165 1170

Gly Lys Gly Asp Asp Gly Trp Pro Gly Ala Pro Gly Leu Pro Gly

1175 1180 1185

Phe Pro Gly Leu Arg Gly Ile Arg Gly Leu His Gly Leu Pro Gly

1190 1195 1200

Thr Lys Gly Phe Pro Gly Ser Pro Gly Ser Asp Ile His Gly Asp

1205 1210 1215

Pro Gly Phe Pro Gly Pro Pro Gly Glu Arg Gly Asp Pro Gly Glu

1220 1225 1230

Ala Asn Thr Leu Pro Gly Pro Val Gly Val Pro Gly Gln Lys Gly

1235 1240 1245

Asp Gln Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Ser Pro Gly

1250 1255 1260

Leu Gln Gly Phe Pro Gly Ile Thr Pro Pro Ser Asn Ile Ser Gly

1265 1270 1275

Ala Pro Gly Asp Lys Gly Ala Pro Gly Ile Phe Gly Leu Lys Gly

1280 1285 1290

Tyr Arg Gly Pro Pro Gly Pro Pro Gly Ser Ala Ala Leu Pro Gly

1295 1300 1305

Ser Lys Gly Asp Thr Gly Asn Pro Gly Ala Pro Gly Thr Pro Gly

1310 1315 1320

Thr Lys Gly Trp Ala Gly Asp Ser Gly Pro Gln Gly Arg Pro Gly

1325 1330 1335

Val Phe Gly Leu Pro Gly Glu Lys Gly Pro Arg Gly Glu Gln Gly

1340 1345 1350

Phe Met Gly Asn Thr Gly Pro Thr Gly Ala Val Gly Asp Arg Gly

1355 1360 1365

Pro Lys Gly Pro Lys Gly Asp Pro Gly Phe Pro Gly Ala Pro Gly

1370 1375 1380

Thr Val Gly Ala Pro Gly Ile Ala Gly Ile Pro Gln Lys Ile Ala

1385 1390 1395

Val Gln Pro Gly Thr Val Gly Pro Gln Gly Arg Arg Gly Pro Pro

1400 1405 1410

Gly Ala Pro Gly Glu Met Gly Pro Gln Gly Pro Pro Gly Glu Pro

1415 1420 1425

Gly Phe Arg Gly Ala Pro Gly Lys Ala Gly Pro Gln Gly Arg Gly

1430 1435 1440

Gly Val Ser Ala Val Pro Gly Phe Arg Gly Asp Glu Gly Pro Ile

1445 1450 1455

Gly His Gln Gly Pro Ile Gly Gln Glu Gly Ala Pro Gly Arg Pro

1460 1465 1470

Gly Ser Pro Gly Leu Pro Gly Met Pro Gly Arg Ser Val Ser Ile

1475 1480 1485

Gly Tyr Leu Leu Val Lys His Ser Gln Thr Asp Gln Glu Pro Met

1490 1495 1500

Cys Pro Val Gly Met Asn Lys Leu Trp Ser Gly Tyr Ser Leu Leu

1505 1510 1515

Tyr Phe Glu Gly Gln Glu Lys Ala His Asn Gln Asp Leu Gly Leu

1520 1525 1530

Ala Gly Ser Cys Leu Ala Arg Phe Ser Thr Met Pro Phe Leu Tyr

1535 1540 1545

Cys Asn Pro Gly Asp Val Cys Tyr Tyr Ala Ser Arg Asn Asp Lys

1550 1555 1560

Ser Tyr Trp Leu Ser Thr Thr Ala Pro Leu Pro Met Met Pro Val

1565 1570 1575

Ala Glu Asp Glu Ile Lys Pro Tyr Ile Ser Arg Cys Ser Val Cys

1580 1585 1590

Glu Ala Pro Ala Ile Ala Ile Ala Val His Ser Gln Asp Val Ser

1595 1600 1605

Ile Pro His Cys Pro Ala Gly Trp Arg Ser Leu Trp Ile Gly Tyr

1610 1615 1620

Ser Phe Leu Met His Thr Ala Ala Gly Asp Glu Gly Gly Gly Gln

1625 1630 1635

Ser Leu Val Ser Pro Gly Ser Cys Leu Glu Asp Phe Arg Ala Thr

1640 1645 1650

Pro Phe Ile Glu Cys Asn Gly Gly Arg Gly Thr Cys His Tyr Tyr

1655 1660 1665

Ala Asn Lys Tyr Ser Phe Trp Leu Thr Thr Ile Pro Glu Gln Ser

1670 1675 1680

Phe Gln Gly Ser Pro Ser Ala Asp Thr Leu Lys Ala Gly Leu Ile

1685 1690 1695

Arg Thr His Ile Ser Arg Cys Gln Val Cys Met Lys Asn Leu

1700 1705 1710

<210> 94

<211> 152

<212> PRT

<213> 智人(Homo sapiens)

<400> 94

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val

1 5 10 15

Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly

20 25 30

Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu

35 40 45

Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu

50 55 60

Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly

65 70 75 80

Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro

85 90 95

Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val

100 105 110

Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys

115 120 125

Glu Ile Gly Leu Trp Phe His Pro Glu Glu Leu Val Asp Tyr Thr Ser

130 135 140

Cys Ala Gln Asn Trp Ile Tyr Glu

145 150

<210> 95

<211> 764

<212> PRT

<213> 智人(Homo sapiens)

<400> 95

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu

1 5 10 15

Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg

20 25 30

Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser

35 40 45

Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser

50 55 60

Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly

65 70 75 80

Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala

85 90 95

Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly

100 105 110

Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser

115 120 125

Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr

130 135 140

Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn

145 150 155 160

Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys

165 170 175

Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser

180 185 190

Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly

195 200 205

Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr

210 215 220

Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu

225 230 235 240

Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln

245 250 255

Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr

260 265 270

Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly

275 280 285

Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly

290 295 300

Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile

305 310 315 320

Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr

325 330 335

Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly

340 345 350

Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp

355 360 365

Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile

370 375 380

Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr

385 390 395 400

Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys

405 410 415

Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro

420 425 430

Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn

435 440 445

Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val

450 455 460

Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met

465 470 475 480

Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln

485 490 495

Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met

500 505 510

Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe

515 520 525

Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu

530 535 540

Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn

545 550 555 560

Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp

565 570 575

Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile

580 585 590

Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg

595 600 605

Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro

610 615 620

Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu

625 630 635 640

Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys

645 650 655

Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile

660 665 670

Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro

675 680 685

Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile

690 695 700

Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly

705 710 715 720

Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala

725 730 735

His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu

740 745 750

Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu

755 760

<210> 96

<211> 472

<212> PRT

<213> 智人(Homo sapiens)

<400> 96

Met Ala Gly Gly Glu Ala Gly Val Thr Leu Gly Gln Pro His Leu Ser

1 5 10 15

Arg Gln Asp Leu Thr Thr Leu Asp Val Thr Lys Leu Thr Pro Leu Ser

20 25 30

His Glu Val Ile Ser Arg Gln Ala Thr Ile Asn Ile Gly Thr Ile Gly

35 40 45

His Val Ala His Gly Lys Ser Thr Val Val Lys Ala Ile Ser Gly Val

50 55 60

His Thr Val Arg Phe Lys Asn Glu Leu Glu Arg Asn Ile Thr Ile Lys

65 70 75 80

Leu Gly Tyr Ala Asn Ala Lys Ile Tyr Lys Leu Asp Asp Pro Ser Cys

85 90 95

Pro Arg Pro Glu Cys Tyr Arg Ser Cys Gly Ser Ser Thr Pro Asp Glu

100 105 110

Phe Pro Thr Asp Ile Pro Gly Thr Lys Gly Asn Phe Lys Leu Val Arg

115 120 125

His Val Ser Phe Val Asp Cys Pro Gly His Asp Ile Leu Met Ala Thr

130 135 140

Met Leu Asn Gly Ala Ala Val Met Asp Ala Ala Leu Leu Leu Ile Ala

145 150 155 160

Gly Asn Glu Ser Cys Pro Gln Pro Gln Thr Ser Glu His Leu Ala Ala

165 170 175

Ile Glu Ile Met Lys Leu Lys His Ile Leu Ile Leu Gln Asn Lys Ile

180 185 190

Asp Leu Val Lys Glu Ser Gln Ala Lys Glu Gln Tyr Glu Gln Ile Leu

195 200 205

Ala Phe Val Gln Gly Thr Val Ala Glu Gly Ala Pro Ile Ile Pro Ile

210 215 220

Ser Ala Gln Leu Lys Tyr Asn Ile Glu Val Val Cys Glu Tyr Ile Val

225 230 235 240

Lys Lys Ile Pro Val Pro Pro Arg Asp Phe Thr Ser Glu Pro Arg Leu

245 250 255

Ile Val Ile Arg Ser Phe Asp Val Asn Lys Pro Gly Cys Glu Val Asp

260 265 270

Asp Leu Lys Gly Gly Val Ala Gly Gly Ser Ile Leu Lys Gly Val Leu

275 280 285

Lys Val Gly Gln Glu Ile Glu Val Arg Pro Gly Ile Val Ser Lys Asp

290 295 300

Ser Glu Gly Lys Leu Met Cys Lys Pro Ile Phe Ser Lys Ile Val Ser

305 310 315 320

Leu Phe Ala Glu His Asn Asp Leu Gln Tyr Ala Ala Pro Gly Gly Leu

325 330 335

Ile Gly Val Gly Thr Lys Ile Asp Pro Thr Leu Cys Arg Ala Asp Arg

340 345 350

Met Val Gly Gln Val Leu Gly Ala Val Gly Ala Leu Pro Glu Ile Phe

355 360 365

Thr Glu Leu Glu Ile Ser Tyr Phe Leu Leu Arg Arg Leu Leu Gly Val

370 375 380

Arg Thr Glu Gly Asp Lys Lys Ala Ala Lys Val Gln Lys Leu Ser Lys

385 390 395 400

Asn Glu Val Leu Met Val Asn Ile Gly Ser Leu Ser Thr Gly Gly Arg

405 410 415

Val Ser Ala Val Lys Ala Asp Leu Gly Lys Ile Val Leu Thr Asn Pro

420 425 430

Val Cys Thr Glu Val Gly Glu Lys Ile Ala Leu Ser Arg Arg Val Glu

435 440 445

Lys His Trp Arg Leu Ile Gly Trp Gly Gln Ile Arg Arg Gly Val Thr

450 455 460

Ile Lys Pro Thr Val Asp Asp Asp

465 470

<210> 97

<211> 572

<212> PRT

<213> 智人(Homo sapiens)

