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Model Systems of Human Intestinal Flora, to SetudAcceptable Daily Intakes of Antimicrobial Residuesud

机译:人体肠道菌群模型系统抗菌素残留的每日可接受摄入量 ud

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摘要

The veterinary use of antimicrobial drugs in food producing animals may result in residues in food, that might modify the consumer gut flora. This review compares three model systems that maintain a complex flora of human origin: (i) human flora associated (HFA) continuous flow cultures in chemostats, (ii) HFA mice, and (iii) human volunteers. The "No Microbial Effect Level" of an antibiotic on human flora, measured in one of these models, is used to set the accept¬able daily intake (ADI) for human consumers. Human volunteers trials are most relevant to set microbio¬log¬ical ADI, and may be considered as the "gold standard". However, human trials are very expensive and unethical. HFA chemostats are controlled systems, but tetracycline ADI calculated from a chemostat study is far above result of a human study. HFA mice studies are less expensive and better controlled than human trials. The tetracycline ADI derived from HFA mice studies is close to the ADI directly obtained in human volunteers.
机译:在生产食物的动物中兽药的兽药使用可能会导致食物中残留,从而可能改变食用者肠道菌群。这篇综述比较了维持人类起源的复杂菌群的三种模型系统:(i)在恒化器中的人类菌群相关(HFA)连续流培养,(ii)HFA小鼠和(iii)人类志愿者。在这些模型之一中测得的抗生素对人类菌群的“无微生物作用水平”用于设定人类消费者的每日可接受摄入量(ADI)。人类志愿者试验与设定微生物ADI最相关,可以认为是“金标准”。但是,人体试验非常昂贵且不道德。 HFA恒温器是受控系统,但是根据恒温器研究计算出的四环素ADI远远超出了人类研究的结果。与人类试验相比,HFA小鼠研究更便宜且可得到更好的控制。来自HFA小鼠研究的四环素ADI接近于人类志愿者直接获得的ADI。

著录项

  • 作者

    Corpet Denis E.;

  • 作者单位
  • 年度 2000
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  • 原文格式 PDF
  • 正文语种 {"code":"en","name":"English","id":9}
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