PET imaging is a non-invasive technique for particle range verification inproton therapy. It is based on measuring the beta+ annihilations caused bynuclear interactions of the protons in the patient. In this work we presentmeasurements for proton range verification in phantoms, performed at the CNAOparticle therapy treatment center in Pavia, Italy, with our 10 x 10 cm^2 planarPET prototype DoPET. PMMA phantoms were irradiated with mono-energetic protonbeams and clinical treatment plans, and PET data were acquired during andshortly after proton irradiation. We created 1-D profiles of the beta+ activityalong the proton beam-axis, and evaluated the difference between the proximalrise and the distal fall-off position of the activity distribution. A goodagreement with FLUKA Monte Carlo predictions was obtained. We also assessed thesystem response when the PMMA phantom contained an air cavity. The system wasable to detect these cavities quickly after irradiation.
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机译：PET成像是用于质子治疗的粒子范围验证的非侵入性技术。它基于测量患者质子核相互作用引起的β+ ations灭。在这项工作中，我们介绍了用于幻影的质子范围验证的测量方法，该测量方法是在我们意大利帕维亚的CNAO粒子治疗中心使用我们的10 x 10 cm ^ 2 planePET原型DoPET进行的。用单能质子束和临床治疗计划辐照PMMA体模，并在质子辐照期间和之后不久获取PET数据。我们创建了质子束轴沿β+活性的一维分布图，并评估了活性分布的近端上升和远端脱落位置之间的差异。获得了与FLUKA Monte Carlo预测的良好协议。当PMMA幻影包含空气腔时，我们还评估了系统响应。该系统能够在辐射后迅速检测到这些空腔。
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