<400> 97

Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Arg Ile Thr Ser Asp Arg

1 5 10 15

Leu Leu Ile Lys Gly Gly Lys Ile Val Asn Asp Asp Gln Ser Phe Tyr

20 25 30

Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn

35 40 45

Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala His Ser Arg Met

50 55 60

Val Ile Pro Gly Gly Ile Asp Val His Thr Arg Phe Gln Met Pro Asp

65 70 75 80

Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala

85 90 95

Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro

100 105 110

Gly Thr Ser Leu Leu Ala Ala Phe Asp Gln Trp Arg Glu Trp Ala Asp

115 120 125

Ser Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Ser Glu Trp

130 135 140

His Lys Gly Ile Gln Glu Glu Met Glu Ala Leu Val Lys Asp His Gly

145 150 155 160

Val Asn Ser Phe Leu Val Tyr Met Ala Phe Lys Asp Arg Phe Gln Leu

165 170 175

Thr Asp Cys Gln Ile Tyr Glu Val Leu Ser Val Ile Arg Asp Ile Gly

180 185 190

Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala Glu Glu

195 200 205

Gln Gln Arg Ile Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly His Val

210 215 220

Leu Ser Arg Pro Glu Glu Val Glu Ala Glu Ala Val Asn Arg Ala Ile

225 230 235 240

Thr Ile Ala Asn Gln Thr Asn Cys Pro Leu Tyr Ile Thr Lys Val Met

245 250 255

Ser Lys Ser Ser Ala Glu Val Ile Ala Gln Ala Arg Lys Lys Gly Thr

260 265 270

Val Val Tyr Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser

275 280 285

His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser

290 295 300

Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Phe Leu Asn Ser Leu

305 310 315 320

Leu Ser Cys Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe

325 330 335

Asn Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro

340 345 350

Glu Gly Thr Asn Gly Thr Glu Glu Arg Met Ser Val Ile Trp Asp Lys

355 360 365

Ala Val Val Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr

370 375 380

Ser Thr Asn Ala Ala Lys Val Phe Asn Leu Tyr Pro Arg Lys Gly Arg

385 390 395 400

Ile Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asp Pro Asp Ser

405 410 415

Val Lys Thr Ile Ser Ala Lys Thr His Asn Ser Ser Leu Glu Tyr Asn

420 425 430

Ile Phe Glu Gly Met Glu Cys Arg Gly Ser Pro Leu Val Val Ile Ser

435 440 445

Gln Gly Lys Ile Val Leu Glu Asp Gly Thr Leu His Val Thr Glu Gly

450 455 460

Ser Gly Arg Tyr Ile Pro Arg Lys Pro Phe Pro Asp Phe Val Tyr Lys

465 470 475 480

Arg Ile Lys Ala Arg Ser Arg Leu Ala Glu Leu Arg Gly Val Pro Arg

485 490 495

Gly Leu Tyr Asp Gly Pro Val Cys Glu Val Ser Val Thr Pro Lys Thr

500 505 510

Val Thr Pro Ala Ser Ser Ala Lys Thr Ser Pro Ala Lys Gln Gln Ala

515 520 525

Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ala

530 535 540

Gln Ile Asp Asp Asn Ile Pro Arg Arg Thr Thr Gln Arg Ile Val Ala

545 550 555 560

Pro Pro Gly Gly Arg Ala Asn Ile Thr Ser Leu Gly

565 570

<210> 98

<211> 2115

<212> PRT

<213> 智人(Homo sapiens)

