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Structural alteration in the MYB protooncogene and deletion within the gene encoding alpha-type protein kinase C in human melanoma cell lines.

机译:人类黑素瘤细胞系中MYB原癌基因的结构改变和编码α型蛋白激酶C的基因内的缺失。

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摘要

A correlative study was done to determine possible relationships between nonrandom aberrations in chromosomes 1, 6, and 7 occurring in human cutaneous malignant melanoma and the structure of oncogenes as well as specific genes encoding growth factors and growth factor receptors. Thirty cell lines derived from primary or metastatic melanomas of 28 patients were analyzed by Southern blotting with nick-translated probes for 28 different genes, some of which map near frequent chromosomal breakpoints observed in melanoma. An alteration in the MYB protooncogene was observed in a cell line derived from a primary melanoma in the vertical growth phase, which correlated with a 6q22 chromosomal abnormality. Another primary melanoma cell line had a cytogenetically undetected tumor-specific deletion within the gene for alpha-type protein kinase C. Polymorphic alleles for the genes encoding the epidermal growth factor receptor and alpha-type protein kinase C were also observed.
机译:进行了一项相关研究,以确定人类皮肤恶性黑色素瘤中发生的染色体1、6和7的非随机畸变与癌基因以及编码生长因子和生长因子受体的特定基因的结构之间的可能关系。通过Southern印迹,使用尼克翻译探针分析了28个不同基因的30例源自原发性或转移性黑素瘤的细胞系,分析了28个不同的基因,其中一些定位于在黑素瘤中观察到的频繁染色体断裂点附近。在垂直生长期,在原发性黑色素瘤衍生的细胞系中观察到MYB原癌基因的改变,这与6q22染色体异常相关。另一个原发性黑素瘤细胞系在α型蛋白激酶C的基因内未发现细胞遗传学上的肿瘤特异性缺失。还观察到了编码表皮生长因子受体和α型蛋白激酶C的基因的多态性等位基因。

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