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A Phenomenological Epidemic Model Based On the Spatio-Temporal Evolution of a Gaussian Probability Density Function

机译:一种基于高斯概率密度函数的时空演化的现象学疫情模型

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摘要

A novel phenomenological epidemic model is proposed to characterize the state of infectious diseases and predict their behaviors. This model is given by a new stochastic partial differential equation that is derived from foundations of statistical physics. The analytical solution of this equation describes the spatio-temporal evolution of a Gaussian probability density function. Our proposal can be applied to several epidemic variables such as infected, deaths, or admitted-to-the-Intensive Care Unit (ICU). To measure model performance, we quantify the error of the model fit to real time-series datasets and generate forecasts for all the phases of the COVID-19, Ebola, and Zika epidemics. All parameters and model uncertainties are numerically quantified. The new model is compared with other phenomenological models such as Logistic Grow, Original, and Generalized Richards Growth models. When the models are used to describe epidemic trajectories that register infected individuals, this comparison shows that the median RMSE error and standard deviation of the residuals of the new model fit to the data are lower than the best of these growing models by, on average, 19.6% and 35.7%, respectively. Using three forecasting experiments for the COVID-19 outbreak, the median RMSE error and standard deviation of residuals are improved by the performance of our model, on average by 31.0% and 27.9%, respectively, concerning the best performance of the growth models.
机译:提出了一种新颖的现象学疫情模型,以表征传染病状态并预测其行为。该模型由新的随机偏微分方程给出,该方程来自统计物理学的基础。该等式的分析解决方案描述了高斯概率密度函数的时空演变。我们的提案可以应用于几种流行病变量,如受感染,死亡或被录取的重症监护室(ICU)。为了测量模型性能,我们量化模型适合的模型的错误,并为Covid-19,Ebola和Zika流行病的所有阶段生成预测。所有参数和模型不确定性都是数值量化的。将新模型与其他现象学模型进行比较,如逻辑生长,原始和广义理查兹生长模型。当模型用于描述注册受感染的个体的流行病轨迹时,这种比较表明,新模型的RMSE误差和标准偏差适合数据的残差低于这些生长模型的最佳,平均而言,分别为19.6%和35.7%。利用三个预测实验对Covid-19爆发,通过我们模型的性能,平均持续31.0%和27.9%的中位数RMSE误差和残差的标准偏差分别提高了增长模型的最佳性能。

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