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Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for Cancer Nanomedicine

机译:杂化有机-无机桥联倍半硅氧烷纳米颗粒用于癌症纳米医学

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摘要

It is well established that cancer is one of the leading causes of death globally. Its complete eradication requires early detection and intensive drug treatment. In many cases it might also require surgery. Unfortunately, current medicine is still more focused on cancer treatment rather than elimination of its reason. The mechanism of tumor emergence and development is quite complicated, although, we are constantly advancing in this field. Nanomedicine is envisioned as the silver bullet against cancer. Thus, nanoscale systems with therapeutic and diagnostic modalities can simultaneously perform several functions: accurate detection of tumor site, precise targeting, and controlled drug release inside abnormal cells and tissues while being nontoxic to healthy ones. Moreover, surface modification of such nanoparticles allows them to be invisible to the immune system and have longer blood circulating time. The performed research in this dissertation is completely based on hybrid organicinorganic bridged silsesquioxane (also known as organosilica) nanomaterials, therefore comprising "soft" organic/bioorganic part which can imitate certain biorelevant structures and facilitates successful escape from the immune system for more efficient accumulation in cancer cells, while "hard" inorganic part serves as a rigid and stable basis for the creation of cargo nanocarriers and imaging agents. This dissertation discusses the 5 critical points of safe biodegradable nanoplatforms, delivery of large biomolecules, and cytotoxicity regarding the shape of nanoparticles. As a result novel fluorescent biodegradable oxamide-based organosilica nanoparticles were developed, light-triggered surface charge reversal for large biomolecule delivery was applied with hollow bridged silsesquioxane nanomaterials, and biocompatibility of periodic mesoporous organosilicas with different morphologies was studied. Furthermore, the current achievements and future perspectives of mesoporous silica organosilica, and silsesquioxane nanoparticles were considered in regards to their biomedical applications and summarized in two reviews.
机译:众所周知,癌症是全球死亡的主要原因之一。彻底根除它需要及早发现和加强药物治疗。在许多情况下,可能还需要手术。不幸的是,当前的医学仍然更多地集中在癌症治疗上,而不是消除其原因。尽管我们在该领域不断发展,但是肿瘤的发生和发展机制却相当复杂。纳米医学被认为是抗癌的灵丹妙药。因此,具有治疗和诊断方式的纳米级系统可以同时执行多种功能:精确检测肿瘤部位,精确靶向以及控制异常细胞和组织内的药物释放,同时对健康细胞和组织无毒。此外,此类纳米颗粒的表面修饰使它们对免疫系统不可见,并具有更长的血液循环时间。本论文所进行的研究完全基于杂化有机-无机桥联倍半硅氧烷(也称为有机硅)纳米材料,因此包含“软”有机/生物有机部分,可模仿某些生物相关结构并有助于成功逃离免疫系统,从而在体内更有效地积累癌细胞,而“硬”无机部分则是产生货物纳米载体和显像剂的刚性和稳定基础。本文讨论了安全,可生物降解的纳米平台,大生物分子的传递以及关于纳米粒子形状的细胞毒性的五个关键点。结果,开发了新型的基于荧光的可生物降解的基于乙酰胺的有机硅纳米粒子,将光触发的表面电荷反转用于大型生物分子的传递与中空桥接倍半硅氧烷纳米材料一起使用,并研究了具有不同形态的周期性介孔有机硅的生物相容性。此外,考虑了中孔二氧化硅有机二氧化硅和倍半硅氧烷纳米粒子的当前成就和未来前景,并就其生物医学应用进行了综述,并在两项综述中进行了总结。

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    Fatieiev Yevhen;

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  • 年度 2017
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