<400> 98

Met Thr Leu His Ala Thr Arg Gly Ala Ala Leu Leu Ser Trp Val Asn

1 5 10 15

Ser Leu His Val Ala Asp Pro Val Glu Ala Val Leu Gln Leu Gln Asp

20 25 30

Cys Ser Ile Phe Ile Lys Ile Ile Asp Arg Ile His Gly Thr Glu Glu

35 40 45

Gly Gln Gln Ile Leu Lys Gln Pro Val Ser Glu Arg Leu Asp Phe Val

50 55 60

Cys Ser Phe Leu Gln Lys Asn Arg Lys His Pro Ser Ser Pro Glu Cys

65 70 75 80

Leu Val Ser Ala Gln Lys Val Leu Glu Gly Ser Glu Leu Glu Leu Ala

85 90 95

Lys Met Thr Met Leu Leu Leu Tyr His Ser Thr Met Ser Ser Lys Ser

100 105 110

Pro Arg Asp Trp Glu Gln Phe Glu Tyr Lys Ile Gln Ala Glu Leu Ala

115 120 125

Val Ile Leu Lys Phe Val Leu Asp His Glu Asp Gly Leu Asn Leu Asn

130 135 140

Glu Asp Leu Glu Asn Phe Leu Gln Lys Ala Pro Val Pro Ser Thr Cys

145 150 155 160

Ser Ser Thr Phe Pro Glu Glu Leu Ser Pro Pro Ser His Gln Ala Lys

165 170 175

Arg Glu Ile Arg Phe Leu Glu Leu Gln Lys Val Ala Ser Ser Ser Ser

180 185 190

Gly Asn Asn Phe Leu Ser Gly Ser Pro Ala Ser Pro Met Gly Asp Ile

195 200 205

Leu Gln Thr Pro Gln Phe Gln Met Arg Arg Leu Lys Lys Gln Leu Ala

210 215 220

Asp Glu Arg Ser Asn Arg Asp Glu Leu Glu Leu Glu Leu Ala Glu Asn

225 230 235 240

Arg Lys Leu Leu Thr Glu Lys Asp Ala Gln Ile Ala Met Met Gln Gln

245 250 255

Arg Ile Asp Arg Leu Ala Leu Leu Asn Glu Lys Gln Ala Ala Ser Pro

260 265 270

Leu Glu Pro Lys Glu Leu Glu Glu Leu Arg Asp Lys Asn Glu Ser Leu

275 280 285

Thr Met Arg Leu His Glu Thr Leu Lys Gln Cys Gln Asp Leu Lys Thr

290 295 300

Glu Lys Ser Gln Met Asp Arg Lys Ile Asn Gln Leu Ser Glu Glu Asn

305 310 315 320

Gly Asp Leu Ser Phe Lys Leu Arg Glu Phe Ala Ser His Leu Gln Gln

325 330 335

Leu Gln Asp Ala Leu Asn Glu Leu Thr Glu Glu His Ser Lys Ala Thr

340 345 350

Gln Glu Trp Leu Glu Lys Gln Ala Gln Leu Glu Lys Glu Leu Ser Ala

355 360 365

Ala Leu Gln Asp Lys Lys Cys Leu Glu Glu Lys Asn Glu Ile Leu Gln

370 375 380

Gly Lys Leu Ser Gln Leu Glu Glu His Leu Ser Gln Leu Gln Asp Asn

385 390 395 400

Pro Pro Gln Glu Lys Gly Glu Val Leu Gly Asp Val Leu Gln Leu Glu

405 410 415

Thr Leu Lys Gln Glu Ala Ala Thr Leu Ala Ala Asn Asn Thr Gln Leu

420 425 430

Gln Ala Arg Val Glu Met Leu Glu Thr Glu Arg Gly Gln Gln Glu Ala

435 440 445

Lys Leu Leu Ala Glu Arg Gly His Phe Glu Glu Glu Lys Gln Gln Leu

450 455 460

Ser Ser Leu Ile Thr Asp Leu Gln Ser Ser Ile Ser Asn Leu Ser Gln

465 470 475 480

Ala Lys Glu Glu Leu Glu Gln Ala Ser Gln Ala His Gly Ala Arg Leu

485 490 495

Thr Ala Gln Val Ala Ser Leu Thr Ser Glu Leu Thr Thr Leu Asn Ala

500 505 510

Thr Ile Gln Gln Gln Asp Gln Glu Leu Ala Gly Leu Lys Gln Gln Ala

515 520 525

Lys Glu Lys Gln Ala Gln Leu Ala Gln Thr Leu Gln Gln Gln Glu Gln

530 535 540

Ala Ser Gln Gly Leu Arg His Gln Val Glu Gln Leu Ser Ser Ser Leu

545 550 555 560

Lys Gln Lys Glu Gln Gln Leu Lys Glu Val Ala Glu Lys Gln Glu Ala

565 570 575

Thr Arg Gln Asp His Ala Gln Gln Leu Ala Thr Ala Ala Glu Glu Arg

580 585 590

Glu Ala Ser Leu Arg Glu Arg Asp Ala Ala Leu Lys Gln Leu Glu Ala

595 600 605

Leu Glu Lys Glu Lys Ala Ala Lys Leu Glu Ile Leu Gln Gln Gln Leu

610 615 620

Gln Val Ala Asn Glu Ala Arg Asp Ser Ala Gln Thr Ser Val Thr Gln

625 630 635 640

Ala Gln Arg Glu Lys Ala Glu Leu Ser Arg Lys Val Glu Glu Leu Gln

645 650 655

Ala Cys Val Glu Thr Ala Arg Gln Glu Gln His Glu Ala Gln Ala Gln

660 665 670

Val Ala Glu Leu Glu Leu Gln Leu Arg Ser Glu Gln Gln Lys Ala Thr

675 680 685

Glu Lys Glu Arg Val Ala Gln Glu Lys Asp Gln Leu Gln Glu Gln Leu

690 695 700

Gln Ala Leu Lys Glu Ser Leu Lys Val Thr Lys Gly Ser Leu Glu Glu

705 710 715 720

Glu Lys Arg Arg Ala Ala Asp Ala Leu Glu Glu Gln Gln Arg Cys Ile

725 730 735

Ser Glu Leu Lys Ala Glu Thr Arg Ser Leu Val Glu Gln His Lys Arg

740 745 750

Glu Arg Lys Glu Leu Glu Glu Glu Arg Ala Gly Arg Lys Gly Leu Glu

755 760 765

Ala Arg Leu Gln Gln Leu Gly Glu Ala His Gln Ala Glu Thr Glu Val

770 775 780

Leu Arg Arg Glu Leu Ala Glu Ala Met Ala Ala Gln His Thr Ala Glu

785 790 795 800

Ser Glu Cys Glu Gln Leu Val Lys Glu Val Ala Ala Trp Arg Glu Arg

805 810 815

Tyr Glu Asp Ser Gln Gln Glu Glu Ala Gln Tyr Gly Ala Met Phe Gln

820 825 830

Glu Gln Leu Met Thr Leu Lys Glu Glu Cys Glu Lys Ala Arg Gln Glu

835 840 845

Leu Gln Glu Ala Lys Glu Lys Val Ala Gly Ile Glu Ser His Ser Glu

850 855 860

Leu Gln Ile Ser Arg Gln Gln Asn Glu Leu Ala Glu Leu His Ala Asn

865 870 875 880

Leu Ala Arg Ala Leu Gln Gln Val Gln Glu Lys Glu Val Arg Ala Gln

885 890 895

Lys Leu Ala Asp Asp Leu Ser Thr Leu Gln Glu Lys Met Ala Ala Thr

900 905 910

Ser Lys Glu Val Ala Arg Leu Glu Thr Leu Val Arg Lys Ala Gly Glu

915 920 925

Gln Gln Glu Thr Ala Ser Arg Glu Leu Val Lys Glu Pro Ala Arg Ala

930 935 940

Gly Asp Arg Gln Pro Glu Trp Leu Glu Glu Gln Gln Gly Arg Gln Phe

945 950 955 960

Cys Ser Thr Gln Ala Ala Leu Gln Ala Met Glu Arg Glu Ala Glu Gln

965 970 975

Met Gly Asn Glu Leu Glu Arg Leu Arg Ala Ala Leu Met Glu Ser Gln

980 985 990

Gly Gln Gln Gln Glu Glu Arg Gly Gln Gln Glu Arg Glu Val Ala Arg

995 1000 1005

Leu Thr Gln Glu Arg Gly Arg Ala Gln Ala Asp Leu Ala Leu Glu

1010 1015 1020

Lys Ala Ala Arg Ala Glu Leu Glu Met Arg Leu Gln Asn Ala Leu

1025 1030 1035

Asn Glu Gln Arg Val Glu Phe Ala Thr Leu Gln Glu Ala Leu Ala

1040 1045 1050

His Ala Leu Thr Glu Lys Glu Gly Lys Asp Gln Glu Leu Ala Lys

1055 1060 1065

Leu Arg Gly Leu Glu Ala Ala Gln Ile Lys Glu Leu Glu Glu Leu

1070 1075 1080

