Chitosan microspheres as drug delivery system have attained importance and attracted the attention of researchers in last few years. This study was aimed toward the elucidation of the effect of viscosity of external oil phase on the properties of microspheres prepared by emulsification method. Chitosan microspheres were prepared utilizing oil phase of different viscosity viz. castor oil, heavy liquid paraffin, light liquid paraffin and mixture of light paraffin, and petroleum ether (1:1 v/v ratio). Microspheres prepared in highly viscous castor oil exhibited an average size of 11.52 ± 0.57 µm with a percentage drug entrapment of 43.12 ± 2.14. On the other hand, very small microspheres of 3.15 ± 0.04 µm and 68.87 ± 1.03% drug entrapment were obtained when mixture of liquid paraffin and petroleum ether was utilized as oil phase. Effect of viscosity on percent mucoadhesion, percent drug entrapment, zeta potential, percent process yield, etc. of microspheres has been observed. In vitro drug release in phosphate buffer pH 7.4 was determined for different batch of microspheres. The results revealed a difference in the drug release pattern of the different microspheres prepared as a function of viscosity of different oil phase. Use of low viscose oil resulted in the formulation of spherical and small size microspheres. This work was a part of our ongoing thrust and project to develop microparticulate drug delivery system.
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机译：近年来，壳聚糖微球作为药物传递系统已变得越来越重要，并引起了研究人员的关注。本研究旨在阐明外相油的粘度对乳化法制备的微球性能的影响。利用不同粘度的油相制备壳聚糖微球。蓖麻油，重质石蜡，轻质石蜡以及轻质石蜡和石油醚的混合物（1：1 v / v比例）。用高粘度蓖麻油制备的微球的平均粒径为11.52±0.57μm，药物截留百分数为43.12±2.14。另一方面，当使用液体石蜡和石油醚的混合物作为油相时，获得了非常小的微球，其微球为3.15±0.04μm和68.87±1.03％的药物截留。已经观察到粘度对微球的粘膜粘附百分数，药物截留百分数，ζ电势，工艺产率百分数等的影响。测定了不同批次微球在磷酸盐缓冲液pH 7.4中的体外药物释放。结果表明，所制备的不同微球的药物释放模式随不同油相的粘度而变化。使用低粘度的油可制成球形和小尺寸的微球。这项工作是我们正在进行的开发微粒药物输送系统的努力和项目的一部分。
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