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Stimulation of Myofibrillar Protein Synthesis in Hindlimb Suspended Rats by Resistance Exercise and Growth Hormone

机译:抵抗运动和生长激素刺激后肢悬吊大鼠肌原纤维蛋白合成

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摘要

The objective of this study was to determine the ability of a single bout of resistance exercise alone or in combination with recombinant human growth hormone (rhGH) to stimulate myofibrillar protein synthesis (Ks) in hindlimb suspended (HLS) adult female rats. Plantar flexor muscles were stimulated with resistance exercise, consisting of 10 repetitions of ladder climbing on a 1 m grid (85 deg.), carrying an additional 50% of their body weight attached to their tails. Saline or rhGH (1 mg/kg) was administered 30' prior to exercise, and Ks was determined with a constant infusion of H-3-Leucine at 15', 60', 180', and 360' following exercise. Three days of HLS depressed Ks is approx. equal to 65% and 30-40% in the soleus and gastrocnemius muscles, respectively (p is less than or equal to 0.05). Exercise increased soleus Ks in saline-treated rats 149% 60' following exercise (p less than or equal to 0.05), decaying to that of non-exercised animals during the next 5 hours. Relative to suspended, non-exercised rats rhGH + exercise increased soleus Ks 84%, 108%, and 72% at 15', 60' and 360' following exercise (p is less than or equal to 0.05). Gastrocnemius Ks was not significantly increased by exercise or the combination of rhGH and exercise up to 360' post-exercise. Results from this study indicate that resistance exercise stimulated Ks 60' post-exercise in the soleus of HLS rats, with no apparent effect of rhGH to enhance or prolong exercise-induced stimulation. Results suggests that exercise frequency may be important to maintenance of the slow-twitch soleus during non-weightbearing, but that the ability of resistance exercise to maintain myofibrillar protein content in the gastrocnemius of hindlimb suspended rats cannot be explained by acute stimulation of synthesis.
机译:这项研究的目的是确定单次抵抗运动或与重组人生长激素(rhGH)联合刺激后肢悬吊(HLS)成年雌性大鼠肌原纤维蛋白合成(Ks)的能力。用阻力运动刺激屈肌,该运动包括在1 m的网格(85度)上进行10次重复的梯子爬升,其体重的50%附加在尾巴上。在运动前30'给予生理盐水或rhGH(1 mg / kg),并在运动后15',60',180'和360'持续注入H-3-亮氨酸确定Ks。三天的HLS压低Ks约为。在比目鱼肌和腓肠肌中分别等于65%和30-40%(p小于或等于0.05)。运动后,在接受盐水处理的大鼠中,比目鱼Ks升高149%(60%)(p小于或等于0.05),在接下来的5小时内衰减至非运动动物。相对于悬挂的非运动大鼠rhGH +运动,在运动后15',60'和360'时,比目鱼肌Ks分别增加84%,108%和72%(p小于或等于0.05)。运动或rhGH和运动后直至运动达360'时,腓肠肌Ks没有明显增加。这项研究的结果表明,抵抗运动刺激了HLS大鼠比目鱼的Ks 60'运动,而rhGH并未明显增强或延长运动诱发的刺激。结果表明,运动频率对于非负重期间慢肌比目鱼的维持可能很重要,但是抵抗运动维持后肢悬吊大鼠腓肠肌肌原纤维蛋白含量的能力不能用合成的急性刺激来解释。

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