Arg Gln Thr Val Lys Gln Leu Lys Glu Gln Leu Ala Lys Lys Glu

1085 1090 1095

Lys Glu His Ala Ser Gly Ser Gly Ala Gln Ser Glu Ala Ala Gly

1100 1105 1110

Arg Thr Glu Pro Thr Gly Pro Lys Leu Glu Ala Leu Arg Ala Glu

1115 1120 1125

Val Ser Lys Leu Glu Gln Gln Cys Gln Lys Gln Gln Glu Gln Ala

1130 1135 1140

Asp Ser Leu Glu Arg Ser Leu Glu Ala Glu Arg Ala Ser Arg Ala

1145 1150 1155

Glu Arg Asp Ser Ala Leu Glu Thr Leu Gln Gly Gln Leu Glu Glu

1160 1165 1170

Lys Ala Gln Glu Leu Gly His Ser Gln Ser Ala Leu Ala Ser Ala

1175 1180 1185

Gln Arg Glu Leu Ala Ala Phe Arg Thr Lys Val Gln Asp His Ser

1190 1195 1200

Lys Ala Glu Asp Glu Trp Lys Ala Gln Val Ala Arg Gly Arg Gln

1205 1210 1215

Glu Ala Glu Arg Lys Asn Ser Leu Ile Ser Ser Leu Glu Glu Glu

1220 1225 1230

Val Ser Ile Leu Asn Arg Gln Val Leu Glu Lys Glu Gly Glu Ser

1235 1240 1245

Lys Glu Leu Lys Arg Leu Val Met Ala Glu Ser Glu Lys Ser Gln

1250 1255 1260

Lys Leu Glu Glu Arg Leu Arg Leu Leu Gln Ala Glu Thr Ala Ser

1265 1270 1275

Asn Ser Ala Arg Ala Ala Glu Arg Ser Ser Ala Leu Arg Glu Glu

1280 1285 1290

Val Gln Ser Leu Arg Glu Glu Ala Glu Lys Gln Arg Val Ala Ser

1295 1300 1305

Glu Asn Leu Arg Gln Glu Leu Thr Ser Gln Ala Glu Arg Ala Glu

1310 1315 1320

Glu Leu Gly Gln Glu Leu Lys Ala Trp Gln Glu Lys Phe Phe Gln

1325 1330 1335

Lys Glu Gln Ala Leu Ser Thr Leu Gln Leu Glu His Thr Ser Thr

1340 1345 1350

Gln Ala Leu Val Ser Glu Leu Leu Pro Ala Lys His Leu Cys Gln

1355 1360 1365

Gln Leu Gln Ala Glu Gln Ala Ala Ala Glu Lys Arg His Arg Glu

1370 1375 1380

Glu Leu Glu Gln Ser Lys Gln Ala Ala Gly Gly Leu Arg Ala Glu

1385 1390 1395

Leu Leu Arg Ala Gln Arg Glu Leu Gly Glu Leu Ile Pro Leu Arg

1400 1405 1410

Gln Lys Val Ala Glu Gln Glu Arg Thr Ala Gln Gln Leu Arg Ala

1415 1420 1425

Glu Lys Ala Ser Tyr Ala Glu Gln Leu Ser Met Leu Lys Lys Ala

1430 1435 1440

His Gly Leu Leu Ala Glu Glu Asn Arg Gly Leu Gly Glu Arg Ala

1445 1450 1455

Asn Leu Gly Arg Gln Phe Leu Glu Val Glu Leu Asp Gln Ala Arg

1460 1465 1470

Glu Lys Tyr Val Gln Glu Leu Ala Ala Val Arg Ala Asp Ala Glu

1475 1480 1485

Thr Arg Leu Ala Glu Val Gln Arg Glu Ala Gln Ser Thr Ala Arg

1490 1495 1500

Glu Leu Glu Val Met Thr Ala Lys Tyr Glu Gly Ala Lys Val Lys

1505 1510 1515

Val Leu Glu Glu Arg Gln Arg Phe Gln Glu Glu Arg Gln Lys Leu

1520 1525 1530

Thr Ala Gln Val Glu Gln Leu Glu Val Phe Gln Arg Glu Gln Thr

1535 1540 1545

Lys Gln Val Glu Glu Leu Ser Lys Lys Leu Ala Asp Ser Asp Gln

1550 1555 1560

Ala Ser Lys Val Gln Gln Gln Lys Leu Lys Ala Val Gln Ala Gln

1565 1570 1575

Gly Gly Glu Ser Gln Gln Glu Ala Gln Arg Leu Gln Ala Gln Leu

1580 1585 1590

Asn Glu Leu Gln Ala Gln Leu Ser Gln Lys Glu Gln Ala Ala Glu

1595 1600 1605

His Tyr Lys Leu Gln Met Glu Lys Ala Lys Thr His Tyr Asp Ala

1610 1615 1620

Lys Lys Gln Gln Asn Gln Glu Leu Gln Glu Gln Leu Arg Ser Leu

1625 1630 1635

Glu Gln Leu Gln Lys Glu Asn Lys Glu Leu Arg Ala Glu Ala Glu

1640 1645 1650

Arg Leu Gly His Glu Leu Gln Gln Ala Gly Leu Lys Thr Lys Glu

1655 1660 1665

Ala Glu Gln Thr Cys Arg His Leu Thr Ala Gln Val Arg Ser Leu

1670 1675 1680

Glu Ala Gln Val Ala His Ala Asp Gln Gln Leu Arg Asp Leu Gly

1685 1690 1695

Lys Phe Gln Val Ala Thr Asp Ala Leu Lys Ser Arg Glu Pro Gln

1700 1705 1710

Ala Lys Pro Gln Leu Asp Leu Ser Ile Asp Ser Leu Asp Leu Ser

1715 1720 1725

Cys Glu Glu Gly Thr Pro Leu Ser Ile Thr Ser Lys Leu Pro Arg

1730 1735 1740

Thr Gln Pro Asp Gly Thr Ser Val Pro Gly Glu Pro Ala Ser Pro

1745 1750 1755

Ile Ser Gln Arg Leu Pro Pro Lys Val Glu Ser Leu Glu Ser Leu

1760 1765 1770

Tyr Phe Thr Pro Ile Pro Ala Arg Ser Gln Ala Pro Leu Glu Ser

1775 1780 1785

Ser Leu Asp Ser Leu Gly Asp Val Phe Leu Asp Ser Gly Arg Lys

1790 1795 1800

Thr Arg Ser Ala Arg Arg Arg Thr Thr Gln Ile Ile Asn Ile Thr

1805 1810 1815

Met Thr Lys Lys Leu Asp Val Glu Glu Pro Asp Ser Ala Asn Ser

1820 1825 1830

Ser Phe Tyr Ser Thr Arg Ser Ala Pro Ala Ser Gln Ala Ser Leu

1835 1840 1845

Arg Ala Thr Ser Ser Thr Gln Ser Leu Ala Arg Leu Gly Ser Pro

1850 1855 1860

Asp Tyr Gly Asn Ser Ala Leu Leu Ser Leu Pro Gly Tyr Arg Pro

1865 1870 1875

Thr Thr Arg Ser Ser Ala Arg Arg Ser Gln Ala Gly Val Ser Ser

1880 1885 1890

Gly Ala Pro Pro Gly Arg Asn Ser Phe Tyr Met Gly Thr Cys Gln

1895 1900 1905

Asp Glu Pro Glu Gln Leu Asp Asp Trp Asn Arg Ile Ala Glu Leu

1910 1915 1920

Gln Gln Arg Asn Arg Val Cys Pro Pro His Leu Lys Thr Cys Tyr

1925 1930 1935

Pro Leu Glu Ser Arg Pro Ser Leu Ser Leu Gly Thr Ile Thr Asp

1940 1945 1950

Glu Glu Met Lys Thr Gly Asp Pro Gln Glu Thr Leu Arg Arg Ala

1955 1960 1965

Ser Met Gln Pro Ile Gln Ile Ala Glu Gly Thr Gly Ile Thr Thr

1970 1975 1980

Arg Gln Gln Arg Lys Arg Val Ser Leu Glu Pro His Gln Gly Pro

1985 1990 1995

Gly Thr Pro Glu Ser Lys Lys Ala Thr Ser Cys Phe Pro Arg Pro

2000 2005 2010

Met Thr Pro Arg Asp Arg His Glu Gly Arg Lys Gln Ser Thr Thr

2015 2020 2025

Glu Ala Gln Lys Lys Ala Ala Pro Ala Ser Thr Lys Gln Ala Asp

2030 2035 2040

Arg Arg Gln Ser Met Ala Phe Ser Ile Leu Asn Thr Pro Lys Lys

2045 2050 2055

Leu Gly Asn Ser Leu Leu Arg Arg Gly Ala Ser Lys Lys Ala Leu

2060 2065 2070

Ser Lys Ala Ser Pro Asn Thr Arg Ser Gly Thr Arg Arg Ser Pro

2075 2080 2085

Arg Ile Ala Thr Thr Thr Ala Ser Ala Ala Thr Ala Ala Ala Ile

2090 2095 2100

Gly Ala Thr Pro Arg Ala Lys Gly Lys Ala Lys His

2105 2110 2115

<210> 99

<211> 1357

<212> PRT

<213> 智人(Homo sapiens)

