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治疗物质滥用相关疾病的方法

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摘要

本发明涉及一种在有需要的患者中预防、治疗或缓解物质滥用相关疾病的方法，该方法包括给予患者有效量的选自式(I)或式(II)的化合物，或其药学上可接受的形式，其中苯基在X上被1－5个选自氟、氯、溴和碘的卤原子取代；以及R1、R2、R3、R4、R5和R6独立选自氢和C1－C4烷基；其中C1－C4烷基任选被苯基取代(且其中苯基任选被独立选自卤素、C1－C4烷基、C1－C4烷氧基、氨基、硝基和氰基的取代基取代)。另外，还包括将本发明化合物与一或多种已知治疗物质滥用相关疾病的化合物共同给药的方法。

著录项

公开/公告号CN101272776A

专利类型发明专利
公开/公告日2008-09-24

原文格式PDF
申请/专利权人詹森药业有限公司;
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申请/专利号CN200580051664.X
发明设计人 C·R·普拉塔-萨拉曼;B·赵;R·E·特怀曼;
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申请日2005-07-26
分类号A61K31/325(20060101);
代理机构72001 中国专利代理(香港)有限公司;
代理人刘冬;段家荣
地址比利时比尔斯
入库时间 2023-12-17 20:53:53

法律信息

法律状态公告日

法律状态信息

法律状态
2018-01-19

专利权的转移 IPC(主分类):A61K31/325 登记生效日:20180102 变更前: 变更后: 申请日:20050726

专利申请权、专利权的转移
2012-10-03

授权

授权
2008-11-19

实质审查的生效

实质审查的生效
2008-09-24

公开

公开

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1. 治疗物质滥用相关疾病的方法 [P] . 中国专利： CN101272776A . 2008-09-24
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机译：肽，规定的肽，成分，药物成分，瓶，消毒溶液，微生物的生长抑制，复制或感染的方法，细菌生长的抑制方法，细菌生长的抑制作用，治疗由微生物感染引起或与之有关的疾病的预防，疾病的抑制方法，一种细菌治疗方法的治疗和一种或多种细菌引起的疾病的治疗感染，预防由细菌感染引起的疾病或与之相关的疾病的方法，在受试者体内抑制病毒复制的方法以及对由细菌引起或与之相关的疾病的治疗在主题中，一种预防由对象中的病毒感染引起或与之相关的疾病的方法，一种用于对INA进行消毒的方法
4. compound, process for preparing a compound, pharmaceutical formulation, use of a compound, methods of treating and / or preventing lipid disorders (dyslipidemia) associated or not with insulin resistance, and atherosclerosis, methods of treatment and / or prophylaxis of cardiovascular disease, hypercholesterolemia, conditions associated with the need to improve reverse cholesterol transport, and to decrease cholesterol absorption in the intestine, to increase HDL cholesterol levels, to lower cholesterol levels. ldl, inflammatory conditions, alzheimer's disease, type 2 diabetes arteriosclerosis, conditions associated with the need to improve hdl function, and pharmaceutical composition [P] . BRPI0412472A . 2006-09-19

机译：化合物，化合物的制备方法，药物制剂，化合物的用途，治疗和/或预防与胰岛素抵抗相关或不相关的脂质疾病（血脂异常）和动脉粥样硬化的方法，心血管疾病，高胆固醇血症的治疗和/或预防方法与需要改善胆固醇逆向转运，减少肠内胆固醇吸收，增加HDL胆固醇水平，降低胆固醇水平相关的疾病。 ldl，炎性疾病，阿尔茨海默氏病，2型糖尿病动脉硬化，与需要改善hdl功能相关的疾病以及药物成分
5. compound, process for preparing a compound, pharmaceutical formulation, use of a compound, methods of treating and / or preventing lipid disorders (dyslipidemia) associated or not with insulin resistance, and atherosclerosis, and methods of treating and / or prophylaxis of cardiovascular disease, hypercholesterolemia, conditions associated with the need to improve reverse cholesterol transport, to decrease cholesterol absorption in the intestine, to increase HDL cholesterol levels, to lower cholesterol levels. ldl, inflammatory conditions, alzheimer's disease, atherosclerosis, type 2 diabetes, and conditions associated with the need to improve hdl function, and pharmaceutical composition [P] . BRPI0412479A . 2006-09-19

机译：化合物，制备化合物的方法，药物制剂，化合物的用途，治疗和/或预防与胰岛素抵抗相关或不相关的脂质疾病（血脂异常）和动脉粥样硬化的方法，以及治疗和/或预防心血管疾病的方法，高胆固醇血症，与需要改善胆固醇逆向转运，减少肠内胆固醇吸收，增加HDL胆固醇水平，降低胆固醇水平相关的疾病。 IDL，炎性疾病，阿尔茨海默氏病，动脉粥样硬化，2型糖尿病以及与需要改善HDL功能相关的疾病以及药物成分