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Mechanisms governing the visco-elastic responses of living cells assessed by foam and tensegrity models

机译:通过泡沫和张力模型评估控制活细胞粘弹性反应的机制

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摘要

The visco-elastic properties of living cells, measured to date by various authors, vary considerably, depending on the experimental methods and/or on the theoretical models used. In the present study, two mechanisms thought to be involved in cellular visco-elastic responses were analysed, based on the idea that the cytoskeleton plays a fundamental role in cellular mechanical responses. For this purpose, the predictions of an open unit-cell model and a 30-element visco-elastic tensegrity model were tested, taking into consideration similar properties of the constitutive F-actin. The quantitative predictions of the time constant and viscosity modulus obtained by both models were compared with previously published experimental data obtained from living cells. The small viscosity modulus values ($10^0-10^3$ pa.s) predicted by the tensegrity model may reflect the combined contributions of the spatially rearranged constitutive filaments and the internal tension to the overall cytoskeleton response to external loading. In contrast, the high viscosity modulus values ($10^3-10^5$ pa.s) predicted by the unit-cell model may rather reflect the mechanical response of the cytoskeleton to the bending of the constitutive filaments and/or to the deformation of internal components. The present results suggest the existence of a close link between the overall visco-elastic response of micromanipulated cells and the underlying architecture.
机译:迄今为止,由不同作者测量的活细胞的粘弹特性,根据实验方法和/或所用理论模型的不同,差别很大。在本研究中,基于细胞骨架在细胞机械反应中起基本作用的想法,分析了两种与细胞粘弹性反应有关的机制。为此,考虑了组成型F-肌动蛋白的相似特性,测试了开放式晶胞模型和30要素粘弹性张力模型的预测。通过两个模型获得的时间常数和粘度模量的定量预测与从活细胞获得的先前发表的实验数据进行了比较。张力模型预测的较小的粘度模量值($ 10 ^ 0-10 ^ 3 $ pa.s)可能反映了空间重排的本构细丝和内部张力对整体细胞骨架对外部负荷反应的综合贡献。相反,由单胞模型预测的高粘度模量值($ 10 ^ 3-10 ^ 5 $ pa.s)可能反映了细胞骨架对构成细丝弯曲和/或变形的机械响应内部组件。目前的结果表明,微观操纵细胞的整体粘弹性反应与基础结构之间存在紧密联系。

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