<400> 99

Met Glu Phe Tyr Glu Ser Ala Tyr Phe Ile Val Leu Ile Pro Ser Ile

1 5 10 15

Val Ile Thr Val Ile Phe Leu Phe Phe Trp Leu Phe Met Lys Glu Thr

20 25 30

Leu Tyr Asp Glu Val Leu Ala Lys Gln Lys Arg Glu Gln Lys Leu Ile

35 40 45

Pro Thr Lys Thr Asp Lys Lys Lys Ala Glu Lys Lys Lys Asn Lys Lys

50 55 60

Lys Glu Ile Gln Asn Gly Asn Leu His Glu Ser Asp Ser Glu Ser Val

65 70 75 80

Pro Arg Asp Phe Lys Leu Ser Asp Ala Leu Ala Val Glu Asp Asp Gln

85 90 95

Val Ala Pro Val Pro Leu Asn Val Val Glu Thr Ser Ser Ser Val Arg

100 105 110

Glu Arg Lys Lys Lys Glu Lys Lys Gln Lys Pro Val Leu Glu Glu Gln

115 120 125

Val Ile Lys Glu Ser Asp Ala Ser Lys Ile Pro Gly Lys Lys Val Glu

130 135 140

Pro Val Pro Val Thr Lys Gln Pro Thr Pro Pro Ser Glu Ala Ala Ala

145 150 155 160

Ser Lys Lys Lys Pro Gly Gln Lys Lys Ser Lys Asn Gly Ser Asp Asp

165 170 175

Gln Asp Lys Lys Val Glu Thr Leu Met Val Pro Ser Lys Arg Gln Glu

180 185 190

Ala Leu Pro Leu His Gln Glu Thr Lys Gln Glu Ser Gly Ser Gly Lys

195 200 205

Lys Lys Ala Ser Ser Lys Lys Gln Lys Thr Glu Asn Val Phe Val Asp

210 215 220

Glu Pro Leu Ile His Ala Thr Thr Tyr Ile Pro Leu Met Asp Asn Ala

225 230 235 240

Asp Ser Ser Pro Val Val Asp Lys Arg Glu Val Ile Asp Leu Leu Lys

245 250 255

Pro Asp Gln Val Glu Gly Ile Gln Lys Ser Gly Thr Lys Lys Leu Lys

260 265 270

Thr Glu Thr Asp Lys Glu Asn Ala Glu Val Lys Phe Lys Asp Phe Leu

275 280 285

Leu Ser Leu Lys Thr Met Met Phe Ser Glu Asp Glu Ala Leu Cys Val

290 295 300

Val Asp Leu Leu Lys Glu Lys Ser Gly Val Ile Gln Asp Ala Leu Lys

305 310 315 320

Lys Ser Ser Lys Gly Glu Leu Thr Thr Leu Ile His Gln Leu Gln Glu

325 330 335

Lys Asp Lys Leu Leu Ala Ala Val Lys Glu Asp Ala Ala Ala Thr Lys

340 345 350

Asp Arg Cys Lys Gln Leu Thr Gln Glu Met Met Thr Glu Lys Glu Arg

355 360 365

Ser Asn Val Val Ile Thr Arg Met Lys Asp Arg Ile Gly Thr Leu Glu

370 375 380

Lys Glu His Asn Val Phe Gln Asn Lys Ile His Val Ser Tyr Gln Glu

385 390 395 400

Thr Gln Gln Met Gln Met Lys Phe Gln Gln Val Arg Glu Gln Met Glu

405 410 415

Ala Glu Ile Ala His Leu Lys Gln Glu Asn Gly Ile Leu Arg Asp Ala

420 425 430

Val Ser Asn Thr Thr Asn Gln Leu Glu Ser Lys Gln Ser Ala Glu Leu

435 440 445

Asn Lys Leu Arg Gln Asp Tyr Ala Arg Leu Val Asn Glu Leu Thr Glu

450 455 460

Lys Thr Gly Lys Leu Gln Gln Glu Glu Val Gln Lys Lys Asn Ala Glu

465 470 475 480

Gln Ala Ala Thr Gln Leu Lys Val Gln Leu Gln Glu Ala Glu Arg Arg

485 490 495

Trp Glu Glu Val Gln Ser Tyr Ile Arg Lys Arg Thr Ala Glu His Glu

500 505 510

Ala Ala Gln Gln Asp Leu Gln Ser Lys Phe Val Ala Lys Glu Asn Glu

515 520 525

Val Gln Ser Leu His Ser Lys Leu Thr Asp Thr Leu Val Ser Lys Gln

530 535 540

Gln Leu Glu Gln Arg Leu Met Gln Leu Met Glu Ser Glu Gln Lys Arg

545 550 555 560

Val Asn Lys Glu Glu Ser Leu Gln Met Gln Val Gln Asp Ile Leu Glu

565 570 575

Gln Asn Glu Ala Leu Lys Ala Gln Ile Gln Gln Phe His Ser Gln Ile

580 585 590

Ala Ala Gln Thr Ser Ala Ser Val Leu Ala Glu Glu Leu His Lys Val

595 600 605

Ile Ala Glu Lys Asp Lys Gln Ile Lys Gln Thr Glu Asp Ser Leu Ala

610 615 620

Ser Glu Arg Asp Arg Leu Thr Ser Lys Glu Glu Glu Leu Lys Asp Ile

625 630 635 640

Gln Asn Met Asn Phe Leu Leu Lys Ala Glu Val Gln Lys Leu Gln Ala

645 650 655

Leu Ala Asn Glu Gln Ala Ala Ala Ala His Glu Leu Glu Lys Met Gln

660 665 670

Gln Ser Val Tyr Val Lys Asp Asp Lys Ile Arg Leu Leu Glu Glu Gln

675 680 685

Leu Gln His Glu Ile Ser Asn Lys Met Glu Glu Phe Lys Ile Leu Asn

690 695 700

Asp Gln Asn Lys Ala Leu Lys Ser Glu Val Gln Lys Leu Gln Thr Leu

705 710 715 720

Val Ser Glu Gln Pro Asn Lys Asp Val Val Glu Gln Met Glu Lys Cys

725 730 735

Ile Gln Glu Lys Asp Glu Lys Leu Lys Thr Val Glu Glu Leu Leu Glu

740 745 750

Thr Gly Leu Ile Gln Val Ala Thr Lys Glu Glu Glu Leu Asn Ala Ile

755 760 765

Arg Thr Glu Asn Ser Ser Leu Thr Lys Glu Val Gln Asp Leu Lys Ala

770 775 780

Lys Gln Asn Asp Gln Val Ser Phe Ala Ser Leu Val Glu Glu Leu Lys

785 790 795 800

Lys Val Ile His Glu Lys Asp Gly Lys Ile Lys Ser Val Glu Glu Leu

805 810 815

Leu Glu Ala Glu Leu Leu Lys Val Ala Asn Lys Glu Lys Thr Val Gln

820 825 830

Asp Leu Lys Gln Glu Ile Lys Ala Leu Lys Glu Glu Ile Gly Asn Val

835 840 845

Gln Leu Glu Lys Ala Gln Gln Leu Ser Ile Thr Ser Lys Val Gln Glu

850 855 860

Leu Gln Asn Leu Leu Lys Gly Lys Glu Glu Gln Met Asn Thr Met Lys

865 870 875 880

Ala Val Leu Glu Glu Lys Glu Lys Asp Leu Ala Asn Thr Gly Lys Trp

885 890 895

Leu Gln Asp Leu Gln Glu Glu Asn Glu Ser Leu Lys Ala His Val Gln

900 905 910

Glu Val Ala Gln His Asn Leu Lys Glu Ala Ser Ser Ala Ser Gln Phe

915 920 925

Glu Glu Leu Glu Ile Val Leu Lys Glu Lys Glu Asn Glu Leu Lys Arg

930 935 940

Leu Glu Ala Met Leu Lys Glu Arg Glu Ser Asp Leu Ser Ser Lys Thr

945 950 955 960

Gln Leu Leu Gln Asp Val Gln Asp Glu Asn Lys Leu Phe Lys Ser Gln

965 970 975

Ile Glu Gln Leu Lys Gln Gln Asn Tyr Gln Gln Ala Ser Ser Phe Pro

980 985 990

Pro His Glu Glu Leu Leu Lys Val Ile Ser Glu Arg Glu Lys Glu Ile

995 1000 1005

Ser Gly Leu Trp Asn Glu Leu Asp Ser Leu Lys Asp Ala Val Glu

1010 1015 1020

His Gln Arg Lys Lys Asn Asn Asp Leu Arg Glu Lys Asn Trp Glu

1025 1030 1035

Ala Met Glu Ala Leu Ala Ser Thr Glu Lys Met Leu Gln Asp Lys

1040 1045 1050

Val Asn Lys Thr Ser Lys Glu Arg Gln Gln Gln Val Glu Ala Val

1055 1060 1065

Glu Leu Glu Ala Lys Glu Val Leu Lys Lys Leu Phe Pro Lys Val

1070 1075 1080

Ser Val Pro Ser Asn Leu Ser Tyr Gly Glu Trp Leu His Gly Phe

1085 1090 1095

Glu Lys Lys Ala Lys Glu Cys Met Ala Gly Thr Ser Gly Ser Glu

1100 1105 1110

Glu Val Lys Val Leu Glu His Lys Leu Lys Glu Ala Asp Glu Met

1115 1120 1125

His Thr Leu Leu Gln Leu Glu Cys Glu Lys Tyr Lys Ser Val Leu

1130 1135 1140

Ala Glu Thr Glu Gly Ile Leu Gln Lys Leu Gln Arg Ser Val Glu

1145 1150 1155

Gln Glu Glu Asn Lys Trp Lys Val Lys Val Asp Glu Ser His Lys

1160 1165 1170

Thr Ile Lys Gln Met Gln Ser Ser Phe Thr Ser Ser Glu Gln Glu

1175 1180 1185

Leu Glu Arg Leu Arg Ser Glu Asn Lys Asp Ile Glu Asn Leu Arg

1190 1195 1200

Arg Glu Arg Glu His Leu Glu Met Glu Leu Glu Lys Ala Glu Met

1205 1210 1215

Glu Arg Ser Thr Tyr Val Thr Glu Val Arg Glu Leu Lys Asp Leu

1220 1225 1230

Leu Thr Glu Leu Gln Lys Lys Leu Asp Asp Ser Tyr Ser Glu Ala

1235 1240 1245

Val Arg Gln Asn Glu Glu Leu Asn Leu Leu Lys Ala Gln Leu Asn

1250 1255 1260

Glu Thr Leu Thr Lys Leu Arg Thr Glu Gln Asn Glu Arg Gln Lys

1265 1270 1275

Val Ala Gly Asp Leu His Lys Ala Gln Gln Ser Leu Glu Leu Ile

1280 1285 1290

Gln Ser Lys Ile Val Lys Ala Ala Gly Asp Thr Thr Val Ile Glu

1295 1300 1305

Asn Ser Asp Val Ser Pro Glu Thr Glu Ser Ser Glu Lys Glu Thr

1310 1315 1320

Met Ser Val Ser Leu Asn Gln Thr Val Thr Gln Leu Gln Gln Leu

1325 1330 1335

Leu Gln Ala Val Asn Gln Gln Leu Thr Lys Glu Lys Glu His Tyr

1340 1345 1350

Gln Val Leu Glu

1355

<210> 100

<211> 393

<212> PRT

<213> 智人(Homo sapiens)

<400> 100

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro

1 5 10 15

Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys

20 25 30

Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg

35 40 45

Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His

50 55 60

Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp

65 70 75 80

Val Leu Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr

85 90 95

Lys Val Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln

100 105 110

Leu Lys Arg Arg Gly Arg Glu Met Phe Glu Val Thr Gly Leu His Asp

115 120 125

Val Asp Gln Gly Trp Met Arg Ala Val Arg Lys His Ala Lys Gly Leu

130 135 140

His Ile Val Pro Arg Leu Leu Phe Glu Asp Trp Thr Tyr Asp Asp Phe

145 150 155 160

Arg Asn Val Leu Asp Ser Glu Asp Glu Ile Glu Glu Leu Ser Lys Thr

165 170 175

Val Val Gln Val Ala Lys Asn Gln His Phe Asp Gly Phe Val Val Glu

180 185 190

Val Trp Asn Gln Leu Leu Ser Gln Lys Arg Val Gly Leu Ile His Met

195 200 205

Leu Thr His Leu Ala Glu Ala Leu His Gln Ala Arg Leu Leu Ala Leu

210 215 220

Leu Val Ile Pro Pro Ala Ile Thr Pro Gly Thr Asp Gln Leu Gly Met

225 230 235 240

Phe Thr His Lys Glu Phe Glu Gln Leu Ala Pro Val Leu Asp Gly Phe

245 250 255

Ser Leu Met Thr Tyr Asp Tyr Ser Thr Ala His Gln Pro Gly Pro Asn

260 265 270

Ala Pro Leu Ser Trp Val Arg Ala Cys Val Gln Val Leu Asp Pro Lys

275 280 285

Ser Lys Trp Arg Ser Lys Ile Leu Leu Gly Leu Asn Phe Tyr Gly Met

290 295 300

Asp Tyr Ala Thr Ser Lys Asp Ala Arg Glu Pro Val Val Gly Ala Arg

305 310 315 320

Tyr Ile Gln Thr Leu Lys Asp His Arg Pro Arg Met Val Trp Asp Ser

325 330 335

Gln Ala Ser Glu His Phe Phe Glu Tyr Lys Lys Ser Arg Ser Gly Arg

340 345 350

His Val Val Phe Tyr Pro Thr Leu Lys Ser Leu Gln Val Arg Leu Glu

355 360 365

Leu Ala Arg Glu Leu Gly Val Gly Val Ser Ile Trp Glu Leu Gly Gln

370 375 380

Gly Leu Asp Tyr Phe Tyr Asp Leu Leu

385 390

<210> 101

<211> 493

<212> PRT

<213> 智人(Homo sapiens)

<400> 101

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys

1 5 10 15

Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly

20 25 30

Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys

35 40 45

Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His

50 55 60

Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn

65 70 75 80

Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly

85 90 95

Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val

100 105 110

Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro

115 120 125

Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala

130 135 140

Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala

145 150 155 160

Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu

165 170 175

Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn

180 185 190

Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg

195 200 205

Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys

210 215 220

His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser

225 230 235 240

Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn

245 250 255

Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu

260 265 270

Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp

275 280 285

Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu

290 295 300

Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys

305 310 315 320

Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn

325 330 335

Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn

340 345 350

Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro

355 360 365

Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala

370 375 380

Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile

385 390 395 400

Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr

405 410 415

Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn

420 425 430

Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met

435 440 445

Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp

450 455 460

Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser

465 470 475 480

Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe

485 490

<210> 102

<211> 245

<212> PRT

<213> 智人(Homo sapiens)

