The wet granulation process is sensitive to changes in product properties and process variables. The optimaludprocess and formulation are based on the knowledge of the granule growth mechanisms and of the effects ofudproduct properties and process variables. This paper presents the study of wet granulation of microcrystallineudcellulose powder, MCC (Avicel PH101) using high-shear mixer granulator. It aims at understanding the effect of operating parameters (impeller rotational speed, liquid binder flow ate) and of physicochemical properties (viscosity, wettability) of a binder solution on solid particles surfaces, on the agglomeration kinetics. The experiments are carried out with water, aqueous solutions of sodium carboxymethylcellulose, polyvinylpyrrolidone, hydroxypropylméthylcellulose or a non ionic surfactant oxo-C10C6 at a critical micellar concentration.udConcerning the process variables the experimental results show that an optimal interval of impeller speedudoperation exists ranging from 150 to 200 rpm for granule growth. Below, an uncontrollable agglomerate sizeudand localised over-wetting occur, and above granule breakage occurs. Increasing the liquid binder flow rateudreduces the extension of the non growth regime, but does not affect the granule mean size.udThe effect of the physicochemical properties is evaluated using a modified capillary viscous number, Ca′, thatudwe define as the ratio between the viscous forces (μLU) and the work of adhesion Wa=γL(1+cosθ). For Ca′b1, the viscosity of the solution does not significantly affect the granulation process. The dominant forces in theudgranulation process are the interfacial forces since increasing the work of adhesion enhances the growthudkinetics. For Ca′N1.6, the viscous forces predominate and control the granule growth.
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