首页> 外文OA文献 >EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific Opinion on Flavouring Group Evaluation 213, Revision 2 (FGE.213Rev2): Consideration of genotoxic potential for α,β-unsaturated alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19.
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EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific Opinion on Flavouring Group Evaluation 213, Revision 2 (FGE.213Rev2): Consideration of genotoxic potential for α,β-unsaturated alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19.

机译:EFsa CEF专家组(EFsa食品接触材料,酶,调味剂和加工助剂专家组),2015年。关于调味品组评价的科学意见213,修订版2(FGE.213Rev2):考虑α,β-不饱和脂环族酮的遗传毒性和来自FGE.19的化学亚组2.7的前体。

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摘要

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel) of the European Food Safety Authority (EFSA) was requested to evaluate the genotoxic potential of 26 flavouring substances from subgroup 2.7 of FGE.19 in Flavouring Group Evaluation (FGE) 213. In the first version of FGE.213 the Panel concluded, based on available genotoxicity data, that a concern regarding genotoxicity could be ruled out for 11 substances [FL-nos: 07.047, 07.056, 07.057, 07.075, 07.076, 07.080, 07.117, 07.118, 07.119, 07.120 and 07.168], but for the remaining 15 substances in subgroup 2.7 further genotoxicity data were required. Based on new submitted genotoxicity data, the Panel concluded in FGE.213Rev1 that the concern regarding genotoxicity could be ruled out for 13 substances in subgroup 2.7 [FL-nos: 02.106, 07.008, 07.010, 07.041, 07.083, 07.089, 07.108, 07.109, 07.127, 07.136, 07.200, 07.224 and 09.305] but not for maltol [FL-no: 07.014] and maltyl isobutyrate [FL-no: 09.525]. In FGE.213Rev2, new data on maltol were considered and the Panel concluded that for maltol [FL-no: 07.014] and maltyl isobutyrate [FL-no: 09.525] in food the concern for genotoxicity could be ruled out. Moreover, the Panel reconsidered the available data on p-mentha-1,4(8)-dien-3-one [FL-no: 07.127], based on new data on the structurally related substance pulegone, and concluded that additional genotoxicity data are needed to rule out the concern for genotoxicity of p-mentha-1,4(8)-dien-3-one [FL-no: 07.127].
机译:欧洲食品安全局(EFSA)的食品接触材料,酶,调味剂和加工助剂小组(CEF小组)被要求在调味剂组评估(FGE)中评估FGE.19 2.7亚组中26种调味剂的遗传毒性潜力。 213.在FGE.213的第一个版本中,小组得出结论,根据现有的遗传毒性数据,可以排除对11种物质的遗传毒性的担忧[FL-nos:07.047、07.056、07.057、07.075、07.076、07.080, 07.117、07.118、07.119、07.120和07.168],但对于2.7亚组中的其余15种物质,还需要进一步的遗传毒性数据。根据新提交的遗传毒性数据,专家组在FGE.213Rev1中得出结论,可以排除对亚组2.7中13种物质的遗传毒性关注[FL-nos:02.106,07.008,07.010,07.041,07.083,07.089,07.108,07.109, 07.127、07.136、07.200、07.224和09.305],但不适用于麦芽酚[FL-no:07.014]和麦芽基异丁酸酯[FL-no:09.525]。在FGE.213Rev2中,考虑了关于麦芽酚的新数据,小组得出结论,对于食品中的麦芽酚[FL-no:07.014]和麦芽糖异丁酸酯[FL-no:09.525],可以排除对基因毒性的关注。此外,专家小组根据有关结构相关物质普乐酮的新数据,重新考虑了有关p-mentha-1,4(8)-dien-3-one [FL-no:07.127]的现有数据,并得出结论认为,其他遗传毒性数据需要排除对p-mentha-1,4(8)-dien-3-one [FL-no:07.127]的遗传毒性的关注。

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