<400> 102

Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala

1 5 10 15

Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln

20 25 30

Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr

35 40 45

Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser

50 55 60

Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg

65 70 75 80

Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp

85 90 95

Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala

100 105 110

Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr

115 120 125

Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln

130 135 140

Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met

145 150 155 160

Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val

165 170 175

Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala

180 185 190

Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu

195 200 205

Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn

210 215 220

Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly

225 230 235 240

Glu Gly Gly Glu Asn

245

<210> 103

<211> 334

<212> PRT

<213> 智人(Homo sapiens)

<400> 103

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu

1 5 10 15

Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val

20 25 30

Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu

35 40 45

Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met

50 55 60

Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala

65 70 75 80

Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr

85 90 95

Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln

100 105 110

Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr

115 120 125

Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu

130 135 140

Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile

145 150 155 160

Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala

165 170 175

Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly

180 185 190

Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala

195 200 205

Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp

210 215 220

Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr

225 230 235 240

Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser

245 250 255

Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His

260 265 270

Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val

275 280 285

Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val

290 295 300

Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser

305 310 315 320

Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu

325 330

<210> 104

<211> 298

<212> PRT

<213> 智人(Homo sapiens)

<400> 104

Met Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile

1 5 10 15

Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala Ile Leu

20 25 30

Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr Pro Arg

35 40 45

Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Glu

50 55 60

Glu Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala Pro Leu Gln Gly

65 70 75 80

Gln Leu Val Ala Arg Pro Ser Ser Ile Asn Tyr Met Val Ala Pro Val

85 90 95

Thr Gly Asn Asp Val Gly Ile Arg Arg Ala Glu Ile Lys Gln Gly Ile

100 105 110

Arg Glu Val Ile Leu Cys Lys Asp Gln Asp Gly Lys Ile Gly Leu Arg

115 120 125

Leu Lys Ser Ile Asp Asn Gly Ile Phe Val Gln Leu Val Gln Ala Asn

130 135 140

Ser Pro Ala Ser Leu Val Gly Leu Arg Phe Gly Asp Gln Val Leu Gln

145 150 155 160

Ile Asn Gly Glu Asn Cys Ala Gly Trp Ser Ser Asp Lys Ala His Lys

165 170 175

Val Leu Lys Gln Ala Phe Gly Glu Lys Ile Thr Met Thr Ile Arg Asp

180 185 190

Arg Pro Phe Glu Arg Thr Ile Thr Met His Lys Asp Ser Thr Gly His

195 200 205

Val Gly Phe Ile Phe Lys Asn Gly Lys Ile Thr Ser Ile Val Lys Asp

210 215 220

Ser Ser Ala Ala Arg Asn Gly Leu Leu Thr Glu His Asn Ile Cys Glu

225 230 235 240

Ile Asn Gly Gln Asn Val Ile Gly Leu Lys Asp Ser Gln Ile Ala Asp

245 250 255

Ile Leu Ser Thr Ser Gly Thr Val Val Thr Ile Thr Ile Met Pro Ala

260 265 270

Phe Ile Phe Glu His Ile Ile Lys Arg Met Ala Pro Ser Ile Met Lys

275 280 285

Ser Leu Met Asp His Thr Ile Pro Glu Val

290 295

<210> 105

<211> 2541

<212> PRT

<213> 智人(Homo sapiens)

