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RNAi Codex: a portal/database for short-hairpin RNA (shRNA) gene-silencing constructs

机译:RNAi Codex:短发夹RNA(shRNA)基因沉默构建物的门户/数据库

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摘要

Use of RNA interference (RNAi) in forward genetic screens is proliferating. Currently, short-interfering RNAs (siRNAs) and short-hairpin RNAs (shRNAs) are being used to silence genes to tease out functional information. It is becoming easier to harness RNAi to silence specific genes, owing to the development of libraries of readymade shRNA and siRNA gene-silencing constructs by using a variety of sources. RNAi Codex, which consists of a database of shRNA related information and an associated website, has been developed as a portal for publicly available shRNA resources and is accessible at http://codex.cshl.org. RNAi Codex currently holds data from the Hannon-Elledge shRNA library and allows the use of biologist-friendly gene names to access information on shRNA constructs that can silence the gene of interest. It is designed to hold user-contributed annotations and publications for each construct, as and when such data become available. We will describe features of RNAi Codex and explain the use of the tool.
机译:在正向遗传筛选中,RNA干扰(RNAi)的使用正在激增。当前,短干扰RNA(siRNA)和短发夹RNA(shRNA)被用于沉默基因以梳理功能信息。利用现成的shRNA和siRNA基因沉默构建物库的开发,利用多种来源来利用RNAi使特定基因沉默变得越来越容易。 RNAi Codex由shRNA相关信息数据库和相关网站组成,已被开发为公开提供shRNA资源的门户,可从http://codex.cshl.org访问。 RNAi Codex当前持有Hannon-Elledge shRNA库中的数据,并允许使用生物学家友好的基因名称来访问有关可沉默目标基因的shRNA构建体的信息。它设计用于在每种数据可用时保存每个结构的用户贡献的注释和出版物。我们将描述RNAi Codex的功能并解释该工具的使用。

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