首页> 外文OA文献 >STUDY OF DRAG REDUCING POLYMERS AND MECHANISMS OF THEIR INTRAVASCULAR EFFECT
【2h】

STUDY OF DRAG REDUCING POLYMERS AND MECHANISMS OF THEIR INTRAVASCULAR EFFECT

机译:药物还原聚合物及其血管内作用机理的研究

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Blood-soluble drag reducing polymers (DRPs) have been shown to produce considerable beneficial effects on blood circulation, including an increase in tissue perfusion and tissue oxygenation and a decrease in vascular resistance, when injected in blood at minute concentrations in animal models of normal and especially pathological circulation. DRPs have potential applications in treating tissue hypoperfusion caused by cardiovascular disease, stroke, peripheral vascular disease, diabetes, and other illnesses. To help to translate this novel therapy from the lab bench to the clinic, standard tests need to be developed for characterization and efficacy testing of candidate polymers. Furthermore, elucidation of the mechanisms of the observed DRP effects on blood circulation is extremely important for their future medical applications. Finally, effective, biocompatible and stable polymers which can be easily produced in large quantities must be identified. In this work a sequence of tests was developed to characterize and assess efficacy of DRPs for possible use in treating circulatory disorders. This research study also provided a better understanding of mechanical degradation of DRPs, especially in the presence of blood cells or particles. It was discovered that an increase in particle concentration led to an increase in degradation rate, and that rigid particles caused an even higher degradation rate than deformable red blood cells (RBCs). Microfluidic studies in models of microvessels showed that DRPs prevented RBC movement from the walls of microchannels toward the center and lessened plasma skimming at bifurcations, delivering more RBCs to smaller branches and thus to capillaries. In vivo, this may lead to a reduction of the near-wall plasma layer, which would facilitate gas transport, increase local wall shear stress and promote vasodilation decreasing vascular resistance in microvessels. Three polymers, including an aloe vera derived polysaccharide (AVP), poly(N-vinyl formamide), and hyaluronic acid (HA), were evaluated and characterized as new drag reducers for potential clinical use and found to be very effective. HA and AVP were found to be the most resistant to mechanical degradation of the tested polymers. Finally, relaxation time and gyration radius were found to be the polymer's physical properties which best predicted their drag reducing effectiveness.
机译:在正常和正常动物模型中,当以微小浓度注入血液时,可溶血的减阻聚合物(DRP)已显示出对血液循环产生相当大的有益影响,包括组织灌注和组织氧合增加以及血管阻力降低。特别是病理循环。 DRP在治疗由心血管疾病,中风,周围血管疾病,糖尿病和其他疾病引起的组织灌注不足中具有潜在的应用。为了帮助将这种新疗法从实验室工作台转化为临床工作,需要开发标准测试来表征候选聚合物并进行功效测试。此外,阐明所观察到的DRP对血液循环的作用机理对于其未来的医学应用极为重要。最后,必须确定可以轻松大量生产的有效,生物相容和稳定的聚合物。在这项工作中,开发了一系列测试来表征和评估DRP的功效,以用于治疗循环系统疾病。这项研究还为DRP的机械降解提供了更好的理解,尤其是在存在血细胞或微粒的情况下。发现颗粒浓度的增加导致降解速率的增加,并且刚性颗粒比可变形的红细胞(RBC)导致更高的降解速率。微血管模型中的微流研究表明,DRP阻止了RBC从微通道壁向中心移动,并减少了分叉处的血浆撇除,从而将更多的RBC传递至较小的分支,进而传递至毛细血管。在体内,这可能导致近壁等离子体层的减少,这将有助于气体传输,增加局部壁切应力并促进血管舒张,从而降低微血管中的血管阻力。评估了三种聚合物,包括芦荟衍生的多糖(AVP),聚(N-乙烯基甲酰胺)和透明质酸(HA),并将其表征为可用于临床的新型减阻剂,并被发现非常有效。发现HA和AVP对测试的聚合物的机械降解最有抵抗力。最后,发现松弛时间和回转半径是聚合物的物理性能,最能预测其减阻效果。

著录项

  • 作者

    Marhefka Joie Nicole;

  • 作者单位
  • 年度 2007
  • 总页数
  • 原文格式 PDF
  • 正文语种 en
  • 中图分类

相似文献

  • 外文文献
  • 中文文献
  • 专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号