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Verbal and visual learning and memory deficits as trait markers for psychosis in bipolar disorder

机译:言语和视觉学习和记忆缺陷作为双相情感障碍精神病的特征标志

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摘要

The presence of neurocognitive deficits in the affective and psychotic psychiatric disorders (i.e., bipolar disorder with psychotic features, bipolar disorder without psychotic features, and schizophrenia) has been well documented, with such these deficits having been found to overlap across these diagnostic categories to a degree. Along with other types of evidence reported, these findings suggest that bipolar disorder and schizophrenia may not be isolated disorders as suggested by the current diagnostic criteria outlined in the DSM-IV (APA, 1994), but rather may be related disorders on a spectrum marked by bipolar disorder without psychosis on one end and by schizophrenia on the other end, with bipolar disorder with psychosis and schizoaffective disorder occupying the middle of the spectrum, an idea known as the spectrum hypothesis.The purpose of this study was primarily to examine the presence of and, if relevant, severity of verbal and visual learning and memory impairments in individuals with bipolar disorder with and without psychotic features. A secondary purpose of this study was to examine, if present, the severity of these same neurocognitive impairments in individuals with schizophrenia, who were included as a validity check for the expected spectrum of performance across the groups. It was anticipated that impairments would be identified that would not only provide support for the spectrum hypothesis, but would also differentiate between psychiatric disorders with and without psychotic features.
机译:情感和精神病性精神障碍(即具有精神病性特征的双相情感障碍,无精神病性特征的双相情感障碍和精神分裂症)中存在神经认知缺陷,已被充分证明,这些缺陷在这些诊断类别中已重叠到一个学位。连同报道的其他类型的证据一起,这些发现表明,双相情感障碍和精神分裂症可能不是DSM-IV(APA,1994)中概述的当前诊断标准所建议的孤立的疾病,而可能是相关疾病一方面是无精神病的双相情感障碍,另一方面是精神分裂症的精神分裂症,伴有精神病和精神分裂症的双相情感障碍占据了频谱的中间位置,这一思想被称为频谱假说。本研究的目的主要是为了检查存在性。患有和没有精神病特征的双相情感障碍患者的言语和视觉学习与记忆障碍的严重程度(如果有的话)。这项研究的第二个目的是检查精神分裂症患者中这些相同的神经认知障碍的严重程度,这些疾病的严重程度被包括在各组预期表现范围的有效性检查中。可以预见,将识别出损伤,这些损伤不仅会为频谱假设提供支持,而且还会区分具有和不具有精神病特征的精神疾病。

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    Sutton Griffin P;

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  • 年度 2010
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  • 正文语种 English
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