<400> 105

Met Val Ala Leu Ser Leu Lys Ile Ser Ile Gly Asn Val Val Lys Thr

1 5 10 15

Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg Ile Ile

20 25 30

Arg Glu Arg Ile Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly

35 40 45

Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala

50 55 60

Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu

65 70 75 80

Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly Thr

85 90 95

Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu

100 105 110

Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn His Asp Glu Tyr Ser

115 120 125

Leu Val Arg Glu Leu Met Glu Glu Lys Lys Glu Glu Ile Thr Gly Thr

130 135 140

Leu Arg Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys

145 150 155 160

Leu Lys Gln Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His

165 170 175

Gly Arg Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu

180 185 190

Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp

195 200 205

Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile Leu

210 215 220

Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly

225 230 235 240

Phe Gln Cys Gln Ile Gln Phe Gly Pro His Asn Glu Gln Lys His Lys

245 250 255

Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys

260 265 270

Gln Lys Gly Glu Arg Lys Ile Phe Gln Ala His Lys Asn Cys Gly Gln

275 280 285

Met Ser Glu Ile Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser

290 295 300

Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys

305 310 315 320

Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys

325 330 335

Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu Trp Asn

340 345 350

Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu

355 360 365

Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Thr Thr Glu

370 375 380

Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile Asp Ile Ile Leu

385 390 395 400

Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu

405 410 415

Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu

420 425 430

Gln Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala

435 440 445

Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln

450 455 460

Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly Gln Met

465 470 475 480

His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln Ala Leu Thr

485 490 495

Gly Thr Ile Asn Ser Ser Met Gln Ala Val Gln Ala Ala Gln Ala Thr

500 505 510

Leu Asp Asp Phe Asp Thr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ser

515 520 525

Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu Ile His

530 535 540

Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu

545 550 555 560

Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala

565 570 575

Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys

580 585 590

Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu

595 600 605

Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg

610 615 620

Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg Gln Asn Leu Leu Gln Ala

625 630 635 640

Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly

645 650 655

Glu Ser Asp Thr Asp Pro His Phe Gln Asp Ala Leu Met Gln Leu Ala

660 665 670

Lys Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser

675 680 685

Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala

690 695 700

Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr

705 710 715 720

Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu

725 730 735

Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Glu Gly Cys Val Ser

740 745 750

Ala Ser Gln Ala Ala Thr Glu Asp Gly Gln Leu Leu Arg Gly Val Gly

755 760 765

Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu Leu Gln His

770 775 780

Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln

785 790 795 800

Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met

805 810 815

Gly Asp Ala Gly Glu Met Val Arg Gln Ala Arg Ile Leu Ala Gln Ala

820 825 830

Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly Glu Ser

835 840 845

Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys Ile Leu Ala

850 855 860

Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His

865 870 875 880

Pro Asp Ser Glu Glu Gln Gln Gln Arg Leu Arg Glu Ala Ala Glu Gly

885 890 895

Leu Arg Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys

900 905 910

Leu Val Gln Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala

915 920 925

Thr Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Thr Pro Lys Ala

930 935 940

Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala

945 950 955 960

Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser Gln Ala Gln

965 970 975

Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser

980 985 990

Phe Leu Gln Pro Gly Gly Lys Met Val Ala Ala Ala Lys Ala Ser Val

995 1000 1005

Pro Thr Ile Gln Asp Gln Ala Ser Ala Met Gln Leu Ser Gln Cys

1010 1015 1020

Ala Lys Asn Leu Gly Thr Ala Leu Ala Glu Leu Arg Thr Ala Ala

1025 1030 1035

Gln Lys Ala Gln Glu Ala Cys Gly Pro Leu Glu Met Asp Ser Ala

1040 1045 1050

Leu Ser Val Val Gln Asn Leu Glu Lys Asp Leu Gln Glu Val Lys

1055 1060 1065

Ala Ala Ala Arg Asp Gly Lys Leu Lys Pro Leu Pro Gly Glu Thr

1070 1075 1080

Met Glu Lys Cys Thr Gln Asp Leu Gly Asn Ser Thr Lys Ala Val

1085 1090 1095

Ser Ser Ala Ile Ala Gln Leu Leu Gly Glu Val Ala Gln Gly Asn

1100 1105 1110

Glu Asn Tyr Ala Gly Ile Ala Ala Arg Asp Val Ala Gly Gly Leu

1115 1120 1125

Arg Ser Leu Ala Gln Ala Ala Arg Gly Val Ala Ala Leu Thr Ser

1130 1135 1140

Asp Pro Ala Val Gln Ala Ile Val Leu Asp Thr Ala Ser Asp Val

1145 1150 1155

Leu Asp Lys Ala Ser Ser Leu Ile Glu Glu Ala Lys Lys Ala Ala

1160 1165 1170

Gly His Pro Gly Asp Pro Glu Ser Gln Gln Arg Leu Ala Gln Val

1175 1180 1185

Ala Lys Ala Val Thr Gln Ala Leu Asn Arg Cys Val Ser Cys Leu

1190 1195 1200

Pro Gly Gln Arg Asp Val Asp Asn Ala Leu Arg Ala Val Gly Asp

1205 1210 1215

Ala Ser Lys Arg Leu Leu Ser Asp Ser Leu Pro Pro Ser Thr Gly

1220 1225 1230

Thr Phe Gln Glu Ala Gln Ser Arg Leu Asn Glu Ala Ala Ala Gly

1235 1240 1245

Leu Asn Gln Ala Ala Thr Glu Leu Val Gln Ala Ser Arg Gly Thr

1250 1255 1260

Pro Gln Asp Leu Ala Arg Ala Ser Gly Arg Phe Gly Gln Asp Phe

1265 1270 1275

Ser Thr Phe Leu Glu Ala Gly Val Glu Met Ala Gly Gln Ala Pro

1280 1285 1290

Ser Gln Glu Asp Arg Ala Gln Val Val Ser Asn Leu Lys Gly Ile

1295 1300 1305

Ser Met Ser Ser Ser Lys Leu Leu Leu Ala Ala Lys Ala Leu Ser

1310 1315 1320

Thr Asp Pro Ala Ala Pro Asn Leu Lys Ser Gln Leu Ala Ala Ala

1325 1330 1335

Ala Arg Ala Val Thr Asp Ser Ile Asn Gln Leu Ile Thr Met Cys

1340 1345 1350

Thr Gln Gln Ala Pro Gly Gln Lys Glu Cys Asp Asn Ala Leu Arg

1355 1360 1365

Glu Leu Glu Thr Val Arg Glu Leu Leu Glu Asn Pro Val Gln Pro

1370 1375 1380

Ile Asn Asp Met Ser Tyr Phe Gly Cys Leu Asp Ser Val Met Glu

1385 1390 1395

Asn Ser Lys Val Leu Gly Glu Ala Met Thr Gly Ile Ser Gln Asn

1400 1405 1410

Ala Lys Asn Gly Asn Leu Pro Glu Phe Gly Asp Ala Ile Ser Thr

1415 1420 1425

Ala Ser Lys Ala Leu Cys Gly Phe Thr Glu Ala Ala Ala Gln Ala

1430 1435 1440

Ala Tyr Leu Val Gly Val Ser Asp Pro Asn Ser Gln Ala Gly Gln

1445 1450 1455

Gln Gly Leu Val Glu Pro Thr Gln Phe Ala Arg Ala Asn Gln Ala

1460 1465 1470

Ile Gln Met Ala Cys Gln Ser Leu Gly Glu Pro Gly Cys Thr Gln

1475 1480 1485

Ala Gln Val Leu Ser Ala Ala Thr Ile Val Ala Lys His Thr Ser

1490 1495 1500

Ala Leu Cys Asn Ser Cys Arg Leu Ala Ser Ala Arg Thr Thr Asn

1505 1510 1515

Pro Thr Ala Lys Arg Gln Phe Val Gln Ser Ala Lys Glu Val Ala

1520 1525 1530

Asn Ser Thr Ala Asn Leu Val Lys Thr Ile Lys Ala Leu Asp Gly

1535 1540 1545

Ala Phe Thr Glu Glu Asn Arg Ala Gln Cys Arg Ala Ala Thr Ala

1550 1555 1560

Pro Leu Leu Glu Ala Val Asp Asn Leu Ser Ala Phe Ala Ser Asn

1565 1570 1575

Pro Glu Phe Ser Ser Ile Pro Ala Gln Ile Ser Pro Glu Gly Arg

1580 1585 1590

Ala Ala Met Glu Pro Ile Val Ile Ser Ala Lys Thr Met Leu Glu

1595 1600 1605

Ser Ala Gly Gly Leu Ile Gln Thr Ala Arg Ala Leu Ala Val Asn

1610 1615 1620

Pro Arg Asp Pro Pro Ser Trp Ser Val Leu Ala Gly His Ser Arg

1625 1630 1635

Thr Val Ser Asp Ser Ile Lys Lys Leu Ile Thr Ser Met Arg Asp

1640 1645 1650

Lys Ala Pro Gly Gln Leu Glu Cys Glu Thr Ala Ile Ala Ala Leu

1655 1660 1665

Asn Ser Cys Leu Arg Asp Leu Asp Gln Ala Ser Leu Ala Ala Val

1670 1675 1680

Ser Gln Gln Leu Ala Pro Arg Glu Gly Ile Ser Gln Glu Ala Leu

1685 1690 1695

His Thr Gln Met Leu Thr Ala Val Gln Glu Ile Ser His Leu Ile

1700 1705 1710

Glu Pro Leu Ala Asn Ala Ala Arg Ala Glu Ala Ser Gln Leu Gly

1715 1720 1725

His Lys Val Ser Gln Met Ala Gln Tyr Phe Glu Pro Leu Thr Leu

1730 1735 1740

Ala Ala Val Gly Ala Ala Ser Lys Thr Leu Ser His Pro Gln Gln

1745 1750 1755

Met Ala Leu Leu Asp Gln Thr Lys Thr Leu Ala Glu Ser Ala Leu

1760 1765 1770

Gln Leu Leu Tyr Thr Ala Lys Glu Ala Gly Gly Asn Pro Lys Gln

1775 1780 1785

Ala Ala His Thr Gln Glu Ala Leu Glu Glu Ala Val Gln Met Met

1790 1795 1800

Thr Glu Ala Val Glu Asp Leu Thr Thr Thr Leu Asn Glu Ala Ala

1805 1810 1815

Ser Ala Ala Gly Val Val Gly Gly Met Val Asp Ser Ile Thr Gln

1820 1825 1830

Ala Ile Asn Gln Leu Asp Glu Gly Pro Met Gly Glu Pro Glu Gly

1835 1840 1845

Ser Phe Val Asp Tyr Gln Thr Thr Met Val Arg Thr Ala Lys Ala

1850 1855 1860

Ile Ala Val Thr Val Gln Glu Met Val Thr Lys Ser Asn Thr Ser

1865 1870 1875

Pro Glu Glu Leu Gly Pro Leu Ala Asn Gln Leu Thr Ser Asp Tyr

1880 1885 1890

Gly Arg Leu Ala Ser Glu Ala Lys Pro Ala Ala Val Ala Ala Glu

1895 1900 1905

Asn Glu Glu Ile Gly Ser His Ile Lys His Arg Val Gln Glu Leu

1910 1915 1920

Gly His Gly Cys Ala Ala Leu Val Thr Lys Ala Gly Ala Leu Gln

1925 1930 1935

Cys Ser Pro Ser Asp Ala Tyr Thr Lys Lys Glu Leu Ile Glu Cys

1940 1945 1950

Ala Arg Arg Val Ser Glu Lys Val Ser His Val Leu Ala Ala Leu

1955 1960 1965

Gln Ala Gly Asn Arg Gly Thr Gln Ala Cys Ile Thr Ala Ala Ser

1970 1975 1980

Ala Val Ser Gly Ile Ile Ala Asp Leu Asp Thr Thr Ile Met Phe

1985 1990 1995

Ala Thr Ala Gly Thr Leu Asn Arg Glu Gly Thr Glu Thr Phe Ala

2000 2005 2010

Asp His Arg Glu Gly Ile Leu Lys Thr Ala Lys Val Leu Val Glu

2015 2020 2025

Asp Thr Lys Val Leu Val Gln Asn Ala Ala Gly Ser Gln Glu Lys

2030 2035 2040

Leu Ala Gln Ala Ala Gln Ser Ser Val Ala Thr Ile Thr Arg Leu

2045 2050 2055

Ala Asp Val Val Lys Leu Gly Ala Ala Ser Leu Gly Ala Glu Asp

2060 2065 2070

Pro Glu Thr Gln Val Val Leu Ile Asn Ala Val Lys Asp Val Ala

2075 2080 2085

Lys Ala Leu Gly Asp Leu Ile Ser Ala Thr Lys Ala Ala Ala Gly

2090 2095 2100

Lys Val Gly Asp Asp Pro Ala Val Trp Gln Leu Lys Asn Ser Ala

2105 2110 2115

Lys Val Met Val Thr Asn Val Thr Ser Leu Leu Lys Thr Val Lys

2120 2125 2130

Ala Val Glu Asp Glu Ala Thr Lys Gly Thr Arg Ala Leu Glu Ala

2135 2140 2145

Thr Thr Glu His Ile Arg Gln Glu Leu Ala Val Phe Cys Ser Pro

2150 2155 2160

Glu Pro Pro Ala Lys Thr Ser Thr Pro Glu Asp Phe Ile Arg Met

2165 2170 2175

Thr Lys Gly Ile Thr Met Ala Thr Ala Lys Ala Val Ala Ala Gly

2180 2185 2190

Asn Ser Cys Arg Gln Glu Asp Val Ile Ala Thr Ala Asn Leu Ser

2195 2200 2205

Arg Arg Ala Ile Ala Asp Met Leu Arg Ala Cys Lys Glu Ala Ala

2210 2215 2220

Tyr His Pro Glu Val Ala Pro Asp Val Arg Leu Arg Ala Leu His

2225 2230 2235

Tyr Gly Arg Glu Cys Ala Asn Gly Tyr Leu Glu Leu Leu Asp His

2240 2245 2250

Val Leu Leu Thr Leu Gln Lys Pro Ser Pro Glu Leu Lys Gln Gln

2255 2260 2265

Leu Thr Gly His Ser Lys Arg Val Ala Gly Ser Val Thr Glu Leu

2270 2275 2280

Ile Gln Ala Ala Glu Ala Met Lys Gly Thr Glu Trp Val Asp Pro

2285 2290 2295

Glu Asp Pro Thr Val Ile Ala Glu Asn Glu Leu Leu Gly Ala Ala

2300 2305 2310

Ala Ala Ile Glu Ala Ala Ala Lys Lys Leu Glu Gln Leu Lys Pro

2315 2320 2325

Arg Ala Lys Pro Lys Glu Ala Asp Glu Ser Leu Asn Phe Glu Glu

2330 2335 2340

Gln Ile Leu Glu Ala Ala Lys Ser Ile Ala Ala Ala Thr Ser Ala

2345 2350 2355

Leu Val Lys Ala Ala Ser Ala Ala Gln Arg Glu Leu Val Ala Gln

2360 2365 2370

Gly Lys Val Gly Ala Ile Pro Ala Asn Ala Leu Asp Asp Gly Gln

2375 2380 2385

Trp Ser Gln Gly Leu Ile Ser Ala Ala Arg Met Val Ala Ala Ala

2390 2395 2400

Thr Asn Asn Leu Cys Glu Ala Ala Asn Ala Ala Val Gln Gly His

2405 2410 2415

Ala Ser Gln Glu Lys Leu Ile Ser Ser Ala Lys Gln Val Ala Ala

2420 2425 2430

Ser Thr Ala Gln Leu Leu Val Ala Cys Lys Val Lys Ala Asp Gln

2435 2440 2445

Asp Ser Glu Ala Met Lys Arg Leu Gln Ala Ala Gly Asn Ala Val

2450 2455 2460

Lys Arg Ala Ser Asp Asn Leu Val Lys Ala Ala Gln Lys Ala Ala

2465 2470 2475

Ala Phe Glu Glu Gln Glu Asn Glu Thr Val Val Val Lys Glu Lys

2480 2485 2490

Met Val Gly Gly Ile Ala Gln Ile Ile Ala Ala Gln Glu Glu Met

2495 2500 2505

Leu Arg Lys Glu Arg Glu Leu Glu Glu Ala Arg Lys Lys Leu Ala

2510 2515 2520

Gln Ile Arg Gln Gln Gln Tyr Lys Phe Leu Pro Ser Glu Leu Arg

2525 2530 2535

Asp Glu His

2540

<210> 106

<211> 470

<212> PRT

<213> 智人(Homo sapiens)

