Recent advances in computational modeling of fibrin clot formation: A review

摘要

The study of thrombosis is crucial to understand and develop new therapiesfor diseases like deep vein thrombosis, diabetes related strokes, pulmonaryembolism etc. The last two decades have seen an exponential growth in studiesrelated to the blood clot formation using computational tools and throughexperiments. Despite of this growth, the complete mechanism behind thrombusformation and hemostasis is not known yet. The computational models and methodsused in this context are diversified into different spatiotemporal scales, yetthere is no single model which can predict both physiological and mechanicalproperties of the blood clots. In this review, we will attempt to list out allmajor strategies attempted by researchers so far to model the blood clotformation using existing computational techniques. This review classifies theminto continuum level, system level, discrete particles and multi-scale methods.We will also discuss the strength and weakness of various methods and possiblefuture directions in which the computational blood clot research can thrive.