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Potential BSE risk posed by the use of ruminant collagen and gelatine in feed for non‐ruminant farmed animals

机译:在非反刍动物养殖动物饲料中使用反刍动物胶原蛋白和明胶的潜在BSE风险

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摘要

Abstract EFSA was requested to estimate the cattle bovine spongiform encephalopathy (BSE) risk (C‐, L‐ and H‐BSE) posed by ruminant collagen and gelatine produced from raw material fit for human consumption, or from material classified as Category 3 animal by‐products (ABP), to be used in feed intended for non‐ruminant animals, including aquaculture animals. Three risk pathways (RP) were identified by which cattle could be exposed to ruminant feed cross‐contaminated with ruminant collagen or gelatine: 1) recycled former foodstuffs produced in accordance with Regulation (EC) No 853/2004 (RP1), 2) technological or nutritional additives or 3) compound feed, produced either in accordance with Regulation (EC) No 853/2004 (RP2a) or Regulation (EU) No 142/2011 (RP2b). A probabilistic model was developed to estimate the BSE infectivity load measured in cattle oral ID50 (CoID50)/kg, in the gelatine produced from the bones and hide of one infected animal older than 30 months with clinical BSE (worst‐case scenario). The amount of BSE infectivity (50th percentile estimate) in a member state (MS) with negligible risk status was 7.6 × 10–2 CoID50/kg, and 3.1 × 10–4 CoID50/kg in a MS with controlled risk status. The assessment considered the potential contamination pathways and the model results (including uncertainties) regarding the current epidemiological situation in the EU and current statutory controls. Given the estimated amount of BSE infectivity to which cattle would be exposed in a single year, and even if all the estimated undetected BSE cases in the EU were used for the production of collagen or gelatine (either using raw materials fit for human consumption or Category 3 ABP raw materials), it was concluded that the probability that no new case of BSE in the cattle population would be generated through any of the three RP is 99–100% (almost certain).
机译:摘要要求EFSA估计由反刍动物胶原蛋白和由原料贴合的反刍动物胶原蛋白和凝胶的牛牛海绵状脑病(BSE)风险(C-,L-和H-BSE),或由归类为3类动物的材料 - 用于用于非反刍动物的饲料的产品(ABP),包括水产养殖动物。鉴定了三种风险途径(RP),通过该牛可能会暴露于用反刍动物胶原或明胶的反刍动物饲料,如反刍动物胶原或明胶:1)根据调节(EC)NO 853/2004(RP1),2)技术产生的再生前食品或营养添加剂或3)复合饲料,根据调节(EC)NO 853/2004(RP2A)或调节(EU)NO 142/2011(RP2B)。开发了一种概率模型,以估算牛口服ID50(CoID50)/ kg中测量的BSE感染载荷,在骨骼生产的明胶中,并用临床BSE(最差情况)的30个月内的一个感染动物的隐藏。具有可忽略的风险状态的成员国(MS)中的BSE感染性(50百分位数)的量为7.6×10-2 CoID50 / kg,3.1×10-4 CoID50 / kg,MS中有受控风险状态。评估审议了潜在的污染途径和模型结果(包括不确定性)关于欧盟目前的流行病学情况和现行法定管制。鉴于牛的估计数量的牛在一年内暴露,甚至欧盟的所有估计未检测到的BSE病例用于生产胶原蛋白或明胶(使用适合人类消费或类别的原料3 ABP原料),它的结论是,在牛群中没有新的BSE案例的可能性将通过三个RP中的任何一个产生99-100%(几乎某些)。

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