首页> 外文OA文献 >Protective coatings for intraocular wirelessly controlled microrobots for implantation: Corrosion, cell culture, andin vivoanimal tests
【2h】

Protective coatings for intraocular wirelessly controlled microrobots for implantation: Corrosion, cell culture, andin vivoanimal tests

机译:用于植入的眼内无线微型机器人的保护涂层:腐蚀,细胞培养和体内动物试验

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Diseases in the ocular posterior segment are a leading cause of blindness. The surgical skills required to treat them are at the limits of human manipulation ability, and involve the risk of permanent retinal damage. Instrument tethering and design limit accessibility within the eye. Wireless microrobots suturelessly injected into the posterior segment, steered using magnetic manipulation are proposed for procedures involving implantation. Biocompatibility is a prerequisite for these procedures. This article investigates the use of polypyrrole- and gold-coated cobalt-nickel microrobots. While gold has been used in ocular implants, no ocular implantation involving polypyrrole is reported, despite its well-established biocompatibility properties. Coated and uncoated microrobots were investigated for their corrosion properties, and solutions that had contained coated and uncoated microrobots for one week were tested for cytotoxicity by monitoring NIH3T3 cell viability. None of the microrobots showed significant corrosion currents and corrosion potentials were as expected in relation to the intrinsic nobility of the materials. NIH3T3 cell viability was not affected by the release medium, in which coated/uncoated microrobots were stored. In vivo tests inside rabbit eyes were performed using coated microrobots. There were no significant inflammatory responses during the first week after injection. An inflammatory response detected after 2 weeks was likely due to a lack of longer-duration biocompatibility. The results provide valuable information for those who work on implant technology and biocompatibility. Coated microrobots have the potential to facilitate a new generation of surgical treatments, diagnostics and drug-delivery techniques, when implantation in the ocular posterior segment will be possible.
机译:眼后段的疾病是失明的主要原因。治疗它们所需的外科手术技能是人类操纵能力的极限,并且涉及永久性视网膜损伤的风险。仪器的系留和设计限制了眼睛的可及性。对于涉及植入的程序,提出了使用磁力操纵来无缝合地注入后段的无线微型机器人。生物相容性是这些程序的前提。本文研究了聚吡咯和金涂层钴镍微机器人的使用。尽管金已用于眼植入物,但是尽管其具有良好的生物相容性,也没有报道涉及聚吡咯的眼植入物。研究了涂覆的和未涂覆的微型机器人的腐蚀性能,并通过监测NIH3T3细胞活力来测试包含涂覆和未涂覆的微型机器人一周的溶液的细胞毒性。没有一个微型机器人显示出显着的腐蚀电流,并且腐蚀电位与材料的固有贵族性没有关系。 NIH3T3细胞的生存力不受释放介质的影响,该介质中存储有涂层/未涂层的微型机器人。兔眼内部的体内测试是使用带涂层的微型机器人进行的。注射后第一周没有明显的炎症反应。 2周后检测到炎症反应,可能是由于缺乏较长时间的生物相容性。结果为从事植入技术和生物相容性研究的人员提供了宝贵的信息。当有可能植入眼后段时,带涂层的微型机器人有可能促进新一代的外科治疗,诊断和药物输送技术。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号