<400> 106

Met Ser Gln Ala Tyr Ser Ser Ser Gln Arg Val Ser Ser Tyr Arg Arg

1 5 10 15

Thr Phe Gly Gly Ala Pro Gly Phe Pro Leu Gly Ser Pro Leu Ser Ser

20 25 30

Pro Val Phe Pro Arg Ala Gly Phe Gly Ser Lys Gly Ser Ser Ser Ser

35 40 45

Val Thr Ser Arg Val Tyr Gln Val Ser Arg Thr Ser Gly Gly Ala Gly

50 55 60

Gly Leu Gly Ser Leu Arg Ala Ser Arg Leu Gly Thr Thr Arg Thr Pro

65 70 75 80

Ser Ser Tyr Gly Ala Gly Glu Leu Leu Asp Phe Ser Leu Ala Asp Ala

85 90 95

Val Asn Gln Glu Phe Leu Thr Thr Arg Thr Asn Glu Lys Val Glu Leu

100 105 110

Gln Glu Leu Asn Asp Arg Phe Ala Asn Tyr Ile Glu Lys Val Arg Phe

115 120 125

Leu Glu Gln Gln Asn Ala Ala Leu Ala Ala Glu Val Asn Arg Leu Lys

130 135 140

Gly Arg Glu Pro Thr Arg Val Ala Glu Leu Tyr Glu Glu Glu Leu Arg

145 150 155 160

Glu Leu Arg Arg Gln Val Glu Val Leu Thr Asn Gln Arg Ala Arg Val

165 170 175

Asp Val Glu Arg Asp Asn Leu Leu Asp Asp Leu Gln Arg Leu Lys Ala

180 185 190

Lys Leu Gln Glu Glu Ile Gln Leu Lys Glu Glu Ala Glu Asn Asn Leu

195 200 205

Ala Ala Phe Arg Ala Asp Val Asp Ala Ala Thr Leu Ala Arg Ile Asp

210 215 220

Leu Glu Arg Arg Ile Glu Ser Leu Asn Glu Glu Ile Ala Phe Leu Lys

225 230 235 240

Lys Val His Glu Glu Glu Ile Arg Glu Leu Gln Ala Gln Leu Gln Glu

245 250 255

Gln Gln Val Gln Val Glu Met Asp Met Ser Lys Pro Asp Leu Thr Ala

260 265 270

Ala Leu Arg Asp Ile Arg Ala Gln Tyr Glu Thr Ile Ala Ala Lys Asn

275 280 285

Ile Ser Glu Ala Glu Glu Trp Tyr Lys Ser Lys Val Ser Asp Leu Thr

290 295 300

Gln Ala Ala Asn Lys Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu

305 310 315 320

Met Met Glu Tyr Arg His Gln Ile Gln Ser Tyr Thr Cys Glu Ile Asp

325 330 335

Ala Leu Lys Gly Thr Asn Asp Ser Leu Met Arg Gln Met Arg Glu Leu

340 345 350

Glu Asp Arg Phe Ala Ser Glu Ala Ser Gly Tyr Gln Asp Asn Ile Ala

355 360 365

Arg Leu Glu Glu Glu Ile Arg His Leu Lys Asp Glu Met Ala Arg His

370 375 380

Leu Arg Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Val

385 390 395 400

Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile

405 410 415

Asn Leu Pro Ile Gln Thr Tyr Ser Ala Leu Asn Phe Arg Glu Thr Ser

420 425 430

Pro Glu Gln Arg Gly Ser Glu Val His Thr Lys Lys Thr Val Met Ile

435 440 445

Lys Thr Ile Glu Thr Arg Asp Gly Glu Val Val Ser Glu Ala Thr Gln

450 455 460

Gln Gln His Glu Val Leu

465 470

<210> 107

<211> 770

<212> PRT

<213> 智人(Homo sapiens)

<400> 107

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg

1 5 10 15

Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro

20 25 30

Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln

35 40 45

Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp

50 55 60

Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu

65 70 75 80

Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn

85 90 95

Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val

100 105 110

Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu

115 120 125

Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys

130 135 140

Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu

145 150 155 160

Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile

165 170 175

Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu

180 185 190

Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val

195 200 205

Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys

210 215 220

Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu

225 230 235 240

Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu

245 250 255

Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile

260 265 270

Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg

275 280 285

Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile

290 295 300

Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe

305 310 315 320

Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr

325 330 335

Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr

340 345 350

Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala

355 360 365

Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp

370 375 380

Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala

385 390 395 400

Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala

405 410 415

Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile

420 425 430

Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn

435 440 445

Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met

450 455 460

Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu

465 470 475 480

Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys

485 490 495

Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe

500 505 510

Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser

515 520 525

Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser

530 535 540

Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp

545 550 555 560

Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val

565 570 575

Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala

580 585 590

Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro

595 600 605

Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe

610 615 620

Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val

625 630 635 640

Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser

645 650 655

Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp

660 665 670

Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu

675 680 685

Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly

690 695 700

Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu

705 710 715 720

Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val

725 730 735

Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met

740 745 750

Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met

755 760 765

Gln Asn

770

<210> 108

<211> 895

<212> PRT

<213> 智人(Homo sapiens)

<400> 108

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg

1 5 10 15

Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro

20 25 30

Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala

35 40 45

Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val

50 55 60

Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val

65 70 75 80

Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val

85 90 95

Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser

100 105 110

Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val

115 120 125

His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His

130 135 140

Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp

145 150 155 160

His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu

165 170 175

Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr

180 185 190

Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile

195 200 205

Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn

210 215 220

Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala

225 230 235 240

Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala

245 250 255

Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro

260 265 270

Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala

275 280 285

Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro

290 295 300

Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro

305 310 315 320

Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser

325 330 335

Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu

340 345 350

Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val

355 360 365

Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro

370 375 380

Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln

385 390 395 400

Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val

405 410 415

Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro

420 425 430

Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg

435 440 445

Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr

450 455 460

Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile

465 470 475 480

Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg

485 490 495

Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr

500 505 510

Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp

515 520 525

Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln

530 535 540

Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu

545 550 555 560

Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe

565 570 575

Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu

580 585 590

Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe

595 600 605

Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His

610 615 620

Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg

625 630 635 640

Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val

645 650 655

Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu

660 665 670

Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro

675 680 685

Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser

690 695 700

Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro

705 710 715 720

Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val

725 730 735

Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His

740 745 750

Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly

755 760 765

Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr

770 775 780

Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe

785 790 795 800

Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro

805 810 815

Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro

820 825 830

Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly

835 840 845

Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln

850 855 860

Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro

865 870 875 880

Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro

885 890 895

<210> 109

<211> 23

<212> RNA

<213> 智人(Homo sapiens)

<400> 109

uguaaacauc cuacacucuc agc 23

<210> 110

<211> 104

<212> DNA

<213> 智人(Homo sapiens)

<400> 110

attcttctat agttcatgag catgatgatt gggtgttcat gacatgtgtg agatgtgcca 60

ccctctgaac cttgttccca catcggcaca ttatccatct aacc 104

<210> 111

<211> 20

<212> RNA

<213> 智人(Homo sapiens)

<400> 111

agcccccugg ccccaaaccc 20

<210> 112

<211> 22

<212> RNA

<213> 智人(Homo sapiens)

<400> 112

uuguacaugg uaggcuuuca uu 22

<210> 113

<211> 21

<212> RNA

<213> 智人(Homo sapiens)

<400> 113

ucgaggagcu cacagucuag u 21

<210> 114

<211> 22

<212> RNA

<213> 智人(Homo sapiens)

<400> 114

uguaaacauc cccgacugga ag 22

<210> 115

<211> 22

<212> RNA

<213> 智人(Homo sapiens)

<400> 115

gaaguuguuc gugguggauu cg 22

<210> 116

<211> 22

<212> RNA

<213> 智人(Homo sapiens)

<400> 116

cuuucagucg gauguuugca gc 22

<210> 117

<211> 22

<212> RNA

<213> 智人(Homo sapiens)

<400> 117

ugagguagua guuuguacag uu 22

<210> 118

<211> 22

<212> RNA

<213> 智人(Homo sapiens)

<400> 118

auauaauaca accugcuaag ug 22

<210> 119

<211> 22

<212> RNA

<213> 智人(Homo sapiens)

<400> 119

uagcuuauca gacugauguu ga 22

<210> 120

<211> 22

<212> RNA

<213> 智人(Homo sapiens)

<400> 120

ugagguagua gauuguauag uu 22

<210> 121

<211> 21

<212> RNA

<213> 智人(Homo sapiens)

<400> 121

gcuggucugc guggugcucg g 21

<210> 122

<211> 22

<212> RNA

<213> 智人(Homo sapiens)

<400> 122

uauguaacac gguccacuaa cc 22