首页> 外文OA文献 >[[alternative]]San Huang Shel Shin Tang β-cyclodextrin complex augmented the hepatoprotective effects against carbon tetrachloride-induced acute hepatotoxicity in rats
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[[alternative]]San Huang Shel Shin Tang β-cyclodextrin complex augmented the hepatoprotective effects against carbon tetrachloride-induced acute hepatotoxicity in rats

机译:[[替代]]三黄Shel Shin Tangβ-环糊精复合物增强对四氯化碳诱导的大鼠急性肝毒性的肝保护作用

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摘要

[[abstract]]BACKGROUND: San Huang Shel Shin Tang (SHSST) is a traditional herbal decoction used as a hepato-protective agent and is composed of Rheum officinale Baill, Scutellaria baicalnsis Geprgi and Coptis chinensis Franch (2:1:1 w/w). Beta-cyclodextrin (beta-CD) modification may potentially increase the solubility and spectral properties of SHSST. METHODS: In this research, the hepato-protective effects of unmodified SHSST, beta-CD modified SHSST complex (SHSSTc) and silymarin were evaluated in carbon tetrachloride (CCl4) induced acute hepatotoxicity in rats. RESULTS: SHHSTc (40 mg/kg/day) and silymarin (100 mg/kg/day) both decreased the CCl4-induced cirrhosis pathway-related transforming growth factor beta (TGF-beta) and apoptosis pathway-related caspase-8 protein expressions, but SHSST (40 mg/kg/day) did not reduce TGF-beta and caspase-8 significantly . Moreover, SHHSTc (40 mg/kg/day) enhanced the activation of insulin-like growth factor 1 receptor (IGF1R) mediated survival pathway than the silymarin (100 mg/kg/day) to protect the liver from damage induced by CCl4. CONCLUSIONS: beta-CD modification promotes hepato-protective effects of SHSST and reduces the required-dosage of the SHSST.
机译:[[摘要]]背景:San Huang Shel Shin Tang(SHSST)是一种传统的中药汤剂,可​​作为保肝剂,由大黄(Rheum officinale Baill),黄cut(Scutellaria baicalnsis Geprgi)和黄连(Coptis chinensis Franch)(2:1:1 w / w)。 β-环糊精(β-CD)修饰可能会增加SHSST的溶解度和光谱特性。方法:在这项研究中,未修饰的SHSST,β-CD修饰的SHSST复合物(SHSSTc)和水飞蓟素在四氯化碳(CCl4)诱导的大鼠急性肝毒性中的肝保护作用进行了评估。结果:SHHSTc(40 mg / kg / day)和水飞蓟素(100 mg / kg / day)均降低了CCl4诱导的肝硬化途径相关的转化生长因子β(TGF-beta)和凋亡途径相关的caspase-8蛋白表达。但是SHSST(40 mg / kg / day)并未显着降低TGF-beta和caspase-8。此外,SHHSTc(40 mg / kg / day)比水飞蓟素(100 mg / kg / day)增强了胰岛素样生长因子1受体(IGF1R)介导的生存途径的激活,从而保护肝脏免受CCl4诱导的损害。结论:β-CD修饰可促进SHSST的肝保护作用,并减少SHSST的所需剂量。

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    Yeh, YL;

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