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Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance

机译：使用Cynomolgus猴预测有机阴离子输送多肽基材的人类清除：在肝摄取间隙的体外体内缩放

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Tom De Bruyn; Ayşe Ufuk; Carina Cantrill; Rachel E. Kosa; Yi-an Bi; Mark Niosi; Sweta Modi; A. David Rodrigues; Larry M. Tremaine; Manthena V. S. Varma; Aleksandra Galetin; J. Brian Houston;
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1. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance [J] . De Bruyn Tom, Ufuk Ayse, Cantrill Carina, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2018,第7期

机译：使用Cynomolgus猴预测有机阴离子输送多肽基质的人类清除：在肝摄取间隙的体外缩放
2. Hepatic Organic Anion Transporting Polypeptide-Mediated Clearance in the Beagle Dog: Assessing In Vitro-In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance [J] . Matsunaga Norikazu, Ufuk Ayse, Morse Bridget L., Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2019,第3期

机译：肝脏有机阴离子运输多肽介导的比格犬介导的间隙：在体外关系中评估跨物种实证缩放因子，提高人类清关预测
3. The Phenomenon of Albumin-Mediated Hepatic Uptake of Organic Anion Transport Polypeptide Substrates: Prediction of the In Vivo Uptake Clearance from the In Vitro Uptake by Isolated Hepatocytes Using a Facilitated-Dissociation Model [J] . Miyauchi Seiji, Masuda Masayuki, Kim Soo-Jin, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2018,第3期

机译：白蛋白介导的有机阴离子输送多肽基材的肝脏吸收的现象：使用促进解离模型预测来自分离的肝细胞的体外吸收的体内摄取清除
4. Agent-Based Simulation of In Vitro Hepatic Drug Metabolism: In Silico Hepatic Intrinsic Clearance [C] . Shahab Sheikh-Bahaei, Glen E. P. Ropella, C. Anthony Hunt Spring Simulation Multiconference and Business and Industry Symposium(BIS'05);Agent-Directed Simulation Symposium; 20050403-07;20050403-07; San Diego,CA(US);San Diego,CA(US) . 2005

机译：基于Agent的体外肝药物代谢模拟：硅胶肝内在清除率
5. Dietary effects on drug metabolism and transport: Effect of peppermint oil, St. John's Wort, and fruit juices on cytochrome P450 3A4, P-glycoprotein, and organic anion transporting polypeptides in vitro and in humans [D] . Dresser, George K. 2004

机译：饮食对药物代谢和转运的影响：薄荷油，圣约翰草和果汁对体外和人体中细胞色素P450 3A4，P-糖蛋白和有机阴离子转运多肽的影响
6. Contribution of hepatic organic anion transporting polypeptides (OATPs) to docetaxel uptake and clearance [O] . Hannah H. Lee, Brenda F. Leake, Wendy Teft, -1

机译：肝有机阴离子转运多肽（OATP）对多西他赛摄取和清除的贡献
7. Hepatic Organic Anion Transporting Polypeptide–Mediated Clearance in the Beagle Dog: Assessing In Vitro–In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance [O] . Norikazu Matsunaga, Ayşe Ufuk, Bridget L. Morse, 2018

机译：肝脏有机阴离子在比格犬中运输多肽介导的间隙：在体外关系中评估跨物种实证缩放因子，提高人类清关预测

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance

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