methods for modulating cell uptake and / or clearance, for modulating antigen recognition, processing and / or presentation of cell-derived material, for modulating an immune response to cell-derived material, for detecting a cell with a cell membrane disrupted, a cell infected with a pathogen, an agonizing cell or a dead cell, to diagnose, predict and / or monitor the condition of a disease, to monitor therapy, to identify a ligand of a polypeptide, to distinguish between an apoptotic cell and an end-stage apoptotic cell, necrotic cell or dead cell and to modulate an immune response to an antigen in an individual, and use of a compound

摘要

The present invention relates to methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, which can be used to treat and/or prevent diseases such as cancer, autoimmunity and infections. The present invention also relates to methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof. The present invention further relates to methods of detecting cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof.