This thesis explores spin manipulation, fabrication techniques and boundary conditions of electromagnetism to bridge the macroscopic and microscopic worlds of biology, chemistry and electronics. This work is centered around the design of a novel electromagnetic device scalable from centimeters to micrometers called a microslot. By creating a small slot in a planarized waveguide called a microstrip, the boundary conditions of the system force an electromagnetic wave to create a concentrated magnetic field around the slot that can be used to detect or produce magnetic fields. By constructing suitable boundary conditions, a detector of electric fields can be produced as well. One of the most important applications of this technology is for Nuclear Magnetic Resonance (NMR). As demonstrated experimentally in this thesis, microslots improves the mass-limited detectability of NMR by orders of magnitude over conventional technology and may move us closer to the dream of NMR on a chip.
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