Pharmacokinetics of isoniazid and rifampicin in patients with renal failureudundergoing continuous ambulatory peritoneal dialysis (CAPD)udRunning Head : Pharmacokinetic of INH RMP in renal failure (CAPD)

摘要

The pharmacokinetics of isoniazid (INH) and rifampicin (RMP) was determined in 22 renal failure patients, 11 eachudwith low and high membrane permeabilities (LMP and HMP) undergoing Continuous Ambulatory Peritoneal Dialysisud(CAPD). Blood samples were collected at different time points following oral administration of INH and RMP. Estimationsudof INH and RMP in blood were carried out by standard procedures and certain pharmacokinetic variables wereudcalculated based on their concentrations in blood. The INH inactivation status was determined based on salivary levelsudof INH. The pharmacokinetic variables of INH and RMP did not differ significantly between LMP and HMP groups. Theudstudy results suggest that renal failure patients on CAPD may not require reduction in the dosage of RMP or INH in rapidudacetylators. Slow acetylators might require dose reduction of INH. Determination of INH inactivation status is importantudwhen patients with renal failure and tuberculosis are treated with INH-containing regimens.