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Outpatient treatment of acute poisoning by substances of abuse: a prospective observational cohort study

机译:药物滥用引起的急性中毒门诊治疗:一项前瞻性观察性队列研究

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摘要

Background Procedures for the clinical assessment of acute poisoning by substances of abuse should identify patients in need of hospital admission and avoid hazardous discharges, while keeping the observation time short. We assess the safety of a systematic procedure developed at the Oslo Accident and Emergency Outpatient Clinic (OAEOC). Methods All patients 12 years and older treated for acute poisoning by substances of abuse at the OAEOC were included consecutively from October 2011 to September 2012. Data were collected on pre-set registration forms. Information on re-presentations to health services nation-wide during the first week following discharge was retrieved from the Norwegian Patient Register and from local electronic medical records. Information on fatalities was obtained from the Norwegian Cause of Death Registry. Results There were 2343 cases of acute poisoning by substances of abuse. The main toxic agent was ethanol in 1291 (55 %) cases, opioids in 539 (23 %), benzodiazepines in 194 (8 %), central stimulants in 132 (6 %), and gamma-hydroxybutyrate (GHB) in 105 (4 %). Median observation time was four hours. The patient was hospitalised in 391 (17 %) cases. Two patients died during the first week following discharge, both from a new opioid poisoning. Among 1952 discharges, 375 (19 %) patients re-presented at the OAEOC or a hospital within a week; 13 (0.7 %) with a diagnosis missed at the index episode, 169 (9 %) with a new poisoning, 31 (2 %) for follow-up of concomitant conditions diagnosed at index, and 162 (8 %) for unrelated events. Among the patients with missed diagnoses, five needed further treatment for the same poisoning episode, two were admitted with psychosis, one had hemorrhagic gastritis, another had fractures in need of surgery and four had minor injuries. Conclusion The procedure in use at the OAEOC can be considered safe and could be implemented elsewhere. The high re-presentation rate calls for better follow-up.
机译:背景滥用药物对急性中毒进行临床评估的程序应确定需要住院的患者并避免危险出院,同时要缩短观察时间。我们评估在奥斯陆事故和急诊门诊(OAEOC)开发的系统程序的安全性。方法收集2011年10月至2012年9月在OAEOC接受过滥用药物治疗的急性中毒的所有12岁及12岁以上患者的数据。在预先设置的注册表中收集数据。出院后第一周在全国范围内向卫生服务机构重新陈述的信息可从挪威患者登记簿和当地电子病历中获取。有关死亡的信息是从挪威死亡原因登记处获得的。结果共有2343例滥用药物引起的急性中毒。主要毒物是乙醇(1291(55%)),阿片类药物(539(23%),苯二氮卓类(194)(8%),中枢兴奋剂(132)(6%)和γ-羟基丁酸酯(GHB)105(4) %)。中位观察时间为四个小时。该患者入院391(17%)例。出院后第一周有两名患者因新的阿片类药物中毒而死亡。在1952年的出院中,有375名(19%)患者在一周之内再次到OAEOC或医院就诊; 13例(0.7%)在指数发作时被漏诊; 169例(9%)发生新的中毒; 31例(2%)用于对在该指数下诊断出的伴随疾病进行随访; 162例(8%)涉及无关事件。在漏诊的患者中,有5名因相同的中毒事件需要进一步治疗,其中2名因精神病入院,1名患有出血性胃炎,另一名需要手术治疗,4名轻伤。结论在OAEOC上使用的程序可以被认为是安全的,可以在其他地方实施。高的重新陈述率要求更好的跟进。

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