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Upotreba N,N-dietil-p-fenilenediamin sulfata za spektrofotometrijsko određivanje lijekova iz skupine fenola i amina

机译:N,N-二乙基对苯二胺硫酸盐在分光光度法测定酚和胺类药物中的用途

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摘要

Spectrophotometric methods are proposed for the determination of drugs containing a phenol group salbutamol sulphate (SLB), ritodrine hydrochloride (RTD), isoxsuprine hydrochloride (IXP) and drugs containing an aromatic amine group dapsone hydrochloride (DAP), sulfamethoxazole (SFM) and sulfadiazine (SFD) in pharmaceutical dosage forms. The methods are based on coupling of N,N-diethyl-p-phenylenediamine sulphate with the drugs in the presence of KIO4 to give a green colored product (λmax at 670 nm) and a red colored product (λmax at 550 nm), respectively. Linear relationships with good correlation coefficients (0.99860.9996) were found between absorbance and the corresponding concentration of drugs in the range 17, 222, 117, 1.512, 225, and 221 μg mL1 for SLB, RTD, IXP, DAP, SFM and SFD, respectively. Variable parameters such as temperature, reaction time and concentration of the reactants were analyzed and optimized. The RSD of intra-day and inter-day studies was in the range of 0.21.0 and 0.41.0 %, respectively. No interference was observed from common pharmaceutical adjuvants. The reliability and performance of the proposed methods was validated statistically; percentage recovery ranged from 99.5 ± 0.1 to 99.9 ± 0.3 %. Limits of detection were 0.14, 0.21, 0.51, 0.44, 0.33 and 0.37 µg mL1 for SLB, RTD, IXP, DAP, SFM, and SFD, respectively.
机译:提出了分光光度法测定含有硫酸沙丁胺醇(SLB),盐酸利托君碱(RTD),异苏普林(IXP)的酚基团和含有芳香胺基盐酸氨苯砜(DAP),磺胺甲恶唑(SFM)的药物的测定方法和磺胺嘧啶(SFD)的药物剂型。该方法基于在KIO4存在下将N,N-二乙基-对苯二胺硫酸盐与药物偶联,分别得到绿色产物(λmax在670 nm)和红色产物(λmax在550 nm)。 。吸光度与相应浓度的药物在17、222、117、1.512、225和221μgmL之间发现具有良好相关系数(0.99860.9996)的线性关系SL1分别表示SLB,RTD,IXP,DAP,SFM和SFD。分析和优化了可变参数,例如温度,反应时间和反应物浓度。日内和日间研究的相对标准偏差分别为0.2%1.0%和0.4%1.0%。没有观察到来自普通药物佐剂的干扰。统计方法验证了所提方法的可靠性和性能。回收率百分比范围从99.5±0.1到99.9±0.3%。 SLB,RTD,IXP,DAP,SFM和SFD的检出限分别为0.14、0.21、0.51、0.44、0.33和0.37 µgmL1。

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